• Journal of Korean Society for Quality Management
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• v.49 no.4
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• pp.581-594
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• 2021

Purpose: The purpose of this study is to compare machine learning models for anomaly detection of mechanical facility equipment and suggest an anomaly detection system for mechanical facility equipment in subway stations. It helps to predict failures and plan the maintenance of facility. Ultimately it aims to improve the quality of facility equipment. Methods: The data collected from Daejeon Metropolitan Rapid Transit Corporation was used in this experiment. The experiment was performed using Python, Scikit-learn, tensorflow 2.0 for preprocessing and machine learning. Also it was conducted in two failure states of the equipment. We compared and analyzed five unsupervised machine learning models focused on model Long Short-Term Memory Variational Autoencoder(LSTM-VAE). Results: In both experiments, change in vibration and current data was observed when there is a defect. When the rotating body failure was happened, the magnitude of vibration has increased but current has decreased. In situation of axis alignment failure, both of vibration and current have increased. In addition, model LSTM-VAE showed superior accuracy than the other four base-line models. Conclusion: According to the results, model LSTM-VAE showed outstanding performance with more than 97% of accuracy in the experiments. Thus, the quality of mechanical facility equipment will be improved if the proposed anomaly detection system is established with this model used.

• Journal of Ginseng Research
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• v.45 no.6
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• pp.754-762
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• 2021

Background: Ginsenoside Rh2, a major saponin derivative in ginseng extract, is recognized for its anti-cancer activities. Compared to coding genes, studies on long noncoding RNAs (lncRNAs) and microRNAs (miRNAs) that are regulated by Rh2 in cancer cells, especially on competitive endogenous RNA (ceRNA) are sparse. Methods: LncRNAs whose promoter DNA methylation level was significantly altered by Rh2 were screened from methylation array data. The effect of STXBP5-AS1, miR-4425, and RNF217 on the proliferation and apoptosis of MCF-7 breast cancer cells was monitored in the presence of Rh2 after deregulating the corresponding gene. The ceRNA relationship between STXBP5-AS1 and miR-4425 was examined by measuring the luciferase activity of a recombinant luciferase/STXBP5-AS1 plasmid construct in the presence of mimic miR-4425. Results: Inhibition of STXBP5-AS1 decreased apoptosis but stimulated growth of the MCF-7 cells, suggesting tumor-suppressive activity of the lncRNA. MiR-4425 was identified to have a binding site on STXBP5-AS1 and proven to be downregulated by STXBP5-AS1 as well as by Rh2. In contrast to STXBP5-AS1, miR-4425 showed pro-proliferation activity by inducing a decrease in apoptosis but increased growth of the MCF-7 cells. MiR-4425 decreased luciferase activity from the luciferase/STXBP5-AS1 construct by 26%. Screening the target genes of miR-4425 and Rh2 revealed that Rh2, STXBP5-AS1, and miR-4425 consistently regulated tumor suppressor RNF217 at both the RNA and protein level. Conclusion: LncRNA STXBP5-AS1 is upregulated by Rh2 via promoter hypomethylation and acts as a ceRNA, sponging the oncogenic miR-4425. Therefore, Rh2 controls the STXBP5-AS1/miR-4425/RNF217 axis to suppress breast cancer cell growth.

• Journal of Korean Academy of Nursing
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• v.51 no.1
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• pp.15-26
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• 2021

Purpose: This study aimed to distinguish and describe the types of perceptions of do not resuscitate (DNR) proxy decisions among families of elderly patients in a long-term care facility. Methods: This exploratory study applied Q-methodology, which focuses on individual subjectivity. Thirty-four Q-statements were selected from 130 Q-populations formed based on the results of in-depth interviews and literature reviews. The P-samples were 34 families of elderly patients in a long-term care hospital in Busan, Korea. They categorized the Q-statements using a 9-point scale. Using the PC-QUANL program, factor analysis was performed with the P-samples along an axis. Results: The families' perceptions of the DNR proxy decision were categorized into three types. Type I, rational acceptance, valued consensus among family members based on comprehensive support from medical staff. Type II, psychological burden, involved hesitance in making a DNR proxy decision because of negative emotions and psychological conflict. Type III, discreet decisions, valued the patients' right to self-determination and desire for a legitimate proxy decision. Type I included 18 participants, which was the most common type, and types II and III each included eight participants. Conclusion: Families' perceptions of DNR proxy decisions vary, requiring tailored care and intervention. We suggest developing and providing interventions that may psychologically support families.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.3
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• pp.197-208
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• 2023

Dysregulation of certain long non-coding RNAs may facilitate tumor initiation and progression. However, numerous carcinogenesis-related long noncoding RNAs have not been characterized. The goal of this study was to elucidate the role of LINC00562 in gastric cancer (GC). The expression of LINC00562 was analyzed using real-time quantitative PCR and Western blotting. The proliferative capacity of GC cells was determined using Cell Counting Kit-8 and colony-formation assays. The migration of GC cells were evaluated using wound-healing assays. The apoptosis of GC cells was assessed by measuring the expression levels of apoptosis-related proteins (Bax and Bcl-2). Xenograft models in nude mice were constructed for in vivo functional analysis of LINC00562. The binding relationship between miR-4636 and LINC00562 or adaptor protein complex 1 sigma 3 (AP1S3), obtained from public databases, was confirmed using dual-luciferase and RNA-binding protein immunoprecipitation experiments. LINC00562 was expressed in GC cells at high levels. Knockdown of LINC00562 repressed GC cell growth and migration, promoted apoptosis in vitro, and inhibited tumor growth in nude mouse models. LINC00562 directly targeted miR-4636, and miR-4636 depletion restored the GC cell behavior inhibited by LINC00562 absence. AP1S3, an oncogene, binds to miR-4636. MiR-4636 downregulation increased AP1S3 level, restoring GC cell malignant behaviors inhibited by AP1S3 downregulation. Thus, LINC00562 exerts carcinogenic effects on GC development by targeting miR-4636-mediated AP1S3 signaling.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.22 no.1
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• pp.97-108
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• 1992

The author obtained 120 oblique-lateral transcranial radiograms by two projection methods from 30 subjects with clinically normal TMJ. The relative position of the condyle within the articular fossa and the quality of the radiographic images were compared in the standardized and individualized radiographic groups. The results were as follows: 1. The condylar position in the individualized radiographic group was more posterior than that in the standardized radiographic group (P<0.001). 2. The horizontal angle between the long axis of condyle and intermeatal line in the individualized group ranged from 0° to 31° (14.38°±7.55°), and the highest prevalence was found between 15 and 19° 3. The individualized group showed prominent radiopaque shadow of the anterior condylar border; the image detail was superior in the standardized group to that of the individualized group (P<0.05).

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.16 no.1
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• pp.19-24
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• 1986

The author performed radiographical analysis of the third molar dentition and characteristic relation to anatomical oral structure. For this purpose 506 orthopantomagraph film, male 283cases and female 223 cases, aged from 15 to 30 years were evaluated by means of Winter's classification in conjunction with some other methods. Through the study following results were obtained; 1. The eruption of(equation omitted) were found in 229 cases followed by 61 cases of(equation omitted) and 45 cases showed no evidence of eruption. 2. The classification based on the relation of ramus to distal portion of the 2nd molar revealed class Ⅱ, 460 cases (61.8%) and 182 cases (24.5%) were class Ⅲ. 3. Parallelism between long axis of mandibular third molar and the second molar were found in 302 cases (40.8%) and mesial inclination of the third molar were 280 cases (37.6%). 4. Average inclination degree among these cases showed 138.62±12.56°.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.78.4-79
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• 2015

We present the spatially resolved kinematics of ionized gas and stars along the major axis of 9 pseudo bulge galaxies. Using the high quality long-slit spectra obtained with the FOCAS at the Subaru telescope, we measured the flux, velocity, and velocity dispersion of the [OIII] and $H{\beta}$ lines to determine the size of the narrow-line region, rotation curve, and the radial profile of velocity dispersions. We compare ionized gas kinematics and stellar kinematics to investigate whether ionized gas shows any signs of outflows and whether stars and ionized gas show the same sigma-dip feature (i.e., decrease of velocity dispersion) at the very center.

• The korean journal of orthodontics
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• v.17 no.2
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• pp.321-333
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• 1987

The purpose of this study was to observe the changes of the lower 3rd molars following the extraction of the lower 2nd molars by Lateral Cephalograms and Orthopantomograms. The subjects consisted of twenty malocclusion, 7 males 13 females, were 19 year 5 month old at the removal of the lower 2nd molars, 19 year 1 month old at the end of the orthodontic supervision after the removal of the lower 2nd molars (mean age) The obtained results were as follows, 1 It is recommended to extract the lower 2nd molars when the lower 3rd molars are Nolla's Stage 4 or 5 2 With the pre-extraction variables obtained by factor analysis, it was possible to predict the long axis of the lower 3rd molars after 2nd molar extraction. 3 There were no impacted 3rd molars.

• Journal of the Korean Institute of Rural Architecture
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• v.5 no.1
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• pp.42-61
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• 2003

The purpose of this study was to analyze the characteristics of wooden anglican church architecture in Chungcheong area. For this study, I have selected ten anglican churches, and have studied the characteristic through the actual survey and analysis. This study focuses on the architectural characteristics and evolution of wooden anglican church in chungcheong area, based on the actual survey and historical analysis. The results of this study is as follows:1)The shape of plan is long axis composed of the entry and altar. 2)The shape of elevation is composed of the roof form and existence and nonexistence of bell-tower. 3)The shape of section in divided into one kan and three kan way, by the existence and nonexistence of a row of columns in the interior. 4)The structure and design follows roof-framing.

• Asian-Australasian Journal of Animal Sciences
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• v.20 no.1
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• pp.124-131
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• 2007

There is worldwide interest in buffalo as an animal for meeting the growing demands of meat, milk and work in the developing countries. One of the major constraints to full exploitation of the productive potential of buffalo has been its inherently low reproductive efficiency as reflected by late maturity, poor expression of oestrus, silent oestrus, irregular oestrous cyclicity, seasonality in breeding, anoestrus, low conception rate, long postpartum interval, repeat breeding etc. Ovarian cyclicity is regulated by endocrine and neuroendocrine mechanisms namely hypothalamic hormones, gonadotropins and ovarian steroids. Detailed endocrine investigations are suggested with special reference to the hypothalamo-hypophysial-ovarian axis to gain a better understanding of reproduction in buffalo and to modify it to derive the maximum benefit from this animal.