• 한국동물학회:학술대회논문집
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• 한국동물학회 2003년도 한국생물과학협회 학술발표대회
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• pp.154.2-154
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• 2003

No Abstract, See Full Text

• 한국동물학회:학술대회논문집
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• 한국동물학회 1999년도 한국생물과학협회 학술발표대회
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• pp.312.2-312
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• 1999

No Abstract, See Full Text

• Journal of Ginseng Research
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• 제44권3호
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• pp.519-526
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• 2020

Background: Bisphenol A (BPA), known as an endocrine disruptor, is widely used in the world. BPA is reported to cause inflammation-related diseases. Korean Red Ginseng (KRG) has been used safely in human for a long time for the treatment of diverse diseases. KRG has been reported of its mitigating effect on menopausal symptoms and suppress adipose inflammation. Here, we investigate the protective effect of orally administered KRG on the impacts of BPA in the liver and uterus of menopausal mice model. Methods: The transcriptome analysis for the effects of BPA on mice liver was evaluated by Gene Expression Omnibus (GEO) database-based data (GSE26728). In vivo assay to evaluate the protective effect of KRG on BPA impact in ovariectomized (OVX) mice were designed and analyzed by RNA sequencing. Results: We first demonstrated that BPA induced 12 kinds of gene set in the liver of normal mice. The administration of BPA and KRG did not change body, liver, and uterine weight in OVX mice. KRG downregulated BPA-induced inflammatory response and chemotaxis-related gene expression. Several gene set enrichment analysis (GSEA)-derived inflammatory response genes increased by BPA were inhibited by KRG in OVX mice. Conclusion: Our data suggest that BPA has commonly influenced inflammatory response effects on both normal and OVX mice. KRG protects against BPA impact of inflammatory response and chemotaxis in OVX mouse models. Our comparative analysis will provide new insight into the efficacy of KRG on endocrine disrupting chemicals and OVX mouse.

• Molecular & Cellular Toxicology
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• 제3권1호
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• pp.1-10
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• 2007

The persistent and ubiquitous environmental contaminant, tributyltin chloride (TBT), induces not only imposex in gastropods but also the differentiation of adipocytes in vitro and increases adipose mass in vivo in vertebrates. TBT is a nanomolar affinity ligand for retinoid X receptor (RXR) in the rock shell(Thais clavigera) and for both the RXR and the peroxisome proliferator activated receptor $\gamma(PPAR\gamma)$ in the amphibian (Xenopus laevis), mouse, and human. The molecular mechanisms underlying induction of imposex by TBT have not been clarified, though several hypotheses are proposed. TBT promotes adipogenesis in the murine 3T3-L1 cell model and perturbs key regulators of adipogenesis and lipogenic pathways in vivo primarily through activation of RXR and $PPAR\gamma$. Moreover, in utero exposure to TBT leads to strikingly elevated lipid accumulation in adipose depots, liver, and testis of neonate mice and results in increased adipose mass in adults. In X. laevis, ectopic adipocytes form in and around gonadal tissues following organotin, RXR or $PPAR\gamma$ ligand exposure. TBT represents the first example of an environmental endocrine disrupter that promotes adverse effects from gastropods to mammals.

• 디지털융복합연구
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• 제19권8호
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• pp.75-88
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• 2021

4차산업혁명 시대의 도래와 더불어 융합형 인재양성의 중요성이 부각 되고 있고 이러한 교육을 담당할 예비교사들의 융합수업(STEAM) 구성 능력의 함양이 양질의 미래 교육을 담보할 이슈로 떠오르고 있다. 이에 본 연구는 진정한 융합교육이 이루어지기 위해서는 교수자의 면밀한 피드백의 역할과 기능이 예비교사들의 역량 강화에 주요한 요소임을 제시하며, 교육학에 있어서 피드백에 관한 제반 이론이 이러닝을 활용한 대학 수업에서 예비교사들의 융합적 지식형성을 어떻게 지원하는지를 분석하였다. 예비교사들은 STEAM 수업지도안을 작성하는 과정에서 4단계의 조별 활동과 그에 걸맞은 피드백을 제공 받았으며 5단계에서는 이를 바탕으로 개별 수업지도안을 완성하였다. 수업지도안의 완성 후에는 설문조사를 실시하여 예비교사들의 인식을 조사하였다. 단계별로 적용된 통합적 피드백의 세부적 내용과 융합적 수업구성 역량의 향상 과정을 사다리이론을 근거로 하여 모델링 하였다. 이러한 전략적 모형은 예비교사들의 융합적 지식과 역량을 제고할 뿐 아니라 그들의 성취도와 만족도 향상에도 기여하였다.

• 동의신경정신과학회지
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• 제33권3호
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• pp.259-266
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• 2022

Objectives: The combination of Harm-Avoidance (HA) and Self-Directedness (SD) of Temperament and Character Inventory (TCI) has been reported pivotal for mental health; however its clinical usefulness in integrative medicine has not sufficiently reported. The purpose of this study was to illustrate multi-phasic mental health of subjective satisfaction with life, emotional well-being, and psychopathology, following the HA-SD profile groups. Methods: A total of 527 Korean university students reported HA and SD scores as to render their HA-SD profile, and multi-phasic mental health characteristics using Satisfaction with Life Scale (SWLS), Positive Affect and Negative Affect Schedule (PANAS), and Beck Depression Inventory (BDI) with composite well-being scales of SC (Sum of Self-Directedness and Cooperativeness score) and HI (Happiness Index, subtraction of Negative Affect (NA) score from Positive Affect (PA) score) as standardized. Pearson's correlation was used to report correlation coefficient, and the ANCOVA with age and sex as covariates, to show significant differences in mental health and well-being between the HA-SD profile groups. Results: The HA-SD profile groups showed distinctive multi-phasic mental health characteristics; health related scores of SWLS, PA, SC and HI decreased following the order of hS (low HA and high SD), HS (high HA and high SD), hs (low HA and low SD) and Hs (high HA and low SD) profile groups; however the non-health related scores of NA and BDI showed contrasting order. Conclusions: The HA-SD profile was found to be clinically useful for examining multi-phasic mental health and well-being status, and the TCI may be an imperative personality inventory for integrative medicine.

• Animal cells and systems
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• 제12권4호
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• pp.203-209
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• 2008

Berberine, an isoquinoline alkaloid found in Coptidis Rhizoma(goldenthread) extract, has multiple pharmacological effects such as anti-inflammatory, antimicrobial and anti-ischemic effects. In the present study, we examined the effects of berberine on neuronal survival and differentiation in a hippocampal precursor cell line and in the memory deficient rat model. Berberine increased in a dose dependent manner the survival of hippocampal precursor cells as well as differentiated cells. In addition, berberine promoted neuronal differentiation of hippocampal precursor cells. In the memory deficient rat model induced by stereotaxic injection of ibotenic acid into entorhinal cortex(Ibo model), hippocampal cells were increased about 2.7 fold in the pyramidal layer of CA1 region and about 2 fold in the dentate gyrus by administration of berberine after 2 weeks of ibotenic acid injection. Furthermore, neuronal cells immunoreactive to calbindin were increased in the hippocampus and entorhinal cortex area by administration of berberine. Taken together, these results suggest that berberine has neuroprotective effect in the Ibo model rat brain by promoting the neuronal survival and differentiation.

• Journal of Hospice and Palliative Care
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• 제22권3호
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• pp.105-116
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• 2019

목적: 소아청소년 호스피스 완화의료(이하 소아완화의료)는 생명을 위협하는 질환을 가진 소아청소년의 삶의 질을 향상시기 위한 총체적 돌봄 철학이자 실무의 표준이다. 국내에서는 2018년 7월 국가 지원의 소아완화의료 시범사업을 도입하였는데, 소아완화의료의 발전 방향을 제시하기 위해 국외 선진국의 소아완화의료 제공체계를 고찰하였다. 방법: 소아완화의료 제공 수준을 검토하여 영국, 미국, 일본, 싱가포르를 대상으로 선정하였다. 소아완화의료 제공체계를 다룬 국내외 학술지 등 문헌을 통합적으로 고찰하고 현지 전문가의 자문과 현지 방문조사를 수행하였다. 1990년 이후 영어, 일본어로 발간된 문헌을 중심으로 PubMed, Google, Google Scholar에서 검색하여 학술지, 정책보고서 등을 참고하였다. 각국의 소아완화의료 발전과정, 정책, 재정 모델, 대상 기준, 전달 체계, 질 관리 체계에 대해 분석하였다. 결과: 영국은 지역사회의 독립형 소아전문 완화의료기관이 일차 의료체계와 협력하며 어린이병원의 전문 소아완화의료 자문팀과 의뢰와 자문을 주고받는다. 미국은 병원기반의 전문 소아완화의료 자문팀을 중심으로 지역사회의 호스피스기관, 가정의료기관이 네트워크를 구축하고 돌봄 코디네이터를 지정하여 소아완화의료를 제공한다. 일본은 완화의료, 재택의료, 장애아동 및 만성질환아동 지원체계에서 완화의료 성격의 서비스를 제공한다. 싱가포르는 소아전문 가정 완화의료 단체가 어린이병원의 전문 자문팀과 협력하여 높은 지리적 접근성을 토대로 중추적으로 완화의료를 제공한다. 결론: 국외의 제공체계를 참고하고 국내의 현장의 요구를 반영하여 소아완화의료의 제공체계를 정비하여 미충족 요구가 발생하지 않도록 한국 소아청소년 호스피스완화의료를 최적화해 나가야 한다.

• 대한통합의학회지
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• 제6권1호
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• pp.15-24
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• 2018

Purpose : This study aimed to identify the effects parent-adolescent intimacy, parent-adolescent communication, and empathy on the clinical competency of nursing students. Method : Data were collected by 175 nursing students using a self-questionnaire from May 17 to 31, 2017. The data were analyzed with the SPSS 21.0 using an independent t-test, Pearson correlation coefficients, and multiple regression. Result : There were significant positive correlations between clinical competency and the other variables. The strongest predictors of clinical competency were parent-adolescent intimacy (${\beta}=.33$) and academic record (${\beta}=.21$), and the model explained 11.3% (F=16.04, p<.001) of the variance. Conclusion : The findings indicated that further studies are needed to explore various factors influencing clinical competency and develop education programs for college nursing students.

• 대한통합의학회지
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• 제2권2호
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• pp.1-12
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• 2014

Purpose : The purpose of this study was to investigate the effect that the academic achievement of the students about the evidence based learning investigates the learning utility value about and the request. Method : The agreement of college students explaining the purpose of research for 12 weeks against 17 students and investigate through a questionnaire. The level of academic achievement according to the sex and claim showed a characteristic with a percentage. An utility investigate the descriptive epidemiologic characteristic about the class of the evidence based learning. Result : The most of college students the level of academic achievement and requests the expected grade of the students about the evidence based learning wanted the 'high' grade of 9 persons, 'middle' grade of 8 persons in the part and the expectation for the class taken so much was high(p<.05). There was the significant different in the utility aspect in the need of the evidence based learning, homework solution, learning synergy effect improvement, and reference search ability improvement(p<.05). Conclusion : These finding revealed that the evidence based learning the satisfaction with class raises the improvement and utility value, and provided the need and the has to develop the educational model which the college students contentment raises an improvement after this opportunity for the new recognition.