• The Journal of Korean Obstetrics and Gynecology
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• v.27 no.1
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• pp.167-175
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• 2014

Purpose: This study was performed to find correlations between Edema Index and Pulse Energy in early postpartum period. Methods: Fiftynine postpartum women were participated in this study which was conducted with Inbody 720 (Biospace Co. Ltd) and 3D Blood Pressure Pulse Analyzer (3D-MAC). Edema Index (Extra Cellular Water/Total Body Water) calculated after body composition analysis and 3D-MAC result (Pulse Energy) were analysed within a week after delivery. Results: The results were as follows 1. Edema Indexes of the upper, lower limbs, trunk and whole body were associated with each other respectively. 2. Edema Indexes and Right Kwan pulse energy had significant positive correlation. 3. Right Kwan pulse energy showed positive correlations with Left Kwan, Right Chon, Right Cheok. Conclusions: Viscera associated with Postpartum Edema are Spleen, Lung, Liver and Vital Gate. The most important thing is thought to be Spleen.

• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.3
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• pp.179-199
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• 2008

Purpose: To clarify the influence of "Dongeuibogam" on three important medical books "Euimunbogam", "Jaejungshinpyeon" and "Bangyakhabpyeon", in Chosun Dynasty. Methods: To examine and compare the three medical books, with "Uterus" and "Gynecology" part in "Dongeuibogam" to investigate effects of theories and prescriptions of "Dongeuibogam" upon gynecology. Results: Firstly, "Dongeuibogam" positively and practically reestablished the medical books existing at that time and made the high use of them in practice. Secondly, the three medical books mostly follows the formation of "Pomun" and "Buinmum" in "Dongeuibogam". thirdly, the three medical books inclusively accepted the theory and prescriptions of "Dongeuibogam" and made use of them actively in practice. Furthermore they developed other points of view in 'disease pattern identification and treatment'(辨證施治). Conclusion: "Dongeuibogam" had great influence upon gynecology in the medical books at the latter term of Chosun dynasty. "Dongeuibogam" also have had huge influence upon the clinical practice in gynecology until now by making the foundation of gynecology in traditional Korean medicine.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.3
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• pp.37-55
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• 2022

Objectives: The purpose of this study is to investigate the efficacy and safety of acupuncture on postpartum urinary incontinence. Methods: 'postpartum urinary incontinence', 'postnatal urinary incontinence', 'acupuncture' were searched on 4 online databases (Cochrane Library, Pubmed, CNKI, OASIS). Randomized controlled trials (RCTs) that used acupuncture on postpartum urinary incontinence were included. The methodological quality of each RCT was assessed by using Cochrane risk of bias tool. Results: 12 RCTs were finally selected. The overall risk of bias was evaluated as uncertain. 11 studies showed that combined treatment group was better than control group in effective rate and/or ICIQ-SF total score, but among those 1 study was not statistically significant in ICIQ-SF total score. In the comparison of alone treatment group and control group, 1 study showed favorable effect in ICIQ-SF total score, but 1 study was not significant in effective rate. Conclusions: Treatment that include acupuncture can effect on postpartum urinary incontinence. but considering quality of studies, inconsistent and insufficient evidence, further well-designed studies are needed to confirm the efficacy and safety of this treatment.

• The Journal of Korean Obstetrics and Gynecology
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• v.22 no.3
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• pp.169-184
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• 2009

Purpose: The aim of this study was to estimate the effect of Korean medicine treatment on overactive bladder. Methods: 64 patients of overactive bladder received Korean medicine treatment for at least 30days. We studied retrospectively symptom disappearance rate, the relationship between the improvement rate and age, scale of symptoms, BMI(Body Mass Index), WHR(Waist Hip Ratio). Results: Symptoms of 27 patients were disappeared, and those of 28 patients were improved. But 9 patients didn't show the improvement of their urination problems. The symptom disappearance rate was 43.08%. The improvement rate was 85.15%. The mean${\pm}$standard deviation of daily frequency was reduced from 10.05128 to 7.44872 after treatment(p<0.0001) The symptom disappearance rate was reverse-related with the OABSS score, KHQ and WHR. The improvement rate of married patients was higher than unmarried patients. And especially that was co-related with the frequency of acupuncture and moxibustion treatment. Conclusion: The results of this study suggested that Korean medicine treatments, such as acupuncture, moxibustion and herbal prescriptions have positive efficacy on overactive bladder patients in ordinary clinical practice.

• The Journal of Korean Obstetrics and Gynecology
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• v.37 no.3
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• pp.121-132
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• 2024

Objectives: The purpose of this study is to report the clinical effectiveness of Korean medicine treatment on postmenopausal woman with overactive bladder. Methods: The patient with overactive bladder was treated with Korean medicine treatment including herbal medicine, acupuncture and moxibustion during 5 days of hospitalization. The effect of treatment on overactive bladder was evaluated through the Numeric Rating Scale (NRS) and questionnaires. Results: After the treatment, the overactive bladder symptoms of urinary frequency, urinary urgency and nocturia were improved. This was proven through subjective symptoms complained of by patients and objective measures such as questionnaires. Conclusions: This case report proved that the Korean medicine treatment may be effective for improving overactive bladder. However, further clinical studies with large number of subjects are needed to prove the effectiveness of Korean medicine treatment for overactive bladder.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.1
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• pp.250-257
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• 2007

Uterus myoma is a benign tumor of smooth muscle in the wall of the uterus, In oriental medicine, we used to made an effort to management this patients without surgical operation. Doctors have treated patients of uterus myoma mainly by checking over each symptom they have. Then we think that patients have some symptoms in relation to an etiological cause. So I have carried out this study to investigate association of DSOM scores and an attack of uterus myoma in oriental medicine. We chose 3 groups, the first one is 257 uterus myoma patients who visited Dongeui University Oriental Medical Center from May 2001 to June 2006, the second one is 558 outpatients who didn't have uterus myoma from May 2005 to June 2005, the third one is 129 clinical trials who volunteered for Sasang constitutional medicine. Then we made up 3 groups to checkup DSOM, and investigated the All DSOM Fluents which effect uterus myoma patients using regression model. Logistic regression analysis indicate as follows ; In comparison with 558 outpatients data, blood stasis(血瘀), dryness(燥) is associated positively and insufficiency of Yang(陽虛), spleen(脾), phlegm(痰) negatively, and mean of the index for pathogenic factor(病機指標 平均) of deficiency of qi(氣虛), heart(心) negatively. In comparison with 129 clinical trials data, blood stasis(血瘀) is associated positively and phlegm(痰) negatively, and mean of the index for pathogenic factor(炳機指標 平均) of deficiency of Yin(陰虛), liver(肝), diarrhea positively, heart(心) negatively. 3. In investigation of DSOM items, items of blood stasis(血瘀), deficiency of Yin(陰虛), coldness(寒) is associated positively and items of heart(心), spleen(脾), Phlegm(痰) negatively.

• The Journal of Korean Obstetrics and Gynecology
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• v.19 no.4
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• pp.61-76
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• 2006

Purpose : This study examined the non-toxic and the anti-oxidative effect of Dioscoreae Rhizoma on PC12 cells. Sanyak(Dioscoreae Rhizoma; chinese yam, shan yao) is well-known for its curing power for kidney, lung, spleen. Tonifies and augments the spleen and stomach. Tonifies the lung gi and augments the kidney yin. Tonifies the kidneys and also stabilizes and binds. it also binds the essence and treats spermatorrhea, frequent urination, and vaginal discharge. We are therefore interested in whether Dioscoreae Rhizoma is capable of causing abnormal apoptosis processes, and whether this condition can be rectified through Dioscoreae Rhizoma herb treatment. Methods : We used aqueous extract to treat PC12 cells with different concentrations treated with a water or a MeOH extract of Dioscoreae Rhizoma (0, x10, x20, x40, x80). The MTT (3, (4, 5-dimethyl-thiazol) 2, 5-diphenyl-tetraxolium bromide) reduction assay was employed to quantify the differences in cell activity and viability. The Bax expression level was monitored using western-blotting techniques. The patterns of the changes in expression were scanned and analyzed. Results : Bax and GSK-3${\beta}$ promotes cell death and down-regulated during the development of the PC12 cells. This is indicated that Dioscoreae Rhizoma is capable of inducing apoptosis in PC12 cells. The induced cell death and significantly inhibited by Dioscoreae Rhizoma, which can be explained by the increase in the inhibition of Bax and GSK-3${\beta}$ expression. It was also shown that Dioscoreae Rhizoma inhibits the release of $H_2O_2$ and prevents lipid peroxidation. Furthermore, the accumulation of wild type Bax protein significantly downregulated in a dose-dependent manner upon treatment with Dioscoreae Rhizoma. Conclusion : In conclusion, Dioscoreae Rhizoma can induce apoptosis via a Bax-dependent pathway or GSK-3${\beta}$ dependent pathway in PC12 cells into anti-oxidant and protective effect.

• The Journal of Korean Obstetrics and Gynecology
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• v.18 no.1
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• pp.55-63
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• 2005

Purpose : 자하거(Hominis Placenta; HP)는 건강한 사람의 태반을 홍제(烘製)하여 건조한 것으로 한의학에서는 기혈(氣血)을 대보(大補)하고 신정(腎精)을 보익(補益)시켜 구병(久病)으로 인한 신체허약(身體虛弱)이나 혹은 체질허약(體質虛弱)과 혈기부족(氣血不足) 및 신허정휴(腎虛精虧) 등 등(證)을 치료(治療)하는데 단미(單味) 또는 복방(複方)에 배오(配伍)하여 쓰여왔다. 또한 자하거는 면역학적으로 골대사 활성이 있는 것으로 알려져 있어 본 연구에서는 자하거의 항골다공증 활성을 분자세포생물학적으로 검정하고자 하였다. Methods : Osteoblast cells에서 자하거가 COX-2 mRNA의 발현과 $PGE_2$ 생합성을 억제시키는지를 관찰하기 위해 먼저 TNF-${\alpha}$, IL-${\beta}$ 와 IL-6를 처리한 후 $PGE_2$의 생합성과 더불어 COX-2 mRNA의 발현을 확인하였다. 그 후 TGF-${\beta}$, 자하거(紫河車)와 이 둘의 조합인 자하거+TGF-${\beta}$가 COX-2 mRNA 발현과 $PGE_2$ 생합성을 저해시키는지 관찰하였다. 또한 자하거가 IL-1${\beta}$로 유발된 흰쥐의 과칼슘혈증을 감소시키는지를 확인하였다. Results : IL-6, IL-1${\beta}$와 TNF-${\alpha}$를 동시에 처리하면 이것을 단독으로 처리한 것과 비교해 볼 때 $PGE_2$의 생합성과 더불어 COX-2 mRNA의 수치가 상승작용을 일으키며 증가하였다. TGF-${\beta}$, 자하거와 이 둘의 조합인 자하거+TGF-${\beta}$은 COX-2 mRNA 발현, $PGE_2$ 생합성 및 골재흡수를 감소시켰다. 자하거(紫河車)는 IL-1${\beta}$, TNF-${\alpha}$와 IL-6 각각 또는 이들의 조합으로 인해 증가하는 COX-2 mRNA 발현과 $PGE_2$ 생성을 감소시키는 반면 COX-1 mRNA 발현에는 유의성 있는 영향을 미치지 않았다. 한편 자하거는 농도의존적으로 IL-1${\beta}$로 유발된 흰쥐의 과칼슘혈증을 감소시켰다. 이러한 결과는 흰쥐의 두개골 골아세포에서 $PGE_2$ 생산에 대한 IL-${\beta}$, TNF-${\alpha}$, IL-6의 상승작용이 COX-2의 유전자 발현 증가에 기인함을 보여주었다. Conclusions : 이러한 결과들로부터 자하거가 골대사과정중 골재흡수를 억제하는데 효과적임을 밝히게 되었으며, 자하거의 골다공증의 억제기전이 골재흡수관련 단백질들의 전사조절에 있음을 최초로 해명하게 되었다.

• The Journal of Korean Obstetrics and Gynecology
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• v.25 no.2
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• pp.78-88
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• 2012

Objectives: Paeonia japonica has been widely used for gynecopathy and analgesic effects in Korean Traditional Medicine. The aim of the present study is to determine the antioxidant effect of Paeonia japonica extracts(PJE) by using mouse embryonic fibroblast cells(MEF cells). Methods: We evaluated Radical Scavenging Activity of PJE by the DPPH assay. Protective effect of the PJE on the hydrogen peroxide($H_2O_2$) induced oxidative damage of MEF cells was analyzed by the MTT assay. The Morphological changes of MEF cells induced by P. japonica, $H_2O_2$ and P. japonica+$H_2O_2$ was evaluated by DAPI staining. And effect of PJE on the rate of apoptosis in MEF cells was measured using flow cytometry with Annexin V-FITC and PI double staining. Results: We observed that PJE contain significant DPPH radical scavenging activity. Cell viability of oxidative damaged cells treated with various concentrations of $H_2O_2$ was increased by treatment with PJE. Flow cytometric analysis of the cells treated with $H_2O_2$ in the absence or presence of PJE showed that the crumbled G1 peak was accumulated by the treatment with $H_2O_2$ alone, but restored by addition of PJE. Portion of cells that undergo apoptosis mediated by oxidative stress was decreased by treatment of PJE. The nuclear fragmentation occurred in the oxidative damaged MEF cells was also decreased by PJE treatment. Conclusions: Taken together, our results suggest that PJE exhibits significant antioxidant activity and functions to inhibit cell death mediated by oxidative damage induced apoptotic pathways.

• The Journal of Korean Obstetrics and Gynecology
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• v.35 no.2
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• pp.70-86
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• 2022

Objectives: This study attempted to provide prescriptions that can be used according to the classification of menopausal disorders in order to increase the clinical utilization of CaPSPI (Diagnostic System for Climacteric and Postmenopausal Syndrome Pattern Identification). Methods: Delphi method survey was conducted for expert consensus on the Pattern Identification that could be used for each prescription by selecting frequent prescriptions based on the literature researched on the prescription of Korean medicine used for women with menopausal disorders. 11 experts participated in the questionnaire for posterity and 7 experts for sasang constitution. The survey was divided into the main prescription that can be mainly used for the patterns and the minor prescription that can be used although the suitability is somewhat low. Expert consensus was obtained through the second survey, and the pattern classification of prescriptions that were not confirmed here was confirmed through a face-to-face meeting. Results: There were 56 prescriptions mainly used for treatment for menopause, 45 for posterity and 11 for Sasang constitution. There were 69 identifications of 45 posterity prescriptions and 17 classifications of 11 Sasang constitutional prescriptions including major and minor patterns. By pattern identifications, the number of major/minor prescriptions was as follows. 肝鬱 14/5, 腎陰虛 8/2, 腎陽虛 4/1, 肝腎陰虛 2/7, 腎陰陽兩虛 3/1, 心腎不交 6/3, 心脾兩虛 15/2, 心火 7/6. Conclusions: In the future, by accumulating and analyzing the data on the diagnosis and treatment using CaPSPI, the clinical status of Korean medicine for menopausal disorders can be reviewed, and it can be used as the basis for the clinical practice guidelines for menopausal disorders. In addition, it is thought that analyzing the results of the diagnosis of pattern identifications and the prescription of Sasang constitution can be helpful in research on the posterity and Sasang constitution.