• Korea Trade Review
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• v.42 no.1
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• pp.237-256
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• 2017

The members of Food Valley in Netherlands recognised that the networking function is the most important among demand articulation, network formation and innovation-process support. Furthermore, SMEs expect the support of internationalization from Food Valley organization. It is expected that the function of Food Valley which can establish effective network and environment for open innovation will be more significant in the future. Our government also designated Iksan as a national food cluster for preparing the growth of international food market and promoting the effective growth of domestic food industry. As noted earlier in the case of Food Valley, the government should make Iksan Cluster focus on building network for innovation and development of domestic food industry through making innovative environment between food industry and local university. And then, this food cluster will become the center of export of food products and sophistication of domestic food sector.

• Korean Business Review
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• v.18 no.2
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• pp.197-223
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• 2005

The industrial cluster policy of 21st century rise to the focus method of regional economic promotion, therefore, the importance of study in cluster identification and mapping as policy task will bring into relief. This paper will confirms the estimate index and policy of industrial clusters with regional industry. The result in this case study, Cluster development should embrace the pursuit of competitive advantage and specialization rather than simply imitate successful clusters in other locations. This requires building on local sources of uniqueness. Government should reinforce and building on existing and emerging clusters rather than attempt to create entirely new ones. This sort of role for government is very different from industrial policy. The aim of cluster policy is to reinforce the development of all clusters. Not all clusters will succeed, but market forces should determine the outcomes. In other words, government should build on market- oriented system and innovative infra. The result of this study is meaning to the development of objectivity estimate index and derivation of cluster-focused policy with a case study of industrial clusters.

• Molecular & Cellular Toxicology
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• v.1 no.4
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• pp.248-255
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• 2005

To understand the response of cancer cells to anticancer drugs at the gene expression level, we examined the gene expression changes in response to five anticancer drugs, 5-fluorouracil, cytarabine, cisplatin, paclitaxel, and cytochalasin D in NCI-H460 human lung cancer cells. Of the five drugs, 5-fluorouracil had the most distinctive gene expression signature. By clustering genes whose expression changed significantly, we identified three clusters with unique gene expression patterns. The first cluster reflected the up-regulation of gene expression by cisplatin, and included genes involved in cell death and DNA repair. The second cluster pointed to a general reduction of gene expression by most of the anticancer drugs tested. A number of genes in this cluster are involved in signal transduction that is important for communication between cells and reception of extracellular signals. The last cluster represented reduced gene expression in response to 5-fluorouracil, the genes involved being implicated in DNA metabolism, the cell cycle, and RNA processing. Since the gene expression signature of 5-fluorouracil was unique, we investigated it in more detail. Significance analysis of microarray data (SAM) identified 808 genes whose expression was significantly altered by 5-fluorouracil. Among the up-regulated genes, those affecting apoptosis were the most noteworthy. The down-regulated genes were mainly associated with transcription-and translation-related processes which are known targets of 5-fluorouracil. These results suggest that the gene expression signature of an anticancer drug is closely related to its physiological action and the response of caner cells.

• Biotechnology and Bioprocess Engineering:BBE
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• v.11 no.6
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• pp.510-515
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• 2006

The putative EPA synthesis gene cluster was mined from the entire genome sequence of Shewanella oneidensis MR-1. The gene cluster encodes a PKS-like pathway that consists of six open reading frames (ORFs): ORFSO1602 (multi-domain beta-ketoacyl synthase, KS-MAT-4ACPs-KR), ORFSO1600 (acyl transferase, AT), ORFSO1599 (multi-domain beta-ketoacyl synthase, KS-CLF-DH-DH), ORFSO1597 (enoyl reductase, ER), ORFSO1604 (phosphopentetheine transferase, PPT), and ORFSO1603 (transcriptional regulator). In order to prove involvement of the PKS-like machinery in EPA synthesis, a 20.195-kb DNA fragment containing the genes was amplified from S. oneidensis MR-1 by the long-PCR method. Its identity was confirmed by the methods of restriction enzyme site mapping and nested PCR of internal genes orfSO1597 and orfSO1604. The DNA fragment was cloned into Escherichia coli using cosmid vector SuperCos1 to form pCosEPA. Synthesis of EPA was observed in four E. coli clones harboring pCosEPA, of which the maximum yield was 0.689% of the total fatty acids in a clone designated 9704-23. The production yield of EPA in the E. coli clone was affected by cultivation temperature, showing maximum yield at $20^{\circ}C$ and no production at $30^{\circ}C$ or higher. In addition, production yield was inversely proportional to glucose concentration of the cultivation medium. From the above results, it was concluded that the PKS-like modules catalyze the synthesis of EPA. The synthetic process appears to be subject to regulatory mechanisms triggered by various environmental factors. This most likely occurs via the control of gene expression, protein stability, or enzyme activity.

• Journal of Korea Society of Digital Industry and Information Management
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• v.5 no.1
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• pp.23-32
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• 2009

Although the web is becoming a widely accepted medium, it provides relatively poor performance and low availability. A cluster consists of a collection of interconnected stand-alone computers working together and provides a high-availability solution in application area such as web services or information systems. Web server clusters require a high-availability service with a proactive and practical fault management. However, as the system complexity grows, it is not easy to meet the requirement. Therefore, web server clusters must have self-fault management capability for meeting high-availability requirement. In this paper, we propose high availability web server clusters using self-healing technique with a minimal human intervention. Our experimental results show that a proposed method can be used to improve the availability of web server clusters.

• Journal of Korea Society of Digital Industry and Information Management
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• v.8 no.2
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• pp.41-47
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• 2012

MANET has vulnerable structure on security owing to structural characteristics as follows. MANET consisted of moving nodes is that every nodes have to perform function of router. Every node has to provide reliable routing service in cooperation each other. These properties are caused by expose to various attacks. But, it is difficult that position of environment intrusion detection system is established, information is collected, and particularly attack is detected because of moving of nodes in MANET environment. It is not easy that important profile is constructed also. In this paper, conformal predictor - support vector machine(CP-SVM) based intrusion detection technique was proposed in order to do more accurate and efficient intrusion detection. In this study, IDS-agents calculate p value from collected packet and transmit to cluster head, and then other all cluster head have same value and detect abnormal behavior using the value. Cluster form of hierarchical structure was used to reduce consumption of nodes also. Effectiveness of proposed method was confirmed through experiment.

• Journal of Korea Society of Digital Industry and Information Management
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• v.13 no.3
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• pp.43-51
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• 2017

MANET consists of only wireless nodes having limited processing capability. It processes routing and data transmission through cooperation among each other. And it is exposed to many attack threats due to the dynamic topology by movement of nodes and multi-hop communication. Therefore, the reliability of transmitted data between nodes must be improved and security of integrity must be high. In this paper, we propose a method to increase the reliability of transmitted data by providing a secure cryptography protocol. The proposed method used a hierarchical structure to provide smooth cryptographic services. The cluster authentication node issues the cluster authentication key pair and unique key to the nodes. The nodes performs the encryption through two steps of encryption using cluster public key and block encryption using unique key. Because of this, the robustness against data forgery attacks was heightened. The superior performance of the proposed method can be confirmed through comparative experiment with the existing security routing method.

• Proceedings of the KSR Conference
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• 2009.05a
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• pp.1040-1046
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• 2009

Thanks to the recent development of computing technology, the various forms of high-performance computers are available. Among them, the parallel-clustering CPU machines are realized for the high performance computing. These supercomputers (cluster computers) can be applied to various industries due to the advantages of lower price. Especially in the field of numerical flow simulation, use of supercomputers can produce results quickly, and various engineering problems can be reviewed effectively case by case. In this paper, an application of supercomputers (cluster computers) were examined for railroad industry of fire flow simulation by using parallel computational method. It make sure that the supercomputers are very useful tools for railroad engineering.

• Proceedings of the Technology Innovation Conference
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• 2002.06a
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• pp.238-256
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• 2002

Competitiveness of a nation can be explained by the concept of national innovation systems(NIS). As components of NIS, industry clusters become the issue in analysing innovative activity of an economy. Innovative clusters can be identified by the innovation survey or other economic activity data. Input-output Table was used widely as a tool for quantitative analysis, This paper classifies seven clusters in Korean industry based on inter-industries trade of intermediary goods and services, Maximizing procedure method is used in analysing input-output table. Identified clusters are Textiles/chemicals, Construction/Material, Instrument/Equipment, Automobile, Services, Energy, and Agriculture/Food cluster, Among these clusters, some different characteristics in R&D portfolios are detected. R&D investment characteristics of each cluster give us significant implications in understanding innovative dynamics of Korean industry.

• Korean System Dynamics Review
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• v.7 no.2
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• pp.133-148
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• 2006

This study suggests a Causal Loop Diagram(CLD) of causality mechanism which are integrating matters of localization, networking, embeddedness & institutional thickness and collective learning. These five factors(localization, networking, embeddedness & institutional thickness, collective learning, innovative synergy) have been studied and proofed Also this study suggest a model of industry cluster based on holistic and global system thinking rather than local and linear thinking.