• International Journal of Reliability and Applications
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• 제16권2호
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• pp.123-133
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• 2015

In this paper, the problem of testing exponentiality against net decreasing variance residual lifetime (NDVRL) classes of life distributions is investigated. For this property a nonparametric test is presented based on kernel method. The test is presented for complete and right censored data. Furthermore, Pitman's asymptotic relative efficiency (PARE) is discussed to assess the performance of the test with respect to other tests. Selected critical values are tabulated. Some numerical simulations on the power estimates are presented for proposed test. Finally, numerical examples are presented for the purpose of illustrating our test.

• 대한응급의학회지
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• 제29권5호
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• pp.485-492
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• 2018

Objective: This paper reports the status of the advanced cardiac life support (ACLS) according to the guidelines by residents belonging to other departments other than the department of emergency medicine. The differences in status between the junior group and senior group was also investigated according to grades of residents. Methods: The ACLS performance for in-hospital cardiac arrest cases of one academic hospital, except for the cases occurring in intensive care unit between November 2015 and October 2017, were analyzed retrospectively. Data included the characteristics of residents, patients' outcomes, ACLS performance, and conventional treatment having discordance with the ACLS guidelines. Leaders during cardiopulmonary resuscitation (CPR) were divided into a junior group and senior group. Results: A total of 152 cases were enrolled in this study. Of these, 131 cases (86.2%) showed at least one treatment with inconsistency from the guidelines and the incidence of discordant treatment was similar in the two groups (55 [85.9%] vs. 76 [88.4%], P=0.657). Implicit use of sodium bicarbonate was more frequent in the senior residents group (odds ratio [OR], 3.04; 95% confidence interval [CI], 1.36-6.81). On the other hand, no use of a defibrillator was less frequent in the senior residents group (OR, 0.14; 95% CI, 0.03-0.81). Conclusion: In both groups, the rate of discordance with the ACLS guidelines during CPR were high. The rate of implicit use of sodium bicarbonate and no use of defibrillator were significantly different in the two groups. A customized education strategy for ACLS is needed for each group.

• 중환자간호학회지
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• 제8권2호
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• pp.23-32
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• 2015

Purpose: The purpose of this study was to analyze the effects of simulation-based training on nursing students' knowledge and ability to perform advanced cardiovascular life support. Methods: A nonequivalent control group non-synchronized design was used. The participants were, in total, 59 junior college nursing students (experimental group: 30, control group: 29). The data were analyzed with a ${\chi}^2$-test, independent t-tests, and analysis of covariance (ANCOVA) using IBM SPSS Statistics 23 program. Results: The experimental group ($80.8{\pm}8.4$), who received simulation-based advanced cardiovascular life support education, showed a higher level of knowledge of advanced cardiovascular life support than the control group ($75.0{\pm}9.9$), who received lecture-based education. In addition, the experimental group ($106.4{\pm}11.9$) showed a higher level of ability to perform advanced cardiovascular life support than the control group ($86.5{\pm}9.9$). Conclusion: Simulation-based advanced cardiovascular life support education was more effective for increasing the knowledge and performance ability of college students than lecture-based education. Therefore, simulation-based training should be used to improve the knowledge and ability of nursing students and should be applied with reinforced systematic education programs.

• BMB Reports
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• 제53권2호
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• pp.112-117
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• 2020

A recent study suggested that methylation of ubiquitin-like with PHD and RING finger domain 1 (UHRF1) is regulated by SET7 and lysine-specific histone demethylase 1A (LSD1) and is essential for homologous recombination (HR). The study demonstrated that SET7-mediated methylation of UHRF1 promotes polyubiquitination of proliferating cell nuclear antigen (PCNA), inducing HR. However, studies on mediators that interact with and recruit UHRF1 to damaged lesions are needed to elucidate the mechanism of UHRF1 methylation-induced HR. Here, we identified that poly [ADP-ribose] polymerase 1 (PARP1) interacts with damage-induced methylated UHRF1 specifically and mediates UHRF1 to induce HR progression. Furthermore, cooperation of UHRF1-PARP1 is essential for cell viability, suggesting the importance of the interaction of UHRF1-PARP1 for damage tolerance in response to damage. Our data revealed that PARP1 mediates the HR mechanism, which is regulated by UHRF1 methylation. The data also indicated the significant role of PARP1 as a mediator of UHRF1 methylation-correlated HR pathway.

• 한국주거학회논문집
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• 제9권1호
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• pp.33-42
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• 1998

This study has been designed to analyze longterm trend of home-ownership probability over the family life cycle. In this study, 633 female household heads were interviewed on their critical life event such as pregnancy, birth or death of households, marriage, and residential movement between 1987 and 1990 in Oxaca, Mexico. The raw data composed of 100,000 lines were transformed into yearly segmented observation data, proposed by Allison. The results are drawn as follws: 1) There is significant effect of marriage cohort on residential mobility and home ownership: couples who married in 1960s are likely to change their residence at early stage of family life than those who married in 1940s. They also have lower probability of home ownership for 10 years after marriage than the other cohorts. 2) Over all the cohorts, it is consistent tendency that probability of home ownership continuously increases over the entire family life cycle for 40 years. 3) Of the logistic regression analysis of home ownership on household socioeconomic variables, the homeownership was positively related with age of marriage and time since marriage, and was negatively related with education of female head. Over in this study, it is proven that home owenership is ultimate goal of most families, and it is a function of family event variables.

• 한국간호교육학회지
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• 제25권2호
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• pp.251-262
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• 2019

Purpose: This study aimed to identify the effect of a situational module learning course on critical thinking disposition and metacognition in sophomore nursing students. Methods: This study was a non-equivalent control-group pretest-posttest quasi-experimental design; the participants included 64 nursing students (32 in the experimental and 32 in the control group) from two Korean universities. Critical thinking disposition and metacognition between the control and intervention groups were measured before and after program participation. Data collection was conducted between September 1 and December 15, 2016. An independent t-test was used to determine differences in critical thinking disposition and metacognition between the groups and Pearson's correlations were measured for correlation with critical thinking disposition and metacognition. Results: The intervention group showed higher critical thinking disposition (t=3.16, p=.002); intellectual integrity (t=2.85, p=.006); and open-mindedness (t=3.30, p=.002) relative to those of the control group. However, there were no statistical differences in metacognition between the two groups (t=-0.14, p=.888). A significant positive correlation between metacognition and critical thinking disposition was found. (r=.62, p<.001). Conclusion: The situational module learning course developed in this study could be used to promote critical thinking disposition in nursing students.

• 가정과삶의질연구
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• 제10권1호통권19호
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• pp.53-74
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• 1992

The purpose of this study was to analyse the factors that influence marital conflicts and family life statisfaction, and to predict the future stage of establishment family and extending family, bsed on the theretical model by system approach. For this pourpose, 336 couples of urban households in Seoul were selected. The data were analysed through statistical methods such as, Frequency, percentile, T-test, F-test, ANOVA, Pearson's correlation analysis. The results were as follow : The Martial Conflict and family life satisfaction of surveyed couples were above middle level. It had significantly differences according to family life cycle, husband and wife's educationed levels, husband and wife's occupations, and family income. And Family life satisfaction had significantly differences according to marital conflict. The marital conflict is higher, life satisfaction is lower. In this study, it were appeared that the amount of marital conflict and life satisfaction had differences according to life cycle stages, husband and wife's educational level, husband and wife occupations, and family income, and so that the conflict of phsycho-social system was more affected on family life satisfaction that of managerial system. Such results were indicated that the birth of children was the critical family event affecting on family life satisfaction on and the marital conflict. But the conflict by family's given resources and situational differences also as an environment affection on the family system.

• Molecules and Cells
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• 제47권3호
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• pp.100033.1-100033.13
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• 2024

Considering the recent increase in the number of colorectal cancer (CRC) cases in South Korea, we aimed to clarify the molecular characteristics of CRC unique to the Korean population. To gain insights into the complexities of CRC and promote the exchange of critical data, RNA-sequencing analysis was performed to reveal the molecular mechanisms that drive the development and progression of CRC; this analysis is critical for developing effective treatment strategies. We performed RNA-sequencing analysis of CRC and adjacent normal tissue samples from 214 Korean participants (comprising a total of 381 including 169 normal and 212 tumor samples) to investigate differential gene expression between the groups. We identified 19,575 genes expressed in CRC and normal tissues, with 3,830 differentially expressed genes (DEGs) between the groups. Functional annotation analysis revealed that the upregulated DEGs were significantly enriched in pathways related to the cell cycle, DNA replication, and IL-17, whereas the downregulated DEGs were enriched in metabolic pathways. We also analyzed the relationship between clinical information and subtypes using the Consensus Molecular Subtype (CMS) classification. Furthermore, we compared groups clustered within our dataset to CMS groups and performed additional analysis of the methylation data between DEGs and CMS groups to provide comprehensive biological insights from various perspectives. Our study provides valuable insights into the molecular mechanisms underlying CRC in Korean patients and serves as a platform for identifying potential target genes for this disease. The raw data and processed results have been deposited in a public repository for further analysis and exploration.

• International Journal of Reliability and Applications
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• 제11권2호
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• pp.139-151
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• 2010

The main objective of this study is to present a new approach to obtain moment inequalities for the new better than renewal used (NBRU) class of life distributions. In order to achieve our main objective, the moment inequalities for NBRU class of life distribution using the new approach has been derived and then a new test for testing exponentiality against NBRU class based on these inequalities has been constructed. Then we calculate the Pitman asymptotic efficiency for the proposed test using some alternative distributions and comparing it with the other tests. Moreover, we make a comparison between Pittman asymptotic efficiencies (PAE's) and PAE's of some other tests. A simulation study is conducted to calculate the upper critical values and the power estimate of the proposed test for some common alternatives. Finally, we apply the suggested test to some real data.

• BMB Reports
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• 제41권7호
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• pp.485-494
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• 2008

The Wnt signaling network, which is composed of Wnt ligands, receptors, antagonists, and intracellular signaling molecules, has emerged as a powerful regulator of cell fate, proliferation, and function in multicellular organisms. Over the past two decades, the critical role of Wnt signaling in embryonic cartilage and bone development has been well established, and much has been learnt regarding the role of Wnt signaling in chondrogenesis and cartilage development. However, relatively little is known about the role of Wnt signaling in adult articular cartilage and degenerative cartilage tissue. This review will briefly summarize recent advances in Wnt regulation of chondrogenesis and hypertrophic maturation of chondrocytes, and review data concerning the role of Wnt signaling in the maintenance and degeneration of articular chondrocytes and cartilage.