• Journal of Cadastre & Land InformatiX
• /
• v.45 no.2
• /
• pp.131-147
• /
• 2015

In modern society, as to the underground urban infrastructure facilities(communication electricity water and sewage gas etc.) were contained many risks because of excavating. The exact position of underground facilities and the attribute information should be built in order to prevent accidents. As the result of analyzing the public surveying results from 2004 to 2009, it shows that low detecting rate of water pipeline which is only 52.4%, because the exploration of electromagnetic induction only detect metal pipeline and positioning survey only detect new pipeline before burying. Therefore development and verification of the correct and efficient exploration techniques are needed to improve the detecting rate. In this study, determined based on the location measurement results for the non-metal pipes and metal pipes before burial. It was compared with values that obtained through the ground penetrating radar and electromagnetic induction detecting. As a result, detecting rate of the concrete section showed a 100%, unpaved section showed a 94.7%, asphalt section showed 60%. So it confirmed the applicability of the ground penetrating radar at underground facilities detecting.

• Journal of Microbiology and Biotechnology
• /
• v.28 no.3
• /
• pp.367-374
• /
• 2018

RNA interference provides an effective tool for developing antitumor therapies. Cell-penetrating peptides (CPPs) are delivery vectors widely used to efficiently transport small-interfering RNA (siRNA) to intracellular targets. In this study, we investigated the efficacy of the cancer-specific CPP carrier BR2 to specifically transport siRNA to cancer-target cells. Our results showed that BR2 formed a complex with anti-vascular endothelial growth factor siRNA (siVEGF) that exhibited the appropriate size and surface charge for in vivo treatment. Additionally, the BR2-VEGF siRNA complex exhibited significant serum stability and high levels of gene-silencing effects in vitro. Moreover, the transfection efficiency of the complex into a cancer cell line was higher than that observed in non-cancer cell lines, resulting in downregulated intracellular VEGF levels in HeLa cells and comprehensively improved antitumor efficacy in the absence of significant toxicity. These results indicated that BR2 has significant potential for the safe, efficient, and specific delivery of siRNA for diverse applications.

• International Journal of Highway Engineering
• /
• v.17 no.6
• /
• pp.1-9
• /
• 2015

PURPOSES : The objective of this study is to propose a quality control and quality assurance method for use during asphalt pavement construction using non-destructive methods, such as ground penetrating radar (GPR) and an infrared (IR) camera. METHODS : A 1.0 GHz air-coupled GPR system was used to measure the thickness and in situ density of asphalt concrete overlay during the placement and compaction of the asphalt layer in two test construction sections. The in situ density of the asphalt layer was estimated based on the dielectric constant of the asphalt concrete, which was measured as the ratio of the amplitude of the surface reflection of the asphalt mat to that of a metal plate. In addition, an IR camera was used to monitor the surface temperature of the asphalt mat to ensure its uniformity, for both conventional asphalt concrete and fiber-reinforced asphalt (FRA) concrete. RESULTS : From the GPR test, the measured in situ air void of the asphalt concrete overlay gradually decreased from 12.6% at placement to 8.1% after five roller passes for conventional asphalt concrete, and from 10.7% to 5.9% for the FRA concrete. The thickness of the asphalt concrete overlay was reduced from 7.0 cm to 6.0 cm for the conventional material, and from 9.2 cm to 6.4 cm for the FRA concrete. From the IR camera measurements, the temperature differences in the asphalt mat ranged from $10^{\circ}C$ to $30^{\circ}C$ in the two test sections. CONCLUSIONS : During asphalt concrete construction, GPR and IR tests can be applicable for monitoring the changes in in situ density, thickness, and temperature differences of the overlay, which are the most important factors for quality control. For easier and more reliable quality control of asphalt overlay construction, it is better to use the thickness measurement from the GPR.

• Geophysics and Geophysical Exploration
• /
• v.5 no.3
• /
• pp.185-192
• /
• 2002

We made a study of 3-D migration which could precisely image data of GPR (Ground Penetrating Radar) applied to NDT (Non-Destructive Test) field for the inspection of structural safety. In this study, we obtained 3-D migrated images of important targets in structuresurvey (e.g. steel pipes, cracks) by using 3-D Kirchhoff prestack depth migration scheme developed for seismic data processing. For a concrete model consisting of steel pipe and void, the targets have been well defined with opposite amplitude according to the parameters of the targets. And migrated images using Parallel-Broadside array (XX configuration) have shown higher resolution than those using Perpendicular-Broadside array (YY configuration) when steel pipes had different sizes. Therefore, it is required to analyze the migrated image of XX configuration as well as that of general YY configuration in order to get more accurate information. As the last stage, we chose a model including two steel pipes which cross each other. The upper pipe has been resolved clearly but the lower has been imaged bigger than the model size due to the high conductivity of the upper steel.

• Korean Journal of Acupuncture
• /
• v.25 no.4
• /
• pp.175-185
• /
• 2008

Objective : Acupuncture (from the Latin acus, "needle," and pungere, "to prick") is a technique of inserting and manipulating fine needles at specific points on the body. As a placebo acupuncture needle device was developed based on the visual impact of needling, it has been raised that it is useful only when acupuncture points and needling are visible to subjects. To examine the visual factor of the placebo acupuncture, the present study was aimed to compare the blinding index of the verum and placebo acupuncture between masked and unmasked situation. Methods : Thirty-six patients were randomly alloted to be stimulated with a verum or placebo acupuncture in a cross-over design. They were asked to guess a right answer whether they were stimulated with the verum or placebo acupuncture at LI4 in an unmasked or masked situation. The penetrating, pain, and deqi sensations were also measured after the stimulation using modified visual analogue scale. Results : The correct answer rate of the placebo acupuncture was 22.2% and 16.7% in an unmasked and masked situation, respectively (P>0.767). The blinding index of the placebo acupuncture was -0.56 (95%CI -0.84 to -0.27) and -0.67 (95%CI -0.91 to -0.42) in an unmasked and masked situation, respectively. The penetrating and deqi sensation of the verum acupuncture were significantly higher than those of the placebo acupuncture in both unmasked and masked situation. The pain sensation of the verum acupuncture was significantly higher than that of the placebo acupuncture in masked situation, but not in unmasked situation. Conclusion : Blinding of the placebo acupuncture was successful both in the unmasked and masked situation. These finding indicate that visual factor might not play a critical role in blinding of the placebo needle. We suggest that placebo needle would be also useful in a functional magnetic resonance imaging scan even when the subject could not see the placebo needle.

• Tunnel and Underground Space
• /
• v.7 no.3
• /
• pp.230-237
• /
• 1997

As concrete structure is getting old and decrepit, its inspection and diagnosis is getting important. Therefore, it is necessary to estimate the soundness of structure using non-destructive tests for effective repairs and maintenances. But, applications of non-destructive tests in tunnel have been used restrictively, due to accessibility only from one side in tunnel lining and presence of tunnel installations. Recently, the various non-destructive techniques have been studied. Especially, ground penetrating radar(GPR) and impact echo (IE) methods have been researched for tunnel inspection. In this study, the applicability of impact echo test in tunnel lining inspection has been investigated. This paper described the tunnel inspection for lining thickness and internal flaw using impact echo tests. Model tests were carried out using impact echo test systems on two concrete models, Model I is measuring for lining thickness, Model II is detecting for internal flaw. Also, the test were applied for lining inspections in a tunnel constructed by NATM. From the results of impact echo tests, we have concluded that impact echo test is a very useful and effective technique for inspecting the concrete tunnel linings.

• Journal of Chest Surgery
• /
• v.24 no.11
• /
• pp.1115-1124
• /
• 1991

Recently the thoracic injuries have been markedly increasing due to the vast increase of traffic accident, industrial disaster, and incidental accident as well as the frequent use of the murderous weapons including gun or rifle. Because the thoracic injuries could involve the heart, lung, and great vessels, and would influence the lives, prompt diagnosis and adequate treatment are essential. Most of thoracic injuries can be managed with the conservative treatment and simple surgical procedure such as closed thoracostomy, but certain cases require open thoracotomy to preserve lives and to return to their normal environment. The authors have analysed the result of 53 cases of open thoracotomy after thoracic injuries mainly according to the patient`s chart review. The mean age was 33.4 years old and male to female ratio was about 5: l. Injury mechanisms that elicited thoracic trauma indicated for open thoracotomy were penetrating[47%] and non-penetrating[53%] injuries. The Most common type of the thoracic lesion was hemothorax with or without pneumothorax and diaphragm rupture was the second. 58\ulcornero of thoracic injuries were accompanied by abdominal injuries and 47% by bone fractures. 34 patients were operated within 24 hours after injury and their average elapsed time was 13.6 hour. The remained patients were operated after 24 hours and their average elapsed time was 7.8 days. 71 cases of operative procedures containing some overlappings were performed: diaphragm repair[28], bleeding control[12], pulmonary and cardiac repair[4 cases] Postoperative complication rate was 32.1% and operative mortality rate was 9.4%[5/53].

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.8 no.5
• /
• pp.456-465
• /
• 2016

In order to optimize the performance of a Wells turbine with fixed guide vanes, the designs of an end plate and a ring on the tip of the turbine rotor are proposed as penetrating blade tip treatments. In this study, numerical investigations are made using computational fluid dynamics (CFD)-based ANSYS Fluent software, and validated by corresponding experimental data. The flow fields are analyzed and non-dimensional coefficients $C_A$, $C_T$ and ${\eta}$ are calculated under steady-state conditions. Numerical results show that the stalling phenomenon on a ring-type Wells turbine occurs at a flow coefficient of ${\phi}=0.36$, and its peak efficiency can reach 0.54, which is 16% higher than that of an unmodified turbine and 9% higher than in the case of an endplate-type turbine. In addition, quasi-steady analysis is used to calculate the mean efficiency and output work of a wave cycle under sinusoidal flow conditions. As a result, it has been found that the ring-type turbine is superior to other types of Wells turbines.

• Journal of Chest Surgery
• /
• v.7 no.1
• /
• pp.23-30
• /
• 1974

During the 35 month period from November 1966 to November 1967 and from June 1971 to March 1973 I had experienced 127 cases of non fatal wounds of chest in Viet-Nam. .Among these 127 cases, 62[45.4%] were gun shot wounds, 49[35.8%] were shrapnel wounds and the other were traffic accident. stab wounds and miscellanous. Approximately 21% of gun shot wound were perforating and 79% were penetrating but all cases of shrapnel wounds were penetrating. Of these 127 cases. 90% evacuated to hospital within 6 hours and average time 2.5 hours. The tranfusion requirement of these cases ranged from zero to 36 pints of whole blood with an average of 2.600cc. Initial intrathoracic findings were hemopneumothorax and hemothorax mostly. and the incidence of open thoracotomy was 9.5%[12cases] and closed thoracotomy was 82.8%[104cases], which were contrast to the reports from Korean conflict. I had experienced 24 cases with complication, such as large hematoma in lung parenchyme[8 cases], atelectasis[4 cases], pyothorax [3 cases], pneumonia [3 cases], fibrothorax [3 cases], pleural effusion [2 cases] and wound infection [2 cases]. Mortality rate for entire group was 4.7% but the cases associated with brain injury was 100%, with spinal cord injury was 50%, with large vessel 50%, and abdominal injury was 33.3%, and nobody died solely of thoracic injury.

• Molecules and Cells
• /
• v.28 no.4
• /
• pp.341-345
• /
• 2009

MiRNAs are non-coding RNAs that play a role in the regulation of major processes. The inhibition of miRNAs using antisense oligonucleotides (ASOs) is a unique and effective technique for the characterization and subsequent therapeutic targeting of miRNA function. Recent advances in ASO chemistry have been used to increase both the resistance to nucleases and the target affinity and specificity of these ASOs. Peptide nucleic acids (PNAs) are artificial oligonucleotides constructed on a peptide-like backbone. PNAs have a stronger affinity and greater specificity to DNA or RNA than natural nucleic acids and are resistant to nucleases, which is an essential characteristic for a miRNA inhibitor that will be exposed to serum and cellular nucleases. For increasing cell penetration, PNAs were conjugated with cell penetrating peptides (CPPs) at N-terminal. Among the tested CPPs, Tat-modified peptide-conjugated PNAs have most effective function for miRNA inhibition. PNA-based ASO was more effective miRNA inhibitor than other DNA-based ASOs and did not show cytotoxicity at concentration up to 1,000 nM. The effects of PNA-based ASOs were shown to persist for 9 days. Also, PNA-based ASOs showed considerable stability at storage temperature. These results suggest that PNA-based ASOs are more effective ASOs of miRNA than DNA-based ASOs and PNA-based ASO technology, compared with other technologies used to inhibit miRNA activity can be an effective tool for investigating miRNA functions.