• Journal of Microbiology and Biotechnology
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• 제32권9호
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• pp.1134-1145
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• 2022

SCO6993 (606 amino acids) in Streptomyces coelicolor belongs to the large ATP-binding regulators of the LuxR family regulators having one DNA-binding motif. Our previous findings predicted that SCO6993 may suppress the production of pigmented antibiotics, actinorhodin, and undecylprodigiosin, in S. coelicolor, resulting in the characterization of its properties at the molecular level. SCO6993-disruptant, S. coelicolor ΔSCO6993 produced excess pigments in R2YE plates as early as the third day of culture and showed 9.0-fold and 1.8-fold increased production of actinorhodin and undecylprodigiosin in R2YE broth, respectively, compared with that by the wild strain and S. coelicolor ΔSCO6993/SCO6993⁺. Real-time polymerase chain reaction analysis showed that the transcription of actA and actII-ORF4 in the actinorhodin biosynthetic gene cluster and that of redD and redQ in the undecylprodigiosin biosynthetic gene cluster were significantly increased by SCO6993-disruptant. Electrophoretic mobility shift assay and DNase footprinting analysis confirmed that SCO6993 protein could bind only to the promoters of pathway-specific transcriptional activator genes, actII-ORF4 and redD, and a specific palindromic sequence is essential for SCO6993 binding. Moreover, SCO6993 bound to two palindromic sequences on its promoter region. These results indicate that SCO6993 suppresses the expression of other biosynthetic genes in the cluster by repressing the transcription of actII-ORF4 and redD and consequently negatively regulating antibiotic production.

• 고무기술
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• 제22권2호
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• pp.119-149
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• 2021

Domestic materials & components industry is making a shift from quantitative growth to qualitative growth, while the paradigm of a future society is changing rapidly to energy, mobility, smartification and etc. The main features of materials & components industry are analyzed broadly based on three aspects that are: ① industry Status, ② the value chain structure, ③ the competitiveness. With regard to the national aspect, it is shown that the number of an export and a trade surplus increased consistently after the government advanced the policy on materials & components and Korea's trade deficit with Japan has been decreased. Moreover, the state's export ranking increased from tenth place in 2001 into sixth place in 2017, dedicating to the growth of a national economy. The analysis of the chain value indicates that specifications of an end product are set when the materials & components are combined with manpower, infrastructure and technologies. In terms of the competitiveness, it requires a long time and high costs to develop technologies on materials and it is important for components to have a process innovation and credibility wired. Following the industry structure with priority given on materials, Jeonnam Province accounts for 14.8% of national material production. As a result of analyzing Jeonnam's export competitiveness, it is measured that a serious polarization exists, revealing there are 6 major technology industries by 11 categories for materials & components, Jeonnam has presented 6 major materials & components considering the key industry and the new industry in future to remedy the mentioned problem so far, and plans to knock on the industry development through 10 different strategies.

• International Journal of Internet, Broadcasting and Communication
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• 제15권1호
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• pp.275-280
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• 2023

Currently, the cumulative number of confirmed cases from the coronavirus in Korea is 30.17 million, and the cumulative number of deaths also reaches 33,444 (as of January 31, 2023). Therefore, this study aims to conduct an empirical analysis on the establishment of quarantine systems in major domestic cities as it is necessary to analyze the influencing factors of COVID-19 and discuss policy directions necessary to establish an effective quarantine system in the future. Among them, 16 cities in Korea with a relatively weak quarantine infrastructure were compared with the interrelationship between "number of upper-level hospitals", "number of urban populations", "number of infected", and "number of deaths", and ultimately the results of quarantine for each local government. In conclusion, the average population of 16 cities is 0.792 million, and the average number of infected people is 0.458 million, and the average cumulative infection rate is 57.8%. Seven cities exceed the average cumulative infection rate: Suwon (61.6%), Yongin (59.1%), Seongnam (61.8%), Hwaseong (65.6%), Anyang (60.7%), Cheonan (62.9%), and Jeonju (62.9%). In addition, despite the establishment of excellent treatment facilities in the city (ave=0.0129), the ratio of "accumulated deaths" (ave=0.11%) was high in Changwon (0.12%/0.0193), Ansan (0.12%/0.0138), Cheongju (0.11%/0.0174), and the ratio of "accumulative deaths" was low (0.09%) despite the construction of relatively poor treatment facilities. Through the results of this study, we expect a paradigm shift in the infectious disease management system in major cities in Korea after post-COVID-19.

• 한국컴퓨터정보학회논문지
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• 제27권6호
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• pp.123-130
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• 2022

본 연구는 신종감염병인 COVID-19 팬데믹 상황에서 환자를 간호하는 국내 병원 간호사들의 소진과 관련요인들을 관리하기 위한 방안이 필요함을 제안하였고 COVID-19 유행 기간동안 국내 임상 간호사의 소진과 관련된 요인을 파악하기 위해 체계적 문헌고찰을 실시하였다. 체계적 문헌고찰을 위해 문헌 검색과 분석은 2019년 12월 1일부터 2022년 4월 30일까지 RISS, KISS, DBPIA, 교보스콜라의 데이터베이스를 사용하였고 '임상 간호사의 소진', '간호사의 소진'의 키워드를 사용하였다. 총 55편의 연구 논문이 검색되었고 자료선정기준에 따라 최종 7편의 논문이 선별되었다. 임상간호사 소진 정도와 소진과 관련된 요인을 살펴보면, COVID-19 동안 임상 간호사는 중등도 이상의 소진을 경험하였고 소진과 관련된 요인은 개인적 특성인 신체증상, 우울, 공감만족, 공감피로, 회복탄력성과 직업적 특성인 교대근무와 직무스트레스로 나타났다. 추후 임상 간호사 소진과 관련된 요인들을 조절할 수 있도록 역량 강화 프로그램 개발 및 적용하고 일관성 있는 간호인력 간호인력관리지관리지침이나 정책을 제시하여 간호사 부족 현상을 해소될 수 있기를 기대해 본다.

• Nuclear Engineering and Technology
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• 제55권2호
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• pp.595-602
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• 2023

The EAST ICRF system operating space has been extended in power and phase control with a low-level RF system for the new double-strap antenna. Then the multi-step power and periodic phase scanning experiment were conducted in L-mode plasma, respectively. In the power scanning experiment, the stored energy, radiation power, plasma impedance and the antenna's temperature all have positive responses during the short ramp-ups of P_L;ICRF. The core ion temperature increased from 1 keV to 1.5 keV and the core heating area expanded from |Z| ≤ 5 cm to |Z| ≤ 10 cm during the injection of ICRF waves. In the phasing scanning experiment, in addition to the same conclusions as the previous relatively phasing scanning experiment, the superposition effect of the fluctuation of stored energy, radiation power and neutron yield caused by phasing change with dual antenna, resulting in the amplitude and phase shift, was also observed. The active control of RF output facilitates the precise control of plasma profiles and greatly benefits future experimental exploration.

• Safety and Health at Work
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• 제14권1호
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• pp.85-92
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• 2023

Background: Presenteeism is closely related to work performance, work quality and quantity, and productivity at work. According to the job demand-control-support model, job demand, job control, and support play important roles in presenteeism. The present study investigated job characteristics profiles based on the job demand-control-support model and identify the association between job characteristics profiles and presenteeism. Methods: This secondary data analysis used the Sixth Korean Working Condition Survey, a nationwide cross-sectional dataset. The study included 25,361 Korean wage workers employed in the workplace with two or more workers. Participants were classified into four job characteristics profiles based on the job demand-control-support model, using latent profile analysis, and logistic regression was performed to examine the association between study variables. Results: Overall, 11.0 % of study participants reported experience of presenteeism in the past 12 months. Age, sex, location, monthly income, shift work, work hours, health problems, and sleep disturbances were significantly associated with presenteeism. The rate of presenteeism was the highest in the passive isolate group. The passive collective, active collective, and low-stain collective groups had a 23.0%, 21.0%, and 29.0% lower likelihood of experiencing presenteeism, respectively, than the passive isolate group. Conclusions: The job demand-control-support profiles and the risk of presenteeism were significantly associated. The most significant group that lowered the experience of presenteeism was the low-strain collective group, which had a low level of demand and high levels of control and support. Therefore, we need a policy to reduce job demand and increase job control and support at the organizational and national levels.

• 한국농촌간호학회지
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• 제18권1호
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• pp.57-71
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• 2023

Purpose: This study aims to provide primary data for policy alternatives by identifying the problem of the nursing workforce shortage. Methods: For quantitative data, 446 questionnaires were analyzed. The mean and standard deviation were used for content description. ANOVA analysis and Scheffe? test were used to compare the differences according to the hospital level. For qualitative data, 1:1 in-depth and group interviews were conducted for six participants. Results: The factors nurses prioritized when choosing a workplace were salary, commuting distance, and work-life balance. Clinical nurses cited low wages, heavy workloads, and burnout as the most considerable difficulties in performing their duties. Factors influencing nurse's turnover intention were low wages, unmanageable workload, and rotation to unwanted departments in that order. New nurses tend not to apply to small-medium-sized hospitals, experienced nurses in their 30s-40s leave hospitals due to childcare and shift work difficulties, and nurses in their 50s and older tend to move to nursing homes rather than acute hospital settings. Conclusion: In this study, wage and workload were mentioned as the most critical factors in nurses' workplace selection, job performance difficulties, and turnover intention, so it is necessary to pay attention to this aspect when improving treatment for nurses.

• 한국산업보건학회지
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• 제33권4호
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• pp.464-470
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• 2023

Objectives: This study evaluated occupational exposures to noise and heat stress during routine non-outage works in three coal-fired power plants in the Republic of Korea. Methods: The data were collected during the summer of 2020. Full shift noise exposure of 52 workers were measured using noise dosimeters. Heat stress of 16 worksites were measured for 70 minutes using wet-bulb globe temperature monitors. Results: The noise dosimetry results revealed time-weighted averages that ranged from 47.5 to 88.9 dBA. 2 out of 52 noise measurements exceeded 85 dBA. Based on the arithmetic mean, the coal service group showed the highest level at 80.2 dBA by job tasks. Noise exposures exceeding 85 dBA were measured in the coal service and plant operator group. Heat stress index measurements ranged from 20.3℃ to 37.2℃. 1 out of 9 indices measured in coal facilities and 4 out of 7 indices measured in boiler house exceeded 1 hour TWA during moderate work. Heat stress indices measured from boiler houses were significantly higher than those measured from coal equipment. Conclusions: The results show that overexposure to noise and heat stress may be encountered during routine non-outage work activities in coal-fired power plants. Appropriate actions should be taken to reduce future health outcome from occupational exposure to noise and heat stress in the industry.

• 지능정보연구
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• 제29권4호
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• pp.415-430
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• 2023

소재·부품·장비 산업은 중소기업 중심의 제조업 경쟁력의 원천이 되는 지역경제 활성화에 중요한 산업이다. 충청지역 소재·부품·장비 산업의 경쟁력 분석을 통해 소재·부품·장비 산업 발전에 필요한 시사점을 도출 하고자 충청지역의 소재·부품·장비 산업을 대상으로 사업체 규모계수, 산업 성장률, 산업 특화도, 변이할당분석 기법의 지역 경쟁력 수치 등에 기반하여 각 권역별(대전, 세종, 충남, 충북) 산업 발전 단계 및 경쟁력을 분석하였다. 2014년 및 2019년의 종업원수, 사업체수 및 생산액 등의 자료를 이용하여 산업의 특화 수준과 지역 경쟁력이 고려된 유의미한 권역별 산업군을 확인하고, 이들 유의미한 산업군에 대한 산업 발전 단계상에서의 위치를 파악하여, 충청지역 소재·부품·장비 산업의 발전을 위한 시사점을 제시하였다.

• 벤처창업연구
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• 제19권1호
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• pp.23-31
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• 2024

본 연구는 정부 주도사업이 투자자의 투자의사 결정 준거점에 미치는 영향을 실증적으로 탐색한다. 전망이론과 인적자원 이론을 접목하여 창업자의 인적자원 요소들을 준거점으로 활용하였다. 정부 주도사업의 영향으로 인해 투자자의 준거점에 변화가 있는지 실증적으로 탐색하였으며, 정부가 주도하고 지원하는 사업에 대해 민간이 투자할 때 고려해야 할 점을 시사한다. 연구 자료는 2017년 5월부터 2022년 5월까지 한국판 뉴딜에 해당하는 기업 51개와 해당하지 않는 기업 49개를 조사했으며 창업자 과거 창업 경험, 기술 산업 경력 기간, 경영관리 경력 기간, 최종학력 교육연수, 그리고 최종 졸업학교의 명성을 준거점으로 측정하여 연구를 진행했다. 회귀분석 결과 졸업학교 명성이 정부 주도사업과 부(-)의 영향을 미치는 것으로 나타났으며, 투자자의 준거점이 변화되는 것을 확인하였다.