• Journal of Microbiology and Biotechnology
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• v.18 no.5
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• pp.821-827
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• 2008

The unicellular green alga Dunaliella salina is a halotolerant eukaryotic organism. Its halophytic properties provide an important advantage for open pond mass cultivation, since D. salina can be grown selectively. D. salina was originally described by E. C. Teodoresco in 1905. Since that time, numerous isolates of D. salina have been identified from hypersaline environments on different continents. The new Dunaliella strain used for this study was isolated from the salt farm area of the west coastal side of South Korea. Cells of the new strain were approximately oval- or pear-shaped (approximately $16-24\;{\mu}m$ long and $10-15\;{\mu}m$ wide), and contained one pyrenoid, cytoplasmatic granules, and no visible eyespot. Although levels of $\beta$-carotene per cell were relatively low in cells grown at salinities between 0.5 to 2.5 M NaCl, cells grown at 4.5 M NaCl contained about a ten-fold increase in cellular levels of $\beta$-carotene, which demonstrated that cells of the new Korean strain of Dunaliella can overaccumulate $\beta$-carotene in response to salt stress. Analysis of the ITS1 and ITS2 regions of the new Korean isolate showed that it is in the same clade as D. salina. Consequently, based on comparative cell morphology, biochemistry, and molecular phylogeny, the new Dunaliella isolate from South Korea was classified as D. salina KCTC10654BP.

• Journal of Korean society of Dental Hygiene
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• v.17 no.5
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• pp.827-840
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• 2017

Objectives: The purpose of this study was to investigate the relationship between demographic characteristics, health factors, oral health factors and subjective body shape perception of adolescents in order to provide basic data for adolescents health management. Methods: This study was analyzed using Korea Youth Risk Behavior Web-Based Survey in 2015, where 68,043 adolescents in total participated. Data were analyzed by SPSS Ver. 21.0. Multiple regression analysis was used to analyze the relationships among health factors and oral health factors related to subjective body shape perception. Results: The analysis of the factors influencing the body shape perception of male adolescents showed that they tend to be low in school performance, low in family economic level, and high school students. The worse they perceive their subjective health to be, the more they feel stress, and the less frequently they brush their teeth per day. They had bad breath. The analysis of the factors influencing the body shape perception of female adolescents showed that they tend to be low in school performance, low in family economic level, and high school students. The worse they feel their subjective health is, the more they feel unhappy, and stressful, and the less frequently they brush their teeth per day. They feel pain during chewing, and have bad breath. Conclusions: In conclusion, it is necessary to consider educational intervention in adolescent life that will make them have proper perception of their body shape for proper health management of it. To make the intervention effective, we need to consider various factors such as health factors and oral health factors.

• The Korean Journal of Physiology and Pharmacology
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• v.13 no.2
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• pp.131-138
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• 2009

The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway, where STA T3 plays an important role in cell survival and tumorigenesis. Constitutive activation of STAT3 has been frequently observed in many cancer tissues, and thus, blocking of the gp130 signaling pathway, at the JAK level, might be a useful therapeutic approach for the suppression of STAT3 activity, as anticancer therapy. AG490 is a tyrphostin tyrosine kinase inhibitor that has been extensively used for inhibiting JAK2 in vitro and in vivo. In this study, we demonstrate a novel mechanism associated with AG490 that inhibits the JAK/STAT3 pathway. AG490 induced downregulation of gp130, a common receptor for the IL-6 cytokine family compounds, but not JAK2 or STAT3, within three hours of exposure. The downregulation of gp130 was not caused by enhanced degradation of gp130 or by inhibition of mRNA transcription. It most likely occurred by translation inhibition of gp130 in association with phosphorylation of the eukaryotic initiation factor-2 a. The inhibition of protein synthesis of gp130 by AG490 led to immediate loss of mature gp130 in cell membranes, due to its short half-life, thereby resulting in reduction in the STAT3 response to IL-6. Taken together, these results suggest that AG490 blocks the STAT3 activation pathway via a novel pathway.

• Korean Institute of Interior Design Journal
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• v.17 no.4
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• pp.92-101
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• 2008

A new paradigm of design lays stress on the world of metaphysical concepts, and various attempts are being made to give meaning to psychological values. Hotel is a memorable place to remind of a special moment in one's life such as travel, marriage, meeting and so on. It also contains even more symbolism than other spaces as it is the place where the most primary and private act takes place apart from one's residence. As a result, it is also possible to communicate the message which a designer intends to convey through the user's recognition in the form of various symbolic expressions in space design. The designer communicates a meaning into a space through a symbolic system and creates a mutual consensus by means of the understanding structure of "designer-space-user". The user's diverse interpretations through a symbol are based on epistemology and consist of the primary, the secondary and the tertiary recognition structure system in the aspect of their contents. The primary structure depends on sensual perception, impressive idea and transcendental recognition based on metaphysical and perceptional association. The secondary structure includes casualty, continuous deduction and rational(integral) recognition. Finally, the tertiary structure is sublimation to the transcendental mental world beyond the boundary of emotion and it is classified into fundamental recognition structure on an object and archetypical recognition structure on an ego. These characteristics can derive systematic understandings and diverse interpretations on the symbol from the space of a hotel through the frame of analysis based on the artistic form of monosemous, polysemous and multidimensional frameworks and symbols. The framework of this analysis includes all the cases, and various methods which haven't been attempted in practice are presented. Therefore this study is not just a simple analysis of space but rather it will serve as a methodological tool for design that allows for various attempts of symbolic design concepts in the recognition structure system.

• Journal of the Korea institute for structural maintenance and inspection
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• v.7 no.3
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• pp.241-249
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• 2003

The service life of steel bridges can be assured only when their strength, serviceability and fatigue safety are fulfilled. However, at the present time, the continuous research for fatigue of steel bridges is desperately required since not much research work has been done so far. In this study, a guideline on the fatigue design is suggested for the practical purpose in order to establish the long-term safety of steel bridges against fatigue. The continuous steel truss bridge was analyzed for the cumulative reversals of the actual traffic, stress ranges and fatigue strength. From the results, the domestic fatigue design procedure was found to be fairly overestimated in comparison to the design code of other foreign countries. Therefore, it is necessary to review the current fatigue design specifications and have the new and rationalized design criteria in the future domestic fatigue design guidance.

• The Transactions of the Korean Institute of Power Electronics
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• v.19 no.1
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• pp.91-97
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• 2014

Recently, the LED(Light Emitting Diode) is expected to replace conventional lamps including incandescent, halogen and fluorescent lamps for some general illumination application, due to some obvious features such as high luminous efficiency, safety, long life, environment-friendly characteristics and so on. To drive the LED, a single stage PFC(Power Factor Correction) flyback converter has been adopted to satisfy the isolation, PFC and low cost. The conventional flyback LED driver has the serious disadvantage of high 120Hz output current ripple caused by the PFC operation. To overcome this drawback, a new PFC flyback with low 120Hz output current ripple is proposed in this paper. It is composed of 2 power stages, the DCM(Discontinuous Conduction Mode) flyback converter for PFC and BCM(Boundary Conduction Mode) boost converter for tightly regulated LED current. Since the link capacitor is located in the secondary side, its voltage stress is small. Moreover, since the driver is composed of 2 power stages, small output filter and link capacitor can be used. Especially, since the flyback is operated at DCM, the PFC can be automatically obtained and thus, an additional PFC IC is not necessary. Therefore, only one control IC for BCM boost converter is required. To confirm the validity of the proposed converter, theoretical analysis and experimental results from a prototype of 24W LED driver are presented.

• Tribology and Lubricants
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• v.31 no.2
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• pp.56-61
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• 2015

In this study, we investigated the effectiveness of an ultrasonic nanocrystal surface modification (UNSM) technique on the mechanical and wear properties of tungsten carbide (WC). The UNSM technique is a newly developed surface modification technique that increases the mechanical properties of materials by severe plastic deformation. The objective of this study was to improve the wear resistance of press die made of WC by applying the UNSM technique. We observed the microstructures of the untreated and UNSM-treated specimens using a scanning electron microscope (SEM), and energy-dispersive X-ray spectroscopy (EDX) was used to investigate the chemical composition. The SEM observations showed the pore size and the number of pores decreased after the UNSM treatment. We assessed the wear behavior of both the untreated and UNSM-treated specimens using a scratch test. The test results showed that the wear resistance of the UNSM-treated specimens increased by about 46% compared with the untreated specimens. This may be attributed to increased hardness, reduced surface roughness, induced compressive residual stress, and refined grain size following the application of the UNSM technique. In addition, we found that the UNSM treatment increased the carbon concentration to 63% from 33%. We expect that implementing the findings of this study will lead to an increase in the life of press dies.

• Weed & Turfgrass Science
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• v.3 no.3
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• pp.174-182
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• 2014

This paper provides some of the scientific background on how projected environmental conditions could affect weeds and weed management in crops. Elevated $CO_2$ levels may have positive effects on crop competitiveness with $C_4$ weeds, but these are generally outnumbered by $C_3$ species in weed populations. Moreover, higher temperatures and drought will favor $C_4$ over $C_3$ plants. The implementation of climate change adaptation technologies, such as drought-tolerant germplasm and water-saving irrigation regimes, will have consequences for crop-weed competition. Rainfed production systems are thought to be most vulnerable to the direct effects of climate change and are likely to face increased competition from $C_4$ and parasitic weeds. Biotic stress-tolerant crop cultivars to be developed for these systems should encompass weed competitiveness and parasitic-weed resistance. In irrigated systems, indirect effects will be more important and weed management strategies should be diversified to lessen dependency on herbicides and mechanical control, and be targeted to perennial rhizomatous ($C_3$) weeds. Water-saving production methods that replace a weed-suppressive floodwater layer by intermittent or continuous periods of aerobic conditions necessitate additional weed management strategies to address the inherent increases in weed competition. Thus, climatic conditions have a great effect on weed population dynamics all over the world.

• Journal of Preventive Medicine and Public Health
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• v.35 no.2
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• pp.169-174
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• 2002

Objective : To investigate gamma-Glutamyltransferase (${\gamma}-GTP$) and its related factors in male industrial workers. Method : Five hundred and tony male workers without heart disease, diabetes mellitus, renal disease, hepatitis, and other liver diseases were surveyed in October 1998. Blood samples were collected to test for ${\gamma}-GTP$, total-cholesterol and fasting blood glucose. A self-administered questionnaire survey on life style was also done. Results : The total geometric mean value of ${\gamma}-GTP$ was 30.6 U/L. According to a univariate analysis: age, BMI(body mass index, $kg/m^2$), alcohol consumption, current smoking, stress, diastolic blood pressure, and blood total cholesterol were significantly associated with ${\gamma}-GTP$(p<0.05). From a multiple regression analysis: BMI, alcohol consumption, current smoking, diastolic blood pressure and total-cholesterol were significantly related to ${\gamma}-GTP$(p<0.05). Coffee consumption was negatively related to ${\gamma}-GTP$, but not significantly. Conclusion : We recommend that a change in health behavior (i.e. reducing alcohol intake, controlling BMI and not smoking) is necessary to decrease ${\gamma}-GTP$ in male workers.

• Childhood Kidney Diseases
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• v.17 no.2
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• pp.132-136
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• 2013

Parainfluenza virus infection is one of the causes of fatal rhabdomyolysis. Rhabdomyolysis can be aggravated by mitochondrial fatty acid ${\beta}$-oxidation disorders during prolonged periods of fasting. Moreover, in patients with late-onset isovaleric acidemia, hyperammonemia may occur following catabolic stress. In the present report, we describe a case of a 4-year-old boy with parainfluenza virus infection and late-onset isovaleric acidemia that rapidly progressed to coma, seizures, and cardiorespiratory collapse. His serum ammonia and creatinine kinase (CK) levels were $385{\mu}Mol/L$ and 23,707 IU/L, respectively. Continuous renal replacement therapy (CRRT) was initiated using continuous venovenous hemodiafiltration, after which the ammonia and CK levels returned to normal. Thus, we recommend the immediate initiation of CRRT in the management of patients with life-threatening rhabdomyolysis and hyperammonemia.