• 대한족부족관절학회지
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• 제10권2호
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• pp.196-200
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• 2006

Purpose: To study prognostic factors of unilateral calcaneus fracture underwent surgery. Materials and Methods: We selected appropriate 60 cases of 236 calcaneus fracture cases between March 1985 and March 2004, and analyzed the correlation between sex, age, smoking, injury mechanism, Essex-Lopresti classification of calcaneus fracture, preoperative Bohler angle, postoperative Bohler angle, postoperative 1 year Bohler angle and Visual Analogue Scale (VAS), P.S. Kerr's Calcaneal Fracture Score (CFSS). The average age was 41.4 and average follow up period was 74 (12 to 240) months. Results: For follow up period, average VAS is 3.43 and CFSS is 81.23. The sex, age, smoking, injury mechanism, and preoperative, postoperative, postoperative 1 year Bohler angle had no correlation with the prognosis. But the Essex-Lopresti classification of calcaneus fracture, tongue type had better prognosis than joint depression type (VAS : p=0.041, CFSS : p=0.021). Conclusion: In unilateral calcaneus fracture, the sex, age, smoking, injury mechanism, preoperative Bohler angle, postoperative Bohler angle, postoperative 1 year Bohler angle had no correlation with the prognosis of fracture, but in Essex-Lopresti classification, the tongue type fracture had better prognosis than the joint depression type.

• 한국환경보건학회지
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• 제19권3호
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• pp.58-63
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• 1993

In order to elucidate the alteration of drug-metabolizing enzymes and mechanism in the animal with hepatic injury and ketosis, the regulation of P450IIE was studied in the rats with heaptic injury caused by CCl$_4$ and with ketosis caused by streptozotocin and high-fat diet. P450IIE expression in liver was examined by the combination of enzyme activities, Western immunoblot, and mRNA Northern blot analyses using specific polyclonal antibody and cDNA probe for P450IIE. Enzyme activity and amounts of immunoreactive P450IIE were rapidly decreased in a time-dependent manner after a single dose of CCl$_4$ . However, the decreases in P450IIE enzyme activity and immunoreactive protein by CCl$_4$ were not accompanied by a decline in its mRNA level. The data thus suggested a post-translational reduction of P450IIE by CCl$_4$. The enzyme activities (aniline hydroxylase) in hepatic microsomes were elevated about 2-3-fold by streptozotocin and feeding with a high fat diet. This increases in enzyme activities were also accompanied by 3-fold increases in immunoreactive P450IIE protein and its mRNA. Our data thus indicated that P450IIE induction during the ketosis appears to be due to pretranslational activation.

• 한국산학기술학회논문지
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• 제17권9호
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• pp.472-482
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• 2016

본 연구는 노인 손상의 발생이 특정 지역 내 공간의 안전성과 통계적으로 유의한 관계에 있는지를 실증하는 데 목적이 있다. 이러한 연구 목적 수행을 위해 퇴원손상심층조사와 지역안전지수 자료를 결합해 6,572명의 노인 손상환자를 대상으로 손상의도성, 손상발생장소, 손상 시 활동, 손상기전에 따라 지역안전등급의 평균 차이가 있는지를 독립표본 t-검정과 일원배치 분산분석을 통해 검증하였다. 통계 검증 결과 손상의도성의 하위집단별 지역안전등급의 평균 차이는 유의하지 않았으나, 손상발생장소는 화재(t=-2.513, p<.05), 교통(t=-2.387, p<.05), 안전사고(t=-3.627, p<.001), 자살(t=-3.364, p<.01)의 4개 분야에서 집단 간 평균 차이가 있었다. 손상 시 활동은 화재(F=5.972, p<.01), 자연재해(F=6.454, p<.01), 안전사고(F=11.726, p<.001)의 3개 분야에서 집단 간 평균 차이가 있었다. 손상기전은 화재(F=9.267, p<.001), 교통(F=7.759, p<.001), 안전사고(F=3.285, p<.05), 자살(F=8.973, p<.001), 감염병(F=3.109, p<.05)의 5개 분야에서 집단 간 평균 차이가 있었다. 이러한 분석 결과를 토대로 지역안전지수의 개별 분야를 연구 소재로 삼은 선행연구의 보고 내용과 비교해 논의한 후 공간의 안전성 차원에서 노인 손상의 발생을 사전에 예방하고 발생률을 억제하기 위한 3가지의 정책적 실천적 함의를 도출해 제시하였다.

• Toxicological Research
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• 제7권2호
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• pp.113-128
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• 1991

Hepatotoxicity has many facets. Those to be discussed in this review include the mechanism for the hepatotoxic effects, nature of the injury, and animal models of hepatotoxicity suitable for the detection of chemical injury. Some therapeutic drugs used for treatment of hepatitis are also presented. In addition, as an important and serious problem in future, alternative toxicity testing is discussed.

• 자동차안전학회지
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• 제8권3호
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• pp.10-15
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• 2016

The purpose of this study is to evaluate the injury mechanism of facial injury related to an air-bag's deployment in occupant motor vehicle accident (MVA) by using Hospital Information System (HIS) and reconstruction program, based on the materials related to motor vehicle accidents. Among patients who visited the emergency department of Wonju Severance Christian Hospital due to motor vehicle accidents from August 2012 to February 2014, we collected data on patients with agreement for taking the damaged vehicle's photos. After obtaining the verbal consent from the patient, we asked about the cause of the accident, information on vehicle involved in the accident, and the location of car repair shop. The photos of the damaged vehicle were taken on the basis of front, rear, left side and right side. Damage to the vehicle was presented using the CDC code by analytical study of photo-images of the damaged vehicle, and a trauma score was used for medical examination of the severity of the patient's injury. Among the 309 patients with agreement for an investigation, thirty five (11.3 %) were the severe who had ISS over 15. And also, sixteen (5.2%) derived from the reconstructed data (maximum collision energy, maximum acceleration, delta V) by PC-Crash. As a result, ISS including the facial injuries was affected by the condition. It was high when the number of crash extent, the safety belt was not fastened, and the seating position of occupant and the direction of collision is same. For accurate analysis of the relationship between occupant injury and vehicle damage in MVAs, build-up of an in-depth database through carrying out various policies for motor vehicle accidents is necessary for sure.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제29권5호
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• pp.346-348
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• 2003

A facial nerve palsy is described in a patient who underwent IVRO for the correction of a facial asymmetry and anterior openbite. A possible mechanism of facial nerve injury is discussed.

• 대한정형외과학회지
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• 제55권5호
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• pp.383-396
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• 2020

목적: 중등도 이상의 손상 환자를 대상으로 손상의 중증도에 따른 정형외과적 손상의 손상기전, 부위, 유형, 치료적 접근 및 그 치료결과를 분석하고자 한다. 대상 및 방법: 2014년부터 2019년까지 응급실/외상센터가 운영되지 않은 기간을 제외한 57개월 동안 국립중앙의료원 외상센터로 입원한 손상 중증도 점수(Injury Severity Score, ISS) 9점 이상의 환자들 중 정형외과적 손상이 동반된 778명을 대상으로 후향적 연구를 시행하였다. ISS와 생리학적 지표를 기준으로 한 손상의 중증도에 따라 중등도 손상군(1군, 679명)과 중증 손상군(2군, 99명)으로 분류하고 손상기전, 비정형외과적 손상을 평가하였다. 정형외과적 손상은 침범된 해부학적 영역과 골격구조의 수와 유형을 평가하였고, 치료적 접근 방법을 세분화하여 비교하였다. 치료결과는 재원기간을 포함하여 재원기간 내 발현된 전신 합병증과 사망률을 평가하였고 사망률에 미치는 요인을 분석하였다. 결과: 2군이 보다 젊고, 남성의 빈도가 높았고 고에너지 손상기전 및 동반 손상의 빈도가 유의하게 증가되었다. 정형외과적 손상 중 침범된 골격계의 수는 2군에서 유의하게 많아지면서 하지를 주로 침범한 1군에 비해 2군에서는 골반, 척추, 상지 영역의 침범이 유의하게 증가하였다. 정형외과적 손상은 환자의 임상적 상태에 따라 확정적 또는 단계적 치료가 시행되었으며 다발성 중증 손상을 보이는 2군에서는 일시적 외고정술을 이용한 단계적 수술의 빈도가 유의하게 높았고 1군에서는 생리학적 안정화를 이룬 뒤 확정적 수술을 시행하는 빈도가 유의하게 높았다. 중증도가 높아질수록 재원기간 역시 길어졌으며 재원기간 내 총 전신 합병증은 약 4.9%, 총 사망률는 약 4.5%였다. 중증도가 높아질수록 사망률은 유의하게 높아졌다(1군 2.9%, 2군 15.2%; p<0.0001). 사망률에 미치는 요인 중 고령과 높은 ISS가 중요한 요인으로 확인되었다. 결론: 손상의 중등도가 높을수록 고에너지 손상기전에 의한 손상의 발생 빈도가 높아지며 보다 젊고, 남성의 빈도와 동반 손상의 빈도가 높아졌다. 정형외과적 손상 역시 다발성 손상의 빈도와 중증도가 유의하게 증가되면서 정형외과적 외고정장치를 이용한 내고정술 등이 단계적 치료의 일환으로 시행된 경우가 유의하게 높아지는 경향을 보였다. 또한 재원기간, 전신 합병증 및 사망률 역시 유의하게 증가되는 경향을 보이며, 사망률에는 높은 연령과 ISS가 중요한 영향을 미치는 것으로 확인되었다.

• 대한정형외과스포츠의학회지
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• 제7권1호
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• pp.33-36
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• 2008

목적: 축구에 의해 발생한 전방 십자인대 파열 환자에서 손상의 기전을 알아보고자 하였다. 대상 및 방법: 축구 도중에 발생한 전방 십자인대 파열이 된 환자 92명 중 손상 기전을 정확히 기억하는 환자 50명을 대상으로 하였다. 평균 연령은 27세로, 남자 47명, 여자 3명 이였다. 아마추어 및 프로 축구 선수는 15명이었고, 35명은 비선수였다. 수상 기전은 전화나 의무기록으로 조사하였다. 결과: 수상 기전은 접촉성 손상이 17명, 비접촉성 손상이 33명 이었고, 41명의 환자가 손상 당시 발이 지면에 접촉을 하였고, 9명은 지면에 접촉하지 않았다. 접촉성 손상에서 17명 중 9명에서 슬관절에 외반력, 5명에서 내반력이 가해졌고, 11명의 환자가 손상 당시 발이 지면에 접촉을 하였고, 6명은 발이 지면에 접촉하지 않았다. 발이 지면에 접촉된 상태에서 대퇴부의 회전에 의한 손상은 3명이었고, 과신전 손상은 1 명이었고, 감속 손상은 없었다. 비접촉성 손상에서 33명 중 30명의 환자가 손상 당시 발이 지면에 접촉을 하였고, 3명은 발이 지면에 접촉하지 않았다. 30명 중 대퇴부의 회전에 의한 손상은 16명이 있었고, 6명에서 슬관절에 외반력, 5명에서 내반력이 가해졌고, 과신전 손상은 5 명이었고, 감속 손상은 2명 이었다. 발이 지면에 접촉하지 않은 3명의 환자들은 킥을 할 때 손상을 받았다. 결론: 축구 선수에서 전방 십자인대 파열은 대부분(66%) 비접촉성이 원인이며, 발이 지면에 접촉되면서 상체가 회전되면서 발생했다. 접촉성인 경우 대부분(53%) 외측에서의 태클에 의한 외반력이 원인이었다.

• Journal of Trauma and Injury
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• 제18권2호
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• pp.148-154
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• 2005

Purpose: This study was conducted to gather descriptive data on trauma victims and to observe the general demographic characteristics and clinical profile of trauma victims who were admitted to a regional emergency medical center in the west southern Kyungsangnam-do area. Objects & Method: The study population consisted of 1,909 trauma patients who visited the emergency department of Gyeongsang National University Hospital between January 2003 and December 2004. The medical records were reviewed in a retrospective manner. Demographic data, the mechanism of injury, and clinical information were collected by three professional medical affairs recorders and an emergency physician and a Revised Trauma Score (RTS) and an Injury Severity Score (ISS) were calculated for each patient. Collected data were analyzed with SPSS software version 12.0. Results: Male patients outmembered female patients (M:F=2.54:1), and the mean age of the population was $40.5{\pm}21.4$ years. The mean RTS and ISS were $7.45{\pm}1.11$ and $8.40{\pm}7.44$, respectively. The seventies showed the highest ISS($10.94{\pm}8.66$). The most common mechanism of injury was motor-vehicle accidents (45.57%), followed by falls or slips(28.26%), and other blunt injuries(12.68%). The most frequent causes of death was cerebral herniation due to head injury(68.4%) and irreversible shock(26.3%). Conclusion: The present study clarified the demographic and clinical characteristics of trauma patients in the Kyungsangnam-do area. In the future, prospective clinical data collection is needed for a more sophisticated trauma study.

• Journal of Trauma and Injury
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• 제25권3호
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• pp.79-86
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• 2012

Purpose: The most common cuase of transfusion for trauma victims in an emergency department is hypovolemic shock due to injury. After an injury to an internal organ of the chest or the abdomen, transfusion is needed to supply blood products and to compensate tissue oxygen transport and bleeding. From the 1990's, there have been some reports that transfusion is one of the major factors causing multiple-organ failure. Thus, as much as possible, tranfusion has been minimized in the clinical setting. This study aims to analyze the prognostic factors for mortality among trauma victims transfused with blood products in an emergency department. Methods: We conducted this study for the year of 2010 retrospectively. The study group included adult trauma victims tranfused with blood products in our ED. The exclusion criteria were discharge against medical advice, and missing follow-up due to transfer to another facility. During the study period, 34 adult trauma victims were enrolled. We compared the clinical variables between survivors and non-survivors. Results: the mean age of the 34 victims was 58.06 years, and males account for 58.5% of the study group. The most-frequently used form transportation was ambulance(119, 55.9%), and the most common injury mechanism was mobile vehicle accidents(67.6%). The mean revised trauma score (RTS) was 5.9, and the mean injury severity score (ISS) was 47.76. The mortality rate in the ED was 58.5%, Comparison of survivors with non-survivors showed statistical differences in injury mechanism, initial SBP, DBP, RTS, ISS, and some laboratory data such as AST, ALT, pH, PO2, HCO3, glucose (p<0.05). Regression analyses showed that mortality among adult trauma victims transfused in the ED correlated with RTS. Conclusion: When an adult trauma victim is transported to the ED and needs a tranfusion, the emergency physician carefully assess the victim by using physiologic data.