• Title/Summary/Keyword: Non-aqueous

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Solubility and Physicochemical Stability of Ondansetron Hydrochloride in Various Vehicles (용제 중 염산온단세트론의 용해성 및 안정성)

  • Gwak, Hye-Sun;Oh, Ik-Sang;Chun, In-Koo
    • Journal of Pharmaceutical Investigation
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    • v.33 no.1
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    • pp.45-49
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    • 2003
  • The solubility and stability of ondansetron hydrochloride (OS) in various vehicles were determined. The effect of cyclodextrins (CD) on the solubility of OS in water was determined by equilibrium solubility method. The solubility of OS at $32^{\circ}C$ increased in the rank order of isopropyl myristate (IPM) < propylene glycol laurate (PGL) ${\ll}$ propylene glycol monolaurate < propylene glycol monocaprylate (PGMC) < poly(ethylene glycol) 400 < diethylene glycol mono ethyl ether (DGME) < ethanol < poly(ethylene glycol) 300 < water (36.1 mg/ml) ${\ll}$ propylene glycol (PG) (283 mg/ml). The addition of PG or DGME to non-aqueous vehicles such as IPM, PGL and PGMC markedly increased the solubility of OS. The addition of CDs in water increased the solubility. Apparent stability constant for the CD complexation with OS was calculated to be $25.5\;M^{-1}$ for $2-hydroxypropyl-{\beta}-CD\;(2HP{\beta}CD)$. Twenty mM ${\beta}-CD$, 69.4 mM sulfobutyl ether ${\beta}-CD$ and 115.4 mM $2HP{\beta}CD$ increased the aqueous solubilty of OS 1.27, 2.18 and 1.85 times, respectively. OS was stable in buffered aqueous solution (pH 5.0). However, OS was relatively unstable in non-aqueous vehicles in the order of PG

Formation of Poly(vinylidene difluoride) Membranes with Various Pore Sizes by a Phase Inversion Process and Membrane Performance of Aqueous and Non-aqueous Solution System (상전환법에 의한 다양한 기공크기를 갖는 폴리비닐리덴플루오라이드 막의 제조와 수계 및 비수계 용액 내에서의 막 성능)

  • Lee Kew-Ho;Kim In-Chul
    • Membrane Journal
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    • v.15 no.1
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    • pp.22-33
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    • 2005
  • Asymmetric PVDF membranes were prepared by the phase inversion from casting solutions containing PVDF, NMP as solvent and 1,4-dioxane, DGDE, acetone, or GBL as additives by immersing them in water. The effects of various additives on the casting solution properties, permeation properties, and membrane structures were investigated. Low miscibility of 1,4-dioxane, DGDE and acetone with the coagulant (water) compared with NMP resulted in reducing the membrane pore size. When DGDE is used as an additive, the pore size was reduced because of its incipient sharp interface formation in the water. GBL increased membrane pore size because of its polarity compared to that of NMP. The PVDF membranes with various pore sizes could be obtained by controlling the amount of additive. The effect of mixed solvent (aqueous and non-aqueous solution) on permeation through membrane was investigated. Not only solution viscosity but surface tension affected solvent permeation.

Treatment of non-degrable Organic Pollutants in Aqueous by ultrasonic irradiation (초음파에 의한 수중의 난분해성 오염물질 처리)

  • 손종열;모세영;손진석
    • Journal of environmental and Sanitary engineering
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    • v.10 no.1
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    • pp.76-84
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    • 1995
  • This study was performed to examine the factors influenced on the decomposition of nondegradable organic pollutants( Tricholoroethylene,Benzene ) in aqueous by ultrasonic irradiation. The TCE( Tricholoroethylene ) and Benzene are major hazard compounds causing environmental Pollution and not decomposable substances by conventional treatment. The results shows that the oxidation and reduction reaction of ultrasonic Irradiation was formed the H$_{2}$O$_{2}$ , H$^{+}$ and OH$^{-}$ radical, and then theses was decomposed pollutants of TCE and Benzene in aqueous. We were conformed that the ultrasonic irradiation was excellent in removal efficiency of the nondegradable organic substances any other than processes and utilized the treatment of organic compounds in the industrial wastewater. Conclusively, these results suggest that ultrasonic irradiation may be extremely useful for the treatment of wastewater contaminated organic pollutants, which is difficult to treat economically by conventional treatment.

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Polymeric Gel Electrolytes for Electric Double Layer Capacitors (전기이중층 캐패시터에 관한 폴리머 겔 전해액)

  • Morita, Masayuki;Qiao, Jin-Li
    • Journal of the Korean Electrochemical Society
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    • v.6 no.2
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    • pp.141-144
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    • 2003
  • Proton conducting polymeric gels as the electrolytes of electrochemical capacitors have been prepared by two different methods: 1) swelling a polymethacrylate-based polymer matrix in aqueous solutions of inorganic and organic acids, and 2) polymerizing complexes of anhydrous acids and prepolymers with organic plasticizer. The FT-IR spectra strongly suggest that the carbonyl groups in the polymer matrix interact with protons from the doped acids. High ionic (proton) conductivity in the range of $6\times10^{-4}-4\times10^{-2}\;S\;cm^{-1}$ was obtained at room temperature for the aqueous gels. The non-aqueous polymer complexes showed rather low ionic conductivity, but it was about $10^{-3}\;S\;cm^{-1}\;at\;70^{\circ}C$ for the $H_3PO_4$ doped polymer electrolyte. The mechanisms of ion (proton) conduction in the polymeric systems are discussed.

Sorbent Characteristics of Montmorillonite for Ni2+Removal from Aqueous Solution

  • Ijagbemi, Christianah Olakitan;Kim, Dong-Su
    • Environmental Engineering Research
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    • v.14 no.1
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    • pp.26-31
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    • 2009
  • Sorption of $Ni^{2+}$ in aqueous solution was studied using montmorillonite. The experimental and equilibrium data fitted well to the Langmuir isotherm model. From the kinetics data for nickel sorption onto montmorillonite, the diffusion of $Ni^{2+}$ inside the clay particles was the dorminant step controlling the sorption rate and as such more important for $Ni^{2+}$ sorption than the external mass transfer. $Ni^{2+}$ was sorbed due to strong interactions with the active sites of the sorbent and the sorption process tends to follow the pseudo second-order kinetics. Thermodynamic parameters (${\Delta}G^{\circ},\;{\Delta}H^{\circ},\;{\Delta}S^{\circ}$) indicated a non spontaneous and endothermic adsorption process while the positive low value of the entropy change suggests low randomness of the solid/solution interface during the uptake of $Ni^{2+}$ by montmorilionite. Heavy metals such as $Ni^{2+}$ in aqueous bodies can effectively be sorbed by montmorillonite.

Overview on Ionic Liquid Application Technologies for Back-end Fuel Cycle Processes (핵주기 공정에서의 이온성 액체 활용 기술 개요)

  • Kim, Ki-Sub;Park, Byung Heung
    • Journal of Institute of Convergence Technology
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    • v.3 no.2
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    • pp.1-6
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    • 2013
  • The ionic liquids are known to potential alternative solvents capable of replacing the commercial solvents in various processes including those in nuclear fuel cycle. As to the material, a number of studies have already reviewed the interesting results and addressed the spectroscopic as well as electrochemical behaviors of metal elements included in spent nuclear fuels. It has found that the important properties of metal ions in TBP dissolved ILs have led the development of alternative technologies to traditional solvent extraction processes. On the other hand, the electrochemical deposition of metal ions in ILs have been investigated for the application of the solvents to aqueous as well as to non-aqueous processes. In this work, a review on the application of ILs in nuclear fuel cycle is briefly presented to understand the notable researches on ILs focusing on aqueous processes.

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The Stabilization of 20.0% Ascorbic Acid in Aqueous Cosmetic Formulation (아스코빅애씨드 고함량 안정화 수계 조성물 제조 방법)

  • Park, Jeong Mi;Eun, So Hee;Ko, Eun Ah;Han, Sang Keun;Kang, Hak Hee;Hyun, Seung Min
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.44 no.2
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    • pp.125-131
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    • 2018
  • Ascorbic acid (Vitamin C) has been widely used in skin care formulations. Due to its remarkable effects on anti-oxidation, collagen biosynthesis and whitening, ascorbic acid is considered as an effectible anti-aging active ingredient. But, the instability problems of ascorbic acid in cosmetic formulation such as oxidation, browning and changes in smell is the difficult issue to be overcome for the application of high concentration of ascorbic acid. We tried to stabilize the ascorbic acid in non-aqueous liquid formulation that contains polyol solvent at first. The non-aqueous system was effectible to reduce oxidation. But, ascorbic acid was crystallized in the non-aqueous formulation at the low temperature below $5^{\circ}C$. We tried to develop way to stabilize the ascorbic acid in aqueous solutions to solve the crystallizing problem. In this study, we search the optimal ratio of antioxidant combination, such as zinc sulfate, glutathione and curcuma longa (turmeric) root extract. Formulations were stored at - $16^{\circ}C$, $5^{\circ}C$, $25^{\circ}C$, $40^{\circ}C$, $50^{\circ}C$ and cycle($5-40^{\circ}C$) (in incubator) for a period of eight weeks to investigate their stability. In the stability analysis, the test parameters consisted of color, scent, phase separation and sedimentation. Ascorbic acid stability was checked by HPLC analysis.