• BMB Reports
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• v.37 no.1
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• pp.93-106
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• 2004

The new complexity arising from the genome sequencing projects requires new comprehensive post-genomic strategies: advanced studies in regulatory mechanisms, application of new high-throughput technologies at a genome-wide scale, at the different levels of cellular complexity (genome, transcriptome, proteome and metabolome), efficient analysis of the results, and application of new bioinformatic methods in an integrative or systems biology perspective. This can be accomplished in studies with model organisms under controlled conditions. In this review a perspective of the favourable characteristics of yeast as a touchstone model in post-genomic research is presented. The state-of-the art, latest advances in the field and bottlenecks, new strategies, new regulatory mechanisms, applications (patents) and high-throughput technologies, most of them being developed and validated in yeast, are presented. The optimal characteristics of yeast as a well-defined system for comprehensive studies under controlled conditions makes it a perfect model to be used in integrative, 'systems biology' studies to get new insights into the mechanisms of regulation (regulatory networks) responsible of specific phenotypes under particular environmental conditions, to be applied to more complex organisms (e.g. plants, human).

• Journal of Information Technology Services
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• v.6 no.1
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• pp.101-126
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• 2007

This study aims to construct the integrative performance evaluation model of informatization programs. In order to achieve the purpose of research, first of all, the three major theoretical paradigms (technical/functional, economic/financial, and interpretive/alternative paradigms) are comparatively analyzed concerning their philosophical and methodological perspectives. Also, a number of important studies and research model in the area of IS (Information Systems) evaluation are critically reviewed. And then actual problems and limitations on the process of implementing IS performance evaluation are sought through investigating domestic and foreign practices. Based upon theoretical and practical review of informatization evaluation and logical reasoning, the components of ideal performance evaluation scheme for informatization program are derived, and the integrative performance evaluation model which can comprehensively represent the relationship among the components is conceptually proposed. For researchers, this study provides the theoretical basis for reasonably deriving the performance variables of informatization programs and empirically validating the performance of managing informatization programs. And in real world, the results of this study are very likely to contribute to presenting the practical guideline for desirably implementing performance evaluation of informatization programs.

• Journal of Fisheries and Marine Sciences Education
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• v.20 no.3
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• pp.462-472
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• 2008

Education is a field that has tried to make use of the advantages of computers since they were introduced to the world. Intelligent Tutoring System and multimedia have become methods of teaching students of Computer Science, Education, Psychology, and Cognitive Science. Until now, they have been designed and produced only on the basis of a very specific domain and format. However, in the education field, most learners ask for integrated service that is practical, realizable, and sensitive to technological change. Therefore, in this study, we would like to present the technological and formal integration model as an ITS model which acknowledges changes in the fields of technology and education. As a technological integration model, the integration model of traditional Symbolic Artificial Intelligence and Artificial Neural Networks was presented. As a formal integration model, three integration models were presented according to (a) the process of learning diagnosis (b) learners' action behaviors (c) intelligence service respectively.

• The Journal of the Korea Contents Association
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• v.19 no.10
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• pp.325-340
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• 2019

The purpose of this paper is to develop and suggest an integrative leadership contingency framework of leadership that will state the situational and psychological factors under which leadership effect should be maximized. Our leadership model presents that situational factors, including development, circumstances urgency and task structure, proposes which of transformational, transactional, empowering, and authentic leadership solutions. Also, our integrative leadership contingency model in turn results in a combination of the level of follower commitment, intrinsic motivation, and individual creativity based on inductive research method. This integrative leadership model suggested here has significant contributions for leadership effectiveness and future leadership research agenda. Next leadership research could experimentally examine the structural relationships between each of the leadership styles and levels of contingency and psychological factors of followers.

• Journal of Oriental Neuropsychiatry
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• v.35 no.2
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• pp.191-203
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• 2024

Objectives: To evaluate the effectiveness of an integrated medical service model for a fibromyalgia patient and their caregiver, focusing on reducing pain and improving quality of life. Methods: A single-case study design was employed, involving a fibromyalgia patient and their primary caregiver treated at W University Hospital. The integrated medical service program, based on the Ministry of Health and Welfare's model, included medical consultations and complementary therapies such as psychological counseling, art therapy, music therapy, horticultural therapy, yoga, and meditation. The program was conducted weekly for 8 weeks, with each session lasting up to 100 minutes. Data collection involved both quantitative and qualitative assessments. Quantitative data included demographic surveys, psychological tests, health-related quality of life measures, pain indices, and sleep quality indices. Qualitative data were gathered through feedback evaluations and emotional assessments. Results: The patient showed improvements in mobility, self-care, daily activities, and anxiety/depression, with EQ-VAS scores increasing from 20 to 40 and pain perception decreasing from 67.41 to 42.58. The caregiver reported reduced anxiety/depression and an increase in EQ-VAS scores from 95 to 98. Both patient and caregiver exhibited emotional changes, with decreased depression and increased happiness. However, the patient showed an increase in fear and anger. Conclusions: The integrated medical service model positively impacted the emotional and psychological well-being of the fibromyalgia patient and their caregiver. Despite the limitations of a small sample size and a single-case study design, the findings suggest that an integrated approach can be beneficial. Larger-scale studies are needed to confirm and generalize these results.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2004.11a
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• pp.55-60
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• 2004

This paper aims to provide a multi-dimensional integrative model that can give a comprehensive account for human space experience. Human space experience is too complicated phenomenon, so space designer need to understand about mechanism of space cognition. From psychological point of view, I analyze the mechanism that is based on emotional reaction. This model consist of three dimensions: sensory, reflexive, and reflective dimension. Assuming this model, we have attempt the typological analysis to the space by studying human space experience. Finally, the outcome provides how space designer use this effect for application of human experience.

• Knowledge Management Research
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• v.3 no.1
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• pp.107-119
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• 2002

Under the current dynamic business environment, the corporate knowledge resources are becoming more complicated and diverse. In order to manage these resources effectively, it is necessary to develop an integrative metaschema which accommodates various characteristics of the resources. From this perspective, this paper proposes an integrative metaschema which can manage three types of knowledge resources: schematic model, hypermedia information, and document file. This metaschema can help store and reuse knowledge in a systematic and consistent way. Furthermore, it can support useful and flexible search logics. To demonstrate the usefulness of the metaschema, a prototype system and a real-life bank case are illustrated.

• Journal of Ginseng Research
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• v.46 no.5
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• pp.690-699
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• 2022

Background: Few studies reported the therapeutic effect of Korean Red Ginseng (KRG) in lung inflammatory diseases. However, the anti-inflammatory role and underlying molecular in cadmium-induced lung injury have been poorly understood, directly linked to chronic lung diseases (CLDs): chronic obstructive pulmonary disease (COPD), cancer etc. Therefore, in this study we aim to investigate the therapeutic activities of water extract of KRG (KRG-WE) in mouse cadmium-induced lung injury model. Method: The anti-inflammatory roles and underlying mechanisms of KRG-WE were evaluated in vitro under cadmium-stimulated lung epithelial cells (A549) and HEK293T cell line and in vivo in cadmium-induced lung injury mouse model using semi-quantitative polymerase chain reaction (RT-PCR), quantitative real-time PCR (qPCR), luciferase assay, immunoblotting, and FACS. Results: KRG-WE strongly ameliorated the symptoms of CdSO4-induced lung injury in mice according to total cell number in bronchoalveolar lavage fluid (BALF) and severity scores as well as cytokine levels. KRG-WE significantly suppressed the upregulation of inflammatory signaling comprising mitogen-activated protein kinases (MAPK) and their upstream enzymes. In in vitro study, KRG-WE suppressed expression of interleukin (IL)-6, matrix metalloproteinase (MMP)-2, and IL-8 while promoting recovery in CdSO₄-treated A549 cells. Similarly, KRG-WE reduced phosphorylation of MAPK and c-Jun/c-Fos in cadmium-exposed A549 cells. Conclusion: KRG-WE was found to attenuate symptoms of cadmium-induced lung injury and reduce the expression of inflammatory genes by suppression of MAPK/AP-1-mediated pathway.

• Journal of the Korean Home Economics Association
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• v.37 no.12 s.142
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• pp.179-192
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• 1999

Thesedays, Home Economic in Korea is faced with the danger of a discord caused by the outer pressure of reorganization in the process educational reformation. The first purpose of this study was to examine the characteristics of the informatized society and the changes of families lived in the informatized society. The second was to assert to strengthen Home Economics in the informatized society. Ultimately we suggested an integrative and interdisciplinary model about Home Economics from the ecological and informative perspective. This model consist with three parts: Human development(Child studies, Gerontology, & Adolescent studies) and family studies division(Family relation studies, family resource management studies, & Consumer studies) Environmental division(Clothing and Textiles, Food and Nutrition, & Housing) and HEIS(Home Economics Information System). This classification is correspond with the one Human-Behavioral Environment and Human-Constructed Environment of Ecological theory.

• Journal of Information Technology Applications and Management
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• v.16 no.1
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• pp.51-75
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• 2009

This paper develops an integrative model for IT continuance in the internet shopping environments by integrating the expectation-confirmation and the switching cost factors. Using this model, in addition, this study investigates their differential effects on the mediating variables, such as user satisfaction, commitment, and trust which have been identified as antecedents of users' IT continuance intention. Results show that the product and service-related expectation confirmation factors and the relational switching cost factor can have greater impacts on users continuance intention than the web site design factors, and the financial and procedural switching cost factors. In particular, it is interesting to note that relational switching cost can lead users to more commitment, which is revealed as the strongest antecedent of their continuance intention to use a certain shopping site.