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A New Rat Model of Cisplatin-induced Neuropathic Pain

  • Lin, Hai;Heo, Bong Ha;Yoon, Myung Ha
    • The Korean Journal of Pain
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    • v.28 no.4
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    • pp.236-243
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    • 2015
  • Background: Chemotherapy-induced peripheral neuropathy is a major side effect of anti-cancer drugs, and our knowledge of its mechanisms is lacking. Several models for chemotherapy-induced neuropathy have been introduced. However, the outcomes of these models differ significantly among laboratories. Our object was to create a model of chemotherapy-induced neuropathy in rats with cancer. Methods: Female Sprague-Dawley rats were used. Mammary rat metastasis tumor (MRMT-1) cells were implanted subcutaneously in rats. Chemotherapy-induced peripheral neuropathy was induced by injection of cisplatin once a day for four days. The responses to mechanical and thermal stimuli were examined using von Frey filaments, acetone, and radiant heat. Results: Cisplatin (2 mg/kg/day) produced mechanical allodynia, while it did not induce cold allodynia or thermal hyperalgesia. This dose of cisplatin could work successfully against cancer. Body weight loss was not observed in cisplatin-treated rats, nor were other abnormal behaviors noted in the same rats. Conclusions: Repeated injection of intraperitoneal cisplatin induced peripheral neuropathic pain in rats. Thus, this type of rat model has broad applicability in studies related to searching for the mechanism of cisplatin-induced mechanical allodynia and agents for the treatment of neuropathic pain.

Implementation and Performance Evaluation of a Firm's Green Supply Chain Management under Uncertainty

  • Lin, Yuanhsu;Tseng, Ming-Lang;Chiu, Anthony S.F.;Wang, Ray
    • Industrial Engineering and Management Systems
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    • v.13 no.1
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    • pp.15-28
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    • 2014
  • Evaluation of the implementation and performance of a firm's green supply chain management (GSCM) is an ongoing process. Balanced scorecard is a multi-criteria evaluation concept that highlights implementation and performance measures. The literature on the framework is abundant literature but scarce on how to build a hierarchical framework under uncertainty with dependence relations. Hence, this study proposes a hybrid approach, which includes applied interpretive structural modeling to build a hierarchical structure and uses the analytic network process to analyze the dependence relations. Additionally, this study applies the fuzzy set theory to determine linguistic preferences. Twenty dependence criteria are evaluated for a GSCM implemented firm in Taiwan. The result shows that the financial aspect and life cycle assessment are the most important performance and weighted criteria.

Multiple Network-on-Chip Model for High Performance Neural Network

  • Dong, Yiping;Li, Ce;Lin, Zhen;Watanabe, Takahiro
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.10 no.1
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    • pp.28-36
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    • 2010
  • Hardware implementation methods for Artificial Neural Network (ANN) have been researched for a long time to achieve high performance. We have proposed a Network on Chip (NoC) for ANN, and this architecture can reduce communication load and increase performance when an implemented ANN is small. In this paper, a multiple NoC models are proposed for ANN, which can implement both a small size ANN and a large size one. The simulation result shows that the proposed multiple NoC models can reduce communication load, increase system performance of connection-per-second (CPS), and reduce system running time compared with the existing hardware ANN. Furthermore, this architecture is reconfigurable and reparable. It can be used to implement different applications of ANN.

Relationships Between Cause of Cancer and Breast Cancer-Related Factors in Breast Cancer Survivors

  • Wang, Hsiu-Ho;Chung, Ue-Lin
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.8
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    • pp.3889-3892
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    • 2012
  • Aims: The purposes of this study were to (1) to identify the causes of cancer in breast cancer survivors in Taiwan; and (2) to investigate the influence of demographic characteristics and breast cancer-related factors on the cause of cancer. Materials and method: This study details the related investigative results on survivors with breast cancer using a descriptive and correlational design. A convenience sampling approach was employed. A structured questionnaire was used to assess the participants. Results: A total of 230 breast cancer survivors completed the questionnaire. Low-scoring cause of cancer participants were older adults (OR = 2.49, p<0.05) who were already of menopausal status (OR = 2.28, p < 0.05). Around 72% of particpants agreed high responsibility. Our breast cancer survivors felt stress had caused their breast cancer. Conclusion: These findings are helpful in understanding the relationship between cause of cancer and related factors in breast cancer survivors.

Fuzzy Logic Based Temporal Error Concealment for H.264 Video

  • Lee, Pei-Jun;Lin, Ming-Long
    • ETRI Journal
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    • v.28 no.5
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    • pp.574-582
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    • 2006
  • In this paper, a new error concealment algorithm is proposed for the H.264 standard. The algorithm consists of two processes. The first process uses a fuzzy logic method to select the size type of lost blocks. The motion vector of a lost block is calculated from the current frame, if the motion vectors of the neighboring blocks surrounding the lost block are discontinuous. Otherwise, the size type of the lost block can be determined from the preceding frame. The second process is an error concealment algorithm via a proposed adapted multiple-reference-frames selection for finding the lost motion vector. The adapted multiple-reference-frames selection is based on the motion estimation analysis of H.264 coding so that the number of searched frames can be reduced. Therefore the most accurate mode of the lost block can be determined with much less computation time in the selection of the lost motion vector. Experimental results show that the proposed algorithm achieves from 0.5 to 4.52 dB improvement when compared to the method in VM 9.0.

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Vocabulary Teaching through Using Collocations of '나다 and 들다' -Oriented to Chinese Learners of Korean as Foreign Language- ('나다, 들다'의 연어를 활용한 어휘 교육 방안 -중국인 학습자를 대상으로-)

  • Lin, Chunmei
    • Journal of Korean language education
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    • v.28 no.2
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    • pp.89-112
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    • 2017
  • Grammar has long been regarded as an important element in foreign language learning and has received a lot of attention from foreign language learners and researchers. However, in the process of learning, learners will confront an increasing number of words some of which may have multiple meanings. It is not easy for language learners to memorize and master the correct use of these words, especially in terms of pragmatics. Some learners may use the grammar correctly, but their writing or utterance may feel unnatural in discourse. In Korean, '나다, 들다' are two basic verbs, but they have many different meanings which cause a lot of confusion among learners of Korean as a foreign language. In this article, the writer attempts to make a distinction between the collocations of the two verbs '나다, 들다' and provides an effective method for teaching the learners of Korean in China.

Draft Genome Sequence of Aureobasidium pullulans Strain MHAU2101, a Biological Control Agent against Fire Blight from Korea

  • Lin He;Huan Luo;Mi-Hyun Lee;Jun Myoung Yu
    • Microbiology and Biotechnology Letters
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    • v.51 no.4
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    • pp.538-541
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    • 2023
  • In this study, we present the draft genome of Aureobasidium pullulans strain MHAU2101, which is the first strain to effectively control fire blight caused by Erwinia amylovora in Korea. The genome of strain MHAU2101 was composed of 28,669,322 base pairs, with a C+G content of 50.4%. The assembly comprised 17 contigs and had 99.22% completeness. The results of this study will be a valuable resource for future research on the biocontrol mechanism of A. pullulans strain MHAU2101.

Transforming Growth Factor Beta-1 C-509T Polymorphism and Cancer Risk: A Meta-analysis of 55 Case-control Studies

  • Liu, Yang;Lin, Xian-Fan;Lin, Chun-Jing;Jin, Si-Si;Wu, Jin-Ming
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.9
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    • pp.4683-4688
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    • 2012
  • Aim: To investigate the association of transforming growth factor-beta 1 (TGF-${\beta}1$) C-509T polymorphism and susceptibility to cancer by means of meta-analysis. Methods: An extensive search was performed to identify eligible case-control studies investigating such a link. The strength of the association between TGF-${\beta}1$ C-509T polymorphism and cancer risk was assessed by pooled odds ratios (ORs) and 95%confidence intervals (95%CIs) in fixed or random effects models. Results: 55 published case-control studies with a total number of 21,639 cases and 28,460 controls were included. Overall, there was no association between TGF-${\beta}1$ C-509T and cancer risk in all genetic comparison models (TT vs. CC: OR=1.01, 95%CI=0.89-1.15; T vs. C: OR=1.01, 95%CI=0.94-1.07). However, a stratified analysis by cancer type indicated -509 T allele was significantly associated with decreased risk of colorectal cancer (CRC) (TT vs. CT/CC: OR=0.85, 95%CI=0.76-0.95), especially for Caucasians (TT vs. CT/CC: OR=0.83, 95%CI=0.71-0.98) and for population-based studies (TT vs. CT/CC: OR=0.78, 95%CI=0.68-0.89). Conclusion: This meta-analysis suggested that TGF-${\beta}1$ C-509T polymorphism might contribute to a decreased risk on colorectal cancer susceptibility, especially for Caucasians.

Performance characteristics of dredged silt and high-performance lightweight aggregate concrete

  • Wang, H.Y.;Sheen, Y.N.;Hung, M.F.
    • Computers and Concrete
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    • v.7 no.1
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    • pp.53-62
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    • 2010
  • Dredged silt from reservoirs in southern Taiwan was sintered to make lightweight aggregates (LWA), which were then used to produce high-performance lightweight aggregate concrete (HPLWC). The HPLWC was manufactured using different amounts of mixing water (140, 150, and 160 $kg/m^3$) and LWA of different particle densities (700, 1100, and 1500 $kg/m^3$) at different W/b ratios (0.28, 0.32, and 0.4). Results show that the lightweight aggregates of dredged silt taken in southern Taiwan perform better than the general lightweight aggregates. In addition, the HPLWC possessed high workability with a slump of 230-270 mm, and a slump flow of 450-610 mm, high compressive strength of over 40 MPa after 28 days of curing, good strength efficiency of cement exceeding $0.1MPa/kg/m^3$, low thermal conductivity of 0.4-0.8 $kcal/mh^{\circ}C$, shrinkage of less than $4.8{\times}10^{-4}$, and high electrical resistivity of above 40 $k{\Omega}-cm$. The above findings prove that HPLWC made from dredged silt can help enhance durability of concrete and provide and an ecological alternative use of dredged silt.

Riboflavin and Bacillus subtilis effects on growth performance and woody-breast of Ross 708 broilers with or without Eimeria spp. challenge

  • Sabin, Poudel;George T., Tabler;Jun, Lin;Wei, Zhai;Li, Zhang
    • Journal of Animal Science and Technology
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    • v.64 no.3
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    • pp.443-461
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    • 2022
  • This study was conducted to assess the effects of the dietary supplementation of riboflavin (as a bile salt hydrolase [BSH] inhibitor) and Bacillus subtilis on growth performance and woody breast of male broilers challenged with Eimeria spp. Intestinal bacteria, including supplemented probiotics, can produce BSH enzymes that deconjugate conjugated bile salts and reduce fat digestion. A 3 × 2 × 2 (riboflavin × Bacillus subtilis × Eimeria spp. challenge) factorial arrangement of treatments in randomized complete block design was used. On d 14, birds were gavaged with 20× doses of commercial cocci vaccine (CoccivacR -B52, Merck Animal Health, Omaha, NE). Dietary treatment of riboflavin and B. subtilis did not affect body weight (BW), body weight gain (BWG), and feed conversion (FCR) d 0 to 14 and overall d 0 to 41. Eimeria spp challenge reduced BWG, feed intake (FI), and increased FCR between d 14 to 28, but increased BWG and lowered FCR between d 28 to 35. There were no effects of the Eimeria spp. challenge on the overall d 0 to 41 FCR and FI, but BWG was reduced. Eimeria spp. challenge increased the abdominal fat pad weight and slight woody breast incidences on processed birds on d 42. Dietary inclusion of B. subtilis and riboflavin at tested levels did not help birds to mitigate the negative impact of Eimeria spp. challenge to enhance the growth performance.