Nuclear Medicine and Molecular Imaging

The Korean Society of Nuclear Medicine (대한핵의학회)
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Differences of Tc-99m HMPAO SPECT Imaging in the Early Stage of Subcortical Vascular Dementia Compared with Alzheimer's Disease

초기 단계의 피질하 혈관성 치매와 알쯔하이머병에서 Tc-99m HMPAO SPECT 영상 소견 차이

  • Park, Kyung-Won (Departments of Neurology, College of Medicine, Dong-A University) ;
  • Kang, Do-Young (Departments of Nuclear Medicine, College of Medicine, Dong-A University) ;
  • Park, Min-Jeong (Departments of Neurology, College of Medicine, Dong-A University) ;
  • Cheon, Sang-Myung (Departments of Neurology, College of Medicine, Dong-A University) ;
  • Cha, Jae-Kwan (Departments of Neurology, College of Medicine, Dong-A University) ;
  • Kim, Sang-Ho (Departments of Neurology, College of Medicine, Dong-A University) ;
  • Kim, Jae-Woo (Departments of Neurology, College of Medicine, Dong-A University)
  • 박경원 (동아대학교 의과대학 신경과학교실) ;
  • 강도영 (동아대학교 의과대학 핵의학교실) ;
  • 박민정 (동아대학교 의과대학 신경과학교실) ;
  • 천상명 (동아대학교 의과대학 신경과학교실) ;
  • 차재관 (동아대학교 의과대학 신경과학교실) ;
  • 김상호 (동아대학교 의과대학 신경과학교실) ;
  • 김재우 (동아대학교 의과대학 신경과학교실)
  • Published : 2007.12.31
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Abstract

Purpose: The aim of this study is to assess the specific patterns of regional cerebral blood flow (rCBF) in patients with the early stage of subcortical vascular dementia (SVaD) and Alzheimer's disease (AD) using Tc-99m HMPAO SPECT, and to compare the differences between the two conditions. Materials and Methods: Sixteen SVaD, 46 AD and 12 control subjects participated in this study. We included the patients with SVaD and AD according to NINCDS-ADRDA and NINDS-AIREN criteria. They were all matched for age, education and clinical dementia rating scores. Three groups were evaluated by Tc-99m HMPAO SPECT using statistical parametric mapping (SPM) for measuring rCBF. The SPECT data of patients with SVaD and AD were compared with those of normal control subjects and then compared with each other. Results: SPM analysis of the SPECT image showed significant perfusion deficits on the right temporal region and thalamus, left insula and superior temporal gyrus, both cingulate gyri and frontal subgyri in patients with SVaD and on the left supramarginal gyrus, superior temporal gyrus, postcentral gyrus and inferior parietal lobule, right fugiform gyrus and both cingulate gyri in AD compared with control subjects (uncorrected p<0.01). SVaD patients revealed significant hypoperfusion in the right parahippocampal gyrus with cingulated gyrus, left insula and both frontal subgyral regions compared with AD (uncorrected p<0.01). Conclusion: Our study shows characteristic and different pattern of perfusion deficits in patients with SVaD and AD, and these results may be helpful to discriminate the two conditions in the early stage of illness.

목적: 본 연구는 초기의 피질하 혈관성치매와 알쯔하이머병 환자에서 Tc-99m HMPAO 단일광자방출단층촬영술을 이용하여 국소 뇌 혈류 흐름의 특징적인 양상을 평가하고 두 질환에서의 차이를 비교하고자 하였다. 대상 및 방법: 피질하 혈관성치매 환자 16명, 알쯔하이머병 46명, 12명의 대조군이 포함되었다. 피질하 혈관성치매와 알쯔하이머병은 NINCDS-ADRDA 와 NINDS-AIREN 기준에 합당하였고, 이들의 연령, 교육연수, 한국형 간이정신상태검사 점수와 치매임상척도 점수를 일치시켰다. 세 군에서 국소 뇌혈류 흐름을 측정하고자 SPM 분석을 이용한 TG-99m HMPAO 단일 광자방출단층촬영술을 실시하였다. 피질하 혈관성치매와 알쯔하이머병에서의 단일광자방출단층촬영술 결과를 정상 대조군과 비교하였고, 이어서 두 질환 간의 차이를 비교하였다. 결과: 대조군과의 SPM분석 결과 피질하 혈관성치매에서는 우측 관자엽, 시상, 좌측 뇌섬엽, 상부 관자이랑, 양측 띠이랑, 이마엽에서 의미 있는 관류저하가 있었고, 알쯔하이머병에서는 좌측 모서리위이랑, 상부 관자이랑, 중심뒤이랑, 하부 마루소엽, 우측 뒤통수관자이랑, 양측 띠이랑에서 관류저하을 보였다(uncorrected p<0.01). 피질하 혈관성치매 환자에서 알쯔하이머병 환자에 비해 우측 해마이랑, 띠이랑, 좌측 뇌섬엽, 양측 이마소이랑 부위에 의미있는 관류저하를 보였다(uncorrected p<0.01). 결론: 본 연구는 피질하 혈관성치매와 알쯔하이머병 환자에서의 관류의 특징과 차이를 보여주었고, 이러한 결과는 질병의 초기단계에서 두 질환을 구별하는데 도움을 줄 수 있을 것으로 생각한다.

Keywords

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