• 대한본초학회지
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• 제34권1호
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• pp.43-50
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• 2019

Objectives : The purpose of this study was to proofread 'one ryang' in the Decoction of ${\ll}$Treatise on Cold Damage Diseases${\gg}$. Methods : I found out the ratio of maximum dose and minimum dose in this book. On the basis of the ratio, I corrected 'one ryang' in diverse decoctions. Results : In any decoction, maximum dose of medicinal medica in one decoction could not exceed four times minimum dose. Specifically, in the case that maximum dose in one decoction is sixteen ryang, it could not exceed eight times minimum dose in the same decoction. Any medicinal medica used in two decoctions or more, its maximum dose could not exceed four times minimum dose in other decoctions. On the basis of these results, it should be changed into three ryangs that are one ryang dose of 'Haematitum' of Seonbokdaeja Tang, 'Ginger' of Bujageongang Tang, Baektong Tang, Baektonggajeodamjep Tang and Senggangsasim Tang. Furthermore it should be changed into two ryangs that are one ryang dose of 'Coptidis Rhizoma' of Sohamhyung Tang, 'Ginger' of Dowha Tang, 'Ginseng Radix' of Whubaksenggangbanhagamchoinsam Tang, 'Polyporus, Poria Sclerotium, Alismatis Rhizoma, Talcum and Asini Corii Colla' of Jeoryeong Tang, 'Cimicifugae Rhizoma, Atractylodis Rhizoma Alba and Anemarrhenae Rhizoma' of Mahuangshengma Tang and 'Cassiae Cortex Interior' of Gyejigamchoryonggolmoryeo Tang. Conclusions : These results suggest that one ryang of thirteen medicinal medica such as Haematitum or Ginger of eleven decoctions such as Seonbokdaeja Tang or Bujageongang Tang should be changed into two or three ryangs.

• 응용통계연구
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• 제22권5호
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• pp.1033-1046
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• 2009

신약 개발 연구 또는 임상시험에서 개발된 약이 0용량 대조군과 비교해 유의한 효과 차이가 있어 신체에 반응할 수 있는 최소 복용량을 결정하는데, 이 최소 복용량을 최소 효과 용량(Minimum Effective Dose; MED)이라 한다. 이 논문에서는 최소 효과 용량을 확인하기 위하여 업데이티드 대조군을 이용한 모수적 축차 검정법을 제안하였다. 또한 모의 실험을 통하여 기존의 검정법과 제안한 검정법의 실험유의수준(experimental significance level)과 검정력(power)을 비교하였다.

• Communications for Statistical Applications and Methods
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• 제9권3호
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• pp.693-701
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• 2002

When the lowest dose level compared with zero-dose control has significant difference in effect, it is referred as minimum effective dose (MED). In this paper, we discuss several nonparametric methods for finding MED using updated rank at each sequential test step in small sample size and suggest new nonparametric procedures based on placement. Monte Carlo Simulation is adapted to compare power and Familywise Error Rate(FWE) of the new procedures with those of discussed nonparametric tests for finding MED.

• Communications for Statistical Applications and Methods
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• 제11권3호
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• pp.597-607
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• 2004

The primary interest of drug development studies is identifying the lowest dose level producing a desirable effect over that of the zero-dose control, which is referred as the minimum effective dose (MED). In this paper, we suggest a nonparametric procedure for identifying the MED with binary or ordered categorical response data. Proposed test and Williams' test are compared by Monte Carlo simulation study and discussed.

• Nuclear Engineering and Technology
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• 제56권1호
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• pp.123-131
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• 2024

Electron paramagnetic resonance (EPR) dosimetry for a tooth from an individual exposed is well known as retrospective dosimetry in radiological accidents. A major constraint of the conventional X-band tooth-EPR dosimetry is the necessity to extract the tooth of the exposed patient for dose assessment. In this study, to conduct the dose assessments of exposed patients through part-extraction of tooth enamel, the minimum detectable dose (MDD) of the tooth enamel was evaluated based on the amount of mass. Further, a field test was conducted via intercomparison using various dose assessment methods to verify the feasibility of X-band tooth-EPR dosimetry using the minimum mass of tooth enamel. The intercomparison results demonstrated that effective dose determination via X-band tooth-EPR dosimetry is reliable. Consequently, it was determined that the minimum mass of tooth enamel required to evaluate an absorbed dose above 0.5 Gy is 15 mg. Thus, EPR dosimetry using 15 mg of tooth enamel can be applied in the triage and initial medical response stages for patients exposed during radiological accidents. This approach represents an advancement in managing radiological accidents by offering a more efficient and less invasive method of dose assessment.

• Journal of Radiation Protection and Research
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• 제49권2호
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• pp.68-77
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• 2024

Background: Cone beam computed tomography (CBCT) is essential for correcting and verifying patient position before radiation therapy. However, it poses additional radiation exposure during CBCT scans. Therefore, this study aimed to evaluate radiological safety for the human body through dose assessment for CBCT. Materials and Methods: For CBCT dose assessment, the depth dose was evaluated using a cheese phantom, and the dose in the orbital area was evaluated using a human body phantom self-fabricated with a three-dimensional printer. Results and Discussion: The evaluation of radiation doses revealed maximum doses of 14.14 mGy and minimum doses of 6.12 mGy for pelvic imaging conditions. For chest imaging conditions, the maximum doses were 4.82 mGy, and the minimum doses were 2.35 mGy. Head imaging conditions showed maximum doses of 1.46 mGy and minimum doses of 0.39 mGy. The eyeball doses using a human body phantom model averaged at 2.11 mGy on the left and 2.19 mGy on the right. The depth dose ranged between 0.39 mGy and 14.14 mGy, depending on the change in depth for each imaging mode, and the average dose in the orbit area using a human body phantom was 2.15 mGy. Conclusion: Based on the experimental results, CBCT did not significantly affect the radiation dose. However, it is important to maintain a minimal radiation dose to optimize radiation protection following the as low as reasonable achievable principle.

• Communications for Statistical Applications and Methods
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• 제19권1호
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• pp.33-45
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• 2012

신약 개발 연구 또는 임상시험에서 개발된 약이 0용량 대조군과 비교해 효과 차이가 있는 가장 작은 용량을 최소 효과 용량(MED)이라 한다. 본 논문에서는 다중 그룹 상황에서 동시적(simultaneous)으로 각 각 그룹의 최소 효과 용량을 확인하기 위하여 위치(placement)에 기초한 비모수적 방법을 제시하였다. 또한 Monte Carlo 모의실험을 통하여 기존에 제시된 검정법과 본 논문에서 제안한 검정법의 검정력(power)과 FWE(Family-wise Error Rate)를비교하였다.

• Radiation Oncology Journal
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• 제12권3호
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• pp.387-392
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• 1994

Purpose : This study was done to confirm the reference point variation according to variation in applicator configuration in each fractioation of HDR ICR. Materials and Methods : We analyzed the treatment planning of HDRICR for 33 uterine cervical cancer patients treated in department of therapeutic radiology from January 1992 to February 1992. Analysis was done with respect to three view points-Interfractionation A point variation, interfractionation bladder and rectum dose ratio variation, interfractionation treatment volume variation. Interfractionation A point variation was defined as difference between maximum and minimum distance from fixed rectal point to A point in each patient. Interfractionation bladder and rectum dose ratio variation was defined as difference between maximum and minimum dose ratio of bladder or rectum to A point dose in each patient, Interfractionation treatment volume variation was defined as difference between miximum and minimum treatment volume which absorbed over the described dose-that is, 350 cGy or 400 cGy-in each patient. Results The mean of distance from rectum to A point was 4.44cm, and the mean of interfractionation distance variation was 1.14 cm in right side,1.09 cm in left side. The mean of bladder and rectum dose ratio was $63.8\%$ and $63.1\%$ and the mean of interfractionation variation was $14.9\%$ and $15.8\%$ respectively. With fixed planning administration of same planning to all fractionations as in first fractionation planning-mean of bladder and rectum dose ratio was $64.9\%$ and $72.3\%$.and the mean of interfraction variation was $28.1\%$ and $48.1\%$ reapectively. The mean of treatment volume was $84.15cm^3$ and the interfractionation variation was $21.47cm^2$. Conclusion : From these data, it was confirmed that there should be adapted planning for every fractionation ,and that confirmation device installed in ICR room would reduce the interfractionation variation due to more stable applicator configuration.

• 상하수도학회지
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• 제26권4호
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• pp.521-533
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• 2012

Interest in application of ultraviolet light technology for primary disinfection that used for the treatment of water for consumption and wastewater has increased significantly in recent years. Analysis of these systems has been carried out using Computational Fluid Dynamics (CFD) procedure. It offers advantages over other techniques in specific circumstances. CFD has emerged as a powerful tool to aid design of a UV reactor by providing the UV dose delivered by the proposed reactor design and allowing engineers to evaluate alternative designs in much less time and at a reasonable cost. In this study, five different configurations of the apparatus depending on the location of the exit are evaluated in terms of maximum dose, minimum dose, flow patterns, particle tracks and transient dose. The configuration 3 results have higher minimum UV dose value and uniform particle distribution of the UV dose on the outlet than other's.

• 대한방사선기술학회지:방사선기술과학
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• 제15권1호
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• pp.79-87
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• 1992

It is a matter of common knowledge that madical radiation is most accented for of radiation is doses applied to the whole of people, and of them the radation dose by radiography diagnosis is mainly prevalent. In applying X-rays to a certain man for radiography diagnosis a radiologyist will have to have an absolute sense of mission concerning the reduction and prevention of the patient's radiation dose as the radiologyist obligation. Accordingly, the radiography conditions of the patient's chest employed 197 medical facilites were surveyed and skin dose was computated by the IPH Bit system and examined. As a result, it was shown that the average skin dose was $288\;{\mu}Sv$, its minimum value was $1600\;{\mu}Sv$, which was over 32 times its minimum value. This shows that the appropriate radiography method has not been applied at applying X-ray to the patient. It comes from the performance of X-ray equipment, the choice of auxiliary equipment materials etc. But the most important thing is to master the appropriate radiography condition, and therefore this point will have to be kept in mind.