• The Journal of the Convergence on Culture Technology
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• v.8 no.5
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• pp.749-754
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• 2022

High adhesion and water resistance of the skin surface are required for wearable and skin-attachable electronic patches in various medical applications. In this study, we report a stretchable electronic patch that mimics the drainable structure pattern of the hexagonal channels of frog's pads and the sucker of an octopus based on carbon-based conductive polymer composite materials. The hexagonal channel structure that mimics the pads of frogs drains water and improves adhesion through crack arresting effect, and the suction structure that mimics an octopus sucker shows high adhesion on wet surfaces. In addition, the high-adhesive electronic patch has excellent adhesion to various surfaces such as silicone wafer (max. 4.06 N/cm²) and skin replica surface (max. 1.84 N/cm²) in dry and wet conditions. The high skin-adhesive electronic patch made of a polymer composite material based on a polymer matrix and carbon particles can reliably detect electrocardiogram (ECG) in dry and humid environments. The proposed electronic patch presents potential applications for wearable and skin-attachable electronic devices for detecting various biosignals.

• International Journal of Advanced Culture Technology
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• v.10 no.2
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• pp.187-193
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• 2022

We is configured the honk changing-status technique that is to meld the square-built blow-shock status of the gleam-differential perception level (BIAL) on the honk perception lineament. The perception level condition by the honk perception lineament system is constituted with the blow-shock system. As to experimentation a ductile-dot of the gleam ductile-dot, we are found of the honk value with ductile-dot by the blow upper shift. The concept of perception level is constituted the reference of gleam-differential level for changing-status signal by the honk shock lineament. Further symbolizing a square-built changing-status of the BIAL, of the average in terms of the blow-shock lineament, and the honk ductile-dot shock that was the honk value of the far changing-status of the Ho-PL-FA-θ_AVG with 15.41±8.63 units, that was the honk value of the convenient changing-status of the Ho-PL-CO-θ_AVG with 8.70±3.06 units, that was the honk value of the flank changing-status of the Ho-PL-HO-θ_AVG with 2.65±1.19 units, that was the honk value of the edge changing-status of the Ho-PL-VI-θ_AVG with 0.51±0.18 units. The blow shock will be to investigate at the square-built ability of the blow-shock lineament with ductile-dot by the honk perception level on the BIAL, that is denote the gleam-differential lineament by the perception level system. We will be possible to curb of a lineament by the differential signal and to employ the honk data of blow shock level by the blow perception system.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.26 no.5
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• pp.266-276
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• 2023

Purpose: Human milk oligosaccharides (HMOs) may be genetically determined based on the secretor and Lewis status of the mother. This study aims to determine the HMO profile and the secretor and Lewis gene status of Indonesian lactating mothers. Methods: Baseline data of 120 mother-infant pairs between 0-4 months post-partum obtained from a prospective longitudinal study was used. The concentrations of 2'-fucosyllactose (2'FL), lacto-N-fucopentaose I (LNFP I), lacto-N-tetraose (LNT), lacto-N-neotetraose (LNnT), 3'-sialyllactose (3'SL), and 6'-sialyllactose (6'SL) were measured. Genetic analysis was performed for mothers using targeted next-generation sequencing and Sanger sequencing. Wild-type AA with the rs1047781 (A385T) polymorphism was categorized as secretor positive, while heterozygous mutant AT was classified as a weak secretor. The presence of rs28362459 (T59G) heterozygous mutant AC and rs3745635 (G508A) heterozygous mutant CT genes indicated a Lewis negative status, and the absence of these genes indicated a positive status. Subsequently, breast milk was classified into various groups, namely Group 1: Secretor+Lewis+ (Se+Le+), Group 2: Secretor-Lewis+ (Se-Le+), Group 3: Secretor+Lewis-(Se+Le-), and Group 4: Secretor-Lewis- (Se-Le-). Data were analyzed using the Mann-Whitney and Kruskal-Wallis rank tests, and a p-value of 0.05 indicated statistical significance. Results: A total of 58.3% and 41.7% of the samples had positive and weak secretor statuses, respectively. The proportion of those in Group 1 was 85%, while 15% were Group 3. The results showed that only 2'FL significantly differed according to the secretor status (p-value=0.018). Conclusion: All Indonesian lactating mothers in this study were secretor positive, and most of them had a Lewis-positive status.

• The Journal of Korean Medicine
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• v.43 no.4
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• pp.102-130
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• 2022

Objectives: The persistence and unpredictability of coronavirus disease (COVID-19) and new measures to prevent direct medical intervention (e.g., social distancing and quarantine) have induced various psychological symptoms and disorders that require self-treatment approaches and integrative treatment interventions. To address these issues, the Korean Medicine Mental Health (KMMH) center developed a field manual by reviewing previous literature and preexisting manuals. Methods: The working group of the KMMH center conducted a keyword search in PubMed in June 2021 using "COVID-19" and "SARS-CoV-2". Review articles were examined using the following filters: "review," "systematic review," and "meta-analysis." We conducted a narrative review of the retrieved articles and extracted content relevant to previous manuals. We then created a treatment algorithm and recommendations by referring to the results of the review. Results: During the initial assessment, subjective symptom severity was measured using a numerical rating scale, and patients were classified as low- or moderate-high risk. Moderate-high-risk patients should be classified as having either a psychiatric emergency or significant psychiatric condition. The developed manual presents appropriate psychological support for each group based on the following dominant symptoms: tension, anxiety-dominant, anger-dominant, depression-dominant, and somatization. Conclusions: We identified the characteristics of mental health problems during the COVID-19 pandemic and developed a clinical mental health support manual in the field of Korean medicine. When symptoms meet the diagnostic criteria for a mental disorder, doctors of Korean medicine can treat the patients according to the manual for the corresponding disorder.

• International Journal of Advanced Culture Technology
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• v.11 no.2
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• pp.276-283
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• 2023

Purpose: We aimed to determine the differences in the levels of serum thyroid hormone (free T4 [FT4]) and thyroid stimulating hormone [TSH]) as biomarkers for hepatitis B virus (HBV) infection status, with respect to age and sex. Methods: We retrospectively analyzed serum samples from 200 patients who underwent HBV testing from August 2022 to September 2022. Serum samples were collected from patients suspected of having HBV infection who visited this hospital. Thyroid hormone levels were measured, and patients were grouped according to age and sex. Results: Differences in TSH and FT4 levels in the serum of patients in the HBV-positive and -negative groups were not significant. Among the HBV-positive patients in the younger age group (<60 years), TSH and FT4 levels were 1.78 ± 0.09 µIU/mL (normal: 0.4-5.0 µIU/mL) and 1.24 ± 0.02 ng/mL (normal: 0.8-1.9 ng/mL), respectively, whereas among the HBV-positive patients in the older age group (≥60 years), TSH and FT4 levels were 2.22 ± 0.17 µIU/mL and 1.24 ± 0.07 ng/mL, respectively. Conclusions: The presence of HBV did not markedly affect serum thyroid hormone levels. Our findings shed light on the conflicting evidence on the association between thyroid hormone levels and HBV infection. We, Hyeokjun Yun and Bo Kyeung Jung are co-first authors which made substantial contribution equally to the conception and designed of this work. Jae Kyung Kim, In soo Rheem and Kap No Lee made significant contributions to the acquisition and analysis of the data.

• The Journal of the Convergence on Culture Technology
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• v.9 no.4
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• pp.707-715
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• 2023

This study utilized CART algorithm, a decision tree analysis method, to comparatively analyze factors affecting housing and residential environment satisfaction by region using data from Ministry of Land, Infrastructure and Transport's housing survey in 2020. First, in terms of residential environment satisfaction, accessibility to medical facilities and school district showed higher importance in metropolitan cities and areas compared to other regions, whereas safety from accident showed the opposite trait, showing difference between region. Second, housing characteristics were important in housing satisfaction, indoor environment level satisfaction and indoor safety and hygiene being important in almost all regions, while residential environment characteristics were more important in residential environment satisfaction and influencing factors were relatively evenly distributed. In order to generalize these regional characteristics, research using time series data needs to be conducted later.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.377-383
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• 2023

The movie <Yin Ru Chen Yan> is evaluated to reflect the rural reality of China's northwest region. Although the film also contained the farmer's unique sincerity and pure love, many problems were also raised. The specific issues raised are as follows. First, he accused young Chinese rural people who could not express their intention properly at the time of marriage.This can be said to be largely due to the lack of proper education, medical care, and welfare benefits for a long time. Second, he criticized the rural housing policy that deviated from reality. It warns that unilaterally providing apartments in the city without considering regional characteristics and farmers' situations could be counterproductive. In the movie, the main character abandoned livestock that he thought of and cared for with his family and did not move his residence to an apartment. Third, he criticized the materialism prevalent in rural areas. He criticized the phenomenon of not respecting a human being to solve everything with money and even to receive government housing compensation. In this sense, in order to solve the true Chinese Samnong problem, macro-promoted policies and micro-policies that can encompass some underdeveloped rural areas should also be implemented.

• The Journal of the Convergence on Culture Technology
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• v.9 no.2
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• pp.143-150
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• 2023

As Korea's per capita income increases, participation in various leisure activities to improve the quality of life of the disabled is encouraged. However, in order to participate in leisure activities, movement to the place where the leisure activities are performed must be preceded, so interest in means of transportation for leisure activities of the disabled is increasing. Since manual and electric wheelchairs have their respective disadvantages as means of transportation for leisure activities, interest in power assisting devices for wheelchairs combining the functions of electric wheelchairs with manual wheelchairs is increasing. In this study, the FDA approval process of wheelchair power-assistance products was investigated, and the characteristics of side-attached, front-attached, downward-attached, and rear-attached types of power assist devices for wheelchairs wheelchair in countries around the world were identified. These information will be of great use in helping the disabled and their assistants in Korea to choose the optimal product according to the patient's condition. More usability tests and clinical case studies are needed so that people with disabilities can choose a power assist device suitable for them.

• The Journal of the Convergence on Culture Technology
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• v.9 no.3
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• pp.435-442
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• 2023

The purpose of this study is to analyze the effects of simulation education using standardized patients on respiratory infectious disease knowledge and clinical performance of nursing students. A single-group before-and-after design for the nursing of infectious respiratory patients using standardized patients from March 2 to June 15, 2020, targeting 112 senior nursing students. Respiratory infectious disease education program 'knowledge of lung infectious diseases', 'hand washing', 'wearing a mask', 'encouraging patients and caregivers to wear masks', 'intravenous injection', '3-way injection', 'surgical aseptic technique', 'disinfecting medical devices' , 'contaminated linen management', 'infected person management manual', etc., and 10 educational tasks were performed, and consisted of lectures, technical training, simulation using standardized patients, and debriefing. After simulation education using standardized patients, students' knowledge and clinical performance skills on respiratory infectious diseases showed significant improvement, and it was expected that it could be used for various infection control practices.

• Korean Journal of Clinical Pharmacy
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• v.33 no.2
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• pp.86-96
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• 2023

Background: Using KIDS-KAERS database (KIDS-KD) from 2016 to 2020, the aim is to investigate signals of adverse events of alpha-adrenoceptor antagonists and to present adverse events that are not included in the precautions for use when marketing approval. Methods: This study was conducted by disproportionality analysis. Data mining analysis was performed to detect signals of alpha-adrenoceptor antagonists, such as terazosin, doxazosin, alfuzosin, silodosin, and tamsulosin. The signal was defined by three criteria as proportional reporting ratio (PRR), reporting odds ratio (ROR), and information component (IC). Detected signals were compared with product labeling and the European Medicines Agency-Important Medical Events list. Results: Out of the total number of 408,077 reports for adverse events, 6,750 cases were reported as adverse events of alpha-adrenoceptor antagonists. Dizziness, mouth dryness, hypotension postural, and oedema peripheral are identified as common adverse events of five alpha-adrenoceptor antagonists and are typically listed on drug labels. However, new signals were detected for pneumonia, chronic obstructive airway disease, eye diseases such as glaucoma and cataracts, fracture, and ileus of tamsulosin that were not previously listed on the drug labels in Korea. Conclusions: This study identified signals related to adverse drug reactions of alpha-adrenoceptor antagonists and presented serious adverse events, suggesting new adverse reactions to be aware of when using alpha-adrenoceptor antagonists.