• 생약학회지
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• 제44권2호
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• pp.97-103
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• 2013

Schizophrenia is a severe psychiatric disorder and characterized by positive symptom (i.e., delusions, hallucinations), negative symptom (i.e., lack of emotion, social withdrawal), and cognitive impairment. Previously, we reported that the ethanolic extract of Prunella vulgaris var. lilacina attenuated the MK-801-induced schizophrenia-like behaviors such as prepulse inhibition (PPI) deficits and cognitive impairment in mice. The aim of the present study was to investigate whether danshensu isolated from P. vulgaris var. lilacina attenuates MK-801-induced sensorimotor gating dysfunction (PPI deficits), hyperlocomotion, and memory impairment in mice. Acute administration of danshensu (1, 3, or 10 mg/kg) significantly ameliorated the MK-801-induced PPI deficits in the acoustic startle response test. We also observed that the impaired recognition memory induced by MK-801 was attenuated by danshensu (1 mg/kg) in the novel object recognition test. However, danshensu failed to reverse the MK-801-induced hyperlocomotion in the open-field test. Collectively, the present results indicate danshensu would be an active agent for treating neuropsychiatric disorders such as schizophrenia.

• 대한한방내과학회지
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• 제38권2호
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• pp.172-179
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• 2017

Objectives: The aim of this clinical study is to describe the case of a patient with antibiotic-associated diarrhea, which was improved by treatment with herbal medicine. Methods: The antibiotic-associated diarrhea improved following treatment with Boikyangwi-tang and Opae-san for two months. During this period, western medicine, including antibiotics, was also administered. To evaluate the effect of the treatment, the Bristol Stool Form Scale was used. Results: During the treatment, the Bristol Stool Form Scale changed from type 7 to type 5. Conclusion: The results suggest that traditional Korean medicine may be an effective treatment for antibiotic-associated diarrhea.

• 한국해양공학회지
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• 제22권5호
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• pp.25-30
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• 2008

A B-spline based high order panel method was developed for the motion of bodies in an ideal fluid, either of infinite extent or with a free boundarysurface. In this method, both the geometry and the potential are represented by the B-spline, which guarantees more accurate results than most potential based low order methods. In the present work, we applied this B-spline based high order method to the radiation problem of floating bodies. The boundary condition on the free surface was satisfied by adopting a Kelvin-type Green function and irregular frequencies were removed by placing additional control points on the free surface surrounding the body. The numerical results were validated by comparison with existing numerical and experimental results.

• 대한치과보철학회지
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• 제31권1호
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• pp.77-86
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• 1993

The purpose of this study was to compare the sagittal condylar guidance obtained by the graphic method(pantographic tracing) with that produced by the positional method(check-bite). Ten adults who had normal occlusion and were free of TMJ dysfunction were selected, and the clutches were constructed. At first pantographic survey was performed and the articulator was adjusted with each pantographic recording. And then three protrusive check-bite were taken on the subjects using the polyether$(Lamitec^{(R)})$ on the buccal side of the posterior teeth without the interocclusal record method and the vericheck method was performed with each protrusive check-bite. Sagittal condylar guidances obtained by using the pantograph and Vericheck were compared and analyzed statistically. The results were as follows: 1. The average condylar guidance ankle at 4mm and 7mm from centric relation point on the pantograph $(35.9{\pm}1.10^{\circ},\;32.4{\pm}1.55^{\circ})$ was statisccally significant(P<0.01). 2. The average condylar guidance angle of the Vericheck was $27.0{\pm}3.43^{\circ}$. 3. The comparison of the right and left was not statistically significant in all group(P>0.05). 4. The comparison of pantograph and Vericheck was statistically significant in the right and left(P<0.001).

• Tuberculosis and Respiratory Diseases
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• 제67권6호
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• pp.499-505
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• 2009

Background: Mycobacterial Interspersed Repetitive Units (MIRUs) that are located mainly in intergenic regions dispersed throughout the Mycobacterium tuberculosis genome. The selected MIRU loci, which were composed of a 12-locus set, demonstrated a high power for discrimination of Mycobacterium tuberculosis isolates collected from Kangwon province of Korea. To evaluate its ability to discriminate the M. tuberculosis strains, 45 clinical isolates were genotyped using the methods IS6110 RFLP and MIRU. Methods: All the samples were collected during the period from January 2007 to December 2007 from TB patients, who were residents and registered to a public health center of Kangwon Province in Korea. A total of 45 DNAs were extracted from clinical isolated mycobacterial strains and genotyped using IS6110 RFLP, the MIRU method. Results: We compared the 12-MIRU with IS6110 RFLP in the 45 samples, the 12-locus version offered less discriminatory power (Hunter-Gaston discriminatory index [HGDI]: 0.959 vs 0.998; 57.78% of clustered cases vs 8.89%). Conclusion: This 12-locus MIRU can be useful when additional combinations of other loci for genotyping M. tuberculosis in Korea where the Beijing family strains are dominant.

• 대한수학교육학회지:학교수학
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• 제14권4호
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• pp.565-577
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• 2012

본 연구에서는 중학교 3학년 학생들에게 닮은 삼각형의 대응변 사이에 성립하는 비례적 성질에 기초하여 역동적 기하환경에서 이차방정식 $x^2-ax+b^2=0$의 해를 작도할 수 있는 기회를 제공하였다. 이 예비연구를 통해 이차방정식의 해에 대한 학생들의 기하학적 직관을 촉진시키고 $a$와 $b$의 값에 따라 이차방정식의 해가 어떻게 달라지는지 시각적으로 확인해 보게 하였다. 또한, 이 과정에서 학생들이 이차방정식의 해를 구하기 위해서 어떤 전략을 사용하는지 분석하여 이차방정식 지도 방법의 새로운 가능성을 살펴보고자 하였다.

• 대한미생물학회지
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• 제7권1호
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• pp.51-54
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• 1972

The determination of fungal flora in various kinds of local grains have been carded out in order to obtain an appropriate information of the population of toxigenic fungi in Korean local grains. Results of fungal examination on nine kinds of grain such as soy bean(18 samples), red bean(12 samples), rice(8 samples), kidney bean(8 samples), millet(7 samples), barley(5 samples), malze(5 samples), wheat(4 samples) and sesame(3 samples) were described in this report. 1. Of the 70 various grains, 283 colonies of fungi were isolated. Among the 283 colonies, 262 were possible to identity into 15 genera. 2. Predominant genera of fungi in most local grains were Penicillium sp.(24.39%), Aspergillus sp.(20.49%) and Alternaria sp.(13.43%).

• 생물정신의학
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• 제8권1호
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• pp.153-155
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• 2001

There had been few reports of arachnoid cyst accompanying psychiatric disturbance and no report treated with low-dose risperidone administration. We report a patient, developed first-transient psychotic episode considered to be provoked by an arachnoid cyst, responsive to risperidone, which was found in the middle cranial fossa as follows. A 57-year-old man was admitted by suddenly developed headache, auditory hallucination, delusion of persecution and, an arachnoid cyst in the anteromedial aspect of middle cranial fossa was found on MRI after admission. The psychotic episode was first to him and he was also negative to other clinical evaluation including endocrine abnormality, his psychotic symtom was suspected to be induced by arachnoid cyst and was well controlled to low-dose risperidone administration. He left hospital free from psychotic symptoms on 14 hospital days.

• Archives of Plastic Surgery
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• 제41권6호
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• pp.734-739
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• 2014

Background Rupture is an important complication of breast implants. Before cohesive gel silicone implants, rupture rates of both saline and silicone breast implants were over 10%. Through an analysis of ruptured implants, we can determine the various factors related to ruptured implants. Methods We performed a retrospective review of 72 implants that were removed for implant rupture between 2005 and 2014 at a single institution. The following data were collected: type of implants (saline or silicone), duration of implantation, type of implant shell, degree of capsular contracture, associated symptoms, cause of rupture, diagnostic tools, and management. Results Forty-five Saline implants and 27 silicone implants were used. Rupture was diagnosed at a mean of 5.6 and 12 years after insertion of saline and silicone implants, respectively. There was no association between shell type and risk of rupture. Spontaneous was the most common reason for the rupture. Rupture management was implant change (39 case), microfat graft (2 case), removal only (14 case), and follow-up loss (17 case). Conclusions Saline implants have a shorter average duration of rupture, but diagnosis is easier and safer, leading to fewer complications. Previous-generation silicone implants required frequent follow-up observation, and it is recommended that they be changed to a cohesive gel implant before hidden rupture occurs.

• 대한수학교육학회지:학교수학
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• 제9권4호
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• pp.467-486
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• 2007

이 논문은 스프레드시트를 활용한 수학적 모델링에서 스프레드시트 환경이 수학적 모델의 정교화과정에 어떤 영향을 미치는 지를 고찰한 것이다. 좀 더 자세히 살피면 수학적 모델링에서 스프레드시트 모델의 활용은 학생이 분석 불가능한 수학적모델도 분석할 수 있도록 해줌으로써 모델을 단순화하지 않고, 대신 모델을 정교화 할 수 있는 기회를 제공하고 수학적 개념을 확장해 나갈 수 있음을 보였다. 또한 수학적 모델을 스프레드시트 모델로 변환하여, 수학적 모델로부터 수학적 결론을 얻는 단계를 거치지 않고도 실세계 상황을 해석하고 설명할 수 있는 기회를 제공할 수 있음을 보였다.