• 대한조선학회논문집
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• 제44권3호
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• pp.279-284
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• 2007

As a container vessel becomes larger, the bow flare becomes larger. The large bow flare structures are often subjected to dynamic pressure loads due to bow flare slamming occurring in rough seas. The aim of this paper is to investigate the characteristics of bow flare slamming pressure measured in a real voyage through the North Pacific Ocean. The characteristics of impact pressure load caused by slamming is addressed in terms of the pressure pulse-time history which involves rising time, peak pressure, decaying time and type of pressure decay. The values were presented using non-dimensional parameters.

• Ocean and Polar Research
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• 제43권1호
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• pp.1-14
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• 2021

In this study, extreme wind speeds in the Western North Pacific (WNP) were estimated using reanalysis wind fields synthesized with an empirical typhoon vortex model. Reanalysis wind data used is the Fifth-generation European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis (ERA5) data, which was deemed to be the most suitable for extreme value analysis in this study. The empirical typhoon vortex model used has the advantage of being able to realistically reproduce the asymmetric winds of a typhoon by using the gale/storm-forced wind radii information in the 4 quadrants of a typhoon. Using a total of 39 years of the synthesized reanalysis wind fields in the WNP, extreme value analysis is applied to the General Pareto Distribution (GPD) model based on the Peak-Over-Threshold (POT) method, which can be used effectively in case of insufficient data. The results showed that the extreme analysis using the synthesized wind data significantly improved the tendency to underestimate the extreme wind speeds compared to using only reanalysis wind data. Considering the difficulty of obtaining long-term observational wind data at sea, the result of the synthesized wind field and extreme value analysis developed in this study can be used as basic data for the design of offshore structures.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2023년도 학술발표회
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• pp.87-87
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• 2023

The impact of climate change on typhoons is a major concern in East Asia, especially due to the destructive effects of heavy rainfall on society and the economy, as many megacities are located along coastal regions. Although observations suggest significant changes in typhoon heavy rainfall, the extent to which anthropogenic forcing contributes to these changes has yet to be determined. In this study, we demonstrate that anthropogenic global warming has a substantial impact on the observed changes in typhoon heavy rainfall in the western North Pacific region. Observation data indicates that, in general, typhoon heavy rainfall has increased (decreased) in coastal East Asia (tropical western North Pacific) during the latter half of the 20th century and beyond. This spatial distribution is similar to the "anthropogenic fingerprint" observed from a set of large ensemble climate simulations, which represents the difference between Earth systems with and without human-induced greenhouse gas emissions. This provides evidence to support the claim that the significant increase in the frequency of typhoon heavy rainfall along coastal East Asia cannot be solely explained by natural variability. In addition, our results indicate that the signal of the "anthropogenic fingerprint" has been increasing rapidly since the mid-1970s and departed from natural variability in the early 2000s, indicating that the regional summer climate has already crossed the tipping point.

• 한국지구과학회지
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• 제44권3호
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• pp.185-195
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• 2023

The prolonged and heavy East Asian summer precipitation in 2020 may have been caused by an enhanced Madden-Julian Oscillation (MJO), which requires evaluation using forecast models. We examined the performance of GloSea6, an operational forecast model, in predicting the East Asian summer precipitation during July 2020, and investigated the role of MJO in the extreme rainfall event. Two experiments, CON and EXP, were conducted using different convection schemes, 6A and 5A, respectively to simulate various aspects of MJO. The EXP runs yielded stronger forecasts of East Asian precipitation for July 2020 than the CON runs, probably due to the prominent MJO realization in the former experiment. The stronger MJO created stronger moist southerly winds associated with the western North Pacific subtropical high, which led to increased precipitation. The strengthening of the MJO was found to improve the prediction accuracy of East Asian summer precipitation. However, it is important to note that this study does not discuss the impact of changes in the convection scheme on the modulation of MJO. Further research is needed to understand other factors that could strengthen the MJO and improve the forecast.

• 한국지역지리학회지
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• 제5권1호
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• pp.151-162
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• 1999

본 연구는 한국에 있어서 초가을의 강수 변동성과 표준화된 편차에 의하여 선정된 소우년과 다우년의 지상 및 500hPa 등압면을 비교 분석한 연구이다. 한국의 초가을의 강수량은 감소하지만 강수변동율은 급격히 증가하여 해에 따른 가을장마전선의 성쇠와 태풍성 강수의 유무를 반영하고 있다. 강수변동율의 지역적 분포는 초가을의 강수량이 많은 동해안과 남동해안 지방은 낮은 반면 남서안이 높아서 서고동저현상을 나타내고 있다. 지상 및 500hPa면의 편차분포에서 소우년은 시베리아 북부 및 하계 북태평양고기압의 중심역이 심한 음편차, 다우년은 소우년과 반대로 이 양 지역이 심한 양편차를 이루어 대조를 이루고 있다. 또한 500hPa면 고도장에서 소우년의 한반도는 깊은 trough의 서쪽에 위치하여 한반도 주변은 동서지수가 낮고 다우년은 약한 trough에 속하여 동서지수가 높아 동서류가 강하며, 소우년은 $40^{\circ}N$ 이북에서는 500hPa면 고도가 낮고 다우년은 높다. 따라서 소우년과 다우년의 출현현상은 북태평양 고기압과 시베리아 고기압 성쇠의 계절적 변동을 반영하고 있음을 확인하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7161-7165
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• 2015

Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. Materials and Methods: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry. All patients received neo-adjuvant chemotherapy. Response was assessed clinically and histopathologically with attention to p16 expression. Results: p16 was expressed in 22% of ESCC (22 out of 101) and was more prevalent in patients who were more than 45 years of age (P=0.048). p16 positive tumors appeared more commonly in the upper 2/3 of the thoracic esophagus (18 in 22). Nine of the 22 (41%) p16 positive tumors achieved pathologic complete response following neo-adjuvant chemotherapy (P=0.008). There was a trend towards reduced mortality in this group (P=0.048). Some 9 of the 20 (45%) patients who achieved pathologic complete response were p16 positive. Conclusions: Expression of p16 in ESCC correlates with higher rate of pathologic complete remission in patients undergoing neo adjuvant chemotherapy and could be a predictive marker for response assessment.

• Asian Pacific Journal of Cancer Prevention
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• 제16권16호
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• pp.7243-7248
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• 2015

Background: Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine thought to be responsible for monocyte and T-lymphocyte recruitment in acute inflammatory conditions and recruitment of macrophages in tumors. It is also implicated in cardiovascular disease, rheumatoid arthritis and chronic obstructive pulmonary disease. The aim of the present study was to investigate the correlation between MCP-1 -2518 A/G polymorphism and breast cancer risk in patients from Amritsar city of Punjab state in North-West India. Materials and Methods: We screened DNA samples of 200 sporadic breast cancer patients and 200 age and gender matched unrelated healthy individuals for MCP-1 -2518 A/G polymorphism using the PCR-RFLP method. Results: A significantly increased frequency of the GG genotype was observed in patients as compared to controls. Individuals carrying the MCP1 -2518GG genotype had a two fold risk for breast cancer (OR=2.06, 95%CI, 1.06-3.98; p=0.03). Genetic models analysis revealed a significant association between MCP-1 -2518 A/G polymorphism and cancer risk in homozygous co-dominant (OR=2.06, 95%CI, 1.06-3.98; p=0.03) and recessive (OR=1.97, 95%CI, 1.05-3.70; p=0.03) models. Conclusions: We conclude that the GG genotype of the MCP-1-2518 A/G polymorphism is associated with increased risk to breast cancer in Punjab, North-West India.

• Asian Pacific Journal of Cancer Prevention
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• 제17권5호
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• pp.2459-2464
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• 2016

Background: Cancer treatments can have long-term physical, psychological, financial, sexual and cognitive effects that may influence the quality of life. These can vary from urban to rural areas, survival period and according to the type of cancer. We here aimed to describe demographics and psychosocial analysis of cancer survivors three to five years post-treatment in rural Australia and also assess relationships with financial stress and quality of life domains. Materials and Methods: In this cross-sectional study, 65 participants visiting the outpatient oncology clinic were given a self-administered questionnaire. The inclusion criteria included three to five years post-treatment. Three domains were investigated using standardised and validated tools such as the Standard Quality of Life in Adult Cancer Survivors Scale (QLACS) and the Personal and Household Finances (HILDA) survey. Included were demographic parameters, quality of life, treatment information and well-being. Results: There was no evidence of associations between any demographic variable and either financial stress or cancer-specific quality of life domains. Financial stress was however significantly associated with the cancer-specific quality of life domains of appearance-related concerns, family related distress, and distress related to recurrence. Conclusions: This unique study effectively points to psychosocial aspects of cancer survivors in rural regions of Australia. Although the majority of demographic characteristics were not been found to be associated with financial stress, this latter itself is significantly associated with distress related to family and cancer recurrence. This finding may be of assistance in future studies and also considering plans to fulfil unmet needs.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4797-4802
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• 2016

Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh people. Materials and Methods: The present observational retrospective study was carried out at Regional Oncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). Сlinical and histopathological data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, for whom data on molecular subtype were available for 253. Data from hospital charts were entered into SPSS 20 for analysis by one-way ANOVA analysis of associations of different variables with 1-5 year survival. Pearson correlation and linear regression models were used to examine the relation between parameters with a p-value < 0.05 considered statistically significant. Results: No significant relationships were evident between molecular subtype and survival, site of metastases, stage or ethnicity. Young females below the age of 44 were slightly more likely to have triple negative lesions. While the ductal type greatly predomonated, luminal A and B cases had a higher percentage with lobular morphology. Conclusions: In this select group of metastatice brease cancer, no links were noted for survival with molecular subtype, in contrast to much of the literature.

• Asian Pacific Journal of Cancer Prevention
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• 제17권10호
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• pp.4587-4590
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• 2016

Background: In many countries gastric cancer has the highest incidence among the gastrointestinal cancers and is the second most common cancer in Iran. The aim of this study was to identify and map high risk gastric cancer regions at the county-level in Iran. Methods: In this study we analyzed gastric cancer data for Iran in the years 2003-2010. Area-to-area Poisson kriging and Besag, York and Mollie (BYM) spatial models were applied to smoothing the standardized incidence ratios of gastric cancer for the 373 counties surveyed in this study. The two methods were compared in term of accuracy and precision in identifying high risk regions. Result: The highest smoothed standardized incidence rate (SIR) according to area-to-area Poisson kriging was in Meshkinshahr county in Ardabil province in north-western Iran (2.4,SD=0.05), while the highest smoothed standardized incidence rate (SIR) according to the BYM model was in Ardabil, the capital of that province (2.9,SD=0.09). Conclusion: Both methods of mapping, ATA Poisson kriging and BYM, showed the gastric cancer incidence rate to be highest in north and north-west Iran. However, area-to-area Poisson kriging was more precise than the BYM model and required less smoothing. According to the results obtained, preventive measures and treatment programs should be focused on particular counties of Iran.