• Title/Summary/Keyword: Ningbo

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miR-181b as a Potential Molecular Target for Anticancer Therapy of Gastric Neoplasms

  • Guo, Jian-Xin;Tao, Qing-Song;Lou, Peng-Rong;Chen, Xiao-Chun;Chen, Jun;Yuan, Guang-Bo
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2263-2267
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    • 2012
  • Objective: MicroRNAs (miRNAs) play important roles in carcinogenesis. The aim of the present study was to explore the effects of miR-181b on gastric cancer. Methods: The expression level of miR-181b was quantified by qRT-PCR. MTT, flow cytometry and matrigel invasion assays were used to test proliferation, apoptosis and invasion of miR-181b stable transfected gastric cancer cells. Results: miR-181b was aberrantly overexpressed in gastric cancer cells and primary gastric cancer tissues. Further experiments demonstrated inducible expression of miR-181b by Helicobacter pylori treatment. Cell proliferation, migration and invasion in the gastric cancer cells were significantly increased after miR-181b transfection and apoptotic cells were also increased. Furthermore, overexpression of miR-181b downregulated the protein level of tissue inhibitor of metalloproteinase 3 (TIMP3). Conclusion: The upregulation of miR-181b may play an important role in the progress of gastric cancer and miR-181b maybe a potential molecular target for anticancer therapeutics of gastric cancer.

중국(中國) 수출(輸出) 남성(男性) 기성복(旣成服) 치수에 관(關)한 연구(硏究) -한국(韓國) 남성복(男性服) 치수를 중심(中心)으로 한 중국(中國) 남성복(男性服) 대응(對應)치수의 설정(設定) 및 제시(提示)-

  • Shim, Boo-Ja
    • Journal of Fashion Business
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    • v.11 no.2
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    • pp.155-171
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    • 2007
  • This research aims to present the corresponding dimensions of China men's clothes on the basis of size specification of Korea men's suits. The results of this study, with the cooperation of Sejung Company exporting men's clothes to Ningbo City, Zhejiang Province in China, are as follows: 1. Based on the drop standard of KS K 0050, the body types of Chinese men in their 20s were classified. A body types were 55.77%, Y body types were 32.16%, B body types were 11.55% and BB body types were 1.51%. 2. According to the criteria of ready-made dimensions of normal body type suggested in Korea Standards, and in consideration of the basic distribution reality of body dimensions, representative 5 sizes were selected. 3. Research jackets by different sizes were produced and went through wearing tests. The means of 1st wearing test were 3.86, 4.09, 4.09, 3.57, and 3.69. The mean of 2nd wearing test of 88-73-170 size was 4.32. 4. The corresponding size specification of China men's clothes based on those of Korea men's suits were presented here, showing product sizes and physical items in detail.

A numerical study on ice failure process and ice-ship interactions by Smoothed Particle Hydrodynamics

  • Zhang, Ningbo;Zheng, Xing;Ma, Qingwei;Hu, Zhenhong
    • International Journal of Naval Architecture and Ocean Engineering
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    • v.11 no.2
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    • pp.796-808
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    • 2019
  • In this paper, a Smoothed Particle Hydrodynamics (SPH) method is extended to simulate the ice failure process and ice-ship interactions. The softening elastoplastic model integrating Drucker-Prager yield criterion is embedded into the SPH method to simulate the failure progress of ice. To verify the accuracy of the proposed SPH method, two benchmarks are presented, which include the elastic vibration of a cantilever beam and three-point bending failure of the ice beam. The good agreement between the obtained numerical results and experimental data indicates that the presented SPH method can give the reliable and accurate results for simulating the ice failure progress. On this basis, the extended SPH method is employed to simulate level ice interacting with sloping structure and three-dimensional ice-ship interaction in level ice, and the numerical data is validated through comparing with experimental results of a 1:20 scaled Araon icebreaker model. It is shown the proposed SPH model can satisfactorily predict the ice breaking process and ice breaking resistance on ships in ice-ship interaction.

An Evolution Model of Rumor Spreading Based on WeChat Social Circle

  • Wang, Lubang;Guo, Yue
    • Journal of Information Processing Systems
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    • v.15 no.6
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    • pp.1422-1437
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    • 2019
  • With the rapid development of the Internet and the Mobile Internet, social communication based on the network has become a life style for many people. WeChat is an online social platform, for about one billion users, therefore, it is meaningful to study the spreading and evolution mechanism of the rumor on the WeChat social circle. The Rumor was injected into the WeChat social circle by certain individuals, and the communication and the evolution occur among the nodes within the circle; after the refuting-rumor-information injected into the circle, subsequently,the density of four types of nodes, including the Susceptible, the Latent, the Infective, and the Recovery changes, which results in evolving the WeChat social circle system. In the study, the evolution characteristics of the four node types are analyzed, through construction of the evolution equation. The evolution process of the rumor injection and the refuting-rumor-information injection is simulated through the structure of the virtual social network, and the evolution laws of the four states are depicted by figures. The significant results from this study suggest that the spreading and evolving of the rumors are closely related to the nodes degree on the WeChat social circle.

Comparative Interactivity Analysis in Multiview Video Coding Schemes

  • Yang, You;Dai, Qionghai;Jiang, Gangyi;Ho, Yo-Sung
    • ETRI Journal
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    • v.32 no.4
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    • pp.566-576
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    • 2010
  • In a multiview video system, interactivity is important for users and should be considered in the design of multiview video coding (MVC). In this paper, we present an interactivity evaluation model for MVC schemes by using both weighted random graph and Markov approaches. The main factors that affect both the interactivity and rate-distortion (RD) performances of MVC schemes are analyzed and discussed in detail. By taking these factors into consideration, a new MVC scheme is proposed for high interactivity and RD gains. Experimental results show that the proposed scheme has a significant interactivity gain with little coding loss, compared to the state-of-the-art benchmark. As an extension to RD performance analysis, the interactivity evaluation model can be used as a design tool of alternative schemes for a future interactive multiview video system.

Magnetic Microstructures and Corrosion Behaviors of Nd-Fe-B-Ti-C Alloy by Ga Doping

  • Wu, Qiong;Zhang, Pengyue;Ge, Hongliang;Yan, Aru;Li, Dongyun
    • Journal of Magnetics
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    • v.18 no.3
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    • pp.240-244
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    • 2013
  • The influences of Gallium doping on the magnetic microstructures and corrosion behaviors of Nd-Fe-B-Ti-C alloys are investigated. The cooling rate for obtaining fully amorphous structure is raised, and the glassforming ability is improved by the Ga addition. The High Resolution Transmission Electron Microscopy image shows that the ${\alpha}$-Fe and $Fe_3B$ soft magnetic phases become granular surrounded by the $Nd_2Fe_{14}B$ hard magnetic phase. The rms and $({\Delta}{\varphi})_{rms}$ value of Nd-Fe-B-Ti-C nanocomposite alloy thick ribbons in the typical topographic and magnetic force images detected by Magnetic Force Microscopy(MFM) decreases with 0.5 at% Ga addition. The corrosion resistances of $Nd_9Fe_{73}B_{12.6}C_{1.4}Ti_{4-x}Ga_x$ (x = 0, 0.5, 1) alloys are enhanced by the Ga addition. It can be attributed to the formation of more amorphous phases in the Ga doped samples.

Case-based reasoning approach to estimating the strength of sustainable concrete

  • Koo, Choongwan;Jin, Ruoyu;Li, Bo;Cha, Seung Hyun;Wanatowski, Dariusz
    • Computers and Concrete
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    • v.20 no.6
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    • pp.645-654
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    • 2017
  • Continuing from previous studies of sustainable concrete containing environmentally friendly materials and existing modeling approach to predicting concrete properties, this study developed an estimation methodology to predicting the strength of sustainable concrete using an advanced case-based reasoning approach. It was conducted in two steps: (i) establishment of a case database and (ii) development of an advanced case-based reasoning model. Through the experimental studies, a total of 144 observations for concrete compressive strength and tensile strength were established to develop the estimation model. As a result, the prediction accuracy of the A-CBR model (i.e., 95.214% for compressive strength and 92.448% for tensile strength) performed superior to other conventional methodologies (e.g., basic case-based reasoning and artificial neural network models). The developed methodology provides an alternative approach in predicting concrete properties and could be further extended to the future research area in durability of sustainable concrete.

Prediction of strength development of fly ash and silica fume ternary composite concrete using artificial neural network (인공신경망을 이용한 플라이애시 및 실리카 흄 복합 콘크리트의 압축강도 예측)

  • Fan, Wei-Jie;Choi, Young-Ji;Wang, Xiao-Yong
    • Journal of Industrial Technology
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    • v.41 no.1
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    • pp.1-6
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    • 2021
  • Fly ash and silica fume belong to industry by-products that can be used to produce concrete. This study shows the model of a neural network to evaluate the strength development of blended concrete containing fly ash and silica fume. The neural network model has four input parameters, such as fly ash replacement content, silica fume replacement content, water/binder ratio, and ages. Strength is the output variable of neural network. Based on the backpropagation algorithm, the values of elements in the hidden layer of neural network are determined. The number of neurons in the hidden layer is confirmed based on trial calculations. We find (1) neural network can give a reasonable evaluation of the strength development of composite concrete. Neural network can reflect the improvement of strength due to silica fume additions and can consider the reductions of strength as water/binder increases. (2) When the number of neurons in the hidden layer is five, the prediction results show more accuracy than four neurons in the hidden layer. Moreover, five neurons in the hidden layer can reproduce the strength crossover between fly ash concrete and plain concrete. Summarily, the neural network-based model is valuable for design sustainable composite concrete containing silica fume and fly ash.

Modelling the hydraulic/mechanical behaviour of an unsaturated completely decomposed granite under various conditions

  • Xiong, Xi;Xiong, Yonglin;Zhang, Feng
    • Geomechanics and Engineering
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    • v.25 no.2
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    • pp.75-87
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    • 2021
  • Because the hydraulic/mechanical behaviour of unsaturated soil is more complicated than that of saturated soil, one of the most important issues in modelling unsaturated soil is to properly couple its stress-strain relationship with its water retention characteristics. Based on the results of a series of tests, the stress-strain relationship and the changes in suction and saturation of unsaturated completely decomposed granite (CDG, also called Masado) vary substantially under different loading/hydraulic conditions. To precisely model the hydraulic/mechanical behaviour of unsaturated Masado, in this study, the superloading concept was firstly introduced into an existing saturated/unsaturated constitutive model to consider the structural influences. Then a water retention curve (WRC) model considering the volumetric change in the soil, in which the skeleton and scanning curves of the water retention characteristics were assumed to shift in parallel in accordance with the change in the void ratio, was proposed. The proposed WRC model was incorporated into the constitutive model, and the validity of the newly proposed model was verified using the results of tests conducted on unsaturated Masado, including water retention, oedometer and triaxial tests. The accuracy of the proposed model in describing the stress-strain relationship and the variations in suction and saturation of unsaturated Masado is satisfactory.

The high thermal stability induced by a synergistic effect of ZrC nanoparticles and Re solution in W matrix in hot rolled tungsten alloy

  • Zhang, T.;Du, W.Y.;Zhan, C.Y.;Wang, M.M.;Deng, H.W.;Xie, Z.M.;Li, H.
    • Nuclear Engineering and Technology
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    • v.54 no.8
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    • pp.2801-2808
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    • 2022
  • The synergistic effect of ZrC nanoparticle pining and Re solution in W matrix on the thermal stability of tungsten was studied by investigating the evolution of the microstructure, hardness and tensile properties after annealing in a temperature range of 1000-1700 ℃. The results of metallography, electron backscatter diffraction pattern and Vickers micro-hardness indicate that the rolled W-1wt%Re-0.5 wt% ZrC alloy has a higher recrystallization temperature (1600 ℃-1700 ℃) than that of the rolled pure W (1200 ℃), W-0.5 wt%ZrC (1300 ℃), W-0.5 wt%HfC (1400-1500 ℃) and W-K-3wt%Re alloy fabricated by the same technology. The molecular dynamics simulation results indicated that solution Re atoms in W matrix can slow down the self-diffusion of W atoms and form dragging effect to delay the growth of W grain, moreover, the diffusion coefficient decrease with increasing Re content. In addition, the ZrC nanoparticles can pin the grain boundaries and dislocations effectively, preventing the recrystallization. Therefore, synergistic effect of solid solution Re element and dispersed ZrC nanoparticles significantly increase recrystallization temperature.