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Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme Gene in Coronary Artery Disease in Southern Turkey

  • Acarturk, Esmeray (Cukurova University, School of Medicine, Department of Cardiology) ;
  • Attila, Gulen (Cukurova University, School of Medicine, Department of Biochemistry) ;
  • Bozkurt, Abdi (Cukurova University, School of Medicine, Department of Cardiology) ;
  • Akpinar, Onur (Cukurova University, School of Medicine, Department of Cardiology) ;
  • Matyar, Selcuk (Cukurova University, School of Medicine, Department of Biochemistry) ;
  • Seydaoglu, Gulsah (Cukurova University, School of Medicine, Department of Biostatistics)
  • Published : 2005.07.31

Abstract

Genetic factors are important in the pathogenesis of coronary artery disease (CAD). Angiotensin converting enzyme (ACE) gene insertion(I)/deletion(D) polymorphism is one of the genetic factor found to be related with CAD. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD. Threehundred and seven patients (187 males and 120 females, aged between 35-80, mean $54.3{\pm}9.8$ years) who underwent diagnostic coronary angiography were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. Of the 307, 176 had CAD. The most frequently observed genotype in all subjects was ID (47.9 %). However, in patients with CAD the frequency of II genotype was lower whereas DD genotype was higher compared to the controls (p < 0.05). The number of D allele carrying subjects were also higher (p < 0.05) in CAD patients. The logistic regression analysis indicated that the ACE D allele is an independent risk factor (odds ratio = 1.48, 95% CI = 1.01-2.18, p < 0.05). In conclusion, the I/D polymorphism of ACE gene (carrying D allele) is an independent risk factor for CAD in the studied Turkish population.

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