Backgrounds : Because ventilator-induced lung injury is partly dependent on the intensity of vascular flow, we hypothesized that hypothermia may attenuate the degree of such an injury through a reduced cardiac output. Methods : Twenty-seven male Sprague-Dawley rats were randomly assigned to normothermia ($37{\pm}1^{\circ}C$)-injurious ventilation (NT-V) group (n=10), hypothermia ($27{\pm}1^{\circ}C$)-injurious ventilation (HT-V) group (n=10), or nonventilated control group (n=7). The two thermal groups were subjected to injurious mechanical ventilation for 20 min with peak airway pressure 30 cm $H_2O$ at zero positive end-expiratory pressure, which was translated to tidal volume $54{\pm}6\;ml$ in the NT-V group and $53{\pm}4\;ml$ in the HT-V group (p>0.05). Results : Pressure-volume (P-V) curve after the injurious ventilation was almost identical to the baseline P-V curve in the HT-V group, whereas it was shifted rightward in the NT-V group. On gross inspection, the lungs of the HT-V group appeared smaller in size, and showed less hemorrhage especially at the dependent regions, than the lungs of the NT-V group. [Wet lung weight (g)/body weight (kg)] ($1.6{\pm}0.1$ vs $2.4{\pm}1.2$ ; p=0.014) and [wet lung weight/dry lung weight] ($5.0{\pm}0.1$ vs $6.1{\pm}0.8$ ; p=0.046) of the HT-V group were both lower than those of the NT-V group, while not different from those of the control group($1.4{\pm}0.4$, $4.8{\pm}0.4$, respectively). Protein concentration of the BAL fluid of the HT-V group was lower than that of the NT-V group($1,374{\pm}726\;ug/ml$ vs $3,471{\pm}1,985\;ug/ml$;p=0.003). Lactic dehydrogenase level of the BAL fluid of the HT-V group was lower than that of the NT-V group ($0.18{\pm}0.10\;unit/ml$ vs $0.43{\pm}0.22\;unit/ml$;p=0.046). Conclusions : Hypothermia attenuated pulmonary hemorrhage, permeability pulmonary edema, and alveolar cellular injuries associated with injurious mechanical ventilation, and preserved normal P-V characteristics of the lung in rats.
Park, Kyung-Won;Kang, Do-Young;Park, Min-Jeong;Cheon, Sang-Myung;Cha, Jae-Kwan;Kim, Sang-Ho;Kim, Jae-Woo
Nuclear Medicine and Molecular Imaging
/
v.41
no.6
/
pp.530-537
/
2007
Purpose: The aim of this study is to assess the specific patterns of regional cerebral blood flow (rCBF) in patients with the early stage of subcortical vascular dementia (SVaD) and Alzheimer's disease (AD) using Tc-99m HMPAO SPECT, and to compare the differences between the two conditions. Materials and Methods: Sixteen SVaD, 46 AD and 12 control subjects participated in this study. We included the patients with SVaD and AD according to NINCDS-ADRDA and NINDS-AIREN criteria. They were all matched for age, education and clinical dementia rating scores. Three groups were evaluated by Tc-99m HMPAO SPECT using statistical parametric mapping (SPM) for measuring rCBF. The SPECT data of patients with SVaD and AD were compared with those of normal control subjects and then compared with each other. Results: SPM analysis of the SPECT image showed significant perfusion deficits on the right temporal region and thalamus, left insula and superior temporal gyrus, both cingulate gyri and frontal subgyri in patients with SVaD and on the left supramarginal gyrus, superior temporal gyrus, postcentral gyrus and inferior parietal lobule, right fugiform gyrus and both cingulate gyri in AD compared with control subjects (uncorrected p<0.01). SVaD patients revealed significant hypoperfusion in the right parahippocampal gyrus with cingulated gyrus, left insula and both frontal subgyral regions compared with AD (uncorrected p<0.01). Conclusion: Our study shows characteristic and different pattern of perfusion deficits in patients with SVaD and AD, and these results may be helpful to discriminate the two conditions in the early stage of illness.
The major purpose of this survey is to collect the related information on technical aspects for solving the problems which are facing producing farmers and regions, provide scientific facts to farmers related personals and institutions and aimed at contributing the development of sericultural sector in Korea. The results are as follows; (1) The area of mulberry field per a farmer which was selected as sample ranges from 3.0 to 370a with its average 45. 1a. And yet, the average of new cultivated areas is above than that of ordinary ones by 56.3 to 33.8a. The largest area is Honam hill area with 101. 1a and e smallest is Muzinzang with 20.8a. Shortly, a large number of farmer belongs to 11 to 50a with 66.5 per cent. (2) The ratio of clay and loam soils which are inadequte for growing of mulberry trees is 28.3 per cent and particulary high in new cultivated area with 36.2 per cent. And yet, base soil is occupied with 45 per cent of heavy clay and particularly even 54.2 per cent in new cultivated area. On the other hand, the number of areas which the contents of organic matters is relatively low, with 48.2 per cent is near the half, but the ratio of mulberry fields which seems to contain organic matters abundantly is only 7.2 per cent. (3) The varieties of mulberry trees are Ilgirae, Gaeryangseoban, Suwonsang No.4 and Nosang. The ,ratio of the varieties are 33.3%, 25.7%, 18.0% and 10.5%, respectively. Consequently the four varieties enumerated above occupies 93.5 per cent. (4) The mulberry fields are almost composed of exclusive mulberry fields and its ratio was 92.3 per cent. The number of planted trees per 10a arrange from 480 to 1,390 and its average is 846. But most of them nearly belong to 701 to 1,000 with 91.3per cent. (5) The second year's autumn after planting is generally adopted as the first harvesting season, and its ratio is 73.0 per cent, but autumn of the years and next spring are not few, and its ratio are 12.7 and 8.7 per cent. The first harvesting method is relatively normal with 88.8 per cent of ratio. From the viewpoint of harvesting method, picking leaves was applied with 97.7 per cent of ratio in young larvae rearing and picking shoot and picking shoot after harvest with branches were applied with 80.0 per cent of ratio in grown larvae rearing. The ratio of applying the harvesting method of picking leaves were 97.7 and 91.7 per cent in young larva and grown larva in autumn rearings. But there was also picking leaves absolutely with 7.1 per cent of ratio(Chunwon was 47 per cent) and yet, the farmers applying cutting before shooting in spring was no more than 17.8 percent.
The physico-chemical properties of ten reclaimed saline soils in five soil series of west-south Korea were analyzed according to the years past after reclamation. The soil samples were collected at the same sites two times in 2000 and 2004. The physico-chemical properties in 2000 had been changed in 2004 as follows. Soil salinity was the highest in Podu and desalinization period was the shortest in Munpo and Yeompo. Seasonal ground water level were above 100 cm in all regions that were 30 years old reclaimed tidal land, which was the same results of normal paddy field. In the case of soil physical changes, bulk density increased in fine textured soil (Poseung and Podu) but decreased in coarse textured soil (Gwanghwal, Munpo, and Yeompo). Porosity decreased in fine textured soil(Poseung and Podu) but increased in coarse textured soil. These reason were as follows. Fine textured soil were increased in solid phase but decreased in liquid and gaseous phase. Coarse textured soil, Gwanghwal and Munpo except for Yempo, were increased in gaseous phase but decreased in solid and liquid phase. Yempo that have low water table level were increased in liquid phase but decreased in solid and gaseous phase. Soil hardness increased in 4 soil series except for Munpo. In the case of chemical property changes, although there were more or less difference, it showed decreasing tendencies. Soil pH, the content of organic matter, available phosphate, and available silicate of five soil series were decreased during the four years. The content of exchangeable cation also decreased except for magnesium.
An, Soon-Il;Ha, Kyung-Ja;Seo, Kyong-Hwan;Yeh, Sang-Wook;Min, Seung-Ki;Ho, Chang-Hoi
Journal of Climate Change Research
/
v.2
no.4
/
pp.237-251
/
2011
This study presents a review on the recent climate change over the Korean peninsula, which has experienced a significant change due to the human-induced global warming more strongly than other regions. The recent measurement of carbon dioxide concentrations over the Korean peninsula shows a faster rise than the global average, and the increasing trend in surface temperature over this region is much larger than the global mean trend. Recent observational studies reporting the weakened cold extremes and intensified warm extremes over the region support consistently the increase of mean temperature. Surface vegetation greenness in spring has also progressed relatively more quickly. Summer precipitation over the Korean peninsula has increased by about 15% since 1990 compared to the previous period. This was mainly due to an increase in August. On the other hand, a slight decrease in the precipitation (about 5%) during Changma period (rainy season of the East Asian summer monsoon), was observed. The heavy rainfall amounts exhibit an increasing trend particularly since the late 1970s, and a consecutive dry-day has also increased primarily over the southern area. This indicates that the duration of precipitation events has shortened, while their intensity became stronger. During the past decades, there have been more stronger typhoons affecting the Korean peninsula with landing more preferentially over the southeastern area. Meanwhile, the urbanization effect is likely to contribute to the rapid warming, explaining about 28% of total temperature increase during the past 55 years. The impact of El Nino on seasonal climate over the Korean peninsula has been well established - winter [summer] temperatures was generally higher [lower] than normal, and summer rainfall tends to increase during El-Nino years. It is suggested that more frequent occurrence of the 'central-Pacific El-Nino' during recent decades may have induced warmer summer and fall over the Korean peninsula. In short, detection and attribution studies provided fundamental information that needed to construct more reliable projections of future climate changes, and therefore more comprehensive researches are required for better understanding of past climate variations.
This study analyzes the process of overcoming prejudice and discrimination experiences of mothers with disabilities and looks for improvement points. It is interviewed 9 mothers of children with disabilities who were experiencing prejudice and discrimination while raising children with disabilities. The data collection was conducted from October to November, 2018 and one by on one in depth interview by using semi - structured questionnaires. Data analysis was done through consensual qualitative research (CQR). The result of CQR while it is a experiencing the process of prejudice and discrimination as well as coping the raising disabled children. 'Prejudice and discrimination experience of mothers with disabilities' and 'overcoming of discrimination experiences of mothers with disabilities' were derived. And the seven sub-regions, 28 categories, were finally constructed. The results of the study are as follows. Firstly, Prejudice and discrimination experiences of mothers with disabilities in raising children with disabilities are view of looking at children with disabilities comparing to those of normal children and children with disabilities. It seems that they want to treat the disabled child as the general child with an attitude of understanding and accepting the disabled child rather than looking at the disabled child with wrong perception, prejudice, stereotypes and rejection. Secondly, The process of overcoming the discrimination experiences of the mother of the disabled child is strengthening the cohesion and cohesion within the family in the process of accepting and coping with the disability family of the child with disabilities even if they raise the child with disability and have difficulties such as recognition bias and discrimination of the general public. Based on the results of this study, we suggested practical and policy implications for the mother's psychological stability of the child with disability and the disabled child's healthy life.
Objectives: Brain maturation involves brain lateralization and asymmetry to achieve efficient information processing and cognitive controls. This study elucidates normal brain maturation change during the gap between ages 6-9 and age 14-17 using resting EEG. Methods: An EEG dataset was acquired from open source MIPDB (Multimodal Resource for Studying Information Processing in the Developing Brain). Ages 6-9 (n = 24) and ages 14-17 (n = 26) were selected for analysis, and subjects with psychiatric illness or EEG with severe noise were excluded. Finally, ages 6-9 (n = 14) and ages 14-17 (n = 11) were subjected to EEG analysis using EEGlab. A 120-sec length of resting EEG when eyes were closed was secured for analysis. Brain topography was compartmentalized into nine regions, best fitted with brain anatomical structure. Results: Absolute power of the delta band and theta band in ages 6-9 was greater than that of ages 14-17 in the whole brain, and, also is relative power of delta band in frontal compartment, which is same line with previous studies. The relative power of the beta band of ages 14-17 was greater than that of ages 6-9 in the whole brain. In asymmetry evaluation, relative power of the theta band in ages 14-17 showed greater power in the left than right frontal compartment; the opposite finding was noted in the parietal compartment. For the alpha band, a strong relative power distribution in the left parietal compartment was observed in ages 14-17. Absolute and relative power of the alpha band is distributed with hemispheric left lateralization in ages 14-17. Conclusion: During the gap period between ages 6-9 and ages 14-17, brain work becomes more complicated and sophisticated, and alpha band and beta band plays important roles in brain maturation in typically developing children.
Kim, Dongsu;Seo, Youngcheol;You, Hojun;Gwon, Yeonghwa
Journal of Korea Water Resources Association
/
v.56
no.3
/
pp.195-210
/
2023
Additional deposition and erosion in large rivers in South Korea have continued to occur toward morphological stabilization after massive dredging through the four major river restoration project, subsequently requiring precise bathymetry monitoring. Hyperspectral bathymetry method has increasingly been highlighted as an alternative way to estimate bathymetry with high spatial resolution in shallow depth for replacing classical intrusive direct measurement techniques. This study introduced the conventional Optimal Band Ratio Analysis (OBRA) of hyperspectral bathymetry method, and evaluated the performance in a domestic large river in normal turbid and flow condition. Maximum measurable depth was estimated by applying correlation coefficient and root mean square error (RMSE) produced during OBRA with cascadedly applying cut-off depth, where the consequent hyperspectral bathymetry map excluded the region over the derived maximum measurable depth. Also non-linearity was considered in building relation between optimal band and depth. We applied the method to the Nakdong and Hwang River confluence as a large river case and obtained the following features. First, the hyperspectal method showed acceptable performance in morphological mapping for shallow regions, where the maximum measurable depth was 2.5 m and 1.25 m in the Nakdong and Hwang river, respectively. Second, RMSE was more feasible to derive the maximum measurable depth rather than the conventional correlation coefficient whereby considering various scenario of excluding range of in situ depths for OBRA. Third, highly turbid region in Hwang River did not allow hyperspectral bathymetry mapping compared with the case of adjacent Nakdong River, where maximum measurable depth was down to half in Hwang River.
Flash drought (FD), characterized by the rapid onset and intensification, can significantly impact ecosystems and induce immediate water stress. A more comprehensive understanding of the causes and characteristics of FD events is required to enhance drought monitoring. Therefore, we investigated the FD events took place over the Korean peninsula using Global Land Data Assimilation System (GLDAS) data from 2012 to 2022. We first detected FD events using the stress-based method (Standardized Evaporative Stress Ratio, SESR), and analyzed the frequency and duration of FDs. The FD events were classified into three cases based on the variations in Actual Evapotranspiration (AET) and potential Evapotranspiration (PET), and spatially analyzed. Results revealed that there are regional disparities in frequency and duration of FDs, with a mean frequency of 6.4 and duration of 31 days. When classified into Case 1 (normal condition), Case 2 (AET-driven), and Case 3 (PET-driven), we found that Case 2 FDs emerged approximately 1.5 times more frequently than those driven by PET (Case 3) across the Korean peninsula. Case 2 FDs were found to be induced under water-limited conditions, and led both AET and PET to be decreased. Conversely, Case 3 FDs occurred under energy-limited conditions, with increase in both. Case 2 FDs predominantly affected the northwestern and central-southern agricultural regions, while Case 3 occurred in the eastern region, characterized by forested land cover. These findings offers insights into our understanding of FDs over the Korean peninsula, considering climate factors, land cover, and water availability.
Park, Sang-Joon;Ryu, Young-Hoon;Jeon, Tae-Joo;Kim, Jai-Keun;Nam, Ji-Eun;Yoon, Pyeong-Ho;Yoon, Choon-Sik;Lee, Jong-Doo
The Korean Journal of Nuclear Medicine
/
v.32
no.6
/
pp.490-496
/
1998
Purpose: We evaluated brain perfusion SPECT findings of MELAS syndrome and mitochondrial myopathy in correlation with MR imaging in search of specific imaging features. Materials and Methods: Subjects were five patients (four females and one male; age range, 1 to 25 year) who presented with repeated stroke-like episodes, seizures or developmental delay or asymptomatic but had elevated lactic acid in CSF and serum. Conventional non-contrast MR imaging and Tc-99m-ethyl cysteinate dimer (ECD) brain perfusion SPECT were Performed and imaging features were analyzed. Results: MRI demonstrated increased T2 signal intensities in the affected areas of gray and white matters mainly in the parietal (4/5) and occipital lobes (4/5) and in the basal ganglia (1/5), which were not restricted to a specific vascular territory. SPECT demonstrated decreased perfusion in the corresponding regions of MRI lesions. In addition, there were perfusion defects in parietal (1 patient), temporal (2), and frontal (1) lobes and basal ganglia (1) and thalami (2). In a patient with mitochondrial myopathy who had normal MRI, decreased perfusion was noted in left parietal area and bilateral thalami. Conclusion: Tc-99m ECD SPECT imaging in patients with MELAS syndrome and mitochondrial myopathy showed hypoperfusion of parieto-occipital cortex, basal ganglia, thalamus and temporal cortex, which were not restricted to a specific vascular territory. There were no specific imaging features on SPECT. The significance of abnormal perfusion on SPECT without corresponding MR abnormalities needs to be evaluated further in larger number of patients.
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