• The Journal of Korean Physical Therapy
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• 제7권1호
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• pp.61-67
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• 1995

The silver cation has broad-spectrum antibiotic activity toward Gram-positive, Gram-negative, fungal. aerobic and anerobic micro-organisms. Silver has been used to care of infected wound. pyogenic arthritis, and chronic osteomyelitis. The purpose of this study was to determine whether pure silver wire iontophoresis using milliamperage direct current has an inhibitory effect on growth in vitro of 3 different species of bacteria-Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Using agarose based media, silver iontophoresis performed at 0, 1, 2, 4, 8 mA for 15 minutes. All experiments were performed in triplicate. Following iontophoresis, inhibition zone width of bacterial growth was measured with calliper. The inhibition of bacterial growth occured at the anodal silver electrode. Inhibition zone width of bacterial growth was significantly increased in all three bacterial species (p<0.05). Between bacterial species, inhibition zone width was not significantly different. Inhibition gone and amperage showed a highly significant positive linear relationship (p<0.001). The result of this study showed that pure silver wire iontophoresis with milliamperage direct current, as well as microamperage direct current, can inhibit bacterial growth in vivo.

• 대한물리의학회지
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• 제5권2호
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• pp.255-264
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• 2010

Purpose : The purpose of this study is to analysis effects of resistive exercise on cardiopulmonary fitness and cerebral artery blood flow velocity. Methods : Ten healthy university students had done resistive exercise without aerobic exercise over one year participated resistive exercise group and ten general university students, then were calculated oxygen consumption ($VO_2$) and respiratory exchange rate($VO_2/VCO_2$). After a week, they were measured Transcranial Doppler Ultrasonography(TCD) at moderate exercise(HRmax 50%), maximal exercise (HRmax 100%) for taking cerebral blood flow velocity. Results : In the comparison between groups, resistive exercise group showed significant higher oxygen consumption and lower respiratory exchange than controls(p<0.05). In resistive exercise group, oxygen consumption was significant negative correlation with cerebral artery pulsatory index(p<0.05). but, oxygen consumption was significant positive correlation with systolic blood flow velocity in controls(p<0.05). Conclusions : After considering all the factors, important value in resistive exercise is regular participation and help us increasing contingency response ability.

• 대한물리의학회지
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• 제14권3호
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• pp.47-53
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• 2019

PURPOSE: This study measured the external pressure on abdomen during maximal inspiration. The study determined the correlation between the diaphragmatic contraction pressure and the lung capacities to verify whether or not the measured pressure values can represent diaphragmatic contractility. METHODS: The study included 32 healthy subjects (16 males and 16 females). The researchers fabricated their own diaphragmatic pressure belt (DiP Belt) to measure DCP. DiP Belt device was fixed on the front of the abdomen and the diaphragmatic contractility was measured during maximal inspiration. The lung capacities were measured using a portable digital spirometer device (Pony Fx, COSMED, Italy). A digital spirometer is a device that is used to test the flow of air entering and exiting the lungs. RESULTS: DCP showed significant positive correlations with vital capacity (VC), inspiratory reserve volume (IRV) and inspiratory capacity (IC). Among values of lung capacities, IC showed especially strong positive correlations with the DCP (r =.714, p<.010). For the males, DCP showed significant positive correlations with IRV and IC, and DCP showed significant negative correlation with the expiratory reserve volume (ERV). For the females, DCP showed significant positive correlation with tidal volume (VT), but any significant correlation was not found with any of the other values of lung capacities. CONCLUSION: DCP showed high correlations with IRV and IC associated with inspiratory capacity. Therefore, The DiP Belt can be looked upon as a simple device that is very useful for measuring diaphragmatic contractility.

• Journal of Microbiology and Biotechnology
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• 제28권12호
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• pp.2064-2070
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• 2018

Pseudomonas tolaasii 6264 is a representative strain that causes bacterial blotch disease on the cultivated oyster mushroom, Pleurotus ostreatus. Bacteriophages are able to sterilize the pathogenic P. tolaasii strains, and therefore, they can be applied in creating disease-free mushroom cultivation farms, through a method known as "phage therapy". For successful phage therapy, the characterization of phage-resistant strains is necessary, since they are frequently induced from the original pathogenic bacteria in the presence of phages. When 10 different phages were incubated with P. tolaasii 6264, their corresponding phage-resistant strains were obtained. In this study, changes in pathogenic, genetic, and biochemical characteristics as well as the acquired phage resistance of these strains were investigated. In the phylogenetic analyses, all phage-resistant strains were identical to the original parent strain based on the sequence comparison of 16S rRNA genes. When various phage-resistant strains were examined by three different methods, pitting test, white line test, and hemolytic activity, they were divided into three groups: strains showing all positive results in three tests, two positive in the first two tests, and all negative. Nevertheless, all phage-resistant strains showed that their pathogenic activities were reduced or completely lost.

• 대한간호학회지
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• 제51권3호
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• pp.347-362
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• 2021

Purpose: This study developed a cognitive behavioral therapy program aimed at altering the physical condition, emotions, and behaviors of fibromyalgia patients, and confirmed the program's clinical applicability. The program was developed by analyzing previous studies conducting in-depth interviews with fibromyalgia patients, drawing on cognitive behavior theory to establish the program contents, recruiting experts to test its validity, and conducting a preliminary survey. Methods: To confirm the program's effect, this study used a randomized controlled trial design. The participants were outpatients diagnosed with fibromyalgia in Dong-A University Hospital, Busan. The 30 patients in the experimental group took part in the program, which comprised 8 sessions (90 to 120 minutes) based on cognitive behavior theory, delivered over 8 weeks. Hypothesis testing was carried out using the repeated measures ANOVA. Results: The analysis revealed significant differences between the experimental and control groups in positive automatic thoughts, pain, fatigue, depression, and interpersonal relationships. However, there was no significant difference between the groups in terms of sleep disorders and negative automatic thoughts. Conclusion: This program is a positive effect on physical condition, emotions, and behaviors. It is thus expected to be used to help fibromyalgia patients improve their disease conditions.

• 한국환경과학회지
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• 제30권3호
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• pp.267-277
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• 2021

This study investigates sound, scenery, and soundscape preferences, which are sensory factors that users feel in a healing forest, comparing the difference in recovery by the soundscape. In the barrier-free, wooden walking path of the National Daegwallyeong Healing Forest, a survey site with five different conditions was selected. Users prefer water sounds the most and places with open views for scenery. For the complex sensation of soundscapes, the most preferred is a space where water sounds can be heard, and either a waterfall or an open view can be seen. A profile of mood states test was use to compare users' psychological recovery by the soundscape. It was found that users felt the most positive mood with water sounds and open views. In addition, users' preference for artificial sounds, scenery, and soundscape was the lowest. In the mood state test, it was found that the artificial soundscape incited the most negative emotions.

• The Journal of Korean Physical Therapy
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• 제34권1호
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• pp.1-5
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• 2022

Purpose: The impact of prolonged sitting in a cross-legged posture on physiological factors has not been extensively studied. We therefore attempted to evaluate whether prolonged sitting in a cross-legged posture affects pulmonary function in normal young adults. Methods: Twenty-four participants were recruited in this study, and the participants were equally allocated to the normal sitting posture group (NSP group, n=12) or sitting posture with the cross-legs group (SPCL group, n=12). The NSP group sat on chairs without crossing their legs for 30 minutes, and the SPCL group sat on the chair with legs crossed (the right knee on the left knee or the left knee on the right knee) for 30 minutes. The pulmonary function of the subjects was evaluated based on forced vital capacity (FVC), forced expiratory volume in one second (FEV1), FVC/FEV1, and peak expiratory flow (PEF) measured using a spirometer. Results: In the intra-group comparison, the SPCL group showed significant differences in FVC and FEV1 before and after sitting (p<0.05), but no significant differences (p>0.05) were observed in the NSP group. However, there were no significant differences between the two groups in the pulmonary function parameters measured before and after sitting (p>0.05). Conclusion: Our results confirmed that prolonged sitting in a cross-legged posture could have a negative influence on pulmonary function. Therefore, if a sitting position is maintained for a long time, the correct sitting posture should be maintained to prevent musculoskeletal disorders as well as to maintain normal pulmonary function.

• Physical Therapy Rehabilitation Science
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• 제11권3호
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• pp.376-383
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• 2022

Objective: This study investigated how social support and self-efficacy affect the quality of life of elderly people with chronic diseases. Design: The study consisted of descriptive survey research. Methods: A questionnaire covering social support, self-efficacy, and quality of life was distributed to 320 elderly people with chronic diseases. Pearson's correlation analysis was performed to examine the correlation between the respondents' social support (family support, friend support, medical support), self-efficacy (confidence, self-regulation efficacy, preference for task difficulty), and quality of life. Multiple regression analysis was also performed to identify the factors affecting the respondents'quality of life. Results: "Friend support" and "quality of life" (r=-636, p<0.001), had a negative correlation, "confidence" and "quality of life" (r=0.827, p<0.001), "self-regulating efficacy" and "quality of life" (r=0.736, p<0.001), and "preference for task difficulty" and "quality of life" (r=0.295, p<0.001)-had positive correlations. Friend support (𝛽=-0.164, p<0.001), confidence (𝛽=0.592, p<0.001), and self-regulation efficacy (𝛽=0.160, p<0.001) were found to affect quality of life. The independent variables showed the following degrees of influence, in order: confidence, friend support, and self-regulation efficacy. Their explanatory power was 73.3% (F=146.844, p<0.001). Conclusions: The quality of life of elderly people with chronic diseases can be improved by formulating health-promotion programs that foster a sense of community.

• Journal of Digestive Cancer Research
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• 제10권2호
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• pp.107-111
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• 2022

In 2019, coronavirus disease (COVID-19), which originated in Wuhan, has spread worldwide. In most people, COVID-19 symptoms are not severe. However, the mortality rate and severity were high in risk groups such as in older people and patients with underlying diseases. As patients with cancer are one of the risk groups, the vaccination for COVID-19 is emphasized in these patients. However, COVID-19 vaccines are not tested enough in special groups such as in patients with cancer because these vaccines are developed at an unprecedented speed. This causes confusion about whether patients undergoing chemotherapy should be vaccinated or not. In this study, international guidelines and studies were reviewed. Most of the studies recommended vaccination. No evidences of any negative effects for the efficacy or safety were recorded in patients undergoing cytotoxic, targeted, and immune agents. However, in critical conditions such as cytopenia, vaccination must be decided according to the patient's condition. COVID-19 vaccines were also recommended for patients on surgery or radiation therapy. If possible, vaccine is given before surgery to avoid confusion between surgical complications and side effects of the vaccine. The radiation recall phenomenon after vaccination has been reported in some cases of radiation therapy. Clinicians should consider these situations before vaccinating each patient. We hope that clearer guidelines will be established by accumulating verified data.

• IMMUNE NETWORK
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• 제16권2호
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• pp.99-108
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• 2016

Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%. Over the past decade, advances in combination chemotherapy regimens for colorectal cancer have led to significant improvement in progression-free and overall survival. However, patients with metastatic disease gain little clinical benefit from conventional therapy, which is associated with grade 3~4 toxicity with negative effects on quality of life. In previous clinical studies, cell-based immunotherapy using dendritic cell vaccines and sentinel lymph node T cell therapy showed promising therapeutic results for metastatic colorectal cancer. In our preclinical and previous clinical studies, cytokine-induced killer (CIK) cells treatment for colorectal cancer showed favorable responses without toxicities. Here, we review current treatment options for colorectal cancer and summarize available clinical studies utilizing cell-based immunotherapy. Based on these studies, we recommend the use CIK cell therapy as a promising therapeutic strategy for patients with metastatic colorectal cancer.