• Journal of Pharmacopuncture
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• v.18 no.1
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• pp.63-71
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• 2015

Objectives: This study was carried out to analyze the single-dose toxicity of Eun-Bi San pharmacopuncture injected into the muscle of Sprague-Dawley (SD) rats. Methods: All experiments were performed at Biotoxtech, an institution certified to conduct non-clinical studies under the Good Laboratory Practice (GLP) regulations. Six week old SD rats reared by ORIENTBIO were chosen for this pilot study. The reason SD rats were chosen is that they have been widely used in safety tests in the field of medicine, so the results can be easily compared with many other databases. The Eun-Bi San pharmacopuncture was made in a clean room at the Korean Pharmacopuncture Institute (KPI, K-GMP). The constituents of the Eun-Bi San pharmacopuncture are Angelicae gigantis radix, Strychni semen and Glycyrrhizae radix. These were extracted at low temperature and low pressure in an aseptic room at the KPI. Doses of Eun-Bi San pharmacopuncture, 0.25, 0.5 and 1.0 mL, were administered to the experimental groups, and a dose of normal saline solution, 1.0 mL, was administered to the control group. This study was performed under the approval of the Institutional Animal Ethics Committee of Biotoxtech Co., Ltd. Results: No deaths or abnormalities occurred in any of the four groups. No significant changes in weight, hematological parameters or clinical chemistry between the control group and the experimental groups were observed. To determine if abnormalities existed in any organs and tissues, we used microscopy to examine representative histological sections of each specified organ; the results showed no significant differences in any of the organs or tissues. Conclusion: The results of this study suggest that treatment with Eun-Bi San pharmacopuncture is relatively safe and that its clinical use may be beneficial. Further evaluations and studies on this subject will be needed to provide more concrete evidence in support of these conclusions.

• The Korean Journal of Quaternary Research
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• v.20 no.1 s.26
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• pp.9-27
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• 2006

The East Asian (China, Korea and Japan) summer monsoon precipitation and its variability are examined from the outputs of the 22 coupled climate models performing coordinated experiments leading to the Intergovernmental Panel on Climate Change Fourth Assessment Report (IPCC AR4) following the multi-model ensemble (MME) technique. Results are based on averages of all the available models. The shape of the annual cycle with maximum during the summer monsoon period is simulated by the coupled climate models. However, models fail to simulate the minimum peak in July which is associated with northward shifts of the Meiyu-Changma-Baiu precipitation band. The MME precipitation pattern is able to capture the spatial distribution of rainfall associated with the location of the north Pacific subtropical high and the Meiyu-Changma-Baiu frontal zone. However precipitation over the east coast of China, Korea-Japan peninsular and the adjoining oceanic regions is underestimated. Future projections to the radiative forcing of doubled $CO_2$ scenario are examined. The MME reveals an increase in precipitation varying from 5 to 10 %, with an average of 7.8 % over the East Asian region at the time of $CO_2$ doubling. However the increases are statistically significant only over the Korea-Japan peninsula and the adjoining north China region. The increase in precipitation may be attributed to the projected intensification of the subtropical high, and thus the associated influx of moist air from the Pacific to inland. The projected changes in the amount of precipitation are directly proportional to the changes in the strength of the subtropical high. Further a possible increase in the length of the summer monsoon precipitation period from late spring through early autumn is suggested.

• The Journal of Engineering Geology
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• v.16 no.2 s.48
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• pp.135-143
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• 2006

This study presents the results of a series of laboratory scale slope failure experiments aimed at clarifying the process and the condition leading to the initiation of rainfall-induced slope failures. For the evaluation of hydrologic response of the model slopes in relation the process of failure initiation, measurements were focused on the changes in volumetric water content during the initiation process. The process leading to failure initiation commences by the development of a seepage face. It appears reasonable to conclude that slope failures are a consequence of the instability of seepage area formed at the slope surface during rainfall period. Therefore, this demonstrates the importance of monitoring the development seepage area for useful prediction about the timing of a particular failure event. The hydrologic response of soil slopes leading to failure initiation is characterized by three phases (phase I, II and III) of significant increase in volumetric water content in association with the ingress of wetting front and the rise of groundwater level within the slope. The period of phase III increase in volumetric water content can be used to initiate advance warning towards a failure initiation event. Therefore, for the concept outlined above, direct and continuous monitoring of the change in volumetric water content is likely to provide the possibility for the development of a reliable and effective means of predicting the occurrence of rainfall-induced slope failures.

• Journal of Korean Society of Environmental Engineers
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• v.34 no.3
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• pp.189-194
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• 2012

In this study, a 3-stage biological aerated filter (BAF) system was proposed to enhance nitrogen removal in the treatment of low carbon to nitrogen ratio (C/N ratio) municipal wastewater. Laboratory experiments were conducted to evaluate the effects of dynamic-flow at the HRT of 6 h. Results of the long-term operation of 3-stage BAF systems showed that the dynamic-flow enabled the total nitrogen removal (T-N) removal efficiency of the system to be about 7 % higher than that of non-dynamic-flow system in treating domestic wastewater due to the more efficient use of organic substrates. The overall $NH_4$-N removal performance was stable during the operational period due to the unique system configuration where independent nitrification occurred. It was concluded that the 3-stage BAF system proposed in this study provided excellent performance in the removal of nitrogen by employing dynamic-flow and three columns functioning as sorption, denitrification and nitrification, respectively.

• The Korean Journal of Pesticide Science
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• v.7 no.3
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• pp.207-215
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• 2003

This study was carried out to evaluate toxicities of 3 registered insecticides to greenhouse whitefly(GWF), Trialeurodes vaporariorum and sweetpotato whitefly(SWF), Bemisia tabaci, B-biotype. Insecticide activities were evaluated by testing systemic action, residual effect in the laboratory, and control efficacy in the greenhouse. All experiments were tested at the recommended concentration(RC), half and a quarter concentrations of RC of each insecticides. Acetamiprid showed 45%, 42% ovicidal effect to greenhouse whitefly and sweetpotato whitefly at 40 ppm, respectively. Acetamiprid showed more than 97% larvicidal activities on the 3rd instars larvae of GWF and SWF at the recommended and its half concentrations. On the adults of the two whitefly species, acetamiprid and acetamiprid+ethofenprox showed more than 92% mortality even at half of recommended concentrations. Acetamiprid and acetamiprid+ethofenprox showed both residual effect and systemic activity. In the control efficacy test on GWF and SWF, 90% control values were obtained at the 3th day after treatments of acetamiprid and acetamiprid + ethofenprox by application with recommended concentration. These results indicate that acetamiprid and acetamiprid+ethofenprox can be used in the control of the two whitefly species in field.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.3
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• pp.866-872
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• 2010

In this paper, we developed a digital soldering station based on PID controller, which supply stable power by controlling the current of heater of soldering iron. The proposed system designed PID controller to converge quickly to the set up temperature by user, and regain the lost of heat by external factors quickly. PID controller, designed by Ziegler-Nichols' tuning method, decides triac's trigger timing using setting temperature and present temperature to control the phase of AC 24V power that supply to the heater. Also, we give the function that shows present temperature and setting temperature of iron, and working time by graphic LCD. And during the rest time, we decided the power saving and extension of iron tip by dropping to the optimal temperature. Two experiments had implemented in $25^{\circ}C$ laboratory to confirm the performance of proposed method. The first experiment took 12sec, 13sec, 16sec, 18sec, reaching to $200^{\circ}C$, $300^{\circ}C$, $400^{\circ}C$, $480^{\circ}C$ respectively which result showed shorten of rising time than previous method. In the loading experiment of $300^{\circ}C$, $400^{\circ}C$, $480^{\circ}C$ steady state showed temperature drop of $3.8^{\circ}C$, $4.1^{\circ}C$, $4.5^{\circ}C$ which result showed the low temperature deviation than previous method.

• Journal of Soil and Groundwater Environment
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• v.14 no.5
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• pp.10-17
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• 2009

Bioremediation has been applied as a proven technology in remediation of TPH contaminated soil. However, the efficiency of biodegradation is dependent on temperature as microbial activity is depressed at lower temperature ranges ($30^{\circ}C{\sim}80^{\circ}C$). The objective of this study was to develop microbes with enhanced activities at the stated temperature conditions and to evaluate the remediation effectiveness of these microbes in TPH contaminated soil. Experiments were conducted to isolate hydrocarbon degradable microbial consortia cultured under different temperature conditions. It was found that there were 5 strains of mesophilic ($30^{\circ}C$) and 3 strains of psychrophilic ($80^{\circ}C$) microbes. The TPH concentration was reduced from 4,044 mg/kg to 1,084 mg/kg, (73.2%) in 10 days by using mesophilic microbial consortia and from 5,427 mg/kg to 1,756 (67.6%) in 50 days with psychrophilic microbial consortia in laboratory cultures under controlled conditions. This rate determination excluded physical degradation such as venting and dilution. A field study was then performed to examine the feasibility of applying these microbes in the land-farming process. In this case, 87.1% of the 2,560 mg/kg TPH contaminated soil was degraded in 56 days. The biodegradation rate coefficient (k) was $0.0374\;day^{-1}$. Findings of this study provide viable options for applying microbes for bioremediation of TPH in lower temperature conditions.

• Tunnel and Underground Space
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• v.26 no.3
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• pp.235-252
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• 2016

This study presents a methodology to reproduce the mechanical behavior of isotropic or transversely isotropic rock using the polygonal grain-based distinct element model. A numerical technique to monitor the evolution of micro-cracks during the simulation was developed in the present study, which enabled us to examine the contribution of tensile cracking and shear cracking to the progressive process of the failure. The numerical results demonstrated good agreement with general observations from rock specimens in terms of the behavior and the evolution of micro-cracks, suggesting the capability of the model to represent the mechanical behavior of rock. We also carried out a parametric study as a fundamental work to examine the relationships between the microscopic properties of the constituents and the macroscopic behavior of the model. Depending on the micro-properties, the model exhibited a variety of responses to the external load in terms of the strength and deformation characteristics. In addition, a numerical technique to reproduce the transversely isotropic rock was suggested and applied to Asan gneiss from Korea. The behavior of the numerical model was in good agreement with the results obtained in the laboratory-scale experiments of the rock.

• Journal of Korea Water Resources Association
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• v.50 no.3
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• pp.201-210
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• 2017

This study proposes a numerical model which is able to simulate turbidity currents intruding into a reservoir and resulting sediment depositions. The proposed model is applied to laboratory experiments by Toniolo and Schultz (2005), and propagation of turbidity currents, morphological change, and trap of suspended sediment are simulated. It is simulated that the turbidity current after plunging at the foreset of the model delta, propagates along the bottom. The thickness of the turbidity current increases significantly after being blocked by the dam, and this effect is propagated in the upstream direction. In addition, it is simulated that the foreset moves in the downstream direction due to both the bedload and suspended load and the thickness of the bottom set increases due to the suspended load. It is found that the height of the intake affects the thickness of the turbidity current and the location of the internal hydraulic jump. The impact of the height of the intake on the trap efficiency is not clear in the experimental results, however, overall trap efficiency is predicted quite successfully by the model. Also, sensitivity analysis is carried out, and the results indicates that the particle size affects the trap efficiency most.

• Korean Journal of Ecology and Environment
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• v.42 no.1
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• pp.115-123
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• 2009

Grazing effects of a freshwater bivalve, Unio douglasiae, on both the phytoplankton communities of cold- and warm eutrophic lakes were examined in aquarium with sediment. The animal U. douglasiae used in the study was collected from the Gunsan (Jeonbuk), acclimatized in laboratory aquaria with washed sand from the mussel collection stream, and starved for $2{\sim}3$ days by the experiment. Grazing experiments were performed with the surface waters collected from Lake Ilgam (Seoul) in the cold period (March 31, 2008), and the warm period (June 19, 2008), respectively. Results clearly showed that the concentration of chlorophyll-a (chl-a) and algal abundance were decreased with the increase of mussel-treated density and treated-time. At the same animal density, U. douglasiae effectively decreased the chl-a of cold-lake water (CW), compared to warm-lake water (WW). Increasing the mussel density, the filtering rate (or algal abundance) of the mussel on the CW gradually decreased, while those of WW did not increase or decrease. Major phytoplankton species Synedra ulna and Stephanodiscus hantzschii, and Scenedesmus ecornis in CW, and those of Tetraedron regulare and Pediastrum simplex in WW, were quickly decreased after the mussel stocking. Interestingly, cyanobacterium Microcystis aeruginosa in WW, not dominant species, were less removed. These results suggest that a freshwater bivalve U. douglasiae have a strategic potential to control dense hibernal diatom or green algae, rather than the cyanobacterial bloom in eutrophic water.