• 한국BIM학회 논문집
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• 제6권4호
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• pp.18-26
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• 2016

Recently, for the purpose of maintenance of facilities and energy, there have been growing cases of the 3D image scan-based reverse design technology mostly in the manufacturing field. In the MEP field, because of differences between design and physical model, the reverse technology has been utilized in factory facilities such as a semiconductor factory. Because 3D point clouds from scanning include accurate 3D object information, the efficiency of management works related to the complex MEP facilities can be enhanced. In this study, the reverse technology was surveyed, and the MEP facility management based on 3D image scanning was analyzed. Based on the results, a method of 3D image scan-based MEP facility management was proposed.

• 콘크리트학회지
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• 제24권5호
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• pp.41-45
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• 2012

• 대한안전경영과학회지
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• 제5권1호
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• pp.83-92
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• 2003

Scheduling plays an important role in shop floor planning. A scheduling shows the planned time when processing of a specific job will start on each machine that the job requires. It also indicates when the job will be completed on every process. Thus, it is a timetable for both jobs and machines. There is only one server available and arriving work require services from this server. Job are processed by the machine one at a time. The most common objective is to sequence jobs on the severs so as to minimize the penalty for being late, commonly called tardiness penalty. Based on other objectives, many criteria may serve as s basis for developing job schedules. The process also comprises all strategic planning, capital investments, management decisions, and tasks necessary to create a new product. manufacturing processes must be created so that the product can be produced in the product facility. Purchasing new equipment and training workers may be required if new technology is to be used. Tools, fixtures, and the sequence of steps in the manufacturing processes must all be developed to allow rapid, high-quality, cost effective production. Also, it may be needed to be rearrange the production facility to adapt to the new manufacturing processes. Therefore, this study tries to proposed that Scheduling by customer needs group for minimizing the problem and reducing inventory, product development time, cycle time, and order lead time.

• 산업경영시스템학회지
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• 제8권12호
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• pp.1-6
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• 1985

The purpose of this study is to consider the criteria for decision-making of facility location in view of Minimax. As an illustration of the location of storerooms in a manufacturing plant that minimizes the maximum distance workers must travel to reach a storeroom, the number and variety of location problems that can be formulated appropriately as minimax problems are sizable. A minimax solution can be interpreted as a grease the squeaky wheel solution In solving a minimax location problem, costs other than the maximum cost are not considered.

• Safety and Health at Work
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• 제10권4호
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• pp.518-526
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• 2019

Background: Additive manufacturing (AM) is a rapidly expanding new technology involving challenges to occupational health. Here, metal exposure in an AM facility with large-scale metallic component production was investigated during two consecutive years with preventive actions in between. Methods: Gravimetric analyzes measured airborne particle concentrations, and filters were analyzed for metal content. In addition, concentrations of airborne particles <300 nm were investigated. Particles from recycled powder were characterized. Biomonitoring of urine and dermal contamination among AM operators, office personnel, and welders was performed. Results: Total and inhalable dust levels were almost all below occupational exposure limits, but inductively coupled plasma mass spectrometry showed that AM operators had a significant increase in cobalt exposure compared with welders. Airborne particle concentrations (<300 nm) showed transient peaks in the AM facility but were lower than those of the welding facility. Particle characterization of recycled powder showed fragmentation and condensates enriched in volatile metals. Biomonitoring showed a nonsignificant increase in the level of metals in urine in AM operators. Dermal cobalt and a trend for increasing urine metals during Workweek Year 1, but not in Year 2, indicated reduced exposure after preventive actions. Conclusion: Gravimetric analyses showed low total and inhalable dust exposure in AM operators. However, transient emission of smaller particles constitutes exposure risks. Preventive actions implemented by the company reduced the workers' metal exposure despite unchanged emissions of particles, indicating a need for careful design and regulation of the AM environments. It also emphasizes the need for relevant exposure markers and biomonitoring of health risks.

• 한국산업보건학회지
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• 제28권4호
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• pp.393-405
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• 2018

Objective: This study examines the types of hazardous factors in the working environment and the time-trend for their exposure levels over 10 years (2007 to 2016). Study Design and Method: The types of hazardous factors and exposure levels were drawn from the 19 measurement reports on the working environment over 10 years at a shock absorber manufacturing facility. Risk assessment of the types of factors and time-trend of exposure levels were evaluated using the factors and exposure levels. Results: A total of 34 hazardous factors were evaluated. The types were noise, 15 organic compounds, seven kinds of acid sand alkalis, eight kinds of heavy metals, and three other compounds. Special management materials used were nickel, hexavalent chrome, and sulfuric acid. Human carcinogens (1A) used were trichloroethylene, nickel, and sulfuric acid. There were six types of substances belonging to the IARC's 2B (body carcinogens) classification or higher, including, methyl isobutyl ketone, ethyl benzene, and trichloroethylene. No detection was found for 627 out of the 2065 total measurements in 19 exposure survey reports, representing 30.4%. Organic solvents, acid and alkali products, and heavy metals showed continuous low exposure concentrations. Noise, welding fumes, and the evaluation of mixed solvents show a gradual decrease in geometric mean and maximum over the time-trend of 10 years. Conclusions: In the case of a shock absorber manufacturing facility, the hazardous factors of noise and the evaluation of mixed solvents still indicate high concentrations exceeding the exposure limits and necessitate reduction studies. These two factors and welding fumes showed a continuous decrease in their ten-year tendency. Organic compounds, acids/alkalis, and heavy metals were managed smoothly in a work environment of continuous low concentrations.

• 대한방사성의약품학회지
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• 제1권2호
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• pp.98-103
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• 2015

Good manufacturing Practice (GMP) regulation for diagnostic and therapeutic radiopharmaceuticals was prepared at 2014. The mandatory GMP regulation becomes effective on $1^{st}$, July 2015,with two years of grace periods. Korean radiopharmaceuticals GMP regulation was consisted of quality management, personnel, premise and facility, documentation, production, quality control and self-audit and they have a very similar structure to European Union and PIC/S GMP regulation. Here, we describe detailed description of GMP regulation each part and application to radiopharmaceuticals production. And we also compare Korea, Japan and USA radiopharmaceuticals GMP regulation. GMP is a method to maintain quality of radiopharmaceuticals in daily production and it must be embedded on the manufacturing operation and management.

• Molecules and Cells
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• 제45권5호
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• pp.284-290
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• 2022

Exosome, a type of nanoparticles also known as small extracellular vesicles are gaining attention as novel therapeutics for various diseases because of their ability to deliver genetic or bioactive molecules to recipient cells. Although many pharmaceutical companies are gradually developing exosome therapeutics, numerous hurdles remain regarding manufacture of clinical-grade exosomes for therapeutic use. In this mini-review, we will discuss the manufacturing challenges of therapeutic exosomes, including cell line development, upstream cell culture, and downstream purification process. In addition, developing proper formulations for exosome storage and, establishing good manufacturing practice facility for producing therapeutic exosomes remains as challenges for developing clinical-grade exosomes. However, owing to the lack of consensus regarding the guidelines for manufacturing therapeutic exosomes, close communication between regulators and companies is required for the successful development of exosome therapeutics. This review shares the challenges and perspectives regarding the manufacture and quality control of clinical grade exosomes.

• 융합신호처리학회논문지
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• 제23권4호
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• pp.216-221
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• 2022

4차산업혁명은 사회 전반에 걸쳐 디지털 혁신으로의 전환을 가속화하고 있으며, 제조업에서는 스마트공장을 비롯해 4차산업혁명 기반 제조업 혁신을 위한 노력이 이어지고 있다. 제조업에서의 4차산업혁명 기술의 접목은 AI, 빅데이터, IoT, 클라우드, 로봇 등을 활용해 기존 자동화에서 업그레이드된 생산설비 데이터 수집 및 분석시스템 구축과 제품 불량 원인 파악 및 불량률을 최소화하기 위한 기술개발이 요구된다. 본 논문에서는 생산설비 현장에서의 전력, 환경, 설비 상태 데이터를 IoT 디바이스를 통해 수집하고, 수집한 데이터를 클라우드 컴퓨팅 환경에서 실시간으로 수치화하여 나타내고 위젯을 활용하여 MQTT기반 실시간 인포그래픽 형태로 표시할 수 있는 시스템을 구현하였다. IoT 디바이스로부터 전송된 실시간 센서 데이터를 Rest API 방식으로 클라우드 서버에 저장하고, 대시보드에서 데이터를 원격에서도 모니터링이 가능함은 물론 시간별, 일자별로 분석이 가능하였다.

• 한국산학기술학회논문지
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• 제19권4호
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• pp.132-137
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• 2018

2015년 화학물질관리법 시행 이후 화학 사고 발생 수는 감소 추세에 있으나, 최근 인쇄회로기판(PCB) 제조시설에서 유사한 유형의 사고가 반복적으로 발생함에 따라 실험을 통해 사고 원인을 조사 분석하였다. 해당 사고는 인쇄회로기판 제조공정 내 에칭용액으로 사용한 유해화학물질인 염산과 과산화수소가 월류하여 발생한 사고로 작업자 부주의와 시설 관리 미흡이 주된 사고 원인으로 조사되었다. 사고 원인을 규명하기 위해 실시한 $Cl^-$의 함량 분석 결과 과산화수소 시료에서 66.85 ppm로 측정되어 사고 물질인 염산과 과산화수소의 혼합경로를 확인할 수 있었으며, 반응실험을 통해 반응열이 $50.5^{\circ}C$까지 발생함에 따라 PVC 저장탱크의 변형과 유독가스인 염소가스 발생을 확인하였다. 본 연구를 통해 인쇄회로기판 제조시설의 에칭공정에서의 과충전, 역류방지, 누출감지장치와 혼합방지를 위한 저장탱크 분리 설계 등 시설 안전 관리 방안과 해당 장치의 장외영향평가 검토 필요성을 제시하고자 하였다. 또한 동일 유형의 사고 재발 방지를 위하여 주기적인 시설 안전점검과 작업자의 안전교육 강화의 필요성에 대하여 논의하였다.