• 대한한방내과학회지
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• 제43권2호
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• pp.320-325
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• 2022

Objective: The purpose of this report is to present the effects of integrative cancer treatment (ICT) on a patient diagnosed with glioblastoma multiforme (GBM). Methods: A 71-year-old male GBM patient received ICT from May 14 to October 12, 2021 and concurrently received temozolomide and radiotherapy. The effect on symptoms was evaluated using a visual analog scale (VAS), and changes in tumor size were assessed using magnetic resonance imaging. Results: After treatment, the VAS score for nausea decreased from 5 to 1, and the tumor size also reduced. Conclusion: ICT could be effective in treating GBM patients by reducing the size of the tumor as well as alleviating the side effects.

• 대한통합의학회지
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• 제9권2호
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• pp.165-172
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• 2021

Purpose : This study was conducted to find out the effect on the activity of trunk and lower limbs muscles during abdominal drawing-in bridging exercises by verbal cue on the unstable supporting surface after pelvic rearward sloping taping for trunk stabilization movement. Methods : The study subjects were recruited by using the on-campus bulletin boards for healthy adult males and females in their 20s attending K University in Changwon-city, South Gyeongsang Province. The subjects were 30 persons (15 males and 15 females) who agreed to the study purpose in accordance with the criteria for selection and exclusion. Results : The results were obtained by measuring the muscle activity of the trunk and lower limbs during abdominal drawing-in bridging exercises by verbal cue on the unstable supporting surface after pelvic fixed tapping. The effects on erector spinae and hamstring muscles was statistically significantly lower (p<.05), it was confirmed that there were no statistically significant differences between the multifidus and gluteus maximus muscle (p>.05). Conclusion : Through this study, it was found that the excessive flexion of the waist was significantly reduced from erector spinalis and hamstring muscle after abdominal drawing-in bridging exercises by verbal cue on the unstable supporting surface after pelvic rearward sloping tapping compared to the general bridging exercises.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.276-284
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• 2023

Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved in the development progress of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. The objective of this study was to investigate the effect of SA in microglia neuroinflammation models. Our results demonstrated that SA inhibited secretion of the nitric oxide (NO) and interleukin (IL)-6, reduced the expression of inducible nitric oxide synthase (iNOS) and enhanced the release of IL-10 in a dose-dependent manner. Besides, our further investigation revealed that SA attenuated the phosphorylation of AKT and MAPK cascades in LPS-induced microglia. Consistently, oral administration of SA in mouse regulated the production of inflammation-related cytokines and also suppressed the phosphorylation of MAPK cascades and AKT in the mouse cerebral cortex. These results suggested that SA may be a possible therapy candidate for anti-inflammatory activity by targeting the AKT/MAPK signaling pathway.

• 대한감각통합치료학회지
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• 제9권2호
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• pp.29-39
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• 2011

목적 : 본 연구는 고유-전정감각 중심의 감각통합중재가 감각방어를 가진 아동의 적응반응에 미치는 효과를 알아보고자 하였다. 연구방법 : 연구 대상은 2011년 감각통합치료과정에 참여한 만 6세 5개월 된 남아이다. 평가결과에 따라 치료목표, 치료계획을 제시하였고, 4회기 동안의 적응반응을 기술하였다. 결과 : 치료회기 동안 아동은 과 각성 되지 않고 촉각활동에 참여할 수 있었으며, 사회적 상호작용의 질적인 측면에서 향상을 보였고, 놀이에서도 확장을 보였다. 결론 : 본 연구를 통하여 고유-전정감각 중심의 감각통합 중재가 감각방어 아동의 적응반응에 긍정적인 영향을 미치는 것을 알 수 있었다. 그러나 향후 연구에서는 표준화된 평가를 통한 변화와 더불어 일상에서의 변화를 제시하는 것이 필요할 것으로 사료된다.

• 대한약침학회지
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• 제16권4호
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• pp.14-21
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• 2013

Objectives: The objective of this study was to examine how an integrated approach to type 2 diabetes mellitus treatment could improve glycemic control and immune-potentiating activities adherent to oral hypoglycemic agents along with a botanical compound, among primary care patients. Methods: In this study, we used the self-control and the group-control methods. Candidates meeting the trial conditions were selected from among volunteers who had taken the test substance for 45 days. During the trial, all groups were on a controlled diet; neither were the original medications nor their dosages changed. Results: The results showed that the botanical compound (Glyco-Persica$^{(R)}$) significantly reduced the main clinical symptoms in diabetes type 2. In the treatment group, 36 of 52 patients (69.23%) and in the control group 10 of 52 patients (19.23%) showed reduced symptoms, and this difference was statistically significant (P < 0.05). The fasting blood sugar in the treatment group after treatment compared with that before treatment and with that in the control group after treatment was statistically different (P < 0.05). The post-prandial glucose in the treatment group after treatment was significantly different from that before treatment and from that in the control group after treatment (P < 0.05); the post-prandial blood sugar in the treatment group was reduced by 8.98%. Conclusions: The results revealed that the botanical compound (Glyco-Persica$^{(R)}$) has significant hypoglycemic properties which affect main clinical symptoms in diabetes type 2. Body weight, blood pressure, heart rate, routine blood, stool and urine tests showed no meaningful negative changes after the course of treatment. There was no significant adverse reaction during the trial.

• 대한통합의학회지
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• 제7권1호
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• pp.99-112
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• 2019

Purpose : The purpose of this study was to analyze Korean qualitative research studies on cerebral palsy and provide a basis for future direction of research. Methods : Twenty-six articles were selected by searching 4 Korean databases (NDSL, DBpia, KISS, and RISS) and reviewing the list of additional references. All the articles were analyzed and assessed using the Consolidated criteria for Reporting Qualitative research (COREQ). Results : Seventeen qualitative studies and 9 mixed quantitative and qualitative studies were selected, and methodologies such as case study (42.3 %), constant comparative method (23.1 %) and phenomenology (23.1 %) were used. The studies investigated the effects of interventions (38.5 %), support programs (30.8 %), and life experiences (26.9 %). Among the participants, 50.0 % were persons with disabilities only, 19.2 % were parents only, and 30.8 % were combination of persons with disabilities, parents, teachers, and therapists. The number of participants in most studies was 2-9 (57.7 %). The COREQ evaluation of the selected articles revealed many shortcomings in the studies. Interview guidelines were used only in 26.9 % of the studies. In particular, many articles did not describe in detail the characteristics of researchers and the relationship between researchers and the participants. Conclusion : In future, various research methodologies and research checklists must be used to stimulate high-quality qualitative research with on cerebral palsy.

• 대한한방내과학회지
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• 제43권4호
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• pp.751-760
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• 2022

Objective: To show a decrease in tumor recurrence and improvement in quality of life in patients with recurrent cervical cancer. Method: A 58-year-old female patient diagnosed with recurrent cervical cancer in February 2021 was treated for 14 months with integrative cancer treatment (ICT) to decrease the tumor size and improve chemotherapy-induced peripheral neuropathy (CIPN) and nausea. The patient underwent chemotherapy or concomitant chemoradiation therapy (CCRT) with ICT. Radiologic outcomes were assessed by abdomen & pelvis computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography-computed tomography (PET-CT) based on the Response Evaluation Criteria in Solid Tumors (RECIST) protocol. Clinical outcomes were assessed by the National Cancer Institute Common Terminology Criteria for Adverse Event (NCI-CTCAE), Eastern Cooperative Oncology Group (ECOG), and a numeric rating scale (NRS). Result: During the 14 months of treatment, the size and metabolic activity of the recurrent tumor decreased and underwent partial remission based on RECIST. The NRS scores for CIPN and nausea were improved, and the ECOG score improved from grade 2 to 1. No serious side effects of grade 3 or higher were noted on the NCI-CTCAE test. Conclusion: This case suggests that ICT may have a synergetic effect with chemotherapy or radiotherapy for recurrent cervical cancer.

• 산업융합연구
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• 제21권5호
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• pp.87-95
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• 2023

본 연구는 국내 노인을 대상으로 한 변비 비약물적 중재 연구에 대한 통합적 문헌고찰을 통해 노인 변비 비약물적 중재에 대한 특성과 효과를 분석하여 노인 변비 비약물적 중재 프로그램 개발을 위한 방향을 제시하기 위해 시행되었다. 2개의 국내 검색엔진을 통해 2010년 1월부터 2023년 1월까지 발표된 문헌을 검색하였으며, 11편의 문헌을 최종 분석하였다. 연구결과 노인 변비 비약물적 중재유형은 복부마사지, 발마사지, 지압, 뜸요법, 생활습관중재, 탄산수 섭취, 복합요법이 있었으며, 중재의 효과로 변비, 수면의 질, 우울을 확인하였다. 비약물적 중재 모두 노인 변비에 유의한 효과가 있었으며, 발마사지, 지압의 경우 노인의 수면의 질, 우울에도 유의한 효과가 있었다. 그러나 노인의 변비 관련 삶의 질을 확인한 연구는 없는 실정으로 추후, 노인의 삶의 질을 고려한 변비 비약물적 중재 프로그램 개발 및 적용이 필요하다.

• 한방재활의학과학회지
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• 제34권3호
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• pp.97-106
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• 2024

The aim of this case report was to present the effects of intensive integrative Korean medicine treatment in a patient with lower back pain, both under extremity numbness, neck pain induced by adrenoleukodytrophy. A 49-year-old male patient was treated with Cheongpajeon-H, acupuncture, pharmacoacupuncture (Shinbaro2), chuna therapy for total 50 days of hospitalization. Lower back pain, both under extremity numbness, neck pain were assessed with a Oswestry disability index (ODI), Vernon-Mior neck disability index (NDI), numeric rating scale (NRS) and EuroQoL-5 dimension (EQ-5D). With 50 days of treatment, the pain was relieved from NRS 6 to 2. EQ-5D score increased from 0.75 to 0.779, ODI decreased from 34 to 15.56, NDI decreased from 30 to 15.56. These results show that lower back pain, both under extremity numbness, neck pain can be relieved with intensive integrative Korean medicine treatment. However, further well-designed studies are required to confirm these findings.

• 대한감각통합치료학회지
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• 제14권2호
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• pp.33-45
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• 2016

목적 : 아동을 대상으로 실시한 그룹 작업치료에 대한 효과를 체계적 고찰을 통해 알아보고 이를 통해 아동 그룹작업치료에 대한 근거를 마련하고자 한다. 연구방법 : 국외 검색 데이터베이스는 Pubmed와 Ovid를 국내 검색 데이터베이스는 학술연구정보서비스(RISS), 한국학술정보(KISS), 디비피아(DBpia)를 사용하여 2014년까지의 국외/국내 학회지를 검색하였다. 국외/국내 검색어를 다르게 사용하여 총 14개의 연구를 선정하였으며 근거의 질적 수준에 따라 나누고 PICO(Patient, Intervention, Comparison, Outcome) 형식으로 정리하였다. 결과 : 대상자는 정상아동보다 진단을 받은 아동이 많았고, 감각통합장애 아동(28.6%)이 가장 많았다. 중재방법은 그룹감각통합치료(40%)가 가장 많았고, 중재 결과 분석을 위해 사용된 평가 영역 및 평가도구로는 사회성(31.0%)을 측정하기 위한 것이 가장 많았다. 중재 효과는 통계학적으로 유의한 결과가 전체의 40.7%이었다. 결론 : 앞으로 아동을 대상으로 실시하는 그룹 작업치료는 다양한 진단군을 대상으로 폭 넓은 중재내용을 통해 높은 근거수준의 효과가 입증 되어야 할 것이다.