Communications for Statistical Applications and Methods

The Korean Statistical Society (한국통계학회)
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Nonparametric Procedure for Identifying the Minimum Effective Dose with Ordinal Response Data

  • Kang, Jongsook (Department of Biostatistics, The Catholic University of Korea) ;
  • Kim, Dongjae (Department of Biostatistics, The Catholic University of Korea)
  • Published : 2004.12.01
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Abstract

The primary interest of drug development studies is identifying the lowest dose level producing a desirable effect over that of the zero-dose control, which is referred as the minimum effective dose (MED). In this paper, we suggest a nonparametric procedure for identifying the MED with binary or ordered categorical response data. Proposed test and Williams' test are compared by Monte Carlo simulation study and discussed.

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References

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