• Title/Summary/Keyword: Interaction Matrix

Search Result 532, Processing Time 0.027 seconds

Advanced Analytical Techniques for Dissolved Organic Matter and Their Applications in Natural and Engineered Water Treatment Systems (최근 용존 유기물 분석 기법 및 자연환경과 수 처리 시스템 내 활용방안)

  • Lee, Yun Kyung;Hur, Jin
    • Journal of Korean Society on Water Environment
    • /
    • v.38 no.1
    • /
    • pp.31-42
    • /
    • 2022
  • Dissolved organic matter (DOM), which changes according to various factors, is ubiquitously present from natural environments to engineered treatment systems. Only limited information is available regarding the environmental functions of DOM after bulk analyses are only applied for characterization. In this paper, latest DOM analytical techniques are briefly introduced, which include fluorescence excitation-emission matrix with parallel factor analysis (EEM-PARAFAC), size-exclusion chromatography with an organic carbon detector (SEC-OCD), carbon/nitrogen stable-isotope ratio, and Fourier transform-ion cyclotron resonance-mass spectroscopy (FT-ICR-MS). Recent examples of using advanced analyses to interpret the phenomena associated with DOM occurring in natural and engineered systems are presented here. Through EEM-PARAFAC, different components like protein-like, fulvic-like, and humic-like can be identified and tracked individually through the investigated systems. SEC-OCD allows researchers to quantify different size fractions. FT-ICR-MS provides thousands of molecular formulas present in bulk DOM samples. Lastly, carbon/nitrogen stable-isotope ratio offers reasonable tools for tracking the sources in environments. We also discuss the advantages and weakness of the above-mentioned characterizing tools. Specifically, they focus on single environmental factors (different sourced-DOM and interaction of sediment-pore water) or simple changes after individual treatment processes. Through collaboration with the advanced techniques later, they help the researchers to better understand environmental behaviors in aquatic systems and serve as essential tools for addressing various pending problems associated with DOM.

Snail Promotes Cancer Cell Proliferation via Its Interaction with the BIRC3

  • Rho, Seung Bae;Byun, Hyun-Jung;Kim, Boh-Ram;Lee, Chang Hoon
    • Biomolecules & Therapeutics
    • /
    • v.30 no.4
    • /
    • pp.380-388
    • /
    • 2022
  • Snail is implicated in tumour growth and metastasis and is up-regulated in various human tumours. Although the role of Snails in epithelial-mesenchymal transition, which is particularly important in cancer metastasis, is well known, how they regulate tumour growth is poorly described. In this study, the possible molecular mechanisms of Snail in tumour growth were explored. Baculoviral inhibitor of apoptosis protein (IAP) repeat-containing protein 3 (BIRC3), a co-activator of cell proliferation during tumourigenesis, was identified as a Snail-binding protein via a yeast two-hybrid system. Since BIRC3 is important for cell survival, the effect of BIRC3 binding partner Snail on cell survival was investigated in ovarian cancer cell lines. Results revealed that Bax expression was activated, while the expression levels of anti-apoptotic proteins were markedly decreased by small interfering RNA (siRNA) specific for Snail (siSnail). siSnail, the binding partner of siBIRC3, activated the tumour suppressor function of p53 by promoting p53 protein stability. Conversely, BIRC3 could interact with Snail, for this reason, the possibility of BIRC3 involvement in EMT was investigated. BIRC3 overexpression resulted in a decreased expression of the epithelial marker and an increased expression of the mesenchymal markers. siSnail or siBIRC3 reduced the mRNA levels of matrix metalloproteinase (MMP)-2 and MMP-9. These results provide evidence that Snail promotes cell proliferation by interacting with BIRC3 and that BIRC3 might be involved in EMT via binding to Snail in ovarian cancer cells. Therefore, our results suggested the novel relevance of BIRC3, the binding partner of Snail, in ovarian cancer development.

Numerical Formulation of Thermo-Hydro-Mechanical Interface Element (열-수리-역학 거동 해석을 위한 경계면 요소의 수식화)

  • Shin, Hosung;Yoon, Seok
    • Journal of the Korean Geotechnical Society
    • /
    • v.38 no.9
    • /
    • pp.45-52
    • /
    • 2022
  • Because discontinuity in the rock mass and contact of soil-structure interaction exhibits coupled thermal-hydromechanical (THM) behavior, it is necessary to develop an interface element based on the full governing equations. In this study, we derive force equilibrium, fluid continuity, and energy equilibrium equations for the interface element. Additionally, we present a stiffness matrix of the elastoplastic mechanical model for the interface element. The developed interface element uses six nodes for displacement and four nodes for water pressure and temperature in a two-dimensional analysis. The fully coupled THM analysis for fluid injection into a fault can model the complicated evolution of injection pressure due to decreasing effective stress in the fault and thermal contraction of the surrounding rock mass. However, the result of hydromechanical analysis ignoring thermal phenomena overestimates hydromechanical variables.

Influence of Blending Method on the Generation of Wear Particulate Matters and Physical Properties in TBR Tire Tread Compounds

  • Sanghoon Song;Junhwan Jeong;Jin Uk Ha;Daedong Park;Gyeongchan Ryu;Donghyuk Kim;Kiwon Hwang;Sungwook Chung;Wonho Kim
    • Elastomers and Composites
    • /
    • v.58 no.4
    • /
    • pp.161-172
    • /
    • 2023
  • Because particulate matter has emerged as a major contributor to air pollution, the tire industry has conducted studies to reduce particulate matters from tires by improving tire performance. In this study, we compared the conventional blending method, in which rubber, filler, and additives are mixed simultaneously, to the Y-blending method, in which masterbatches are blended. We manufactured carbon black (CB)-filled natural rubber (NR)/butadiene rubber (BR) blend and silica-filled epoxidized NR/BR blend compounds to compare the effects of the two blending methods on the physical properties of the compounds and the amount of particulate matter generated. The Y-blending method provided uniform filler distribution in the heterogeneous rubber matrix, improved processability, and exhibited low rolling resistance. This method also improved physical properties owing to the excellent filler-rubber interaction. The results obtained from measuring the generation of particulate matter indicated that, the Y-blending method reduced PM2.5 particulate matter generation from the CB-filled and silica-filled compounds by 38% and 60%, and that of PM10 by 29% and 67%, respectively. This confirmed the excellence of the Y-blending method regarding the physical properties of truck bus radial tire tread compounds and reduced particulate matter generated.

Design of Translator for generating Secure Java Bytecode from Thread code of Multithreaded Models (다중스레드 모델의 스레드 코드를 안전한 자바 바이트코드로 변환하기 위한 번역기 설계)

  • 김기태;유원희
    • Proceedings of the Korea Society for Industrial Systems Conference
    • /
    • 2002.06a
    • /
    • pp.148-155
    • /
    • 2002
  • Multithreaded models improve the efficiency of parallel systems by combining inner parallelism, asynchronous data availability and the locality of von Neumann model. This model executes thread code which is generated by compiler and of which quality is given by the method of generation. But multithreaded models have the demerit that execution model is restricted to a specific platform. On the contrary, Java has the platform independency, so if we can translate from threads code to Java bytecode, we can use the advantages of multithreaded models in many platforms. Java executes Java bytecode which is intermediate language format for Java virtual machine. Java bytecode plays a role of an intermediate language in translator and Java virtual machine work as back-end in translator. But, Java bytecode which is translated from multithreaded models have the demerit that it is not secure. This paper, multhithread code whose feature of platform independent can execute in java virtual machine. We design and implement translator which translate from thread code of multithreaded code to Java bytecode and which check secure problems from Java bytecode.

  • PDF

A Generalized Adaptive Deep Latent Factor Recommendation Model (일반화 적응 심층 잠재요인 추천모형)

  • Kim, Jeongha;Lee, Jipyeong;Jang, Seonghyun;Cho, Yoonho
    • Journal of Intelligence and Information Systems
    • /
    • v.29 no.1
    • /
    • pp.249-263
    • /
    • 2023
  • Collaborative Filtering, a representative recommendation system methodology, consists of two approaches: neighbor methods and latent factor models. Among these, the latent factor model using matrix factorization decomposes the user-item interaction matrix into two lower-dimensional rectangular matrices, predicting the item's rating through the product of these matrices. Due to the factor vectors inferred from rating patterns capturing user and item characteristics, this method is superior in scalability, accuracy, and flexibility compared to neighbor-based methods. However, it has a fundamental drawback: the need to reflect the diversity of preferences of different individuals for items with no ratings. This limitation leads to repetitive and inaccurate recommendations. The Adaptive Deep Latent Factor Model (ADLFM) was developed to address this issue. This model adaptively learns the preferences for each item by using the item description, which provides a detailed summary and explanation of the item. ADLFM takes in item description as input, calculates latent vectors of the user and item, and presents a method that can reflect personal diversity using an attention score. However, due to the requirement of a dataset that includes item descriptions, the domain that can apply ADLFM is limited, resulting in generalization limitations. This study proposes a Generalized Adaptive Deep Latent Factor Recommendation Model, G-ADLFRM, to improve the limitations of ADLFM. Firstly, we use item ID, commonly used in recommendation systems, as input instead of the item description. Additionally, we apply improved deep learning model structures such as Self-Attention, Multi-head Attention, and Multi-Conv1D. We conducted experiments on various datasets with input and model structure changes. The results showed that when only the input was changed, MAE increased slightly compared to ADLFM due to accompanying information loss, resulting in decreased recommendation performance. However, the average learning speed per epoch significantly improved as the amount of information to be processed decreased. When both the input and the model structure were changed, the best-performing Multi-Conv1d structure showed similar performance to ADLFM, sufficiently counteracting the information loss caused by the input change. We conclude that G-ADLFRM is a new, lightweight, and generalizable model that maintains the performance of the existing ADLFM while enabling fast learning and inference.

Roles of Acid-Base Surface Interaction on Thermal and Mechanical Interfacial Behaviors of SiC/PMMA Nanocomposites (산-염기 표면반응이 탄화규소/PMMA 나노복합재료의 열적·기계적 계면특성에 미치는 영향)

  • Park, Soo-Jin;Oh, Jin-Seok
    • Korean Chemical Engineering Research
    • /
    • v.43 no.5
    • /
    • pp.632-636
    • /
    • 2005
  • In this work, the effect of chemical treatments on surface properties of SiC was investigated in thermal and mechanical interfacial behaviors of SiC/PMMA nanocomposites. The acid/base value, contact angles, and FT-IR analysis were performed for the study of surface characteristics of the SiC studied. The thermal stabilities of the SiC/PMMA nanocomposites were investigated by thermogravimetric analysis (TGA). Also the mechanical interfacial properties of the composites were studied in critical stress intensity factor ($K_{IC}$) and critical strain energy release rate ($G_{IC}$) measurements. As a result, the acidically treated SiC (A-SiC) had higher acid value than that of untreated SiC (V-SiC) or basically treated SiC (B-SiC). The acidic solution treatment led to an increase in surface free energy of the SiC, mainly due to the increase of its specific component. Thermal and mechanical interfacial properties of the SiC/PMMA nanocomposites, including initial decomposition temperature (IDT), $K_{IC}$, and $G_{IC}$ had been improved in the acidic treatment on SiC. This was due to the improvement in the interfacial bonding strength, resulting from the acid-base interfacial interactions between the fillers and polymeric matrix.

Estimating Interregional Trade Coefficient of Service Industry using the Gravity Model (중력모형을 이용한 서비스업의 지역간 교역계수 추정)

  • Yun, Kap-Sik;Kim, Jae-Koo
    • Journal of the Economic Geographical Society of Korea
    • /
    • v.13 no.3
    • /
    • pp.457-469
    • /
    • 2010
  • The study aims to estimate interregional trade coefficient of service industry using the gravity model. The gravity model has been widely used for prediction of the level of human interaction between two regions which is positively related to attraction of them and negatively related to the distance between them. To apply the gravity model for explaining the interregional trade flow of service industry, the choice of proper proxy variables which represent a dependent variable and independent variables is most important. However, the literature shows that there are few studies on this issue. Four models concerned to the choice of proxy variables are considered. Finally, this paper employs the least-squares regression analysis to test the model's goodness-of-fit, and suggests the most appropriate model based on the result from the analysis. The result shows that the interregional trade of service industry in regional input-output table developed by The Bank of Korea is desirable as a dependent variable, the service industry output of export region, the population of import region, and the spatial distance between regions are desirable as independent variables.

  • PDF

Comparative Assessment of Usability of Web-storming System between Administrator and Designer Groups in Space Design Process (공간디자인 프로세스에서 관리자·실무자 그룹의 웹스토밍 시스템 활용성 비교평가)

  • Choi, Gil-Dong;Kim, Kwang-Myung
    • The Journal of the Korea Contents Association
    • /
    • v.11 no.9
    • /
    • pp.154-165
    • /
    • 2011
  • Considering the online idea generation, or web-storming, system would be used differently by space designers depending on their job characteristics, the present study tested the usability of web-storming using a factor correlation table with a designer group in the field. Then, for analyses, the results were compared with the previous findings on the usability of web-storming in a design administrator group to suggest comprehensive measures applicable to web-storming. The questionnaire results were analysed following a process of observation-interpretation-application, and the space design process and web-storming function factors were also analysed based on a factor correlation table. The analyses found that the most correlated space design process in both administrator and designer groups was the schematic design phase, and that the correlation started to lower upon division of labour. The assessment phase was found significantly different between the designer group and the administrator group. The assessment phase showed the second highest correlation in the designer group. In terms of the aspects related to project operation, the correlation was found higher in the designer group. Based on the findings, new applicable measures to each phase of web-storming were derived and summed up to suggest how to take advantage of web-storming in the field.

Multiscale modeling of reinforced/prestressed concrete thin-walled structures

  • Laskar, Arghadeep;Zhong, Jianxia;Mo, Y.L.;Hsu, Thomas T.C.
    • Interaction and multiscale mechanics
    • /
    • v.2 no.1
    • /
    • pp.69-89
    • /
    • 2009
  • Reinforced and prestressed concrete (RC and PC) thin walls are crucial to the safety and serviceability of structures subjected to shear. The shear strengths of elements in walls depend strongly on the softening of concrete struts in the principal compression direction due to the principal tension in the perpendicular direction. The past three decades have seen a rapid development of knowledge in shear of reinforced concrete structures. Various rational models have been proposed that are based on the smeared-crack concept and can satisfy Navier's three principles of mechanics of materials (i.e., stress equilibrium, strain compatibility and constitutive laws). The Cyclic Softened Membrane Model (CSMM) is one such rational model developed at the University of Houston, which is being efficiently used to predict the behavior of RC/PC structures critical in shear. CSMM for RC has already been implemented into finite element framework of OpenSees (Fenves 2005) to come up with a finite element program called Simulation of Reinforced Concrete Structures (SRCS) (Zhong 2005, Mo et al. 2008). CSMM for PC is being currently implemented into SRCS to make the program applicable to reinforced as well as prestressed concrete. The generalized program is called Simulation of Concrete Structures (SCS). In this paper, the CSMM for RC/PC in material scale is first introduced. Basically, the constitutive relationships of the materials, including uniaxial constitutive relationship of concrete, uniaxial constitutive relationships of reinforcements embedded in concrete and constitutive relationship of concrete in shear, are determined by testing RC/PC full-scale panels in a Universal Panel Tester available at the University of Houston. The formulation in element scale is then derived, including equilibrium and compatibility equations, relationship between biaxial strains and uniaxial strains, material stiffness matrix and RC plane stress element. Finally the formulated results with RC/PC plane stress elements are implemented in structure scale into a finite element program based on the framework of OpenSees to predict the structural behavior of RC/PC thin-walled structures subjected to earthquake-type loading. The accuracy of the multiscale modeling technique is validated by comparing the simulated responses of RC shear walls subjected to reversed cyclic loading and shake table excitations with test data. The response of a post tensioned precast column under reversed cyclic loads has also been simulated to check the accuracy of SCS which is currently under development. This multiscale modeling technique greatly improves the simulation capability of RC thin-walled structures available to researchers and engineers.