• Title/Summary/Keyword: Non-linear Effect

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Systemic White Blood Cell Count as a Biomarker Associated with Severity of Chronic Obstructive Lung Disease

  • Koo, Hyeon-Kyoung;Kang, Hyung Koo;Song, Pamela;Park, Hye Kyeong;Lee, Sung-Soon;Jung, Hoon
    • Tuberculosis and Respiratory Diseases
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    • v.80 no.3
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    • pp.304-310
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    • 2017
  • Background: Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome. Methods: The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses. Results: The WBC count was negatively associated with forced vital capacity (FVC, L), FVC (% predicted), forced expiry volume in one second ($FEV_1$, L), and $FEV_1$ (% predicted) in COPD patients. Additionally, the WBC count was independently associated with the quality of life measure, by EQ5D-index score. However, this relationship between WBC count, and disease severity, was not significant in current smokers, because of the confounding effect of smoking, on the WBC count. Conclusion: The WBC count is associated with current smoking status and COPD severity, and a risk factor for poor lung function, and quality of life, especially in non-currently smoking COPD patients. The WBC count can be used, as an easily measurable COPD biomarker.

Pressure loading, end- shortening and through- thickness shearing effects on geometrically nonlinear response of composite laminated plates using higher order finite strip method

  • Sherafat, Mohammad H.;Ghannadpour, Seyyed Amir M.;Ovesy, Hamid R.
    • Structural Engineering and Mechanics
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    • v.45 no.5
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    • pp.677-691
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    • 2013
  • A semi-analytical finite strip method is developed for analyzing the post-buckling behavior of rectangular composite laminated plates of arbitrary lay-up subjected to progressive end-shortening in their plane and to normal pressure loading. In this method, all the displacements are postulated by the appropriate harmonic shape functions in the longitudinal direction and polynomial interpolation functions in the transverse direction. Thin or thick plates are assumed and correspondingly the Classical Plate Theory (CPT) or Higher Order Plate Theory (HOPT) is applied. The in-plane transverse deflection is allowed at the loaded ends of the plate, whilst the same deflection at the unloaded edges is either allowed to occur or completely restrained. Geometric non-linearity is introduced in the strain-displacement equations in the manner of the von-Karman assumptions. The formulations of the finite strip methods are based on the concept of the principle of the minimum potential energy. The Newton-Raphson method is used to solve the non-linear equilibrium equations. A number of applications involving isotropic plates, symmetric and unsymmetric cross-ply laminates are described to investigate the through-thickness shearing effects as well as the effect of pressure loading, end-shortening and boundary conditions. The study of the results has revealed that the response of the composite laminated plates is particularly influenced by the application of the Higher Order Plate Theory (HOPT) and normal pressure loading. In the relatively thick plates, the HOPT results have more accuracy than CPT.

Experimental Study on the Heat Transfer and Turbulent Flow Characteristics of Jet Impinging the Non-isothermal Heating Plate (비균일 온도분포를 갖는 평판에 대한 충돌제트의 열전달 및 난류유동특성에 관한 연구)

  • 한충호;이계복;이충구;이창우
    • Journal of Energy Engineering
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    • v.10 no.3
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    • pp.272-277
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    • 2001
  • An experimental study of jet impinging the non-isothermal heating surface with linear temperature gradient is conducted with the presentation of the turbulent flow characteristics and the heat transfer rate, represented by the Nusselt number. The jet Reynolds number ranges from 15,000 to 30,000, the temperature gradient of the plate is 2~4.2$^{\circ}C$/cm and the dimensionless nozzle to plate distance (H/D) is from 2 to 10. The results show that the peak of heat transfer rate occurs at the stagnation point, and the heat transfer rate decreases as the radial distance from the stagnation point increases. A remarkable feature of the heat transfer rate is the existence of the second peak. This is due to the turbulent development of the wall jet. Maximum heat transfer rate occurs when the axial distance from the nozzle to nozzle diameter (H/D) is 6 or 8. The heat transfer rate can be correlated as a power function of Prandtl number, Reynolds number, the dimensionless nozzle to plate distance (H/D) and temperature gradient (dT/dr). It has been found that the heat transfer rate increases with increasing turbulent intensity. The wall jet is influenced by temperature gradient and the effect becomes more important at higher radii.

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The Effect of Resilience on Posttraumatic Stress Disorder Symptoms and Comorbid Symptoms in Firefighters (강원지역 소방관에서 외상후 스트레스 증상 및 동반증상에 미치는 리질리언스의 영향)

  • Lee, Hong-Eui;Kang, Suk-Hoon;Ye, Byoung Seok;Choi, Jong-Hyuck
    • Anxiety and mood
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    • v.8 no.2
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    • pp.86-92
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    • 2012
  • Objective : This study investigated the relationship between the resilience and posttraumatic stress symptoms, as well as comorbid symptoms in firefighters. Methods : We collected 764 firefighters, who worked at six fire department stations in Gangwon-do. We investigated the impact of event scale-revised (IES-R), the life events checklists (LEC), Connor-Davidson resilience scale (CD-RISC), Beck depression inventory (BDI), state trait anxiety inventory (STAI) and alcohol use disorder identification test (AUDIT). Full PTSD groups, partial PTSD groups and non-PTSD groups, which were classified by IES-R scores, were compared in the LEC, CD-RISC, BDI, STAI and AUDIT, ; multiple linear regression analyses were done for independent predictors of variables. Results : Of the 764 firefighters, there were significant differences in LEC (p<0.001), CD-RISC (p<0.001), BDI (p<0.001), and AUDIT (p=0.001) among the full PTSD groups, partial PTSD groups and non-PTSD groups. However, STAI did not show significant difference among three groups. In multiple regression analysis, CD-RISC (${\beta}=-0.168$, p<0.001), LEC (${\beta}=0.211$, p<0.001) and AUDIT (${\beta}=0.115$, p=0.001) were significant predictors for IES-R. Conclusion : The results of the present study suggested that resilience might be a protective factor in PTSD and comorbid symptoms of PTSD.

Association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome in Korean women with type 2 diabetes mellitus

  • Oh, Ji Soo;Kim, Hyesook;Vijayakumar, Aswathy;Kwon, Oran;Choi, Young Ju;Huh, Kap Bum;Chang, Namsoo
    • Nutrition Research and Practice
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    • v.10 no.1
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    • pp.67-73
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    • 2016
  • BACKGROUND/OBJECTIVES: This study was aimed at examining the association between dietary flavanones intake and lipid profiles according to the presence of metabolic syndrome (MetS) in Korean women with type 2 diabetes mellitus (T2DM). SUBJECTS/METHODS: A cross-sectional analysis was performed among 502 female T2DM patients (non-MetS group; n = 129, MetS group; n = 373) who were recruited from the Huh's Diabetes Clinic in Seoul, Korea between 2005 and 2011. The dietary intake was assessed by a validated semi-quantitative food frequency questionnaire (FFQ) and the data was analyzed using the Computer Aided Nutritional Analysis program (CAN-Pro) version 4.0 software. The intake of flavanones was estimated on the basis of the flavonoid database. RESULTS: In the multiple linear regression analysis after adjustment for confounding factors, daily flavanones intake was negatively associated with CVD risk factors such as total cholesterol, LDL-cholesterol, and apoB and apoB/apoA1 ratio only in the MetS group but not in the non-MetS group. Multiple logistic regression analysis revealed that the odds ratio for a higher apoB/apoA1 ratio above the median (${\geq}0.74$) was significantly low in the $4^{th}$ quartile compared to that in the $1^{st}$ quartile of dietary flavanones intake [OR: 0.477, 95% CI: 0.255-0.894, P for trend = 0.0377] in the MetS group. CONCLUSIONS: Dietary flavanones intake was inversely associated with the apoB/apoA1 ratio, suggesting a potential protective effect of flavanones against CVD in T2DM women with MetS.

Ultrasonic characterization of exhumed cast iron water pipes

  • Groves, Paul;Cascante, Giovanni;Knight, Mark
    • Smart Structures and Systems
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    • v.7 no.4
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    • pp.241-262
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    • 2011
  • Cast iron pipe has been used as a water distribution technology in North America since the early nineteenth century. The first cast iron pipes were made of grey cast iron which was succeeded by ductile iron as a pipe material in the 1940s. These different iron alloys have significantly different microstructures which give rise to distinct mechanical properties. Insight into the non-destructive structural condition assessment of aging pipes can be advantageous in developing mitigation strategies for pipe failures. This paper examines the relationship between the small-strain and large-strain properties of exhumed cast iron water pipes. Nondestructive and destructive testing programs were performed on eight pipes varying in age from 40 to 130 years. The experimental program included microstructure evaluation and ultrasonic, tensile, and flexural testing. New applications of frequency domain analysis techniques including Fourier and wavelet transforms of ultrasonic pulse velocity measurements are presented. A low correlation between wave propagation and large-strain measurements was observed. However, the wave velocities were consistently different between ductile and grey cast iron pipes (14% to 18% difference); the ductile iron pipes showed the smaller variation in wave velocities. Thus, the variation of elastic properties for ductile iron was not enough to define a linear correlation because all the measurements were practically concentrated in single cluster of points. The cross-sectional areas of the specimens tested varied as a result of minor manufacturing defects and levels of corrosion. These variations affect the large strain testing results; but, surface defects have limited effect on wave velocities and may also contribute to the low correlations observed. Lamb waves are typically not considered in the evaluation of ultrasonic pulse velocity. However, Lamb waves were found to contribute significantly to the frequency content of the ultrasonic signals possibly resulting in the poor correlations observed. Therefore, correlations between wave velocities and large strain properties obtained using specimens manufactured in the laboratory must be used with caution in the condition assessment of aged water pipes especially for grey cast iron pipes.

Nonlinear thermoelastic analysis of FGM thick plates

  • Bouhlali, Malika;Chikh, Abdelbaki;Bouremana, Mohammed;Kaci, Abdelhakim;Bourada, Fouad;Belakhdar, Khalil;Tounsi, Abdelouahed
    • Coupled systems mechanics
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    • v.8 no.5
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    • pp.439-457
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    • 2019
  • In this paper, a new application of a four variable refined plate theory to analyze the nonlinear bending of functionally graded plates exposed to thermo-mechanical loadings, is presented. This recent theory is based on the assumption that the transverse displacements consist of bending and shear components in which the bending components do not contribute toward shear forces, and similarly, the shear components do not contribute toward bending moments. The derived transverse shear strains has a quadratic variation across the thickness that satisfies the zero traction boundary conditions on the top and bottom surfaces of the plate without using shear correction factors. The material properties are assumed to vary continuously through the thickness of the plate according to a power-law distribution of the volume fraction of the constituents. The solutions are achieved by minimizing the total potential energy. The non-linear strain-displacement relations in the von Karman sense are used to derive the effect of geometric non-linearity. It is concluded that the proposed theory is accurate and simple in solving the nonlinear bending behavior of functionally graded plates.

Is the association of continuous metabolic syndrome risk score with body mass index independent of physical activity? The CASPIAN-III study

  • Heshmat, Ramin;shafiee, Gita;Kelishadi, Roya;Babaki, Amir Eslami Shahr;Motlagh, Mohammad Esmaeil;Arefirad, Tahereh;Ardalan, Gelayol;Ataie-Jafari, Asal;Asayesh, Hamid;Mohammadi, Rasool;Qorbani, Mostafa
    • Nutrition Research and Practice
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    • v.9 no.4
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    • pp.404-410
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    • 2015
  • BACKGROUND/OBJECTIVES: Although the association of body mass index (BMI) with metabolic syndrome (MetS) is well documented, there is little knowledge on the independent and joint associations of BMI and physical activity with MetS risk based on a continuous scoring system. This study was designed to explore the effect of physical activity on interactions between excess body weight and continuous metabolic syndrome (cMetS) in a nationwide survey of Iranian children and adolescents. SUBJECTS/METHODS: Data on 5,625 school students between 10 and 18 years of age were analyzed. BMI percentiles, screen time activity (STA), leisure time physical activity (LTPA) levels, and components of cMetS risk score were extracted. Standardized residuals (z-scores) were calculated for MetS components. Linear regression models were used to study the interactions between different combinations of cMetS, LTPA, and BMI percentiles. RESULTS: Overall, 984 (17.5%) subjects were underweight, whereas 501 (8.9%) and 451 (8%) participants were overweight and obese, respectively. All standardized values for cMetS components, except fasting blood glucose level, were directly correlated with BMI percentiles in all models (P-trend < 0.001); these associations were independent of STA and LTPA levels. Linear associations were also observed among LTPA and standardized residuals for blood pressure, high-density lipoprotein, and waist circumference (P-trend < 0.01). CONCLUSIONS: Our findings suggest that BMI percentiles are associated with cMetS risk score independent of LTPA and STA levels.

An approach for moment-rotation relationship and bearing strength of segment lining's joint (세그먼트 라이닝 이음부의 모멘트-회전 관계와 지압강도 계산)

  • Lee, Young Joon;Chung, Jee Seung
    • Journal of Korean Tunnelling and Underground Space Association
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    • v.23 no.2
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    • pp.93-106
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    • 2021
  • In general, segment lining tunnel refers to a tunnel formed by connecting precast concrete segments as a ring and connecting such rings to each other in the longitudinal direction of the tunnel. As the structural properties of the segment lining is highly dependent on the behavior of the segment joints, thus correct modelling of joint behavior is crucial to understand and design the segment tunnel lining. When the tunnel is subjected to ground loads, the segment joint behaves like a hinge that resists rotation, and when the induced moment exceeds a certain limit of the rotation then it may enter into non-linear field. In understanding the effect of the segment joint on the lining behavior, a moment-rotation relationship of the segment joint was explored based on the Japanese practice and Janssen's approach commonly used in the actual design. This study also presents a method to determine the rotational stiffness of joint refer to the bearing strength. The rotation of the segment joint was estimated in virtual design conditions based on the existing models and the proposed method. And the sectional force of the segment lining and joint were calculated along with the estimated rotation. As the rotation at the segment joint increases, the joint contact area decreases, so the designer have to verify the segment joint for bearing strength as well. This paper suggests a consistent method to determine the rotational stiffness and bearing strength of joints.

A Study of the Generational Cleavage in Welfare Attitudes: Differentiating Cohort Effect from Age Effect and Finding Its Factors (복지태도의 세대 간 균열 연구: 연령효과와 분리된 코호트 효과와 그 요인의 분석)

  • Jo, Nam Kyoung
    • 한국사회정책
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    • v.24 no.2
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    • pp.245-275
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    • 2017
  • It is attempted here to explain change in welfare attitudes for two decades in 10 countries with the cohort effect, especially differences in societal values between generations. It was found that for the last 20 years pro-welfare attitudes of the public has been strengthened, on which the generation has impact, more by the cohort effect than by the age effect, and that the Millennials/Y-generation are the strongest supporters for the state welfare. Value-differences between cohorts, as a background factor for the cohort effect on welfare attitudes, are clear but show a kind of linear trend from the older to the younger cohorts. As for the cohort effect on welfare attitudes, it is expected, at least for the short-term future, in the direction toward supporting the expansion of the state welfare. Korean welfare attitudes show an exceptional pattern - preferring income inequality as incentives, and at the same time, the expansion of governmental welfare responsibility, which echoes recent arguments of contradictoriness and non-class-orientedness of Korean welfare attitudes. Especially, Korean Millennials/Y-G shows this contradictory welfare attitudes the most strongly, which is unique between 10 countries in this study, implying their fierce competition is being internalized. It is expected that the contradictoriness of Korean welfare attitudes may limit its possibility to back up welfare expansion in Korea.