• Archives of Plastic Surgery
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• 제48권2호
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• pp.185-188
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• 2021

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome can be treated through numerous surgical and nonsurgical methods. We present a surgical technique in which a neovagina was reconstructed and shaped by a vaginal expander with acellular porcine dermal matrix (XCM Biologic Tissue Matrix) and mucosal interposition using microfragments harvested from the hymen. In our case, we found this procedure to be safe and effective, resulting in satisfactory sexual function and good cosmetic results, without donor site morbidity. To our best knowledge, this tissue-engineered biomaterial has never been used for vaginal reconstruction before.

• 한국동물생명공학회지
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• 제37권1호
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• pp.62-66
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• 2022

To date, the development of anticancer drugs has been conducted using two-dimensional (2D) cell culture systems. However, since cancer cells in the body are generated and developed in three-dimensional (3D) microenvironments, the use of 2D anticancer drug screening can make it difficult to accurately evaluate the anticancer effects of drug candidates. Therefore, as a step towards developing a cancer cell-friendly 3D microenvironment based on a combination of vinylsulfone-functionalized polyethylene glycol (PEG-VS) with dicysteine-containing crosslinker peptides with an intervening matrix metalloproteinase (MMP)-specific cleavage site, the types of MMPs secreted from human hepatocarcinoma HepG2 cells, a representative cancer cell, were analyzed transcriptionally and translationally. MMP3 was confirmed to be the most highly expressed protease secreted by HepG2 cells. This knowledge will be important in the design of a crosslinker necessary for the construction of PEG-based hydrogels customized for the 3D culture of HepG2 cells.

• Archives of Plastic Surgery
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• 제50권2호
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• pp.156-159
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• 2023

Breast implants whether used for cosmetic or reconstructive purposes can be placed in pockets either above or below the pectoralis major muscle, depending on clinical circumstances such as subcutaneous tissue volume, history of radiation, and patient preference. Likewise, cardiac implantable electronic devices (CIEDs) can be placed above or below the pectoralis major muscle. When a patient has both devices, knowledge of the pocket location is important for procedural planning and for durability of device placement and performance. Here, we report a patient who previously failed subcutaneous CIED placement due to incision manipulation with prior threatened device exposure requiring plane change to subpectoral pocket. Her course was complicated by submuscular migration of the CIED into her breast implant periprosthetic pocket. With subcutaneous plane change being inadvisable due to patient noncompliance, soft tissue support of subpectoral CIED placement with an acellular biologic matrix (ABM) was performed. Similar to soft tissue support used for breast implants, submuscular CIED neo-pocket creation with ABM was performed with durable CIED device positioning confirmed at 9 months postprocedure.

• 한국경영과학회:학술대회논문집
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• 한국경영과학회 1999년도 추계학술대회 및 정기총회 : 정보통신기술의 활용과 21세기 전자상거래
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• pp.42-46
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• 1999

Knowledge management(KM) is emerging as a robust management mechanism with which an organization can remain highly intelligent and competitive in a turbulent market. Organization memory(or knowledge) is at the heart of KM success. How to create organizational memory has been debated among researchers. In literature, a wide variety of methods for creating organizational memory have been proposed only to prove that its applicability is limited to decision-making problems which require shallow or non-causal knowledge type. However, organizational memory with a sense of causal knowledge is highly required in solving complicated decision-making problems in which complex dynamics exist between various factors and influence each other with cause and effect relationship among them. In this respect, we propose a new approach to creating a causal-typed organizational memory (CATOM), which has a form of causal knowledge and is represented in a matrix form, by using an inference diagram. An algorithm for CATOM creation is suggested and applied to an illustrative example. Results show that our proposed KM approach can effectively equip an organization with semi-automated CATOM creation and inference process which is deemed useful in a highly competitive business environment.

• 문화기술의 융합
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• 제6권4호
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• pp.339-345
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• 2020

본 연구는 테크놀로지 교수내용 지식 (TPACK) 구성 틀을 기반으로 교사 지식에 대한 예비초등교사의 인식을 분석하기 위한 목적으로 수행되었다. 연구의 목적을 달성하기 위하여 중부지역에 위치한 교육대학교 4학년 재학생인 예비초등교사 81명을 대상으로 설문조사를 실시하고 설문조사 결과를 중요도-실행도 분석 방법을 사용하여 분석하였다. 분석결과 TPACK을 구성하는 7개 영역 지식 모두 중요도에 대한 인식이 실행도 인식에 비해 유의미하게 높은 것으로 나타났다. 중요도-실행도 매트릭스를 분석한 결과 예비초등교사가 특별히 개발해야 할 필요성이 높은 영역 지식으로 테크놀로지와 연계된 지식 영역인 테크놀로지 내용지식 (TCK) 과 테크놀로지 교수지식 (TPK), 그리고 테크놀로지 교수내용 지식 (TPACK) 인 것으로 나타났다. 본 연구의 결과는 초등교원 양성기관에서 운영하고 있는 교육과정이나 교육프로그램에서 테크놀로지의 교육적 활용과 관련된 활동이 보다 많이 다루어야 할 필요성을 말해준다. 본 연구는 특히 교육과정과 교육 프로그램에서 테크놀로지 지식은 단절적으로 운영되기 보다는 교과내용 및 교수방법적 지식과 통합적, 융합적으로 연계가 이루어질 수 있도록 구성되어야 할 필요성을 시사한다.

• 한국인터넷방송통신학회논문지
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• 제8권1호
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• pp.53-62
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• 2008

다언어 문서검색(CLTR; Cross-Lingual Text Retrieval)은 하나의 언어로 질의가 주어질 때, 그 질의의 언어와는 다른 언어로 되어 있는 문서들을 검색하는 정보 검색을 말한다. 본 논문에서는 두 언어 사이의 용어들 간에 부분 매칭을 다룰 수 있도록 하기 위해 퍼지 다언어 시소러스 기반의 다언어 문서검색 시스템을 제안한다. 제안된 다언어 문서검색 시스템에서는 효과적인 추론을 위해 퍼지 용어 매트릭스를 정의하여 이용한다. 정의된 퍼지 용어 매트릭스에서 용어들 간의 모든 관련도가 전이폐쇄 알고리즘을 이용하여 추론함으로써 용어들 간의 묵시적인 링크가 모두 검색에 반영된다. 이에 따라 제안된 방법은 인간 전문가에 좀 더 가까운 정보검색을 수행하여 검색 효과를 높이게 된다.

• 지식경영연구
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• 제22권1호
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• pp.105-120
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• 2021

최근 정보기술의 발달과 함께 부동산 시장에도 급속한 변화가 일어나고 있다. 프롭테크는 인공지능, 센싱기술, 빅데이터 등 다양한 정보기술의 적용으로 촉진되는 부동산 거래혁신으로 정의된다. 본 연구의 목적은 프롭테크 비즈니스에서 어떤 가치가 창출되고 공유되는지에 대한 이해를 바탕으로 조직의 전략 및 비즈니스개발에 도움을 주는 프롭테크 비즈니스 가치창출 프레임워크를 제시하는 것이다. 연구의 결과에서는 인지된 가치 활동을 바탕으로 프롭테크 비즈니스 분류 매트릭스를 구분하고 이 매트릭스를 중심으로 프롭테크 비즈니스의 주요 가치를 무형화, 관계화, 고도화가치로 도출하고, 프롭테크 비즈니스 유형별로 이들 가치가 구현되는 사례를 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7393-7400
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• 2015

Matrix metalloproteinase (MMP) 9, a key member of multifunctional family of zinc dependent endopeptidases has been found to be upregulated during inflammation and in some cancers. MMPs cleave extracellular matrix (ECM) proteins and play critical roles in cellular apoptosis, angiogenesis, tumor growth and metastasis. Several genetic polymorphisms have been identified that show allele specific effects on MMP9 regulation and are associated with gastric cancer, the fourth most common malignancy in the world. Besides Helicobacter pylori infection, genetic predisposition is another documented risk factor for gastric carcinoma. The single nucleotide polymorphism (SNP) at position -1562C/T of MMP9 results in the modulation for binding of transcription factors to the MMP9 gene promoter and thereby causes differences in protein expression and enzymatic activity. MMP9 transcriptional regulation during gastric cancer development remains poorly known although several studies have demonstrated associations between MMP9 -1562 C/T polymorphism with different diseases. Knowledge on mechanisms of MMP9 upregulation during gastric cancer may provide new paradigm in diagnostics and therapeutics.

• 대한기계학회논문집A
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• 제28권8호
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• pp.1099-1108
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• 2004

In this paper, a study on the development of expert system for Al matrix composite with shape memory alloy fiber is performed to evaluate termomechanical behavior and mechanical properties. Expert system is very useful computer-based analysis system designed to make analysis technique and knowledge conveniently available to a lot of fabricable condition. In the developed system, it is possible to predict termomechanical behavior and mechanical properties for other composite with shape memory alloy fiber. The smartness of the shape memory alloy is given due to the shape memory effect of the TiNi fiber which generates compressive residual stress in the matrix material when heated after being prestrained. For finite element analysis, an analytical model is assumed two dimensional axisymmetric model compared of one fiber and the matrix. To evaluate the strength of composite using FEM, the concept of smart composite was simulated on computer Thus, in this paper, the FEA was carried out at two critical temperature conditions; room temperature and high temperature(363k). The finite element analysis result was compared with the test result for the analysis validity.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권9호
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• pp.3611-3634
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• 2015

In this paper, we build a theoretical framework for quantitatively measuring and graphically representing the degrees of closeness centralization among performers assigned to enact a workflow procedure. The degree of closeness centralization of a workflow-performer reflects how near the performer is to the other performers in enacting a corresponding workflow model designed for workflow-supported organizational operations. The proposed framework comprises three procedural phases and four functional transformations, such as discovery, analysis, and quantitation phases, which carry out ICN-to-WsoN, WsoN-to-SocioMatrix, SocioMatrix-to-DistanceMatrix, and DistanceMatrix-to-CCV transformations. We develop a series of algorithmic formalisms for the procedural phases and their transformative functionalities, and verify the proposed framework through an operational example. Finally, we expatiate on the functional expansion of the closeness centralization formulas so as for the theoretical framework to handle a group of workflow procedures (or a workflow package) with organization-wide workflow-performers.