• BMB Reports
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• 제43권5호
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• pp.325-329
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• 2010

Protein kinase CKII (CKII), a heterotetramer composed of two catalytic ($\alpha$ or $\alpha$') subunits and two regulatory ($\beta$) subunits, plays a critical role in cell proliferation and anti-apoptosis. Recently, capsaicin was shown to trigger apoptosis. Therefore, we examined the effect of capsaicin on CKII activity. Although capsaicin induced apoptotic death in HeLa cells, CKII activity was increased in the cytosolic fraction of HeLa cells after treatment. Capsaicin did not change the expression of the $CKII{\alpha}$ and $CKII{\beta}$ proteins. Capsaicin stimulated the catalytic activity of recombinant CKII tetramer, but not the $CKII{\alpha}$ subunit. Moreover, capsaicin enhanced the autophosphorylation of $CKII{\alpha}$ and $CKII{\beta}$. Taken together, our data suggest that capsaicin stimulates the phosphotransferase activity of CKII holoenzyme by interacting with the $CKII{\beta}$ subunit.

• Journal of Information Processing Systems
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• 제6권3호
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• pp.295-306
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• 2010

Network lifetime is a critical issue in Wireless Sensor Networks (WSNs). In which, a large number of sensor nodes communicate together to perform a predetermined sensing task. In such networks, the network life time depends mainly on the lifetime of the sensor nodes constituting the network. Therefore, it is essential to balance the energy consumption among all sensor nodes to ensure the network connectivity. In this paper, we propose an energy-efficient data routing protocol for wireless sensor networks. Contrary to the protocol proposed in [6], that always selects the path with minimum hop count to the base station, our proposed routing protocol may choose a longer path that will provide better distribution of the energy consumption among the sensor nodes. Simulation results indicate clearly that compared to the routing protocol proposed in [6], our proposed protocol evenly distributes the energy consumption among the network nodes thus maximizing the network life time.

• 아동학회지
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• 제30권4호
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• pp.241-256
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• 2009

This survey of children's perceptions and experiences of death was conducted with 118 6th-grade elementary school children in Seoul. Data consisted of responses to questionnaires in three categories : (1) perceptions of death, (2) views of afterlife, and (3) death-related experiences (life, education, and media). Results showed that children had negative emotions (61.8%) such as fear and anxiety about death. Children's attitudes about suicide were sympathetic (34.5%) as well as critical (53.7%). There was no relation between religion and view of afterlife. Finally, children experienced death more through mass media (TV, internet, etc.) than through life experience or death education. This study suggests the necessity for death education and warns of negative effects of media and games.

• Agribusiness and Information Management
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• 제4권2호
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• pp.14-21
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• 2012

Since the Free Trade Agreements (FTAs) with Chile, the EU, and the U.S., Korean agricultural produce markets have turned into a fierce competition landscape. Under these competitive circumstances, marketing is critical. The objective of the research presented herein is to understand the characteristics of customer preferences after locating trends of purchased items. So This research establishes sustainable strategies for Korean agricultural produce. This investigation used market-basket analysis techniques and panel data for its research. Market-basket analysis is a technique which attempts to find groups of items that are commonly found together. The results show that, for one year, processed food using wheat, processed marine products, and pork are commonly bought together and that yogurt and milk also are bought together. The characteristics of customers buying these items are 44 years old and live in a four-person household with two children. These customers do not live with their parents.

• 산업경영시스템학회지
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• 제30권3호
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• pp.127-134
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• 2007

Predicting fatigue life of rubber components is an important issue in design procedure for industrial trucks to assure the durability and reliability. Main considerations in designing rubber components against fatigue failure are the compounding technology, shape design, and manufacturing process. Among them the rubber compounding technology is one of the most critical factor to determine more than 50% of component's quality. This paper presents how to improve the durability and reliability of industrial rubber mount during its design, development and prototype testing. The data presented illustrates explicitly the prediction of reliability growth in the product development cycle. The application of these techniques is a part of the product assurance function that plays an important role in rubber components reliability improvement.

• International Journal of Reliability and Applications
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• 제7권2호
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• pp.89-99
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• 2006

A new classes of life distribution, namely harmonic used better than aged in expectation in upper tail (HUBAEUT) is introduced. Testing exponentiality against this class is investigated using kernel method. The limiting null and nonnull distribution of the test statistics is normal and the null variance is calculated exactly. Selected critical values are tabulated for sample sizes of 5(1)40. Power of the test are estimated by simulation. the efficacies of the test statistics used for testing against HUBAEUT are calculated for som common alternatives and are compared to some other procedures. It is shown that proposed test is simple, has high relative efficiency and power for some commonly used alternatives. The set of real data are used as an examples to elucidate the use of the proposed test statistics for practical reliability.

• International Journal of Reliability and Applications
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• 제4권4호
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• pp.191-199
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• 2003

In the present work, a moment inequality is derived for new renewal better (worse) than used in expectation(NRBUE) (NRWUE) distributions. This inequality demonstrates that if the mean life is finite then all higher order moments exist. A new test statistics for testing exponentiality against NRBUE (NRWUE) is introduced based on this inequality. It is shown that the proposed test is simple and has high relative efficiency for some commonly used alternatives. Critical values are tabulated for sample sizes n = 5(1)30. A set of real data is used as an example to elucidate the use of the proposed test statistics for practical reliability analysis.

• 중환자간호학회지
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• 제13권2호
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• pp.1-11
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• 2020

Purpose : The aim of this study was to compare shift satisfaction, sleep, fatigue, quality of life (QOL), and patient safety incidents between a newly implemented two-shift system and a traditional three-shift system. Methods : A total of 127 intensive care unit nurses (48 two-shift nurses and 79 three-shift nurses) working in a tertiary hospital in Seoul were recruited from January 1, 2017, to March 31, 2017. They completed a self-reported questionnaire about their work hours, shift satisfaction, sleep patterns, sleep quality, fatigue, QOL, and patient safety incidents in the past 2 weeks. Data were analyzed using SPSS version 23.0. Results : The two-shift group showed higher shift satisfaction scores compared with the three-shift group (6.93 vs. 4.37, p<.001). Sleep latency was shorter and sleep quality was better in the two-shift group compared with the three-shift group. There were no significant differences in other sleep parameters, fatigue, QOL, and patient safety incidents between the two groups. Conclusion : Although a two-shift system did not improve nurses' fatigue or QOL in this study, it may effectively serve as an alternative shift-work system that can increase sleep quality and shift satisfaction without increasing patient safety incidents.

• 임상간호연구
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• 제18권1호
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• pp.126-135
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• 2012

Purpose: This study was aimed to develop a simulation training program of an advanced cardiac life support (ACLS) based on the mastery learning model (Simulation-MLM), and evaluate the effects of the program on critical care nurses. Methods: As an experimental pre-post test with a non-equivalent control group, the study employed convenience sampling of 38 critical care nurses. The experimental group received the Simulation-MLM including a theoretical lecture, formative evaluation, and simulation training, whereas only a theoretical lecture for the control group. The knowledge, self-efficacy, and performance degrees of respondents were measured to verify the effects of the Simulation-MLM. The statistical processing of the collected data utilized the SPSS WIN 17.0 program. Results: After receiving Simulation-MLM, the participants in the experimental group reported higher marks in the knowledge, self-efficacy and performance of ACLS compared with those in the control group. However, both experimental and control groups demonstrated no significant differences in knowledge, self-efficacy and performance. Conclusion: Despite of the limitation of a small sample size, this study was considered meaningful in a sense that it showed a venue for improving ACLS training efficiency. Future research with more distinct treatment differentiation and better adequate outcome variables was warranted in order to prove the effects of a theory-based simulation education.

• Nuclear Engineering and Technology
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• 제54권6호
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• pp.2107-2119
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• 2022

Accurate remaining useful life (RUL) prediction for critical components of nuclear power equipment is an important way to realize aging management of nuclear power equipment. The electric gate valve is one of the most safety-critical and widely distributed mechanical equipment in nuclear power installations. However, the electric gate valve's extended service in nuclear installations causes aging and degradation induced by crack propagation and leakages. Hence, it is necessary to develop a robust RUL prediction method to evaluate its operating state. Although the particle filter(PF) algorithm and its variants can deal with this nonlinear problem effectively, they suffer from severe particle degeneracy and depletion, which leads to its sub-optimal performance. In this study, we combined the whale algorithm with regularized particle filtering(RPF) to rationalize the particle distribution before resampling, so as to solve the problem of particle degradation, and for valve RUL prediction. The valve's crack propagation is studied using the RPF approach, which takes the Paris Law as a condition function. The crack growth is observed and updated using the root-mean-square (RMS) signal collected from the acoustic emission sensor. At the same time, the proposed method is compared with other optimization algorithms, such as particle swarm optimization algorithm, and verified by the realistic valve aging experimental data. The conclusion shows that the proposed method can effectively predict and analyze the typical valve degradation patterns.