• 한국환경과학회지
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• 제19권12호
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• pp.1361-1374
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• 2010

The impact of urbanization on local meteorology (e.g., surface temperature, PBL height, wind speed, etc.) in the Greater Seoul Area (GSA) was quantitatively evaluated based on a numerical modeling approach during a 1-month period of 2001 (9 Sep. through 8 Oct. 2001). The analysis was carried out by two sets of simulation scenarios: (1) with the global land use and topographic data from the U.S. Geological Survey (USGS) in 1990s (i.e., LU-USGS case) and (2) with the land use data from the Environmental Geographic Information System (EGIS) along with the 3 sec elevation data from the Shuttle Radar Topography Mission (SRTM) in 2000s (i.e., LU-EGIS case). The extension of urban areas in the GSA (especially, the southern parts of Seoul) accounted for 1.8% in the LU-USGS case and 6.2% in the LU-EGIS case. For the simulations, the surface temperature and PBL height due to urbanization in the LU-EGIS case was higher (the differences of up to $0.1^{\circ}C$ and 36 m, respectively) than those in the LU-USGS case, whereas the wind speed (up to 0.3 $ms^{-1}$) in the former was lower than that in the latter at 1500 LST. The increase in surface temperature due to urbanization in the GSA (especially, the southern parts of Seoul) was led to the strong convergence of air masses, causing the early sea breeze and its rapid propagation to inland locations. In addition, the vertical mixing motion in the extended urban areas for the LU-EGIS case was predicted to be stronger than that for the LU-USGS case and vice versa for the original urban areas.

• 한국임상수의학회지
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• 제24권3호
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• pp.419-421
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• 2007

15년령의 중성화한 퍼그견이 거위울음소리 같은 기침 때문에 내원 하였다. 본 환축은 임상증상과 방사선 검사를 이용하여 기관지허탈로 진단하였다. 환축의 치료를 위하여 폐수(BL13), 중부(LU01), 척택(LU05), 공최(LU06), 열결(LU07), 태연(LU09) 및 천돌(CV22)에 10일간 butorphanol 약침을 실시하였으며, BL13, LU01 및 CV22에 9일간 butorphanol 약침을 추가로 실시하였다. 본 환축은 소청용탕(小靑龍湯)을 7일간 투여 받았으며, 소자강기탕(蘇子降氣湯)을 12일간 추가로 투여 받았다. 치료 후 환축은 기침을 하지 않았으며, 기관치의 직경이 방사선 사진에서 치료전보다 증가해 있었다. 3개월 후 정기 진단 시 기침은 전혀 관찰되지 않았으며, 기관지의 직경은 치료 후보다 더욱 증가해있었다. 결론적으로 본 환축은 butorphanol의 약침과 한약제의 병행으로 양호한 치료반응을 나타낸 개 기관지허탈 증례이었다.

• 한국재료학회지
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• 제30권8호
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• pp.413-420
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• 2020

Lu₃Al_5-xGa_xO₁₂:Ce³⁺,Cr³⁺ powders are prepared using a solid-state reaction method. To determine the crystal structure, Rietveld refinement is performed. The results indicate that Ga³⁺ ions preferentially occupied tetrahedral rather than octahedral sites. The lattice constant linearly increases, obeying Vegard's law, despite the strong preference of Ga³⁺ for the tetrahedral sites. Increasing x led to a blue-shift of the Ce³⁺ emission band in the green region and a change in the emission intensity. Persistent luminescence is observed from the powders prepared with x = 2-3, occurring through a trapping and detrapping process between Ce³⁺ and Cr³⁺ ions. The longest persistent luminescence is achieved for x = 2; its lifetime is at least 30 min. The findings are explained using crystal structure refinement, crystal field splitting, optical band gap, and electron trapping mechanism.

• 대한방사성의약품학회지
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• 제3권2호
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• pp.59-64
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• 2017

It has been reported that $^{64}Cu$ was radiolabeled with bombesin (BBN) peptide binding to the gastrin releasing peptide receptor expressed in human prostate cancer cells (PC3), confirming tumor target efficacy in mouse model. In this study, we developed the kit for the diagnosis and treatment of prostate cancer that can be used clinically using bombesin peptide available of $^{64}Cu$ and $^{177}Lu$ radioisotope labeling. The NODAGA-galacto-BBN peptide containing the NODAGA chelator and galactose was dispensed into a sterilized glass vial and lyophilized to prepare a kit. The stability of the kit after long-term storage in the $4^{\circ}C$ cold chamber and the radiolabeling efficiency after $^{64}Cu$ or $^{177}Lu$ labeling were confirmed by thin layer chromatography. When labeling with $^{64}Cu$ at the initial stage of storage, labeling efficiency of NODAGA-galacto-BBN peptide kit was over 96%, labeling efficiency was over 90% when $^{177}Lu$ was labeled. At 11 months after storage, the radiolabeling efficiency of kit against $^{64}Cu$ and $^{177}Lu$ was each over 95% and 90%. The cell viability was significantly reduced in the $^{177}Lu$-NODAGA-galacto-BBN treated group compared with the control and $^{177}Lu$ alone treated group in clonogenic assay. In conclusion, the NODAGA-galacto-BBN kit prepared by the lyophilization showed high stability over time and high yield of radioisotope labeling. Also $^{177}Lu$-NODAGA-galacto-BBN confirmed high cytotoxicity to prostate cancer cells. Therefore, the NODAGA-galacto-bombesin kit is expected to be useful for the diagnosis and treatment of prostate cancer patients.

• 생명과학회지
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• 제17권8호통권88호
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• pp.1082-1089
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• 2007

혈청학적 유전자 검색 방법(SEREX)은 암 환자의 면역계를 인식하는 종양 면역유전체(Cancer Immunome)를 형성하는 수많은 종양항원의 발견을 이끌어왔다. 본 연구는 정상인의 고환 조직으로 만들어진 cDNA liabary을 사용하여 폐암환자의 혈청으로부터 40개의 종양항원을 동정하여 그 항원들을 KP-LuT-1부터 KP-LuT-40까지 명명하였다. 이들 항원 중에서 20개는 기존의 다른 종류의 암에서 분리된 것이며 20개는 본 실험에서 새롭게 동정 된 항원들이었다. 유전자 분석을 통하여 분리된 26개의 항원들은 그 단백질의 기능이 알려진 것이었고 14개의 항원들은 기능이 분석되지 않은 유전체의 산물이었다. 이들 항원 중에서 hypothetic단백질 KP-LuT-6는 정상조직에서 제한적으로 발현되었다. RT-PCR에 의한 발현분석 결과에서 16개의 정상조직 중 고환에서만 강력하게 발현 하였고 다른 조직에서는 발현되지 않으나 폐암(3/10), 위암 (3/10) 과 유방암(1/5)들에서 발현 하였다. 이 결과는 KP-LuT-6의 항원이 암 면역치료를 위한 잠재적 유전자로 사용될 수 있는 Cancer/Testis(CT) 항원과 비슷한 유전 자로 사료된다.

• International Journal of Automotive Technology
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• 제2권3호
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• pp.117-122
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• 2001

For a dynamic analysis of a constrained multibody system, it is necessary to have a routine for satisfying kinematic constraints. LU decomposition scheme, which is used to divide coordinates into dependent and independent coordinates, is efficient but has great difficulty near the singular configuration. Other method such as the projection matrix, which is more stable near a singular configuration, takes longer simulation time due to the large amount of calculation for decomposition. In this paper, the row space and the null space of the Jacobian matrix are proposed by using the pseudo-inverse method and the projection matrix. The equations of the motion of a system are replaced with independent acceleration components using the null space of the Jacobian matrix. Also a new hybrid method is proposed, combining the LU decomposition and the projection matrix. The proposed hybrid method has following advantages. (1) The simulation efficiency is preserved by the LU method during the simulation. (2) The accuracy of the solution is also achieved by the projection method near the singular configuration.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2018년도 추계학술발표대회
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• pp.699-701
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• 2018

본 연구는 인공 신경망 '추론'과정에서 연산량을 줄이는 아이디어를 고안했고, 이를 구현하여 기존 알고리즘과 성능을 비교 분석하였다. 특정 데이터 셋에 대한 실험을 통해 ReLU(Rectified Linear Unit) 함수의 결과를 분석했고, 그 결과를 통해 ReLU 함수의 결과가 예측가능함을 확인했다. 또한 인공 신경망 알고리즘에 ReLU 함수의 결과 예측 기법을 적용하여 인공 신경망 추론과정을 최적화했다. 이 아이디어를 기반으로 구현된 인공 신경망은 기존 아이디어로 구현된 인공 신경망에 비해 약 3배 빠른 성능을 보였다.

• 대한기계학회논문집
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• 제16권10호
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• pp.1915-1927
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• 1992

본 연구에서는 3차원 압축성 내부유동해석 코드를 개발하여 터어빈 정익이나 동익 내부의 차원 익렬 유동을 수치적으로 해석하고자 한다. 여기에서 사용된 코드 는 Obyashi의 LU-ADI기법을 이용한 기존의 2차원 익렬 유동해석 코드를 3차원 유동장 으로 학장한 것이고, 난류유동해석에는, Baldwin-Lomax의 박층 대수모델을 3차원으로 확장한 알고리즘을 적용하였다.Kiock등이 실험한 선형 터어빈 익렬 내부의 천음속 유동장에 적용하여 양끝 벽면에 의한 3차원 유동장 특성을 분석하고, 3차원 익렬 유동 코드의 적합성을 검토하였다.

• Korean Journal of Acupuncture
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• 제37권1호
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• pp.31-36
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• 2020

Objectives : The purpose of this study is to review needling depth and location of LU7, BL62 and KI6 by the medical classics' records. Methods : 1. We researched the medical classics describing LU7, KI6 and BL62, and reorganized data about the location and needling depth. 2. We compared the medical classics' records on LU7, KI6 and BL62 with description of WHO standard acupuncture point location. 3. We reviewed different location and needling depth of LU7, BL62, and KI6 recorded in the medical classics with the anatomical structure. Results : 1. The common needling depth of LU7 is about 0.2 chon. But in some medical classics, the depth of LU7 is 0.8 chon. Needling depth of LU7 varied depending on the patient's hand posture. In the 'half-up' position with the thumb upward, it is possible to stimulate acupuncture on LU7 by 0.8 chon because there is a space between the tendons. 2. In WHO standard acupuncture point location, the locations of BL62 and KI6 are just below the lateral and medial malleolus. But in some medical classics, the locations of BL62 and KI6 are between the bones and muscles below the malleolus. In the locations between the bones and muscles below the malleolus, it is possible to stimulate acupuncture on BL62 and KI6 by penetrating acupuncture because there is no bone structure. Conclusions : 1. By the 'half-up' position with the thumb upward, it is possible to stimulate vertically acupuncture on LU7 by 0.8 chon. 2. By the locations of BL62 and KI6 between the bones and muscles below the malleolus, it is possible to stimulate on BL62 and KI6 by penetrating acupuncture.

• Korean Journal of Acupuncture
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• 제20권2호
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• pp.1-20
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• 2003

This study was examined for characteristics of acupuncture of LU10 on the abdominal thermography of health subject. The volunteers who participating in this study had taken rest for 20 - 30 mins in room temperature $(23-25^{\circ}C)$ before the examination and informed them what to prohibit smoking, drinking and administration of drug for the previous day. The thermography of abdomen including a below part of the chest was taken using Infra-Red Imaging System (IR 2000, MEDI-CORE Co., Korea) by time interval of 15 minutes at 15 min before, just before and 15 min after, 30 min after and 45 min after acupuncture stimulation. Acupuncture was applied to both LU10 for 30 mins. The results showed that acupuncture of LU10 for 30 mins had more potencies of changes on all the ROIs of abdominal thermography than those of control group. Also, those responses were significantly clear at the A1, A3, A6, A7 and A9 areas. It was observed that the quantities of thermal changes following acupuncture of LU10 been increased significantly comparing that of control group at the all ROIs (region of interest). These effects have more potencies at the upper (A1 and A2) and below (A7, A8, A9) abdominal areas than midline ones (A4, A5, and A6). These results suggest that acupuncture of LU10 having the characteristics of controls of chill and fever (寒熱) may modulate thermal distributions and changes of abdominal areas including the below of chest.