• 종양간호연구
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• 제10권1호
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• pp.80-87
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• 2010

Purpose: This study was aimed to analyze the contents and trend of published research in oncology nursing during the past five years in Korea and to suggest the direction for future research. Methods: Using the key words "cancer", "cancer patients", and "tumor", 391 nursing research published from 2003 to 2008 were selected for the analysis. Results: 1) Three hundred fifty-five (90.8%) of the studies used quantitative research approach, whereas most studies were descriptive in nature. 2) The main subjects of the study were cancer patients with mixed diagnosis (36.4%) and breast cancer patients (20.0%). 3) Complementary alternative therapy (28.9%), educational program (25.6%), and psycho-social and spiritual program (16.7%) were the most frequently used nursing interventions. Most frequently measured outcome variables were psycho, socio, and spiritual factors (38.8%), symptoms (28.2%) and physiological factors (14.6%). 4) Most frequently used key words were identified as quality of life, fatigue, coping, pain, anxiety, anorexia, and depression. Conclusion: The number of published research in oncology nursing in Korea has been increased. It is suggested to conduct international studies to develop, compare, and replicate nursing interventions for patients with cancer in future. Increasing funding, establishing research infrastructure, and removing methodological challenges are warranted for better research environment.

• 사상체질의학회지
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• 제23권3호
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• pp.285-293
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• 2011

1. Objectives: This study examines the pathologies that originate from a Common Root Pathologic Category(CRPC; 同出一屬) in the Soyangin that are suggested in the Sasang Constitutional Medicine(SCM). 2. Methods: The changes in concepts and perceptions on the Soyangin pathologies were compared across the different editions of Donguisusebowon, "Donguisusebowon, Gabo edition(東醫壽世保元甲午本) (DGO)" and "Donguisusebowon, Sinchuk edition (東醫壽世保元辛丑本) (DSC)". 3. Results and Conclusions: The Soyangin pathologies originating from a CRPC that are described in Donguisusebowon are actually detailed classifications of the Yin-deficiency Diurnal-heat symptomatology (陰虛午熱證) and the Chest-congestion symptomatology (結胸證). Lee Jema had introduced the concept of "Common Root Pathologic Category(CRPC)" to approach pathologies of similar exterior/interior classification or severity stage (mild/moderate/severe/critical) by combining them in a comprehensive, integrative pathology system. This comprehensive approach, which promotes better understanding of the Soyangin pathology and maximizes the therapeutic efficiency of SCM, constitutes the "Comprehensive Therapeutic Methodology" that is the hallmark of Sasang therapy.

• 성인간호학회지
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• 제24권1호
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• pp.52-63
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• 2012

Purpose: The purpose of this study was to measure the quality of life (QOL) and to identify the factors influencing QOL in gynecological cancer patients. Methods: The subjects of this study were 242 people who were receiving medical therapy or follow-up after surgery from one general hospital in Daegu. Data were collected from August 1, 2010 to January 31, 2011. A questionnaire including questions on QOL, distress score, distress problem, depression, anxiety, insomnia, perceived health status and body image were completed by the subjects. Results: The mean score of QOL was $70.68{\pm}13.40$. Religion, job, presence of spouse, level of education, household income, financial compensation, disease stage and recurrence were the significant factors related to QOL. Distress score, distress problem, depression, anxiety, insomnia, perceived health status and body image were also significant factors influencing QOL. Sixty eight percent of the variance in subjective overall QOL can be explained by body image, distress problem, distress score, anxiety, level of education and perceived health status (Cum $R^2$=0.689, F=76.316, $p$ <.001). Body image was the most important factor related to QOL. Conclusion: An integrative care program which includes general, disease-related and psychosocial characteristics of patients is essential to improve QOL in gynecological cancer patients.

• 대한암한의학회지
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• 제13권1호
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• pp.33-42
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• 2008

Objective: To investigate a clinical effect of Taichichuan training focussing on improvement of quality of life in cancer patients. Methods: The subject of study consisted of 10 cancer patients at the East-West Cancer Center of Dunsan Oriental hospital. The survey method of this study is Functional Assessment of Cancer Therapy-General (FACT-G) korean version. Patients performed Taichichuan twice a week and filled out FACT-G questionnaire before and after training. Results: Although total FACT-G score decreased 0.7 point after training, emotional well-being score increased 1.0 point after training. Male improved FACT-G score better than female. Over 50 age improved FACT-G score better than under 50 age. Over stage Ⅲ improved FACT-G score better than Under Stage II. Patients who were treated integrative treatment improved FACT-G score better than patients who were only treated conventional treatment. But all results were not significant statistically. Conclusions: Emotional well-being tends to improve after training, but this study cannot proved Taichichuan training improve quality of life in cancer patients. Well designed advanced study will be needed to prove its benefits.

• 대한한방내과학회지
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• 제38권5호
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• pp.820-827
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• 2017

The prevalence of breast cancer is very high in Korea. Although the patients receive standard treatments, such as surgery, chemotherapy, or radiotherapy, they frequently experience recurrence or metastasis of their tumors. In addition, many patients with breast cancer also suffer from side effect symptoms induced by these standard treatments. Therefore, increasing numbers of patients now want to undergo treatment with traditional Korean medicine (TKM) in addition to conventional treatment. We present a case of 46-year-old female with recurred breast cancer. She first received two kinds of chemotherapy and then underwent surgery. She then also received 4 cycles of adjuvant chemotherapy. At a follow-up examination, she was informed of recurrent lesions on the right anterior chest wall. She started to receive TKM treatments together with a new chemotherapy. After about one month, the size of the recurred tumor in right chest wall had decreased. Her symptoms, such as shoulder pain, chest pain, and nausea induced by conventional therapy, were also improved. We suggest that a combination of TKM and chemotherapy is a promising treatment for breast cancer.

• 대한물리의학회지
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• 제15권4호
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• pp.55-65
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• 2020

PURPOSE: This study examined the effects of breathing exercises via joint mobilization on the lung function and spinal alignment of 30 straight-necked women in their 20 s and 30 s. METHODS: The participants were divided into two groups: an experimental group who performed breathing exercises via joint mobilization, and a control group who performed general stretching exercises. The differences between the two groups were measured and compared at three points in time: during the pre-examination, after four weeks of intervention, and after a four-week maintenance period. The changes in each group were measured before and after the intervention and after a one-month maintenance period and compared. For data analysis, the SPSS 22 was used to obtain the mean and standard deviation with a significance level of α = .05. RESULTS: Eight weeks of breathing exercises via joint mobilization and general stretching exercises positively impacted the lung function and spinal alignment in straight-necked patients. In particular, the experimental group showed more significant differences in spinal alignment after four weeks period of intervention and four weeks of maintenance. CONCLUSION: Breathing exercises via joint mobilization can be considered an effective intervention that can improve the respiratory volume and spinal alignment for patients with straight necks.

• 한국동물학회지
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• 제8권2호
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• pp.23-27
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• 1965

The present study is an analysis of some alterations occurring in the population of folliclesin the ovary treated with the gonadotrophins in intact and unilaterally ovariectomized mice. the differences between the findings inthe intact and semispayed animals and those in gonadotrophintreated intact and semispayed animals were disucssed. 1) When mice were semispayed at the stage of diestrus, the remaining ovary showed an increase of secondary follicles in number, while a decrease of atretic folicles, compared with those in intact animals. 2) After injection of PMS and HCG following semispaying at the diestrus stage, the remaining ovary contained larger number of secondary follicles and corpora lutea than those in semispayed animals with no treatment , while showed smaller number of atretic follicles. 3) It is sure that follicular development is remarkably accelerated in the intact mice treated with PMS and HCG. 4) The effect of PMS and HCG on the follicular development was gradually decreased with time in the intact and semispayed animals afte rexogenous hormone therapy. 5) It is believed in the experiment that a decrease of follicular atresia in number and an increase of secondary follicles may be responsible for compensatory reaction after semispaying.

• PNF and Movement
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• 제7권1호
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• pp.33-46
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• 2009

Purpose : N.A.P.(Neuromuscular Skeletal Plasticity) an integrative neuro-orthopedic concept to facilitate motor strategies in daily life. The primary thesis is, that treatment of body functions and structural impairments should be integrated within goal-oriented activities. The purpose of this article is to demonstrate that the functional activity itself, determines the structure. Material and Methods : A case report of a dentist with brachial plexus lesion after a motor vehicle accident is presented. The necessity for training body functions within relevant tasks is undermined by references which emphasize the importance of training realistic activities to enhance long-term changes in neural representation. Results : The treatment methods presented in this case show significant effects for the patient's ability to participate in his profession within less than a year's time after his motor vehicle accident. Conclusions : Current evidence supports the treatment methods of this concept. The inability to flex his elbow and supinate his forearm placed a considerable doubt to his ability to ever be able to participate in his profession again. Structural reorganization is possible and depends on functional demands, which need to be trained task-specifically. Single case reports may serve as the basis for further randomized controlled studies to support the efficacy of the treatment methods within the N.A.P. concept.

• Animal cells and systems
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• 제15권1호
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• pp.9-17
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• 2011

Colorectal cancer is the third leading cause of cancer-related death in Western countries. Chemotherapeutic agents with different mechanisms of action have shown an increase in cure rates. In the present study, we investigated the effect of a combination of low concentration of paclitaxel (taxol, 5 nM) and topoisomerase 1 inhibitor camptothecin (CPT) on HCT116 colon cancer cells. Although the viability of cells treated with taxol alone was similar to that of control cells, sequential treatment with taxol and CPT exhibited high cytotoxicity. However, the opposite sequence of treatment did not exert cytotoxic effects on HCT116 cells. This enhanced cytotoxicity of the sequential combination therapy was the result of mitotic arrest, which increased the level of $p21^{Cip1/WAF1}$ through the p38 mitogen-activated protein kinase (MAPK) pathway. Knockdown by $p21^{Cip1/WAF1}$ siRNA or treatment with a p38 inhibitor reduced the viability of cells sequentially exposed to taxol and CPT. Taken together, a low taxol concentration in combination with CPT induced mitotic arrest in HCT116 cells, leading to synergistic cell death through enhanced expression of $p21^{Cip1/WAF1}$ and p38 MAPK pathway. Therefore, taxol could playa role as a sensitizer of CPT in colon cancer cells.

• 한국임상수의학회지
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• 제25권6호
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• pp.476-481
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• 2008

A retrospective study of 17 dogs with hyperadrenocorticism (HAC) was performed to evaluate the clinical and clinicopathological outcomes in dogs with pituitary-dependent HAC or adrenal gland-dependent HAC. Sixteen dogs were monitored at day 10, 30 and 90 then every 3 month after first presentation. In each examination, physical examination and ACTH stimulation test and client questionnaire were performed. In 17 cases, eight dogs were successfully treated with mitotane therapy (median dose 16.7 mg/kg; range 5.3 to 50 mg/kg, SID); another one dog showed favorable response, but the clients declined to further treatment before the full control of the disease had been achieved; four dogs showed poor response to treatment. One dog was euthanized due to septicemia. These results showed canine HAC can be medically managed successfully without side effects at the doses used in this study.