• Maxillofacial Plastic and Reconstructive Surgery
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• v.28 no.5
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• pp.404-416
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• 2006

Purpose : This study was to clarify the changes in mandibular condyle after unilateral mandibular distraction osteogenesis throughout histological changes and expression of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of matrix metalloproteinase-2 (TIMP-2). Materials & Methods : Intraoral distractors were placed via submandibular incision in 8 dogs. Two unoperated animals served as controls. Distraction was performed five days after osteotomy as a rate of 0.5 mm twice per day for 10 days. Two animals were sacrificed on 7, 14, 28, and 56 days after completion of distraction, respectively. Ipsilateral condyles were harvested and processed for histological and immunohistochemical examinations. Results : The condyle cartilage is separated into four layers: fibrous layer, proliferative layer, hypertrophic layer, and calcified layer. At 7 days and 14 days after distraction, the condylar cartilage showed the decreased thickness of the articular cartilage and reduced cellularity. At 28 days after distraction, there was an increase in cellularity of fibrous, proliferative, and hypertrophic layer. However, it demonstrated reduced cellularity compared to the control. At 56 days of after distraction, the articular cartilage was an almost normal histologic structure. Positive Safranin-O staining, indicative of sulfated proteoglycans, was examined in the condylar cartilge of nonloaded control. At 7 days and 14 days after distraction, the sulfated proteoglycans is almost completely depleted from the noncalcified part of the condylar cartilage. At 28 days after distraction, there was an increase in Safranin-O staining intensity. However, the staining intensity of the experimental condyle was weaker than that of the control. At 56 days of after distraction, the condylar cartilage showed almost normal Safranin-O staining pattern. In control condyle, MMP-2 immunostaining was seen in fibrous, proliferative, and hypertrophic layer of condylar cartilage, however, it demonstrated lack of staining in fibrous and proliferative layer. At 7 days and 14 days after distraction, strong MMP-2 immunoreactivity was seen in the fibrous, proliferative and hypertrophic layer of the condylar cartilage. At 28 days after distraction, MMP-2 immunostaining was seen in the fibrous and hypertrophic layer of condylar cartilage, however, their immunoactivity was reduced. At 56 days after distraction, MMP-2 immunoreactivity showed almost normal immunostaining pattern. In control condyle, TIMP-2 immunostaining was primarily seen in fibrous and hypertrophic layer of condylar cartilage, however, it demonstrated lack of staining in proliferative layer. At 7 days after distraction, very weak TIMP-2 immunoreactivity appeared in fibrous, proliferative and hypertrophic layer of the condylar cartilage. At 14 days after distraction, weak TIMP-2 immunoreactivity was seen in the fibrous, proliferative and hypertrophic layer of the condylar cartilage. At 28 days after distraction, TIMP-2 immunoreactivity was increased in the fibrous and hypertrophic layer of condylar cartilage. At 56 days after completion of distraction, TIMP-2 immunoreactivity showed almost normal immunostaining pattern. Conclusions : The results show that short-term outcome of physiologic distraction osteogenesis may lead to degenerative changes in the condylar cartilage. These alterations in the condylar cartilage may be considered as a pressure-related degeneration of the cartilage tissue. However, the long-term results suggest that the condylar cartilage display repair activity after mandibular distraction osteogenesis.

• Journal of the Korea Safety Management & Science
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• v.17 no.2
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• pp.89-96
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• 2015

The weapon systems development has some distinct characteristics in that a big size of government budget (derived from national tax) has been expended frequently and the completion of the development projects seems to take long. Thus, the impact of the potential changes in the required operational capability on the development activities can induce some type of project risks. As such, proper management of project risk has been one of crucial subjects in the weapon systems development. Although a variety of methods can be considered, an approach based on the test and evaluation (T&E) process has been selected in this paper in order to appropriately handle those potential risks. In the study of the underlying T&E process, the safety consideration (for instance, explosiveness) of weapon systems is also included. To achieve the objective of the paper, a step-by-step procedure is first presented in the analysis of the T&E process. Then, to pursue some enhancement on the process, a set of necessary and useful activities are added in terms of risk and safety management. The resultant process is further analyzed and tailored based on a design structure matrix method. The case study of a tank development is also discussed.

• International Journal of Control, Automation, and Systems
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• v.2 no.1
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• pp.76-82
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• 2004

A robust fuzzy controller is designed to stabilize a class of solvable nonlinear descriptor systems with time-varying delay. First, a new modeling and control method for nonlinear descriptor systems is presented with a fuzzy descriptor model. A sufficient condition for the existence of the fuzzy controller is given in terms of a series of LMIs. Then, a less conservative fuzzy controller design approach is obtained based on the fuzzy rules and weights. This method includes the interactions of the different subsystems into one matrix. The effectiveness of the presented approach and the design procedure of the fuzzy controller are illustrated by way of an example.

• Journal of Construction Engineering and Project Management
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• v.3 no.2
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• pp.49-57
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• 2013

A sea dike construction has been increased in Korea because of the actively deployed reclamation project in basis of efficient application in land. The degree of completion in sea dike construction is affected by final closing construction, which has a lot of uncertainty that often results in higher accidents rate. Therefore, this research identified risk factors of final closing construction and classified them. This research examines the likelihood and its impact for each risk factor and calculates the risk degree as to the risk matrix. Based on this, the impact and the environmental conditions that affect to risk factors are investigated and further responsive methods are established for each risk factor. Ultimately, this research attempts to provide the risk retrenchment method for inspectors by proposing risk estimation model, responsive action list, and risk management process.

• Industrial Engineering and Management Systems
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• v.3 no.1
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• pp.1-11
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• 2004

This paper proposes a new algorithm for determining an optimal control input for production systems. In many production systems, completion time should be planned within the due dates by taking into account precedence constraints and processing times. To solve this problem, the max-plus algebra is an effective approach. The max-plus algebra is an algebraic system in which the max operation is addition and the plus operation is multiplication, and similar operation rules to conventional algebra are followed. Utilizing the max-plus algebra, constraints of the system are expressed in an analogous way to the state-space description in modern control theory. Nevertheless, the formulation of a system is currently performed manually, which is very inefficient when applied to practical systems. Hence, in this paper, we propose a new algorithm for deriving a state-space description and determining an optimal control input with several constraint matrices and parameter vectors. Furthermore, the effectiveness of this proposed algorithm is verified through execution examples.

• Nuclear Engineering and Technology
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• v.51 no.4
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• pp.954-962
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• 2019

It is well known that the variance of tally is biased in a Monte Carlo calculation based on the power iteration method. Several studies have been conducted to estimate the real variance. Among them, the batch method, which was proposed by Gelbard and Prael, has been utilized actively in many Monte Carlo codes because the method is straightforward, and it is easy to implement the method in the codes. However, there is a problem when utilizing the batch method because the estimated variance varies depending on batch size. Often, the appropriate batch size is not realized before the completion of several Monte Carlo calculations. This study recognizes this shortcoming and addresses it by permitting selection of an appropriate batch size.

• Communications for Statistical Applications and Methods
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• v.26 no.4
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• pp.411-430
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• 2019

Tumor development is driven by complex combinations of biological elements. Recent advances suggest that molecularly distinct subtypes of breast cancers may respond differently to pathway-targeted therapies. Thus, it is important to dissect pathway disturbances by integrating multiple molecular profiles, such as genetic, genomic and epigenomic data. However, missing data are often present in the -omic profiles of interest. Motivated by genomic data integration and imputation, we present a new statistical framework for pathway significance analysis. Specifically, we develop a new strategy for imputation of missing data in large-scale genomic studies, which adapts low-rank, structured matrix completion. Our iterative strategy enables us to impute missing data in complex configurations across multiple data platforms. In turn, we perform large-scale pathway analysis integrating gene expression, copy number, and methylation data. The advantages of the proposed statistical framework are demonstrated through simulations and real applications to breast cancer subtypes. We demonstrate superior power to identify pathway disturbances, compared with other imputation strategies. We also identify differential pathway activity across different breast tumor subtypes.

• Tuberculosis and Respiratory Diseases
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• v.65 no.1
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• pp.7-14
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• 2008

Background: Residual pleural thickening (RPT) is the most frequent complication of tuberculous pleurisy (TP), and this can happen despite of administering adequate anti-tuberculous (TB) therapy. Yet there was no definite relation between RPT and other variables. The aim of this study was to examine matrix metalloproteinases (MMPs) and the inhibitors of metalloproteinases (TIMPs) and to identify the factors that can predict the occurrence of RPT. Methods: The patients with newly-detected pleural effusions were prospectively enrolled in this study from January 2004 to June 2005. The levels of MMP-1, -2, -8 and -9, and TIMP-1 and -2 were determined in the serum and pleural fluid by ELISA. The residual pleural thickness was measured at the completion of treatment and at the point of the final follow-up with the chest X-ray films. Results: The study included 39 patients with pleural fluid (PF). Twenty-three had tuberculous effusion, 7 had parapneumonic effusion, 7 had malignant effusion and 2 had transudates. For the 17 patients who completed the anti-TB treatment among the 23 patients with TP, 7 (41%) had RPT and 10 (59%) did not. The level of PF TIMP-1 in the patients with RPT ($41,405.9{\pm}9,737.3ng/mL$) was significantly higher than that of those patients without RPT ($29,134.9{\pm}8,801.8$) at the completion of treatment (p=0.032). In 13 patients who were followed-up until a mean of $8{\pm}5$ months after treatment, 2 (15%) had RPT and 11 (85%) did not. The level of PF TIMP-2 in the patients with RPT ($34.4{\pm}6.5ng/mL$) was lower than that of those patients without RPT ($44.4{\pm}15.5$) at the point of the final follow-up (p=0.038). Conclusion: The residual pleural thickening in TP might be related to the TIMP-1 and TIMP-2 levels in the pleural fluid.

• Geomechanics and Engineering
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• v.8 no.4
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• pp.477-493
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• 2015

In rock drilling, the most important characteristic to clarify is the wear of the drill bits. The reason that the rock drill bits fail with time is wear. In dry sliding contact adhesive wear deteriorates the materials in contact, quickly, and is the result of shear fracture in the momentary contact joins between the surfaces. This paper aims at presenting an overview of the assessment of WC/Co cemented carbide (CC) tricone bit in rotary drilling. To study wear of these bits, two approaches have been used in this research. Firstly, the new bits were weighted before they mounted on the drill rigs and also after completion their useful life to obtain bit weight loss percentage. The characteristics of the rock types drilled by using such this bit were measured, simultaneously. Alternatively, to measure contact wear, namely, matrix wear a micrometer has been used with a resolution of 0.02 mm at different direction on the tricone bits. Equivalent quartz content (EQC), net quartz content (QC), muscovite content (Mu), coarseness index (CI) of drill cuttings and compressive strength of rocks (UCS) were obtained along with thin sections to investigate mineralogical properties in detail. The correlation between effective parameters and bit wear were obtained as result of this study. It was observed that UCS shows no significant correlation with bit wear. By increasing CI and cutting size of rocks wear of bit increases.

• Journal of the Korean Society for Railway
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• v.12 no.1
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• pp.135-143
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• 2009

The majority of development projects fail to meet their target schedule and cost, with the overrun typically between 40 and 200 percent. These overruns happen because the planners underestimate the work or do not consider the need to rework at project planning. Representative schedule planning/management techniques such as Gantt Chart, PERT/CPM etc. that are used in domestic project planning are unable to reflect rework. This paper proposes a method to consider rework to provide more realistic estimates at schedule planning. Additionally, to prevent the underestimation of the work this paper proposes a simulation method that calculates a probabilistic estimated schedule and the associated variance based on the random variable modeling of individual task completion dates.