• 약학회지
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• 제36권1호
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• pp.56-65
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• 1992

The present study examined the effects of carbon monoxide (CO) intoxication and aging on learning and memory deficit in young($5{\sim}8$ weeks) and aged($52{\sim}66$ weeks) mice, using the step down and step through passive avoidance failure techniques. We also investigated the effects of ginseng saponins on memory deficit. Significant decrease in memory registration, retention and retrieval function in young mice and decrease in memory registration and retention function in aged mice were observed. Normal young mice were apt to perform to a great degree of passive avoidance response than normal aged mice, but there was no difference between both groups by CO exposure. Administration of ginseng saponins showed an improvement on passive avoidance failure induced by CO exposure.

• Kidney Research and Clinical Practice
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• 제37권4호
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• pp.315-322
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• 2018

The high mortality rates associated with acute kidney injury are mainly due to extra-renal complications that occur following distant-organ involvement. Damage to these organs, which is commonly referred to as multiple organ dysfunction syndrome, has more severe and persistent effects. The brain and its sub-structures, such as the hippocampus, are vulnerable organs that can be adversely affected. Acute kidney injury may be associated with numerous brain and hippocampal complications, as it may alter the permeability of the blood-brain barrier. Although the pathogenesis of acute uremic encephalopathy is poorly understood, some of the underlying mechanisms that may contribute to hippocampal involvement include the release of multiple inflammatory mediators that coincide with hippocampus inflammation and cytotoxicity, neurotransmitter derangement, transcriptional dysregulation, and changes in the expression of apoptotic genes. Impairment of brain function, especially of a structure that has vital activity in learning and memory and is very sensitive to renal ischemic injury, can ultimately lead to cognitive and functional complications in patients with acute kidney injury. The objective of this review was to assess these complications in the brain following acute kidney injury, with a focus on the hippocampus as a critical region for learning and memory.

• 한국수산과학회지
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• 제56권2호
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• pp.243-252
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• 2023

Fluctuations in the price of aquaculture products have recently intensified. In particular, wholesale price fluctuations are adversely affecting consumers. Therefore, there is an emerging need for a study on forecasting the wholesale price of aquaculture products. The present study forecasted the wholesale price of olive flounder Paralichthys olivaceus, a representative farmed fish species in Korea, by constructing multivariate long-short term memory (LSTM) and gated recurrent unit (GRU) models. These deep learning models have recently been proven to be effective for forecasting in various fields. A total of 191 monthly data obtained for 17 variables were used to train and test the models. The results showed that the mean average percent error of LSTM and GRU models were 2.19% and 2.68%, respectively.

• Educational Technology International
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• 제10권2호
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• pp.145-166
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• 2009

The purpose of this study was to investigate why advance organizers (AO) are effective in promoting comprehension and mental model formation in terms of cognitive load. Two experimental groups: a concept-map AO group and a key-word AO group and one control group were used. This study considered cognitive load in view of Baddeley's working memory model: central executive (CE), phonological loop (PL), and visuo-spatial sketch pad (VSSP). The present experiment directly examined cognitive load using dual task methodology. The results were as follows: central executive (CE) suppression task achievement for the concept map AO group was higher than the key word AO group and control group. Comprehension and mental model construction for the concept map AO group were higher than the other groups. These results indicated that the superiority of concept map AO owing to CE load decrement occurred with comprehension and mental model construction in learning. Thus, the available resources produced by CE load reduction may have been invested for comprehension and mental model construction of learning contents.

• 한국기계연구소 소보
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• 통권19호
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• pp.93-115
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• 1989

Cerebellar Model Arithmetic Controller(CMAC) has been introduced as an adaptive control function generator. CMAC computes control functions referring to a distributed memory table storing functional values rather than by solving equations analytically or numerically. CMAC has a unique mapping structure as a coarse coding and supervisory delta-rule learning property. In this paper, learning aspects and a convergence of the CMAC were investigated. The efficient training algorithms were developed to overcome the limitations caused by the conventional maximum error correction training and to eliminate the accumulated learning error caused by a sequential node training. A nonlinear function generator and a motion generator for a two d. o. f. manipulator were simulated. The efficiency of the various learning algorithms was demonstrated through the cpu time used and the convergence of the rms and maximum errors accumulated during a learning process; A generalization property and a learning effect due to the various gains were simulated. A uniform quantizing method was applied to cope with various ranges of input variables efficiently.

• 감성과학
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• 제15권4호
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• pp.527-540
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• 2012

학습자의 학습 스트레스 수준(stress level)과 금전적 보상(monetary rewards)의 제시 시점 차이가 장, 단기 기억수행에 미치는 영향을 알아보았다. 지연-파지 효과(delay-retention effect)에서는 지연 보상 (delayed reward)이 기억의 공고화(consolidation) 과정을 촉진시켜 결과적으로 장기 기억 수행을 향상시키게 된다고 주장한다. 본 연구에서는 지연 보상과 즉시 보상(immediate reward)이 학습 스트레스가 높고, 낮은 맥락의 차이에 따라 기억 수행에 미치는 영향력이 다를 것이라 예상하였다. 따라서 학습 맥락을 학습 스트레스가 높고, 낮은 두 조건으로 나누고, 보상 조건과 기억의 인출 시점을 구분하여 실험하였다. 보상 조건은 보상 제시 시점(5초 후 제시, 바로 제시)과 보상의 유무(500원, 0원)를 구분하였고, 기억 검사는 바로 인출하는 경우와 기억 공고화 과정을 거치고 일주일 후 인출하는 경우로 나누었다. 실험 결과 지연 보상은 장기 기억에 이점 효과가 있었고, 즉시 보상은 단기 기억에만 이점 효과가 나타났다. 이러한 보상의 기억 이점 효과는 스트레스가 높은 학습 맥락에서만 관찰되었다. 본 결과는 학습자가 지각하는 학습 스트레스 수준이 높을수록 보상에 대한 민감도가 높으며, 학습 후 즉시 보상 보다 지연 보상이 기억 공고화 과정에서 기억을 촉진시키는 역할을 수행하여 결과적으로 장기 기억력을 향상시킴을 시사한다.

• Journal of Information Processing Systems
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• 제18권1호
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• pp.12-25
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• 2022

In recent years, deep convolutional neural networks have made significant progress in the research of single image super-resolution. However, it is difficult to be applied in practical computing terminals or embedded devices due to a large number of parameters and computational effort. To balance these problems, we propose CSRNet, a lightweight neural network based on channel split residual learning structure, to reconstruct highresolution images from low-resolution images. Lightweight refers to designing a neural network with fewer parameters and a simplified structure for lower memory consumption and faster inference speed. At the same time, it is ensured that the performance of recovering high-resolution images is not degraded. In CSRNet, we reduce the parameters and computation by channel split residual learning. Simultaneously, we propose a double-upsampling network structure to improve the performance of the lightweight super-resolution network and make it easy to train. Finally, we propose a new evaluation metric for the lightweight approaches named 100_FPS. Experiments show that our proposed CSRNet not only speeds up the inference of the neural network and reduces memory consumption, but also performs well on single image super-resolution.

• International Journal of Computer Science & Network Security
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• 제22권2호
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• pp.131-138
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• 2022

Soft sensors are used to anticipate complicated model parameters using data from classifiers that are comparatively easy to gather. The goal of this study is to use artificial intelligence techniques to design and build soft sensors. The combination of a Long Short-Term Memory (LSTM) network and Grey Wolf Optimization (GWO) is used to create a unique soft sensor. LSTM is developed to tackle linear model with strong nonlinearity and unpredictability of manufacturing applications in the learning approach. GWO is used to accomplish input optimization technique for LSTM in order to reduce the model's inappropriate complication. The newly designed soft sensor originally brought LSTM's superior dynamic modeling with GWO's exact variable selection. The performance of our proposal is demonstrated using simulations on real-world datasets.

• Nutrition Research and Practice
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• 제5권4호
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• pp.294-300
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• 2011

Takju is a Korean alcoholic beverage made from rice, and is brewed with the yeast Saccharomyces cerevisiae. This study was conducted to evaluate the effects of exercise training and moderate Takju consumption on learning ability in 6-week old Sprague-Dawley male rats. The rats were treated with exercise and alcohol for 4 weeks in six separate groups as follows: non-exercised control (CC), exercised control (EC), non-exercised consuming ethanol (CA), exercised consuming ethanol (EA), non-exercised consuming Takju (CT), and exercised consuming Takju (ET). An AIN-93M diet was provided ad libitum. Exercise training was performed at a speed of 10 m/min for 15 minutes per day. Ethanol and Takju were administered daily for 6-7 hours to achieve an intake of about 10 ml after 12 hours of deprivation, and, thereafter, the animals were allowed free access to deionized water. A Y-shaped water maze was used from the third week to understand the effects of exercise and alcohol consumption on learning and memory. After sacrifice, brain acetylcholinesterase (AChE) activity was analyzed. Total caloric intake and body weight changes during the experiment were not significantly different among the groups. AChE activity was not significantly different among the groups. The number of errors for position reversal training in the maze was significantly smaller in the EA group than that in the CA and ET groups, and latency times were shorter in the EA group than those in the CC, EC, CT, and ET groups. The latency difference from the first to the fifth day was shortest in the ET group. The exercised groups showed more errors and latency than those of the non-exercised groups on the first day, but the data became equivalent from the second day. The results indicate that moderate exercise can increase memory and learning and that the combination of exercise and Takju ingestion may enhance learning ability.

• 대한한의학회지
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• 제27권4호
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• pp.125-134
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• 2006

During the prenatal period, the development of the individual is influenced by a host of environmental factors. Exposure to noise stress during pregnancy was determined to result in the retardation of growth, a reduction in neurogenesis, and an impairment of spatial learning ability in the rat pups. In the present study, we have attempted to characterize the effects of prenatal treatment with Cnidium officinale Makino on spatial memory and neurogenesis in the hippocampus of rat pups born from maternal rats exposed to noise stress during pregnancy. Prenatal treatment with Cnidium officinale Makino was shown to increase neurogenesis and enhanced spatial learning ability in rat pups born from maternal rats exposed to noise stress. In this study, we have determined that prenatal treatment with Cnidium officinale Makino can stimulate spatial development and neurogenesis in the brain of the fetuses exposed to prenatal stresses.