• Journal of Ginseng Culture
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• v.3
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• pp.54-73
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• 2021

The Natural Products Research Institute (NPRI, 生藥硏究所), an institution affiliated with Keijo Imperial University (京城帝國大學), was the predecessor of the NPRI at Seoul National University and a comprehensive research institute that focused on ginseng research during the Japanese colonial era. It was established under the leadership of Noriyuki Sugihara (杉原德行), a professor of the second lecture in pharmacology at the College of Medicine in Keijo Imperial University. Prof. Sugihara concentrated on studying Korean ginseng and herbal medicine beginning in 1926 when the second lecture of pharmacology was established. In addition to Prof. Sugihara, who majored in medicine and pharmacology, Kaku Tenmin (加來天民), an assistant professor who majored in pharmacy; Tsutomu Ishidoya (石戶谷勉), a lecturer who majored in agriculture and forestry; and about 36 researchers actively worked in the laboratory before the establishment of the NPRI in 1939. Among these personnel, approximately 14 Korean researchers had basic medical knowledge, derived mostly from specialized schools, such as medical, dental, and pharmaceutical institutions. As part of the initiative to explore the medicinal herbs of Joseon, the number of Korean researchers increased beginning in 1930. This increase started with Min Byung-Ki (閔丙祺) and Kim Ha-sik (金夏植). The second lecture of pharmacology presented various research results in areas covering medicinal plants in Joseon as well as pharmacological actions and component analyses of herbal medicines. It also conducted joint research with variousinstitutions. Meanwhile, in Gaesong (開城), the largest ginseng-producing area in Korea, the plan for the Pharmaceutical Industry Complex was established in 1935. This was a large-scale project aimed at generating profits through research on and the mass production of drugs and the reformation of the ginseng industry under collaboration among the Gaesong Ministry, Kwandong (關東) military forces, Keijo Imperial University, and private organizations. In 1936 and 1938, the Gyeonggi Provincial Medicinal Plant Research Institute (京畿道立 藥用植物硏究所) and the Herb Garden of Keijo Imperial University (京城帝國大學 藥草園) and Pharmaceutical Factory were established, respectively. These institutions merged to become Keijo Imperial University's NPRI, which wasthen overseen by Prof. Sugihara as director. Aside from conducting pharmacological research on ginseng, the NPRI devoted efforts to the development and sale of ginseng-based drugs, such as Sunryosam (鮮麗蔘), and the cultivation of ginseng. In 1941, the Jeju Urban Test Center (濟州島試驗場) was established, and an insecticide called Pancy (パンシ) was produced using Jeju-do medicinal herbs. However, even before research results were published in earnest, Japanese researchers, including Prof. Sugihara, hurriedly returned to Japan in 1945 because of the surrender of Japanese forces and the liberation of Korea. The NPRI was handed over to Seoul National University and led by Prof. Oh Jin-Sup (吳鎭燮), a former medical student at Keijo Imperial University. Scholars such as Woo Lin-Keun (禹麟根) and Seok Joo-Myung (石宙明) worked diligently to deal with the Korean pharmaceutical industry.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.47 no.1
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• pp.1-11
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• 2014

This study was carried out to investigate nutritional and physiologically active characterizations of sikhae and the seasoned products from the sea squirt Halocynthia roretzi. The total taste values of sikhae fermented for 4 and 5 days were 10.9 and 15.4, respectively, which was lower than for commercially seasoned sea squirts. The sikhaes contained mostly glutamic and aspartic acids. The total amino acid contents of sikhaes fermented for 4 and 5 days were 5.5 and 6.0 g/100 g, respectively, which were lower than those of commercial seasoned-sea squirts or similar. An amount of 100 g of sikhae and its seasoned products contained P, K, Mg and Fe, and these minerals, which are deemed good for our health, were at 10% above the recommended daily requirements. The functional properties of sikhae fermented for 4 and 5 days were as follows: for ACE inhibiting activity, 69 and 69.5%, respectively; for antioxidative activity, 28.9 and 29.3%, respectively; for xanthine oxidase inhibitory activity, 52.8 and 53.1%, respectively; and for ${\alpha}$-glucosidase inhibitory activity, 2.4 and 1.4%, respectively. Antimicrobial activity of the 5 day fermented sikhae against Vibrio parahaemolyticus and Staphyloccus aureus was detected in 8 mm and in 7 mm against Escherichia coli.

• Journal of Digital Convergence
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• v.18 no.11
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• pp.73-79
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• 2020

With the recent strengthening of local autonomy and the recognition of the culture and tourism industry as a driving force for the fourth industrial revolution, the importance of research on the revitalization of the local culture and tourism industry is further emphasized. Thus, in this paper, the concept and type of local culture and tourism products were summarized and the research direction was presented through this. As a research method, the internal and external factors of the culture and tourism industry in Korea were used as the SWOT analysis method. In the text, three representative sites were selected and analyzed for the development of local cultural and tourism products, and Seoul, Jeju Island, and Gyeongju all found that they lacked local cultural and tourism products. It also found another value through its role of cultural development as well as the economic aspect of the development of cultural tourism products. In order to revitalize the local culture and tourism industry, which has become more important, the government proposed measures to promote differentiated creative products, efficient marketing, and legal security in various ways. In order for this study to be better data for researchers in the culture and tourism industry and related industries, research should be conducted with detailed surveys that could not be conducted due to various restrictions in the future.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.56 no.1
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• pp.26-36
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• 2020

Thousands of pelagic and demersal fishes inhabit the waters around Korea and many of them are overexploited. One of the reasons is technological development, which increases the efficiency of the vessels continuously. The analysis was conducted to identify the change of fishing power index to develop the vessel and gear technology that may have improved the fishing efficiency of the otter trawl fishery from 1960s to 2010s. Gross tonnage was decreased stably, but horse power was increased annually. The perimeter of net mouth was somewhat longer, but little changed. Color fish finder was utilized from the mid-1960s. Hydraulic net drum were introduced in the early 1990s, and supply rate was gradually increased. Surveys on the supply and upgrading of fishing equipment utilized visiting research. Therefore, the relative fishing power index in the trawl fishery increased about two to three times in the 2010s compared to the 1980s. The results are expected to contribute to reasonable fisheries stock management.

• Journal of the Korea Furniture Society
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• v.19 no.6
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• pp.439-446
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• 2008

High Tech Design manner is a design concept that had been constantly discussed in constitution process of the West art history and modem ideology and had been experimented in industry, having started from futurism and structuralism in the early 20th century through Kinetic Art & Technology Art and up to now. High Tech Design had a great influence also on Post Modernism and more important is that this manner of design will be existing continually in the future too. From the modem times when machine civilization started, the artist and designers expressed a utopia will showing the future world with help of High Tech Design and modem people are realizing technology images as a utopia, in the space and material presented by this high tech design. And this utopia imply the images of dynamic power, speed making a voyage in universe, dream of future, hope, mass production, earth's environment, wealth etc. High Tech furniture was lightly designed by using thin steel wire, structure stressing the metallic characteristic and tempered glass, and it was used for presenting a convenient interior space visually, and with that it can make a unified sense in High Tech interior space, and a contrary effect compared with minimal space. High Tech Design equipped with glass and metal materials looking inappropriate for our interior space due to their sharp and cold image has been regularly used as living furniture, not only decoration function, and then there must be reasons for that. This study intends to research how High Tech Design has been changed and developed in the design history & West art history from the early 20th century, and to present it's value of development as data orienting, namely a direction for the industry of the next-generation and furniture design.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.49 no.4
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• pp.352-359
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• 2013

To estimate the mesh selectivity of gillnet for ocellate spot skate (Okamejei kenojei), the field tests were carried out 12 times with six different mesh sizes (121.2mm, 137.7mm, 151.5mm, 168.3mm, 178.2mm, 189.4mm) in the coastal waters of Taean, Chungcheongnamdo of Korea, 2010~2011. In the field tests, the total number of species was 31, and that of catch was 1,410 and the total weight was 618,006g. The number and weight of ocellate spot skate which is main target in this study were 1,004 and 434,592g, respectively. The catch in number of ocellate spot skate occupied about 71.2% in total catch. The others of catch species were marbled sole (8.4%), sea raven (4.4%), japanese swimming crab (4.2%) and flatfish (4.1%) and so on. The range of body disk width (DW) of ocellate spot skates which were caught in this study was 15.2~35cm and the mode was 27~29cm. The estimation equation of mesh selectivity using the extended Kitahara's method was expressed as s $(R)=s(DW/m)={\exp}\{(-0.56R^3-1.80R^2+12.96R-9.99)-4.26\}$. The optimum value of DW/m for 1.0 of retention probability in this estimation equation was estimated 1.899 and DW/m was estimated to be 1.194, 1.314, 1.395, 1.461 and 1.520 when the retention probability were 0.1, 0.2, 0.3, 0.4 and 0.5, respectively. When applied to the retention probability of 0.5, the optimum mesh size was estimated to be 177.0mm on first maturity disk width 26.9cm of ocellate spot skate.

• Nutrition Research and Practice
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• v.8 no.2
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• pp.132-137
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• 2014

BACKGROUND/OBJECTIVES: In this study, the apoptogenic activity and mechanisms of cell death induced by hexane extract of aged black garlic (HEABG) were investigated in human leukemic U937 cells. MATERIALS/METHODS: Cytotoxicity was evaluated by MTT (3-(4, 5-dimethyl-thiazol-2-yl)-2, 5-diphenyl tetrazoliumbromide) assay. Apoptosis was detected using 4,6-diamidino-2-phenyllindile (DAPI) staining, agarose gel electrophoresis and flow cytometry. The protein levels were determined by Western blot analysis. Caspase activity was measured using a colorimetric assay. RESULTS: Exposure to HEABG was found to result in a concentration- and time-dependent growth inhibition by induction of apoptosis, which was associated with an up-regulation of death receptor 4 and Fas legend, and an increase in the ratio of Bax/Bcl-2 protein expression. Apoptosis-inducing concentrations of HEABG induced the activation of caspase-9, an initiator caspase of the mitochodrial mediated intrinsic pathway, and caspase-3, accompanied by proteolytic degradation of poly(ADP-ribose)-polymerase. HEABG also induced apoptosis via a death receptor mediated extrinsic pathway by caspase-8 activation, resulting in the truncation of Bid, and suggesting the existence of cross-talk between the extrinsic and intrinsic pathways. However, pre-treatment of U937 cells with the caspase-3 inhibitor, z-DEVD-fmk, significantly blocked the HEABG-induced apoptosis of these cells, and increased the survival rate of HEABG-treated cells, confirming that HEABG-induced apoptosis is mediated through activation of caspase cascade. CONCLUSIONS: Based on the overall results, we suggest that HEABG reduces leukemic cell growth by inducing caspase-dependent apoptosis through both intrinsic and extrinsic pathways, implying its potential therapeutic value in the treatment of leukemia.

• Journal of The Korean Association of Information Education
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• v.18 no.2
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• pp.265-274
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• 2014

Rising rate of IT industry in world economy, major countries strengthen IT education. Especially, Owing to SW become significant in IT industry, curriculums of school to enlarge SW education are made in major country. Korea Association of Information Education have studied a new curriculum and suggest a new plan that content of information education classify by 'computer system', 'SW production' and 'fusion activity'. Therefore we study on a curriculum for information of SW production of elementary and middle school. In this paper we firstly suggest object to achieve on information of SW production of elementary and middle school. Next we suggest teaching learning method and evaluation method on them. we expect that the object to achieve on information of SW production we suggest will contribute to develop the curriculum of ICT subject.

• Journal of the Korean Society of Costume
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• v.59 no.2
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• pp.59-69
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• 2009

This study aims to identify how Korean women's traditional costume, Hanbok, has changed according to the times in terms of color coordination of Jeogori and Chima. Photos had been taken at wedding places and streets at 5 major cities(Seoul, Pusan, Kwangju, Daejon, Jeju) at two weekends of each season in 1999, 2001, and 2003. Total 1617 photos were used as final data. Data were analyzed by hue coordination and value level. Hue coordination exist in one-color and two-color coordination. In one-color coordination, red color(R & RP) was the most frequently used and blue green(BG) was the next, and the least was blue purple(BP) for each year. In value scale, high level was the most frequent and followed by middle level and low level. Pink was the most preferred color for one-color coordination. In two-color coordination, white and blue were widely used for Jeogori and red and blue far chima for each year, which seemed to be the basic color coordination for Jeogori and Chima. While there was a certain basic color coordination types across year, but a few new color coordination appeared each year and maintained as popular color coordination for one or two year.

• Mycobiology
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• v.34 no.2
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• pp.67-72
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• 2006

Efficacy of resistance induction by the bacterial isolates Pseudomonas putida (TRL2-3), Micrococcus luteus (TRK2-2) and Flexibacteraceae bacterium (MRL412), which were isolated from the rhizosphere of plants growing in Jeju Mountain, were tested in a greenhouse. The disease severity caused by Phytophthora infestans was effectively reduced in the potato plants pre-inoculated with bacterial isolates compared with those of the untreated control plants growing in a greenhouse. In order to estimate the level of protection by the bacterial isolates, Mancozeb WP (Diesen $M^{(R)}$, Kyong nong) and DL-3-amino butyric acid (BABA) were pre-treated, whereas Dimethomorph WP ($Forum^{(R)}$, Kyong nong) and phosphonic acid ($H_{3}PO_{3}$) were post-treated the challenge inoculation with the pathogen. Disease severities of chemical pre-treated as well as post-treated plants were reduced compare to those of the untreated. The disease reduction in the plants pre-treated with Mancozeb WP was the highest, whereas that of post-treated with Dimethomorph WP was the lowest. The yields of plants pre-inoculated with three bacterial isolates were greatly increased than those of control plants. These results suggest that biological control by bacterial isolates might be an alternative strategy against late blight disease in potato plants growing in greenhouse.