• Genomics & Informatics
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• v.12 no.3
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• pp.87-97
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• 2014

Although the number of protein-coding genes is not highly variable between plant taxa, the DNA content in their genomes is highly variable, by as much as 2,056-fold from a 1C amount of 0.0648 pg to 132.5 pg. The mean 1C-value in plants is 2.4 pg, and genome size expansion/contraction is lineage-specific in plant taxonomy. Transposable element fractions in plant genomes are also variable, as low as ~3% in small genomes and as high as ~85% in large genomes, indicating that genome size is a linear function of transposable element content. Of the 2 classes of transposable elements, the dynamics of class 1 long terminal repeat (LTR) retrotransposons is a major contributor to the 1C value differences among plants. The activity of LTR retrotransposons is under the control of epigenetic suppressing mechanisms. Also, genome-purging mechanisms have been adopted to counter-balance the genome size amplification. With a wealth of information on whole-genome sequences in plant genomes, it was revealed that several genome-purging mechanisms have been employed, depending on plant taxa. Two genera, Lilium and Fritillaria, are known to have large genomes in angiosperms. There were twice times of concerted genome size evolutions in the family Liliaceae during the divergence of the current genera in Liliaceae. In addition to the LTR retrotransposons, non-LTR retrotransposons and satellite DNAs contributed to the huge genomes in the two genera by possible failure of genome counter-balancing mechanisms.

• BMB Reports
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• v.53 no.2
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• pp.65-73
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• 2020

Life expectancy has dramatically increased around the world over the last few decades, and staying healthier longer, without chronic disease, has become an important issue. Although understanding aging is a grand challenge, our understanding of the mechanisms underlying the degeneration of cell and tissue functions with age and its contribution to chronic disease has greatly advanced during the past decade. As our immune system alters with aging, abnormal activation of immune cells leads to imbalance of innate and adaptive immunity and develops a persistent and mild systemic inflammation, inflammaging. With their unique therapeutic properties, such as immunomodulation and tissue regeneration, mesenchymal stem cells (MSCs) have been considered to be a promising source for treating autoimmune disease or as anti-aging therapy. Although direct evidence of the role of MSCs in inflammaging has not been thoroughly studied, features reported in senescent MSCs or the aging process of MSCs are associated with inflammaging; MSC niche-driven skewing of hematopoiesis toward the myeloid lineage or oncogenesis, production of pro-inflammatory cytokines, and weakening their modulative property on macrophage polarization, which plays a central role on inflammaging development. This review explores the role of senescent MSCs as an important regulator for onset and progression of inflammaging and as an effective target for anti-aging strategies.

• Journal of the Korean Society of Costume
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• v.56 no.1 s.100
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• pp.32-43
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• 2006

Excavated fabrics from Papyeung-yun's tomb totals at 208 in their numbers. They comprised 118 pieces of silk tabby(紬), 16 pieces of thin silk tabby, 8 pieces of thin filament silk tabby (絹), 43 pieces of satin damask(段), 8 pieces of compound satin(金線), 1 piece of twill(綾), 1 piece of complex gauze(羅), l piece of simple gauze(紗), 4 pieces of cotton(綿布), 4 pieces of hemp(麻布) and 3 pieces of ramie(苧布). As shown in the preceding list, $95\%$ of all the items are weaved from silk. To list a few characteristics of excavated fabrics from Papyoung-Yun's lineage, there are A vivid gold-colored compound satin, a uniquely patterned satin damask, various silk tabbies, and 4-end complex gauze of Neoul that is women's head cover. To note, names of the fabrics used in this article are based on the information from the literatures and are as following silk tabby(紬), thin silk tabby, filament silk tabby(絹), satin damask(段), compound satin(金線), complex gauze(羅), simple gauze(紗), cotton(綿布), twill(綾), hemp(麻布)and ramie(苧布).

• Development and Reproduction
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• v.15 no.4
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• pp.331-338
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• 2011

MicroRNAs (miRNAs) function as a key regulator of diverse cellular functions. To find out novel miRNAs that promote the differentiation of mouse embryonic stem cells (mESCs), we compared the miRNAs expression profiles of mESCs under self-renewal vs. differentiation states. We noticed that miR-222 was highly expressed during the differentiation of mESCs. Quantitative RT-PCR analysis revealed that expression of miR-222 was up-regulated during the embryonic bodies formation and retinoic acid -dependent differentiation. When miR-222 was suppressed by antogomiR-222, the differentiation of mESCs was delayed compared to control. Self-renewal marker expression or cell proliferation was not affected but the expression of lineage specific marker was suppressed by the treatment of miR-222 inhibitor during the differentiation of mESCs. Taken together, these results suggest that miR-222 functions to promote the differentiation of mESCs by regulating expression of differentiation related genes.

• Journal for History of Mathematics
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• v.30 no.4
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• pp.233-246
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• 2017

$Ces{\grave{a}}ro$ summability is a generalized convergence criterion for infinite series. We have investigated the classical results of summability for Fourier series from 1897 to 1957. In this paper, we are concerned with the summability and summation methods for Fourier Series from 1960 to 2010. Many authors have studied the subject during this period. Especially, G.M. Petersen,$K{\hat{o}}si$ Kanno, S.R. Sinha, Fu Cheng Hsiang, Prem Chandra, G. D. Dikshit, B. E. Rhoades and others had studied neoclassical results on the summability of Fourier series from 1960 to 1989. We investigate the results on the summability for Fourier series from 1990 to 2010 in section 3. In conclusion, we present the research minor lineage on summability for Fourier series from 1960 to 2010. $H{\ddot{u}}seyin$ Bor is the earliest researcher on ${\mid}{\bar{N}},p_n{\mid}_k$-summability. Thus we consider his research results and achievements on ${\mid}{\bar{N}},p_n{\mid}_k$-summability and ${\mid}{\bar{N}},p_n,{\gamma}{\mid}_k$-summability.

• The Plant Pathology Journal
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• v.33 no.2
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• pp.103-108
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• 2017

World wheat production is now under threat due to the wheat blast outbreak in Bangladesh in early March 2016. This is a new disease in this area, indicating the higher possibility of this pathogen spreading throughout the Asia, the world's largest wheat producing area. Occurrence of this disease caused ~3.5% reduction of the total wheat fields in Bangladesh. Its economic effect on the Bangladesh wheat market was little because wheat contributes to 3% of total cereal consumption, among which ~70% have been imported from other countries. However, as a long-term perspective, much greater losses will occur once this disease spreads to other major wheat producing areas of Bangladesh, India, and Pakistan due to the existing favorable condition for the blast pathogen. The wheat blast pathogen belongs to the Magnaporthe oryzae species complex causing blast disease on multiple hosts in the Poaceae family. Phylogenetic analysis revealed that the Bangladesh outbreak strains and the Brazil outbreak strains were the same phylogenetic lineage, suggesting that they might be migrated from Brazil to Bangladesh during the seed import. To protect wheat production of Bangladesh and its neighbors, several measures including rigorous testing of seed health, use of chemicals, crop rotation, reinforcement of quarantine procedures, and increased field monitoring should be implemented. Development of blast resistant wheat varieties should be a long-term solution and combination of different methods with partial resistant lines may suppress this disease for some time.

• Journal of Dairy Science and Biotechnology
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• v.29 no.1
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• pp.1-15
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• 2011

Kefir originated from the Caucasian mountains is a cultured milk beverage of ancient lineage obtained by a combined acidic and alcoholic fermentation. Many scientists revealed the kefir has lots of good effect for human health. Unfortunately, there is no study to improve the diabetic symptoms taking kefir diet. Hence the objective of this review paper was to research the possibility for diabetic diet supplementary as Kefir.

• Genomics & Informatics
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• v.5 no.4
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• pp.179-187
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• 2007

An increasing number of primate genomes are being sequenced. A direct comparison of repeat elements in human genes and their corresponding chimpanzee orthologs will not only give information on their evolution, but also shed light on the major evolutionary events that shaped our species. We have developed REPEATOME to enable visualization and subsequent comparisons of human and chimpanzee repeat elements. REPEATOME (http://www.repeatome.org/) provides easy access to a complete repeat element map of the human genome, as well as repeat element-associated information. It provides a convenient and effective way to access the repeat elements within or spanning the functional regions in human and chimpanzee genome sequences. REPEATOME includes information to compare repeat elements and gene structures of human genes and their counterparts in chimpanzee. This database can be accessed using comparative search options such as intersection, union, and difference to find lineage-specific or common repeat elements. REPEATOME allows researchers to perform visualization and comparative analysis of repeat elements in human and chimpanzee.

• Proceedings of the Korean Information Science Society Conference
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• 2003.10c
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• pp.49-51
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• 2003

Developers of network games have used several prediction techniques for hiding transmission delay to support the real­time requirement of network games. Nowadays many researches that are related with network game are in progress to solve delay problems more radically, such as to propose new routers architecture and transport protocols suitable to characteristics of network game traffic. So for these advanced researches the tasks to grasp the traffic characteristics of a network game are needed. In this paper we aimed to capture the traffic of MMORPG and present the statistical analysis of measured data. The measurement and the analysis were accomplished with the server of 'Lineage' that regarded as the most successful MMORPG. Next, we have implemented a traffic generator that reflects the characteristics of MMORPG and shown that the trace generated by MMORPG traffic generator had identical characteristics with actual traffic using statistical testing method. We expect that this traffic generator can be used in many researches related with a network game.

• BMB Reports
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• v.38 no.6
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• pp.633-638
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• 2005

Biosynthesis of prostanoids is regulated by three sequential enzymatic steps, namely phospholipase $A_2$ enzymes, cyclooxygenase (COX) enzymes, and various lineage-specific terminal prostanoid synthases. Prostaglandin E synthase (PGES), which isomerizes COX-derived $PGH_2$ specifically to $PGE_2$, occurs in multiple forms with distinct enzymatic properties, expressions, localizations and functions. Two of them are membrane-bound enzymes and have been designated as mPGES-1 and mPGES-2. mPGES-1 is a perinuclear protein that is markedly induced by proinflammatory stimuli, is down-regulated by anti inflammatory glucocorticoids, and is functionally coupled with COX-2 in marked preference to COX-1. Recent gene targeting studies of mPGES-1 have revealed that this enzyme represents a novel target for anti-inflammatory and anti-cancer drugs. mPGES-2 is synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme. This enzyme is rather constitutively expressed in various cells and tissues and is functionally coupled with both COX-1 and COX-2. Cytosolic PGES (cPGES) is constitutively expressed in a wide variety of cells and is functionally linked to COX-1 to promote immediate $PGE_2$ production. This review highlights the latest understanding of the expression, regulation and functions of these three PGES enzymes.