RECENT ADVANCES IN HEPATOTOXICITY STUDIES

  • Satoh, Tetsuo (Laboratory of Biochemical Phamacology and Biotoxicology Faculty of Pharmaceutical Sciences.)
  • Published : 1991.12.01

Abstract

Hepatotoxicity has many facets. Those to be discussed in this review include the mechanism for the hepatotoxic effects, nature of the injury, and animal models of hepatotoxicity suitable for the detection of chemical injury. Some therapeutic drugs used for treatment of hepatitis are also presented. In addition, as an important and serious problem in future, alternative toxicity testing is discussed.

Keywords

References

  1. Br. Med. J. v.292 Antiviral treatment in chronic infection with hepatitis B virus Alexander,G.;Williams,R.
  2. J. Med. Pharm. Soc. WAKAN-YAKU v.5 Effect of Syo-saiko-to on liver regeneration in partially hepatectomized rats Amagaya,S.;Miyake,A.;Ogihara,Y.;Fujiwara,K.
  3. J. Ethnopharmacol v.25 Treatment of chronic liver injury in mice by oral administration of Xiao-Chai-Hu-Tang Amagaya,S.;Hayakawa,M.;Ogihara,Y.;Ohta,Y.;Fujiwara,K.;Oka,H.;Oshio,H.;Kishi,T.
  4. Gastroenterology v.94 Interleukin-1 and interleukin-2 activity in chronic hepatitis B virus infection Anastassakos,Ch.;Alexander,G.J.M.;Wolstencroft,R.A.;Avery,J.A.;Portmann,B.C.;Panayi,G.S.;Dumonde,D.C.;Eddleston,A.L.W.F.;Williams,R.
  5. Gastroenterology v.80 Adenine arabinoside therapy in HBsAg-positive chronic liver disease: a controlled study Bassendine,M.F.;Chadwick,R.G.;Salmerson,J.;Shipton,U.;Thomas,H.C.;Sherlock,S.
  6. Gastroenterology v.99 Parenterally transmitted nonA, nonB hepatitis: virus-specific antibody response patterns in hepatitis C virus-infected chimpanzees Bradley,D.W.;Krawczynski,K.;Ebert,J.W.;McCaustland ,K.A.;Choo,R.L.;Houghton,M.A.;Kuo,G.
  7. Biochem. Pharmacol. v.37 Antidotal effectiveness of acetylcysteine in reversing acetaminophen-induced hepatotoxicity. Enhancement of the proteolysis of arylated proteins Bruno,M.K.;Cohen,S.D.;Kharallah,E.A.
  8. Gastroenterology v.96 β- and γ-interferon in chronic active hepatitis B. A pilot trial of short-term combination therapy Caselmann,W.C.;Eisenburg,J.;Hofschneider,P.H.;Koshy,R.
  9. Adv. Chinese Medicinal Materials Research Plants with liver-protective activities: Pharmacology and Toxicology of aucubin Chang,I.M.;Yun(Choi),H.S.;Chang,H.M.(ed.);Yeung,H.W.(ed.);Tso,W.W.(ed.);Koo,A.(ed.)
  10. Science v.244 Isolation of a cDNA clone derived from a blood-borne nonA, nonB viral hepatitis genome Choo,Q.L.;Kuo,G.;Weiner,A.J.;Overby,L.R.;Bradley,D.W.;Houghton,M.
  11. J. Pharmacol. Exp. Ther. v.214 Bioactivation and covalent binding of halothane in vitro: Studies with $(^{3}H)$- and $(^{14}C)$-halothane Gandolfi,A.J.;White,R.D.;Sipes,I.G.;Pohl,L.R.
  12. Ann. Interna. Med. v.107 Adenine arabinoside mono-phosphate in combination with human leukocyte interferon in the treatment of chronic hepatitis B: a randomized double-blind, placebo-controlled trial Garcia,G.;Smith,C.I.;Weissberg,J.I.
  13. Biochem. Pharmacol. v.42 Comparative cytotoxic effects of acetaminophen(N-acetyl-p-aminophenol), a non-hepa-totoxic regioisomer acetyl-m-aminophenol and their postulated reactive hydroquinone and quinone metabolites in monolayer cultures of mouse hepatocytes Holme,J.A.;Hongslo,J.K.;Bjorge,C.;Nelson,S.D.
  14. Jpn. J. Cancer Res. v.82 Changes in carboxylesterase isozymes of rat liver microsomes during hepatocarcinogenesis Maki,T.;Hosokawa,M.;Satoh,T.;Sato,K.
  15. Hepatology v.3 Ground squirrel hepatitis virus infection Marion,P.L.;Knight,S.S.;Salazar,F.H.;Popper,H.;Robinson,W.S.
  16. Hepatology v.4 Experimental transmission of duck hepatitis B virus to Pekin ducks and to domestic geese Marion,P.L.;Cullen,J.M.;Azcarraga,R.R.;Van Davlaar, M.J.;Robinson,W.S.
  17. J. Virol. v.36 Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus Mason,W.S.;Seal,G.;Summers,J.
  18. Biochem. Genet. v.24 Identity of esterase-22 and egasyn, the protein which complexes with microsomal β-glucuronidase Medda,S.;van Deimling, O.;Swank,R.T.
  19. J. Biol. Chem. v.257 Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits Morgan,E.T.;Koop,D.R.;Coon,M.J.
  20. Jpn. Cancer Res. v.82 Hereditary low level of plasma ceruloplasmin in LEC rats associated with spontaneous development of hepatitis and liver cancer Ono,T.;Abe,S.;Yoshida,M.C.
  21. J. Biol. Chem. v.252 Reconstitution of the microsomal ethanol-oxidizing system-Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption Ohnishi,K.;Lieber,C.S.
  22. Drug Metab. Rev. v.20 Neoantigens associated with halothane hepatitis Pohl,R.L.;Kenna,J.G.;Satoh,H.;Christ,D.;Martin,J.L.
  23. Science v.247 Isolation of a cDNA from the virus responsible for enterically transmitted nonA, nonB hepatitis Reyes,G.R.;Purdy,M.A.;Kim,J.P.
  24. Arch. Biochem. Biophys. v.246 Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a Ryan,D.E.;Koop,D.R.;Thomas,P.E.;Coon,M.J.;Levin,W.
  25. J. Biol. Chem. v.261 Reaction of acetaldehyde with hemoglobin San George, R.C.;Hoberman,H.D.
  26. Pesticides and and the Future: Toxicological Studies of Risks and Benefits Multiplicity and toxicological implications of liver microsomal carboxylesterases Satoh,T.;Maki,T.;Kobayashi,S.;Hosokawa,M.;Hodgson,E.(ed.);Motoyama,N.(ed.)
  27. Proc. 5th Annual Meeting of Japanese Society for Alternatives to Animal Experiments A novel testing of hepatotoxicity using liver microsomal esterase as a marker Satoh,T.;Kobayashi,S.;Takano,A.
  28. Lancet v.ⅱ Acyclovir enhances the antiviral effect of interferon in chronic hepatitis B Schalm,S.W.;Heijtink,R.A.;van Buuren,H.R.
  29. Korean J. Toxicol v.3 Protective action of N-acetylcystein against hepatotoxic agents in isolated rat liver cells Soo-Hee Park;Mi-Sook Dong;Dong-Chul Kang;Kiwan Lee;Young-Nam Cha
  30. Ann. N.Y. Acad. Sci. v.492 The functional implications of acetaldehyde binding to cell constitutents Sorrell,M.F.;Tuma,D.J.
  31. Res. Commun. Chem. Pathol. Pharmacol. v.72 Copper metabolism in LEC rats aged 30 and 80 days old: Induction of Cu-metallothionein and status of zinc and iron Sugawara,N.;Sugawara,C.;Sato,M.;Natamura,M.;Takahashi,H.;Mori,M.
  32. Proc. Natl. Acad. Sci. v.75 A virus similar to hepatitis B virus associated with hepatitis and hepatoma in woodchucks Summers,J.M.;Smolec,R.A.;Snyder,R.A.
  33. Bio/Technology v.8 Cell culture on a thermoresponsive polymer surface Takezawa,T.;Mori,Y.;Yoshizato,K.
  34. J. Cell Sci. Morphological and immuno-cytochemical characterization of a hetero-spheroid composed of fibroblasts and hepatocytes Takezawa,T.;Yamazaki,M.;Tomohide,Y.;Mori,Y.;Yoshizato,K.
  35. Arch. Biochem. Biophys. v.258 Purification and characterization of ethanol-inducible human hepatic cytochrome P-450j Wrighton,S.A.;Thomas,P.E.;Ryan,D.E.;Levin,W.
  36. J. Hered. v.78 New mutation causing hereditary hepatitis in the laboratory rat Yoshida,M.C.;Masuda,R.;Sakai,M.;Takeichi,N.;Kobayashi,H.;Dempo,K.;Mori,M.
  37. Jpn. J. Cancer Res. v.82 Abnormal copper accumulation in non-cancerous and cancerous liver tissues of LEC rats developing hereditary hepatitis and spontaneous hepatoma Yu,Li;Tagashi,Y.;Sato,S.;Emoto,T.;Jong-Hon,Kang;Takeichi,N.;Kobayashi,H.;Kojima,Y.;Une,Y.;Uchino,J.
  38. Hepatology Zimmerman,H.L.