• Title/Summary/Keyword: Mimic

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Development of Novel Pyrone Derivative Retaining Retinoidal Anti-aging Activity with Low Skin Irritation

  • Rho, H.S;Kim, D.H;Kim, S.N;Kim, S.J;Chang, I.S;Kang, H.H;Lee, O.S
    • Proceedings of the SCSK Conference
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    • 2003.09b
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    • pp.184-191
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    • 2003
  • New pyranone derivative, 2-((3E)-4(2H, 3H, -benzo[3, 4-d] 1, 3-dioxolan-5-yl)-2-oxo-but-3-enyloxy)-5-hydroxy-4H-pyran-4-one (Seletinoid $G^{TM}$), was designed as a novel retinoid on the assumption that the pyranone ring may mimic the carboxylic acid moiety in retinoid structure. The enolic hydroxy of pyranone at five position was easily deprotonated to form an enolate. The role of enolate was similar to that of carboxylic acid. To evaluate the value of Seletinoid G as an anti-aging ingredient, various tests were performed for example inhibitory effect for MMP-l expression, anti-oxidative activity, procollagen synthesis in hairless mouse and primary skin irritation. The result of this study suggested that our new synthetic retinoid could be used as a safe material for anti-aging cosmetics.

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Detection of Foreign Body in Esophageal Foreign Body Model Using Three Dimensional Reconstruction Technique (식도 이물 모델에서 이물 탐색을 위한 삼차원 재구성법의 활용)

  • Woo, Kuk Sung;Yoo, Young Sam;Kim, Dong Won
    • Korean Journal of Bronchoesophagology
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    • v.18 no.1
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    • pp.13-18
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    • 2012
  • Objective This study was conducted to gather basic information of 3D CT in detecting and gaining information of esophageal foreign body (FB) models. Materials and Methods The chest model was made using PVC bottle, rubber balloon and plaster. Fish bone, Persimmon stone were used to mimic foreign bodies of esophageal model. The foreign body models were inserted into the balloon removing air from it and the balloon was sealed. The esophageal FB model was inserted into the chest model. The remaining space in the chest model was filled with fish paste and water to simulate soft tissue around esophagus. CT of chest model was reconstructed three-dimensionally by Rapidia software to make images of foreign body models. The axial CT, MPR image and VOI image were compared with real foreign body materials as to shape, size, location and orientation. Results Esophageal FB models were easily made. CT data gave good 3D images and showed realistic foreign body materials. Conclusion The results indicate the usefulness of 3D CT technique to help in diagnosis of esophageal foreign body models.

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Fractured styloid process masquerading as neck pain: Cone-beam computed tomography investigation and review of the literature

  • Khan, Hassan M.;Fraser, Andrew D.;Daws, Steven;Thoppay, Jaisri;Mupparapu, Mel
    • Imaging Science in Dentistry
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    • v.48 no.1
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    • pp.67-72
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    • 2018
  • Historically, Eagle syndrome is a term that has been used to describe radiating pain in the orofacial region, foreign body sensation, and/or dysphagia due to a unilateral or bilateral elongated styloid process impinging upon the tonsillar region. Because elongated styloid processes-with or without associated Eagle syndrome-can present with various symptoms and radiographic findings, it can be challenging for healthcare practitioners to formulate an accurate diagnosis. Abnormal styloid anatomy can lead to a multitude of symptoms, including chronic orofacial/neck pain, thus masquerading as more commonly diagnosed conditions. In this report, we describe a patient who presented to our department with styloid process elongation and fracture. A careful history, physical examination, and a cone-beam computed tomography (CBCT) investigation led to the diagnosis. The patient was then referred for appropriate care. This case report demonstrates the utilization of CBCT in differentiating a fracture site from a pseudo-joint that might mimic a fracture.

Neuron Circuit Using a Thyristor and Inter-neuron Connection with Synaptic Devices

  • Ranjan, Rajeev;Kwon, Min-Woo;Park, Jungjin;Kim, Hyungjin;Park, Byung-Gook
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.15 no.3
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    • pp.365-373
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    • 2015
  • We propose a simple and compact thyristor-based neuron circuit. The thyristor exhibits bi-stable characteristics that can mimic the action potential of the biological neuron, when it is switched between its OFF-state and ON-state with the help of assist circuit. In addition, a method of inter-neuron connection with synaptic devices is proposed, using double current mirror circuit. The circuit utilizes both short-term and long-term plasticity of the synaptic devices by flowing current through them and transferring it to the post-synaptic neuron. The double current mirror circuit is capable of shielding the pre-synaptic neuron from the post synaptic-neuron while transferring the signal through it, maintaining the synaptic conductance unaffected by the change in the input voltage of the post-synaptic neuron.

3D CT Image Processing for 3D Printed Auricular Reconstruction of Unilateral Microtia Patient

  • Roh, Tae Suk;Yun, In Sik
    • Journal of International Society for Simulation Surgery
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    • v.1 no.2
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    • pp.80-82
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    • 2014
  • Purpose Microtia is congenital anomaly of external ear and the reconstruction method for the external ear of microtia patient was based on autogenous costal cartilage framework. The application of 3D printing technique in medical science has made more possibility of human tissue restoration, and we tried to apply this technique in auricular reconstruction field. Materials and Methods As for unilateral microtia patient, the contralateral side ear is normal and reconstructive surgeon tried to mimic it for reconstruction of affected ear. So, we obtained facial CT scan of microtia patient and made mirror image of normal side ear. Moreover, to make the 3D scaffold based on the mirror image of normal ear and to apply this scaffold for the auricular reconstruction surgery, we included auriculocephalic sulcus and anterior fixation part. Results We could successfully obtain mirror image of normal ear, auriculocephalic sulcus and anterior fixation part for 3D scaffold printing. Conclusions Using this CT image processing and 3D printing technique, we will be able to make the scaffold for auricular reconstruction of unilateral microtia patient, and perform auricular reconstruction in near future.

Design and Implementation of Computational Model Simulating Language Phenomena in Lexical Decision Task (어휘판단 과제 시 보이는 언어현상의 계산주의적 모델 설계 및 구현)

  • Park, Kinam;Lim, Heuiseok;Nam, Kichun
    • The Journal of Korean Association of Computer Education
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    • v.9 no.2
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    • pp.89-99
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    • 2006
  • This paper proposes a computational model which can simulate peculiar language phenomena observed in human lexical decision task. The model is designed to mimic major language phenomena such as frequency effect, lexical status effect, word similarity, and semantic priming effect. The experimental results show that the propose model replicated the major language phenomena and performed similar performance with that of human in LDT.

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Hardware Implementation of Social Insect Behavior for Adaptive Routing in Packet Switched Networks (패킷 방식 네트워크상의 적응적 경로 선정을 위한 군집체 특성 적용 하드웨어 구현)

  • 안진호;오재석;강성호
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.41 no.3
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    • pp.71-82
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    • 2004
  • Recently, network model inspired by social insect behavior attracts the public attention. The AntNet is an adaptive and distributed routing algorithm using mobile agents, called ants, that mimic the activities of social insect. In this paper. we present a new hardware architecture to realize an AntNet-based routing in practical system on a chip application. The modified AntNet algorithm for hardware implementation is compared with the original algorithm on the various traffic patterns and topologies. Implementation results show that the proposed architecture is suitable and efficient to realize adaptive routing based on the AntNet.

ON THE TRIANGULAR EQUILIBRIUM POINTS IN THE ELLIPTIC RESTRICTED THREE-BODY PROBLEM UNDER RADIATION AND OBLATENESS EFFECTS

  • DERMAWAN, B.;HUDA, I.N.;WIBOWO, R.W.;HIDAYAT, T.;UTAMA, J.A.;MANDEY, D.;TAMPUBOLON, I.
    • Publications of The Korean Astronomical Society
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    • v.30 no.2
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    • pp.293-294
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    • 2015
  • This work considers the elliptic restricted three-body problem under effects of radiation of the bigger primary, and an oblate spheroid for the smaller primary to mimic an exoplanetary system with a gas giant planet. Under the influences of both effects we look for the existence of the triangular equilibrium points and the influences of the radiation and oblateness on the locations and motion of the points. We set the system in a normalized rotating coordinate system and derive equations of motion for the third infinitesimal object. Our study shows that the effects modify the equilateral/isosceles triangle shape with respect to the primaries. The triangular points also have non-planar motion with period depending on the value of the planet oblateness.

Using Light Travel Time Effect to Detect Circumbinary Planets with Ground-Based Telescopes

  • Hinse, Tobias Cornelius
    • The Bulletin of The Korean Astronomical Society
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    • v.37 no.2
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    • pp.109.1-109.1
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    • 2012
  • In the past few years, two-planet circumbinary systems (e.g., HW Vir, NN Ser, DP Leo and HU Aqr) have been detected around short-period eclipsing binaries using ground-based telescopes. The existence of these planets has been inferred by interpreting the O-C variations of the mid-eclipse times. We have tested the orbital stability of these systems and propose to use Light Travel Time Effect (LITE) to detect such circumbinary planets from the ground. We generated synthetically the LITE signal of a two-planet circumbinary system with the aim to apply an analytic LITE model to recover the underlying synthetic system. To mimic a degree of realism inherent to ground-based observations, we added to the synthetic LITE data white noise with a Gaussian distribution and sampled the synthetic LITE signal randomly. We successfully recovered the original system demonstrating that two-planet circumbinary systems can be detected using ground-based telescopes, provided the timing measurements of the mid-eclipses are sufficiently accurate and the observing baseline is long enough to ensure a sufficient coverage of all involved periods. We used HU Aqr as a test system and applied our model to its proposed planetary bodies considering near-circular orbits. We present the results of our calculations and discuss the LITE-detectability of a HU Aqr-like system.

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Advantages of the outgrowth model for evaluating the implantation competence of blastocysts

  • Kim, Jihyun;Lee, Jaewang;Jun, Jin Hyun
    • Clinical and Experimental Reproductive Medicine
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    • v.47 no.2
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    • pp.85-93
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    • 2020
  • The implantation process is highly complex and difficult to mimic in vitro, and a reliable experimental model of implantation has yet to be established. Many researchers have used embryo transfer (ET) to assess implantation potential; however, ET with pseudopregnant mice requires expert surgical skills and numerous sacrificial animals. To overcome those economic and ethical problems, several researchers have tried to use outgrowth models to evaluate the implantation potential of embryos. Many previous studies, as well as our experiments, have found significant correlations between blastocyst outgrowth in vitro and implantation in utero by ET. This review proposes the blastocyst outgrowth model as a possible alternative to animal experimentation involving ET in utero. In particular, the outgrowth model might be a cost- and time-effective alternative method to ET for evaluating the effectiveness of culture conditions or treatments. An advanced outgrowth model and further culture of outgrowth embryos could provide a subtle research model of peri- and postimplantation development, excluding maternal effects, and thereby could facilitate progress in assisted reproductive technologies. Recently, we found that outgrowth embryos secreted extracellular vesicles containing specific microRNAs. The function of microRNAs from outgrowth embryos should be elucidated in further researches.