• BMB Reports
• /
• v.38 no.4
• /
• pp.486-490
• /
• 2005

Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean $54.3{\pm}9.8$ years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %). However, in patients with CAD the frequency of II genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95% CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.

• The KIPS Transactions:PartA
• /
• v.9A no.2
• /
• pp.225-230
• /
• 2002

The constrained off-line competitive deletion problem is a simple form of the set manipulation operations problem. It excludes the insertion operation from the off-line competitive deletion problem. An optimal sequential algorithm and a CREW PRAM algorithm which runs $O(log^2nloglogn)$ time using O(n/loglogn) processors were already presented in the literature. In this paper, we present a reconfigurable mesh algorithm for the constrained off-line competitive deletion problem. The proposed algorithm is executed in a constant time on an $n{\times}n$ reconfigurable mesh, and the result is $AT^2$ optimal.

• Phonetics and Speech Sciences
• /
• v.1 no.3
• /
• pp.3-18
• /
• 2009

Do loanword properties emerge in the acquisition of a foreign language and if so, how? Classic studies in adult language learning assumed loanword properties that range from near-ceiling to near-chance level of appearance depending on speech proficiency. The present research argues that such variations reflect different phonological types, rather than speech proficiency. To investigate the difference between learner speech and loanword phonology, the current research analyzes the speech data from five different proficiency levels of 92 Korean speakers who read 19 pairs of English words and sentences that contained loanwords. The experimental method is primarily an acoustical one, by which the phonological cause in the loanwords (e.g., the insertion of [$\Box$] at the end of the word stamp) would be attested to appear in learner speech, in comparison with native speech from 11 English speakers and 11 Korean speakers. The data investigated for the research are of segment deletion, insertion, substitution, and alternation in both learner speech and the native speech. The results indicate that learner speech does not present the loanword properties in many cases, but depends on the types of phonological causes. The relatively easy acquisition of target pronunciation is evidenced in the cases of segment deletion, insertion, substitution, and alternation, except when the loanword property involves the successful command of the target phonology such as the de-aspiration of [p] in apple. Such a case of difficult learning draws a sharp distinction from the cases of easy learning in the development of learner speech, particularly beyond the intermediate level of proficiency. Overall, learner speech departs from loanword phonology and develops toward the native speech value, depending on phonological contrasts in the native and foreign languages.

• Journal of Korea Spatial Information System Society
• /
• v.7 no.3 s.15
• /
• pp.55-65
• /
• 2005

This paper presents a bulk insertion technique for efficiently inserting data items. Traditional moving object database focused on efficient query processing that happens mainly after index building. Traditional index structures rarely considered disk I/O overhead for index rebuilding by inserting data items. This paper, to solve this problem, describes a new bulk insertion technique which efficiently induces the current positions of moving objects and reduces update cost greatly. This technique uses buffering technique for bulk insertion in spatial index structures such as R-tree. To analyze split or merge node, we add a secondary index for information management on leaf node of primary index. And operations are classified to reduce unnecessary insertion and deletion. This technique decides processing order of moving objects, which minimize split and merge cost as a result of update operations. Experimental results show that this technique reduces insertion cost as compared with existing insertion techniques.

• The Plant Pathology Journal
• /
• v.22 no.3
• /
• pp.215-221
• /
• 2006

Gibberella zeae (anamorph: Fusarium graminearum) is an important pathogen of cereal crops. This fungus produces a broad range of secondary metabolites, including polyketides such as aurofusarin (a red pigment) and zearalenone (an estrogenic mycotoxin), which are important mycological characteristics of this species. A screen of G. zeae insertional mutants, generated using a restriction enzyme-mediated integration (REMI) procedure, led to the isolation of a mutant (Z43R606) that produced neither aurofusarin nor zearalenone yet showed normal female fertility and virulence on host plants. Outcrossing analysis confirmed that both the albino and zearalenone-deficient mutations are linked to the insertional vector in Z43R606. Molecular characterization of Z43R606 revealed a deletion of at least 220 kb of the genome at the vector insertion site, including the gene clusters required for the biosynthesis of aurofusarin and zearalenone, respectively. A re-creation of the insertional event of Z43R606 in the wild-type strain demonstrated that the 220-kb deletion is responsible for the phenotypic changes in Z43R606 and that a large region of genomic DNA can be efficiently deleted in G. zeae by double homologous recombination. The results showed that 52 putative genes located in the deleted genomic region are not essential for phenotypes other than the production of both aurofusarin and zearalenone. This is the first report of the molecular characterization of a large genomic deletion in G. zeae mediated by the REMI procedure.

• Animal cells and systems
• /
• v.3 no.4
• /
• pp.393-397
• /
• 1999

Length variations in human mitochondrial DNA (mtDNA) offer useful markers in the study of female aspects of human population history. One such length variation is a 9-bp deletion in the small noncoding segment located between the COII and Iysine tRNA genes (COII/tRNA/$^{Lys}$ intergenic region) which usually contain two tandemly arranged copies of a 9-bp sequence (ccccctcta) in human mtDNA. The mtDNA 9-bp deletion and polymorphic variants of expanded 9-bp repeat motif in the intergenic COII/tRNA$^{Lys}$ region have been found at varying frequencies among different human ethnic groups. We have examined the length variation of the mtDNA COII/tRNA$^{Lys}$ intergenic region from a total of 813 individuals in east Asian populations. The occurrence of the 9-bp deletion was found to be relatively homogeneous in northeast Asian populations (Chinese, 14.2%; Japanese, 14.3%: Koreans, 15.5%), with the exception of Mongolians (5.1%). In contrast, Indonesians (25.0%) and Vietnamese (23.2%) of the southeast Asian populations appeared to have relatively high frequencies of the 9-bp deletion. We identified the existence of a new expanded 9-bp repeat motif which likely resulted from a slipped mispairing insertion of six more cytosines in the intergenic COII$^{Lys}$ region. It was present at low frequencies in the Korean (2/349) and Japanese populations (2/147). Based on the results of this study, the Korean population may reflect a close genetic affinity with the Japanese and Chinese populations than the others surveyed east Asian populations.

• Journal of the Korea Society of Computer and Information
• /
• v.15 no.12
• /
• pp.93-100
• /
• 2010

In this paper, we propose a technique which makes it faster to delete prefixes in an IP address lookup architecture based on parallel TCAMs. In previous deletion schemes, more than one memory movement is needed for the prefix ordering and keeping the available memory space consecutive. For deletion, our scheme stores the address of the deleted prefix in a stack implemented by SRAM instead of actual movement in TCAM. Since SRAM has very short latency compared to TCAM, the proposed scheme can accomplish fast updating. From the experiment with the real forwarding table and update trace, we evaluate the performance of our scheme in terms of the memory access time for the prefix insertion and deletion. The experiment result also shows good performance with considerably small size of stack.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.13
• /
• pp.5249-5252
• /
• 2014

Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms by different splicing, named Nogo-A Nogo-B and Nogo-C. Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence the efficiency of transcription and translation thus being related with an individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within RTN4 3'-UTR has been reported to be associated with many cancer types. In order to investigate the relationship between this polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in the Chinese population, we conducted the present case-control study including 411 NSCLC patients and 471 unrelated healthy controls. The genotype distributions were significantly different between cases and controls (p=0.014). We found that the del allele could significantly increase NSCLC risk (ins/ins vs ins/del: p=0.007, OR 1.46, 95%CI=1.11-1.93; dominant model: p=0.004, OR 1.47, 95%CI=1.13-1.92 and allele model: p=0.008, OR 1.35, 95%CI=1.08-1.67). This association was stronger in participants over 60 years old, males and smokers. We therefore conclude that the CAA insertion/deletion polymorphism (rs34917480) contributes to non-small cell lung cancer risk in Chinese population. Age, sex and environmental exposure are also related to carcinogenic effects of rs34917480.

• Korean Journal of Plant Taxonomy
• /
• v.51 no.2
• /
• pp.176-180
• /
• 2021

Arabidopsis thaliana (L.) Heynh. is a small plant species that serves as a model organism of plant biology and genetics. Here, we present the first complete mitochondrial genome of Korean A. thaliana natural isolate (named as 180404IB4), which is 368,875 bp long and contains 58 genes (33 protein-coding genes, 22 tRNAs, and three rRNAs), with a GC ratio of 44.8%. Sixty-four single-nucleotide polymorphisms and 11 insertion and deletion regions (1,089 bp in length) are identified against the Col-0 ecotype, showing one large insertion of 1,069 bp without structural variation. Phylogenetic trees constructed from 30 conserved genes indicate that the 180404IB4 mitochondrial genome is clustered with Col-0 and three East Asian ecotypes.

• Proceedings of the KSRS Conference
• /
• 2007.10a
• /
• pp.3-5
• /
• 2007

Many continuous queries are important to be process efficiently in a data stream environment. It is applied a query index technique that takes linear performance irrespective of the number and width of intervals for processing many continuous queries. Previous researches are not able to support the dynamic insertion and deletion to arrange intervals for constructing an index previously. It shows that the insertion and search performance is slowed by the number and width of interval inserted. Many intervals have to be inserted and searched linearly in a data stream environment. Therefore, we propose Hashed Multiple Lists in order to process continuous queries linearly. Proposed technique shows fast linear search performance. It can be utilized the systems applying a sensor network, and preprocessing technique of spatiotemporal data mining.