• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.10
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• pp.79-85
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• 2009

The design of a 3.2 Gb/s serial link receiver in $0.18{\mu}m$ CMOS process is presented. The major factors limiting the performance of high-speed links are transmission channel bandwidth, timing uncertainty. The design uses a multi-level signaling(4-PAM) to overcome these problems. Moreover, to increase data bit-rate and lower BER, we designed this circuit by using a current mode amplifier, Current-mode Logic(CML) sampling latches. The 4-PAM receiver achieves 3.2 Gb/s and BER is less than $1.0\;{\times}\;10^{-12}$. The $0.5\;{\times}\;0.6\;mm^2$ chip consumes 49 mA at 3.2 Gb/s from a 1.8-V supply.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.1297-1300
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• 2008

A conventional linear accelerator system requires a flat-topped pulse with less than ${\pm}$ 0.5% ripple to meet the beam energy spread requirements and to improve pulse efficiency of RF systems. A pulse transformer is one of main determinants on the output pulse voltage shape. The pulse transformer was investigated and analyzed with the pulse response characteristics using a simplified equivalent circuit model. The damping factor ${\sigma}$ must be >0.86 to limit the overshoot to less than 0.5% during the flat-top phase. The low leakage inductance and distributed capacitance are often limiting factors to obtain a fast rise time. These parameters are largely controlled by the physical geometry and winding configuration of the transformer. A rise time can be improved by reducing the number of turns, but it produces larger pulse droop and requires a larger core size. By tradeoffs among these parameters, the high-voltage pulse transformer with a pulse width of 10 ${\mu}s$, a rise time of 0.84 ${\mu}s$, and a pulse droop of 2.9% has been designed and fabricated to drive a klystron which has an output voltage of 284 kV, 30-MW peak and 60-kW average RF output power. This paper describes design optimization of a high-voltage pulse transformer for high-power pulsed applications. The experimental results were analyzed and compared with the design. The design and optimal tuning parameter of the system was identified using the model simulation.

• Journal of Korean Society of Forest Science
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• v.98 no.2
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• pp.170-177
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• 2009

There are remarkable differences in growth and morphological characters of roots between mountain and field cultivated Panax ginseng. Growth of root in mountain cultivated ginseng was much slower than that of field cultivated ginseng. However, the factor affecting the retarded growth in mountain ginseng was not known. Soil analysis revealed that phosphorus (P) content of mountain soil was exceptionally low at least ten-fold lower compared to that of field soil. Thus, we suggest that low availability of P in mountain soil may be one of the limiting factors for growth of ginseng in mountain soil environment. We had monitored the growth of ginseng plants after one and three years of phosphate fertilizer application. Three kinds of phosphate fertilizers: fused magnesium phosphate, fused superphosphate, and single superphosphate were applied to mountain soil. Application of phosphate fertilizers increased the fresh-, dry weight, and diameter of ginseng roots and resulted in increased P accumulation in roots. These results demonstrate that slow growth of ginseng in mountain soil environment might be attributed to the low P content in mountain soil. Thus, analysis of P amount in mountain soil will be a good indicator for the selection of suitable site the ginseng cultivation in forest.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.8
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• pp.3817-3823
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• 2014

Background: The MDM2 oncogene, a negative regulator of p53, has a functional polymorphism in the promoter region (SNP309) that is associated with multiple kinds of cancers including non-melanoma skin cancer. SNP309 has been shown to associate with accelerated tumor formation by increasing the affinity of the transcriptional activator Sp1. It remains unknown whether there are other factors involved in the regulation of MDM2 transcription through a trans-regulatory mechanism. Methods: In this study, SNP309 was verified to be associated with overexpression of MDM2 in tumor cells. Bioinformatics predicts that the T to G substitution at SNP309 generates a stronger E2F1 binding site, which was confirmed by ChIP and luciferase assays. Results: E2F1 knockdown downregulates the expression of MDM2, which confirms that E2F1 is a functional upstream regulator. Furthermore, tumor cells with the GG genotype exhibited a higher proliferation rate than TT, correlating with cyclin D1 expression. E2F1 depletion significantly inhibits the proliferation capacity and downregulates cyclin D1 expression, especially in GG genotype skin fibroblasts. Notably, E2F1 siRNA effects could be rescued by cyclin D1 overexpression. Conclusion: Taken together, a novel modulator E2F1 was identified as regulating MDM2 expression dependent on SNP309 and further mediates cyclin D1 expression and tumor cell proliferation. E2F1 might act as an important factor for SNP309 serving as a rate-limiting event in carcinogenesis.

• Korean Institute of Interior Design Journal
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• v.19 no.3
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• pp.136-144
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• 2010

Since most domestic apartment, built in bearing wall system limiting variability of space, in spite of its good durability, cannot accept life style change and is being wasted, dumped scraps of which cause environmental pollution and waste of resources. As a response for this, researches on sustainable housing, that is, 'long-life housing' which has high durability, and variability responding life style change of the resident are in progress in and out of country. Therefore, this article aims, in suggesting the various status appearing on apartment and the interior plan responding the problem, to research on the house plan in the future which can be used continuously instead consuming type of apartment shortly used and discarded with understanding of long-life housing developed in foreign countries, and grasping the factors of application plan. Various reports from previous researches were comparatively analyzed and the studies on the characteristics, the real examples and the types of the surfaces were performed on the experimental model of long-life housing and similar residential surfaces to find the concept to be applied to Long-Life Housing and the introduction method of such concept. This article tries not only to prevent 'scarp and build', the serious cause of environmental pollution, but also to be basic materials for interior construction plan afterwards through 'long-life housing interior design plan' as the new conception which can accept life style and life cycle change.

• Journal of Microbiology and Biotechnology
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• v.23 no.12
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• pp.1765-1773
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• 2013

The cathode reaction is one of the most seriously limiting factors in a microbial fuel cell (MFC). The critical dissolved oxygen (DO) concentration of a platinum-loaded graphite electrode was reported as 2.2 mg/l, about 10-fold higher than an aerobic bacterium. A series of MFCs were run with the cathode compartment inoculated with activated sludge (biotic) or not (abiotic) on platinum-loaded or bare graphite electrodes. At the beginning of the operation, the current values from MFCs with a biocathode and abiotic cathode were $2.3{\pm}0.1$ and $2.6{\pm}0.2mA$, respectively, at the air-saturated water supply in the cathode. The current from MFCs with an abiotic cathode did not change, but that of MFCs with a biotic cathode increased to 3.0 mA after 8 weeks. The coulomb efficiency was 59.6% in the MFCs with a biotic cathode, much higher than the value of 15.6% of the abiotic cathode. When the DO supply was reduced, the current from MFCs with an abiotic cathode decreased more sharply than in those with a biotic cathode. When the respiratory inhibitor azide was added to the catholyte, the current decreased in MFCs with a biotic cathode but did not change in MFCs with an abiotic cathode. The power density was higher in MFCs with a biotic cathode ($430W/m^3$ cathode compartment) than the abiotic cathode MFC ($257W/m^3$ cathode compartment). Electron microscopic observation revealed nanowire structures in biofilms that developed on both the anode and on the biocathode. These results show that an electron-consuming bacterial consortium can be used as a cathode catalyst to improve the cathode reaction.

• Journal of Korean Society on Water Environment
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• v.22 no.2
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• pp.342-348
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• 2006

Changes in water quality and algal growth according to the differences in the inflow volume were investigated in the Daecheong Lake from 1998 to 2001. Until year 2000, inflow volume considerably depended on the rainfall throughout the basin. However, the correlation was low since 2001 when water storage in the upstream Yongdam Lake was started. According to inflow volume-TP relationship analyses, significant correlation was found at up- and middle-stream sites, excluding down-stream site of the Daechong Lake. For chlorophyll-a, correlation was found with flow volume at all sites except for Choo-So. In a dry year, although nutrients loads were relatively lower than those in rainy years, there were higher concentrations of chlorophyll-a and massive bloom of Microcystis. Limiting factors for algal growth seems to be not the volume of nutrients load but retention time and physical disturbance of the water body influenced by inflow volume. Thus, in the Daecheong lake, it would be more important to focus on the management of eutrophication in dry years than in rainy ones.

• Molecules and Cells
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• v.41 no.10
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• pp.923-932
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• 2018

Ethylene regulates numerous aspects of plant growth and development. Multiple external and internal factors coordinate ethylene production in plant tissues. Transcriptional and post-translational regulations of ACC synthases (ACSs), which are key enzymes mediating a rate-limiting step in ethylene biosynthesis have been well characterized. However, the regulation and physiological roles of ACC oxidases (ACOs) that catalyze the final step of ethylene biosynthesis are largely unknown in Arabidopsis. Here, we show that Arabidopsis ACO1 exhibits a tissue-specific expression pattern that is regulated by multiple signals, and plays roles in the lateral root development in Arabidopsis. Histochemical analysis of the ACO1 promoter indicated that ACO1 expression was largely modulated by light and plant hormones in a tissue-specific manner. We demonstrated that point mutations in two E-box motifs on the ACO1 promoter reduce the light-regulated expression patterns of ACO1. The aco1-1 mutant showed reduced ethylene production in root tips compared to wild-type. In addition, aco1-1 displayed altered lateral root formation. Our results suggest that Arabidopsis ACO1 integrates various signals into the ethylene biosynthesis that is required for ACO1's intrinsic roles in root physiology.

• The Plant Pathology Journal
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• v.29 no.1
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• pp.42-51
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• 2013

One of the most important limiting factors for the production of the grafted cactus in Korea is the qualitative and quantitative yield loss derived from stem rots especially caused by Bipolaris cactivora. This study is aimed to develop microbial control agents useful for the control of the bipolaris stem rot. Two bacteria (GA1-23 and GA4-4) selected out of 943 microbial isolates because of their strong antibiotic activity against B. cactivora were identified as Bacillus subtilis and B. amyloliquefaciens, respectively, by the cultural characteristics, Biolog program and 16S rRNA sequencing analyses. Both bacterial isolates significantly inhibited the conidial germination and mycelial growth of the pathogen with no significant difference between the two, of which the inhibitory efficacies varied depending on the cultural conditions such as temperature, nutritional compositions and concentrations. Light and electron microscopy of the pathogen treated with the bacterial isolates showed the inhibition of spore germination with initial malformation of germ tubes and later formation of circle-like vesicles with no hyphal growth and hyphal disruption sometimes accompanied by hyphal swellings and shrinkages adjacent to the bacteria, suggesting their antibiotic mode of antagonistic activity. Control efficacy of B. subtilis GA1-23 and B. amyloliquefaciens GA4-4 on the cactus stem rot were not as high as but comparable to that of fungicide difenoconazole when they were treated simultaneously at the time of pathogen inoculation. All of these results suggest the two bacterial isolates have a good potential to be developed as biocontrol agents for the bipolaris stem rot of the grafted cactus.

• Journal of Soil and Groundwater Environment
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• v.15 no.6
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• pp.114-121
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• 2010

Oxygen sensitivity and substrate requirement have been known as possible reasons for the intricate growth of Dehalococcoides spp. and limiting factors of for routinely applying bioaugmentation using anaerobic Dehalococcoides-containing microbes for remediating chlorinated organic compounds. To explore the effect of the short-term exposure of the short-term exposure of oxygen on Dehalococcoides capability, dechlorination performance, and hydrogen production fermentation from formate, an anaerobic reductive dechlorination mixed-culture (Evanite culture) including dehalococcoides spp. was in this study. In the results, once the mixed-culture were exposed to oxygen, trichloroethylene (TCE) degradation rate decreased and it was not fully recovered even addition of excess formate for 40 days. In contrast, hydrogen was continuously produced by hydrogen-fermentation process even under oxygen presence. The results indicate that although the oxygen-exposed cells cannot completely dechlorinate TCE to ethylene (ETH), hydrogen fermentation process was not affected by oxygen presence. These results suggest that dechlorinating microbes may more sensitive to oxygen than fermenting microbes, and monitoring dechlorinators activity may be critical to achieve an successful remediation of a TCE contaminated-aquifer through bioaugmentation using Dehalococcoides spp..