Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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A Case Report of Cyanopsia after Taking Sildenafil

실데나필 복용 이후 발생한 청색시증에 대한 사례

  • Lee, Chan Hee (College of Pharmacy, Gachon University) ;
  • Yoon, Joong Sik (Regional Pharmacovigilance Center, Korean Pharmaceutical Association) ;
  • Ji, Eunhee (College of Pharmacy, Gachon University)
  • 이찬희 (가천대학교 약학대학) ;
  • 윤중식 (대한약사회 지역의약품안전센터) ;
  • 지은희 (가천대학교 약학대학)
  • Received : 2019.11.11
  • Accepted : 2020.02.11
  • Published : 2020.03.31
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Abstract

The emergence of phosphodiesterase (PDE) 5 inhibitors gave rise to the solution for erectile dysfunction, starting with the development of sildenafil. Although their efficacy in treating erectile dysfunction has been shown, the side effects of PDE5 inhibitors, especially sildenafil, must be taken into consideration. A 64-year-old man received 100 mg of sildenafil and experienced blue vision in both eyes; however, after a day or so, his symptoms improved. The symptoms disappeared when he stopped administering sildenafil, but reappeared when the medication was re-administered. Therefore, he discontinued sildenafil treatment and was prescribed udenafil instead. After that, visual adverse events no longer occurred. Causality assessment showed that in this case, sildenafil-induced cyanopsia was "certain" under the World Health Organization-Uppsala Monitoring Center (WHO-UMC) criteria and Korean causality assessment algorithm (Ver.2), and was "probable" according to the Naranjo scale. In addition, sildenafil also led to abnormal visual reactions in other cases. Sildenafil can also inhibit PDE6, which is present in retinal cells, unlike other PDE5 inhibitors. Thus, visual adverse reactions, such as blue vision, are the unique results of sildenafil, and other PDE5 inhibitors may be used to prevent them.

Keywords

References

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