• Korean Journal of Clinical Pharmacy
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• v.30 no.1
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• pp.59-64
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• 2020

The emergence of phosphodiesterase (PDE) 5 inhibitors gave rise to the solution for erectile dysfunction, starting with the development of sildenafil. Although their efficacy in treating erectile dysfunction has been shown, the side effects of PDE5 inhibitors, especially sildenafil, must be taken into consideration. A 64-year-old man received 100 mg of sildenafil and experienced blue vision in both eyes; however, after a day or so, his symptoms improved. The symptoms disappeared when he stopped administering sildenafil, but reappeared when the medication was re-administered. Therefore, he discontinued sildenafil treatment and was prescribed udenafil instead. After that, visual adverse events no longer occurred. Causality assessment showed that in this case, sildenafil-induced cyanopsia was "certain" under the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria and Korean causality assessment algorithm (Ver.2), and was "probable" according to the Naranjo scale. In addition, sildenafil also led to abnormal visual reactions in other cases. Sildenafil can also inhibit PDE6, which is present in retinal cells, unlike other PDE5 inhibitors. Thus, visual adverse reactions, such as blue vision, are the unique results of sildenafil, and other PDE5 inhibitors may be used to prevent them.

• Biomedical Science Letters
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• v.24 no.2
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• pp.64-75
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• 2018

CCN3 (also known as NOV, Nephroblastoma overexpressed) proteins are involved in various pathologies during different developmental stages. We have previously shown that intracellular levels and normal extracellular secretion of CCN3 are important for neuronal differentiation. Furthermore, we demonstrated that a single amino acid in the CCN3 TSP-1 domain is important for extracellular secretion and that palmitoylation of CCN3 is required in this process. However, the effect of abnormal CCN3 accumulation on cells remains to be studied. Here, we found mutations in the TSP-1 domain of CCN3 that led to intracellular accumulation and abnormal aggregation of CCN3. It was observed that this mutation resulted in a phenomenon similar to neurodegeneration when overexpressed in the developing mouse cortex. This mutation also confirmed the activation of apoptotic gene expression in Neuro2a cells. In addition, we confirmed the in vivo transcriptional changes induced by this mutation using microarray analysis. We observed a significant increase in the expression of Anp32a, an apoptosis-related gene. Collectively, these results indicate that a single mutation in CCN3 can lead to abnormal cell death if it shows intracellular accumulation and abnormal aggregation.

• Journal of the Korean Society of Costume
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• v.64 no.4
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• pp.150-161
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• 2014

The purpose of this study was to examine the differences in image perception, and to investigate the differences in age and income inferences according to the wearing of accessories with black dress. A quasi-experimental method was used for this study. The experimental design was a $2{\times}3{\times}3$(necklace${\times}$earrings${\times}$corsage) factorial design. The subjects were 610 female college students residing in Seoul. The model in the stimulus photographs was a woman with straight long hair. She wore a black one-piece dress with round neckline and short sleeves. The findings indicated that the wearing of a necklace enhanced individuality, attractiveness, and cuteness in women. Professionalism and individuality were heightened when she wore an earring. The red corsage enhanced individuality, but it had a negative effect in professionalism. As for the effect on interaction, attractiveness was more highly perceived when both necklace and large earrings were worn without a corsage. The absence of both necklace and earrings led to a low perception of professionalism, attractiveness, and individuality. The wearing of a necklace was more strongly linked to older age and high income than not wearing it, and it was perceived as more youthful if earrings were not worn. As for interactions, the wearing of small earrings and a red corsage was linked to the oldest age.

• Journal of the Korean Society of Costume
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• v.64 no.4
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• pp.52-75
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• 2014

The purpose of this research is to classify the historical features of mid-to-late twentieth century Korean fashion with a focus on 'Nora Noh', who is a first generation Korean fashion designer. The specific questions of this research are as follows: how did mid-to-late twentieth century Korean fashion and the Nora Noh brand develop and what is the relationship between the two? What are the important features of Korean women's fashion design in the mid-to-late twentieth century? What are the characteristics exhibited in each decade in Korean women's fashion and Nora Noh's fashion? This paper conducted the research by focusing on the Korean fashion development as a background of simplification in the way of dressing and specific historical incident. Researchers deployed a qualitative research method providing a systematic review of the previous studies by analyzing content as well as eleven oral statement interviews and the case study of Nora Noh. The result shows that Nora Noh is one of the first generation of Korean fashion designers who led fashion trend and system in Korea. The designer also influenced Korean commercial fashion in the 1970s and American fashion trends in the 1980s.

• Korean Journal of Environmental Agriculture
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• v.14 no.2
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• pp.179-185
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• 1995

Three aminothio derivatives of carbofuran including carbosulfan, furathiocarb and benfuracarb were subjected to the degradation study in soils to investigate how fast and efficiently carbofuran would be evolved from them. Carbofuran was rapidly released from the derivatives in soils as the carbamoyl nitrogen-sulfur bond cleaved. Their degradation rates in soils, with half-lives of $23{\sim}68$ hours, were largely affected by structures of aminothio moieties and soil moisture conditions. Conversion rates into carbofuran ranged from 64 to 84% in soils on the basis of parent compounds 5 days after treatment. Application of aminothio derivatives led to less drastic increase in the carbofuran level in soils than when carbofuran was applied as such, and hence this might result in lower side effects in situ.

• Journal of the Korean Society of Costume
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• v.64 no.6
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• pp.120-130
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• 2014

The present study aimed to find out the most effective instructional method for illustration to aid the $21^{st}$-century post digital generation learners in their education. Although the literature discusses government-led enactment and revision of educational policy and curriculums and research reports by the Ministry of Education and other government agencies as well as many other research articles deal with futuristic instructional methods, the instructional methods in practice have not fully changed yet. Illustration is a means of visual communication and a subject that best represent 'expressionism' and 'speed' of the post digital generation. The present study exemplifies instructional methods to establish the need for lesson plans that best suit individuality of students and for re-training instructors. Also, the feedback process with students proved that the post digital generation learned Photoshop quickly and improved creativity via image synthesis even in short-term instructions. The present findings can be possibly used as reference data for instructional methods for illustration using digital media that best suits learners of the post digital generation. This being said, further studies should delve into specific instructional methods.

• Corrosion Science and Technology
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• v.17 no.4
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• pp.166-175
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• 2018

In this study, the electrochemical properties of CP-Ti (commercially pure titanium) and Ti-64 (Ti-6Al-4V) were evaluated and the effect of hydrofluoric acid on corrosion resistance and electrochemical properties was elucidated. Additive manufactured materials were made by DMT (Directed Metal Tooling) method. Samples were heat-treated for 1 hour at $760^{\circ}C$ and then air cooled. Surface morphologies were studied by optical microscope and SEM. Electrochemical properties were evaluated by anodic polarization method and AC-impedance measurement. The oxide film formed on the surface was analyzed using an XPS. The addition of HF led to an increase in the passive current density and critical current density and decreased the polarization resistance regardless of the alloys employed. Based on the composition of the oxide film, the compositional difference observed by the addition of HF was little, regardless of the nature of alloys. The Warburg impedance obtained by AC-impedance measurement indicates the dissolution of the constituents of CP-Ti and Ti-64 through a porous oxide film.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.04a
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• pp.64-64
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• 1995

Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesterol ester and triglyceride between high-density lipoprotein (HDL) and other low-density lipoproteins, therefore, it might influence HDL levels. The levels of HDL is closely related to the atherogenic diseases in human and there were several reports that the trasgenic mice expressing CETP had much worse atherosclerosis than non-expressing control one. Therefore, selective inhibitors of CETP have the potential to be used as antiatherosclerotic agents. Continued screening for potent inhibitors of CETP led to the isolation of Suberitenone B from marine sponge. Suberitenone B, sesterterpenoids of a new skeletal class have been isolated from the sponge Suberites sp. collected from King George Island the Antartic. The structure of the metabolite has been determined by NMR experiments and chemical methods.

• Food Science and Preservation
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• v.31 no.1
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• pp.64-79
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• 2024

The rise in popularity of vegetarian and plant-based diets has led to extensive research into plant-based whipped creams. Whipped cream is an oil-in-water emulsion that creates foam through whipping, stabilizing the foam with proteins and fats. Pea protein is an excellent emulsifier and foaming agent among plant-based proteins, but its application in whipped cream is currently limited. The objective of this study was to investigate the quality characteristics of plant-based whipped cream made with ultrasonicated pea protein. The whipped creams were evaluated based on their quality characteristics. A commercially available dairy whipped cream (CON) was used as a control. Plant-based creams were evaluated using pea protein solution, cocoa butter, and canola oil to produce un-ultrasonicated pea protein whipped cream (PP) and ultrasonicated pea protein whipped cream (UPP) at 360 W for 6 min. UPP significantly reduced whipping time and foam drainage compared with CON and PP, resulting in significantly increased overrun, fat destabilization, and hardness. Optical microscopy showed that UPP had smaller fat globules and bubble size than PP. The fat globules of UPP and CON were mostly below 5 ㎛, whereas those of PP were distributed at 5-20 ㎛. Finally, ultrasonication significantly improved the overrun, foam drainage, fat destabilization, and hardness of UPP, which are significant quality characteristics of whipped creams. Therefore, ultrasonicated plant-based pea protein whipped cream is believed to be a viable alternative to dairy whipped cream.

• Journal of the Korean Wood Science and Technology
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• v.21 no.1
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• pp.59-64
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• 1993

The purpose of this study is to investigate the preparation of the carboxymethylcellulose from recycled fiber, especially on the reactivity of carboxymethylation. Using a deinked pulp and a dissolving pulp. Green's method is adapted to the carboxymethylation. We conformed that the carboxymethyl group is led for recycled fiber by FT-IR analysis. The recycled fiber is more reactive than the dissolving pulp because the recycled fiber had been defiberated and pretreated with alkali. It suggests that deinking process is in accordance with pretreatment of CMC process. Therefore, it may be possible to prepare CMC from the recylced fiber economically.