• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.5
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• pp.59-67
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• 2014

In tension lap splices of straight deformed bars, KCI Code (KCI2012) and ACI Code (ACI318-11) requires that the lap lengths for class B splice are 1.3 times as development length. KCI2012 contains development length provisions for the use of headed deformed bars in tension and does not allow their tension lap splices. The purpose of this experimental study is to evaluate that KCI2012 equation for the development length, $l_{dt}$, of headed bars can be used to calculate the lap length, $l_s$, of headed deformed bars in grade SD400 and SD500, having specified yield strength of 400 and 500 MPa. Test results showed that specimens with $l_s$ equal to $1.3l_{dt}$ had maximum flexural strengths as 1.16~1.31 times as the nominal flexural strengths, flexural failure mode, and ductility. These observations indicate that $1.3l_{dt}$ is suitable to the tensile lap length of headed deformed bars in grade SD400 and SD500.

• Biomolecules & Therapeutics
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• v.27 no.2
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• pp.178-184
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• 2019

Parkinson's disease is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons within the substantia nigra pars compacta. In the present study, we investigated whether ${\beta}-Lapachone$ (${\beta}-LAP$), a natural naphthoquinone compound isolated from the lapacho tree (Tabebuia avellanedae), elicits neuroprotective effects in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson's disease mouse model. ${\beta}-LAP$ reduced the tyrosine hydroxylase (TH)-immunoreactive fiber loss induced by MPTP in the dorsolateral striatum, and alleviated motor dysfunction as determined by the rotarod test. In addition, ${\beta}-LAP$ protected against MPTP-induced loss of TH positive neurons, and upregulated B-cell lymphoma 2 protein (Bcl-2) expression in the substantia nigra. Based on previous reports on the neuroprotective role of nuclear factor-E2-related factor-2 (Nrf2) in neurodegenerative diseases, we investigated whether ${\beta}-LAP$ induces upregulation of the Nrf2-hemeoxygenae-1 (HO-1) signaling pathway molecules in MPTP-injected mouse brains. Western blot and immunohistochemical analyses indicated that ${\beta}-LAP$ increased HO-1 expression in glial fibrillary acidic protein-positive astrocytes. Moreover, ${\beta}-LAP$ increased the nuclear translocation and DNA binding activity of Nrf2, and the phosphorylation of upstream adenosine monophosphate-activated protein kinase (AMPK). ${\beta}-LAP$ also increased the localization of p-AMPK and Nrf2 in astrocytes. Collectively, our data suggest that ${\beta}-LAP$ exerts neuroprotective effect in MPTP-injected mice by upregulating the p-AMPK/Nrf2/HO-1 signaling pathways in astrocytes.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.11a
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• pp.449-452
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• 2004

The lap splice lengths of deformed steel reinforcing bars and GFRP bars with two different to surface type were experimentally compared using beam specimens. The purpose was to evaluate the length required of the GFRP bar to develop strength equivalent to the conventional steel reinforcing bar. The main test variable was the lap splice length. Two different GFRP bar surfaces were tested: (1) spiral-type GFRP bars and (2) sand coated GFRP bars. For the conventional steel bars (SD400 grade), strength over 400 MPa in tension was reached using the lap splice length of $30d_b$. Splice failure was observed in the specimen with the lap splice length of $20d_b$. For the spiral-type and sand coated GFRP bars, the tensile strength developed in the GFRP bars decreased with decreasing splice lengths. Development of the cracks on beam surfaces was clearly visible for the beams reinforced with the GFRP bars. Mid-span deflections, however, were significantly smaller than the comparable beams with conventional steel bars indicating potential ductility problem.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.5
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• pp.570-576
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• 2018

In reinforced concrete structures, the joints of ordinary rebars are usually lap joints, which are bound by binding wires with rebars, and mechanical joints by couplers. In domestic design standards (concrete design code), welded lap joints are restricted for ordinary rebars, but overseas standards allow welded lap joints of ordinary rebars through pre-heating. This study investigated the domestic and international standards/criteria and evaluated the fracture strength by performing the tensile test on the lap welded joint of SD400 grade rebars, which is used the most in the construction sites. The weld length of the specimen for weld lap joints is based on the minimum weld length (8d) given in the KS standard (KS B ISO 17660-1). According to AWS D1.4, the preheating temperature was set to $150^{\circ}C$ for D19 and below, and $260^{\circ}C$ for D22 and above. In the test results, the tensile strength of rebars with welded lap joints exceeded the required strength (125% of the yield strength) according to the concrete design code. To analyze the effect of preheating, the tensile strength of the welded rebars after preheating was not significantly different from that of the welded rebars without preheating. The carbon equivalent content (Ceq) of the rebars used in the test was 0.45% or less. Under AWS D1.4, no preheating is required if the carbon equivalent is less than 0.45%. All specimens with a welded lap length of 8d failed by a bar fracture. The effect of preheating was confirmed to be insignificant due to the low carbon equivalent of the rebar.

• Journal of the Earthquake Engineering Society of Korea
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• v.7 no.5
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• pp.25-35
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• 2003

Scale model tests were performed to investigate the seismic behavior of the solid and hollow rectangular RC piers with 50% of lap-spliced longitudinal bars in plastic hinge regions. Continuous bars and lap-spliced ones with a lap length of 39 times the bar diameter were arranged alternately in the sections. In order to clarify the influence of lap splice on a ductility the effect of axial force and lateral confinement were excluded in the test. The typical flexural failure conducting a ductile behavior were observed in both models. It is confirmed that the 50% of lap-spliced bars can be considered as an alternative of seismic detailing for longitudinal bars.

• Journal of the Earthquake Engineering Society of Korea
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• v.16 no.6
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• pp.47-56
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• 2012

It is known that seismic performance of existing bridges having insufficient lateral confinements and lap-splices of longitudinal reinforcements at the base of column decreases dramatically. In this study, small-scaled model tests have been performed to confirm the seismic behaviors of RC bridge piers with various lap-splice lengths. The 8 test models have circular section with diameters of 0.65 m, 0.8 m, 1.0 m, and lap-splice lengths of B-class or C-class. The test results show that the failure modes of models are not depending on the lap-splice length itself but depend on the ratio of lap-splice length to diameter, and that the displacement ductility is also affected by this ratio.

• Proceedings of the Korean Biophysical Society Conference
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• 2003.06a
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• pp.80-80
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• 2003

${\beta}$-lapachone(${\beta}$-Lap), a natural o-naphthoquinone, presents in the bark of the Lapacho tree. ${\beta}$-Lap is cytotoxic against a variety of human cancer cells and it potentiates the anti-tumor effect of Taxol. In addition, ${\beta}$-Lap has been reported to radiosensitize cancer cells by inhibiting the repair of radiation-induced DNA damage.In the present study, we investigated the cytotoxicity of ${\beta}$-Lap against RKO human colorectal cancer cells as well as the combined effect of ${\beta}$-LaP and ionizing radiation. An incubation of RKO cells with 5 ${\mu}$M of ${\beta}$-Lap for 4 h killed almost 90％ of the clonogenic cells. An incubation of RKO cells with 5 ${\mu}$M of ${\beta}$-Lap for 4 h or longer also caused massive apoptosis. Unlike other cytotoxic agents, ${\beta}$-Lap did not increase the expression of p53 and p21 and it suppressed the NFkB expression. The expression of Caspase 9 and 3 was minimally altered by ${\beta}$-Lap. Radiation and ${\beta}$-Lap acted synergistically in inducing clonogenic cell death and apoptosis in RKO cells when ${\beta}$-Lap treatment was applied after but not before the radiation exposure of the cells. Interestingly, a 4 h treatment with 5 ${\mu}$M of ${\beta}$-Lap starting 5 h after irradiation was as effective as that starting immediately after irradiation. The mechanisms of ${\beta}$-Lap-induced cell killing is controversial but a recent hypothesis is that ${\beta}$-Lap is activated by NAD(P)H: quinone-onidoreductase (NQO1) in the cells followed by an elevation of cytosolic Ca$\^$2+/ level and activation of proteases leading to apoptosis. It has been reported that NQO1 level in cells is markedly up-regulated for longer than 10 h after irradiation. Indeed, using immunological staining of NQO1, we observed a significant elevation of NQO1 expression in RKO cells 5h after 2-4 Gy irradiation. Such a prolonged elevation of NQO1 level after irradiation may be the reasons why the ${\beta}$-Lap treatment applied S h after irradiation was as effective as that applied immediately after irradiation in killing the cells. In view of the fact that the repair of radiation-induced damage is usually completed within 1-2 h after irradiation, it is highly likely that the ${\beta}$-Lap treahment applied 5 h after irradiation could not inhibit the repair of radiation-induced damage. For in vivo study, RKO cells were injected S.C. into the hind-leg of Nu/Nu mice, and allowed to grow to 130 mm3 tumor. The mice were i.p. injected with ${\beta}$-lapachone or saline 2 h after irradiation of tumors with 10 Gy of X-rays. The radiation induced growth delay was increased by 2.4 $\mu\textrm{g}$/g of ${\beta}$-lapachone. Taken together, we may conclude that the synergistic interaction of radiation and ${\beta}$-Lap in killing cancer cells is not due to radiosensitization by ${\beta}$-Lap but to an enhancement of ${\beta}$-Lap cytotoxicity by radiation through an upregulation of NQO1. The fact that NQO1 is elevated in tumors and that radiation causes prolonged increase of the NQO1 expression may be exploited to preferentially kill tumor cells using ${\beta}$-Lap in combination with radiotherapy.

• Korean Journal of Applied Biomechanics
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• v.26 no.3
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• pp.315-321
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• 2016

Objective: The aim of this study was to analyze effects of the toe-spring angle of bobsleigh shoes on start speed lap time to develop Korean-specific bobsled shoes suitable for winter environments and for domestic players on the basis of sports science and optimized biomechanical performance. Method: Seven Korean bobsleigh athletes participated in this study, with three pairs of sprint spikes from three companies (Type A, Type B, Type C). To analyze sprint lap time and forefoot bending angle for each shoe, participants were instructed to drag a sled 15 meters from the start line at a maximum sprint. forefoot bending angle was collected by a high speed camera, and lap time speed was measured. Results: Lap time for type B shoes was $3.52{\pm}0.17sec$, type A was $3.55{\pm}0.19sec$, and type C was $3.56{\pm}0.18sec$. Forefoot bending angles were: angle 1, $6.88{\pm}5.55^{\circ}$; angle 2, $9.23{\pm}6.38^{\circ}$; angle 3, $15.56{\pm}5.39^{\circ}$; angle 4, $9.54{\pm}3.85^{\circ}$; angle 5, $9.22{\pm}5.08^{\circ}$; angle 6, $7.66{\pm}6.44^{\circ}$; and angle 7, $4.30{\pm}6.24^{\circ}$ (p<.001). Forefoot bending in angle 3 was as follows: type A, $16.47{\pm}6.01^{\circ}$; type B, $14.30{\pm}4.96^{\circ}$; and type C, $15.90{\pm}5.17^{\circ}$. Conclusion: Hard outsoles and midsoles are better than soft type for reduced start lap time when developing a prototype Korean bobsled shoe.

• Journal of the Korean Wood Science and Technology
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• v.39 no.1
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• pp.53-59
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• 2011

A connection was made between a single stretcher and 2 headers with 2 threaded nails (Type-A), and another one between 2 stretchers and 2 headers with 4 threaded nails (Type-B) to use as specimens. Type-C was the stretchers that are connected with 2 threaded nails by half lap joint at end-distance 5D to reinforce Type-B, Type-C1 the stretchers that are connected by half lap joint at end-distance 10D, and Type-C2 with 3 threaded nails at end-distance 10D. Compressive shear strength of Type-C, the supplementation of Type-B, was decreased by 30%, compared with that of Type-B. Those of Type-B and Type-C1 that used longer end-distance than Type-C were about the same, and that of Type-C2 connected with 3 threaded nails was 1.28-times stronger than that of Type-C1. Connection of the retaining wall using existing square timber has a problem between long and short stretchers and 2 headers. So it was investigated in the experiment to replace it. Therefore, if Type-B is replaced with Type-C2 in constructing the retaining wall, the crack and the rupture of timber caused by threaded nail as well as construction period can be reduced, and also it can be expected to increase their own strength.

• Journal of the Korea institute for structural maintenance and inspection
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• v.20 no.4
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• pp.144-152
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• 2016

This paper focuses on the experimental study for investigating the performance for lap splice of hooked or headed reinforcement in beam with different depths. In the experiment, seven specimens, with its variables as the lap length of headed or hooked bar, the existence of stirrups, etc., was manufactured. Bending test was conducted. Lap strengths by test were compared with the theoretical model based on KCI2012. The result showed that the cracks at failure mode occurred along the axial direction to a headed bar. The initial stiffness and the stiffness after initial crack were similar for all specimens. For HS series specimens without stirrups, a 25% increase in lap length was increased 11.8~18.1% maximum strengths. For HH series specimens without stirrups, a increase in lap length did not affect the maximum strengths because of the pryout failure of headed bar. For HS series specimens, the theoretical lap strengths based on KCI2012 considering the B grade lap and the reduction factor for stirrup were evaluated. They are smaller than the test strengths and can ensure the safety in terms of strength capacity. For HH series specimens, the stirrups in the lap zone are needed to prevent the pryout behaviour of headed bar.