• 무역학회지
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• 제42권1호
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• pp.237-256
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• 2017

세계적 식품 클러스터인 네덜란드 푸드밸리의 회원사들은 클러스터의 주요 기능으로 거론되는 네트워크 형성, 수요 창출 그리고 혁신 프로세스 관리 지원 중, 구성원들을 연결하는 네트워크 형성 기능이 푸드밸리의 가장 중요한 역할로 인식하고 있다. 또한 중소기업 입장에서는 국제화 지원도 푸드밸리의 주요 역할로 기대하고 있는 것으로 확인하였다. 이에 효과적인 네트워크 구축과 개방형 혁신을 위한 적절한 환경을 조성할 수 있는 네덜란드 푸드벨리는 네덜란드 농식품 업계에서 앞으로 더욱 중요해질 것으로 전망된다. 세계 식품시장의 성장에 대응하고 국내 식품산업의 성장을 효율적으로 도모하기 위하여 정부는 2008년부터 전라북도 익산시에 '국가식품클러스터'를 조성하고 있다. 우리 정부도 와게닝겐 대학을 연구 중심으로 성공을 주도하는 푸드밸리를 거울삼아 익산 지역의 농·생명 융합 중심 대학을 농·식품 창조혁신의 연구 거점으로 활용하여 익산 식품클러스터가 회원사간 네트워크 활동을 이끌어 국내 식품 산업의 혁신과 발전을 이끌 수 있는 역할을 최우선적으로 수행해야 한다. 이와 함께 국가식품 클러스터가 식품 산업과 문화의 수출 거점이자 식품산업의 고부가가치화를 통한 농·식품 성장을 주도할 수 있는 중심으로 자리매김할 수 있도록 지원을 아끼지 않아야 한다.

• 산학경영연구
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• 제18권2호
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• pp.197-223
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• 2005

21세기 산업 클러스터 정책이 지역경제 활성화의 핵심 수단으로 부상하면서 정책 대상으로서의 클러스터 도출(identification) 및 확인(mapping) 연구의 중요성이 부각되고 있다. 본 연구에서는 지역단위의 클러스터에 대한 사례연구를 통하여 클러스터 지향적 정책과제(focused cluster policy)의 도출하고, 지역산업 클러스터의 네트워크를 파악함에 있어서 타 클러스터와의 비교 및 시계열별 비교, 정책목표의 달성정도 평가를 위하여 클러스터 평가지표를 제시하고자 하였다. 산업클러스터 사례분석은 클러스터 유형화분석과 네트워크분석을 통해 이루어졌다. 연구결과 요약하면, 클러스터를 개발하려는 시도는 다른 지역에서 성공한 클러스터를 모방하기보다는 경쟁우위와 전문성을 토대로 추진되어야 하고, 산업정책과 다른 산업클러스터 정책을 개발해야하고, 시장지향적인 클러스터 생태계를 구축해야 하며, 각 지역 여건 및 산업특성에 적합한 혁신체제를 구축과 혁신창출의 인프라를 조성해야 한다는 것이다.

• Molecular & Cellular Toxicology
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• 제1권4호
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• pp.248-255
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• 2005

To understand the response of cancer cells to anticancer drugs at the gene expression level, we examined the gene expression changes in response to five anticancer drugs, 5-fluorouracil, cytarabine, cisplatin, paclitaxel, and cytochalasin D in NCI-H460 human lung cancer cells. Of the five drugs, 5-fluorouracil had the most distinctive gene expression signature. By clustering genes whose expression changed significantly, we identified three clusters with unique gene expression patterns. The first cluster reflected the up-regulation of gene expression by cisplatin, and included genes involved in cell death and DNA repair. The second cluster pointed to a general reduction of gene expression by most of the anticancer drugs tested. A number of genes in this cluster are involved in signal transduction that is important for communication between cells and reception of extracellular signals. The last cluster represented reduced gene expression in response to 5-fluorouracil, the genes involved being implicated in DNA metabolism, the cell cycle, and RNA processing. Since the gene expression signature of 5-fluorouracil was unique, we investigated it in more detail. Significance analysis of microarray data (SAM) identified 808 genes whose expression was significantly altered by 5-fluorouracil. Among the up-regulated genes, those affecting apoptosis were the most noteworthy. The down-regulated genes were mainly associated with transcription-and translation-related processes which are known targets of 5-fluorouracil. These results suggest that the gene expression signature of an anticancer drug is closely related to its physiological action and the response of caner cells.

• Biotechnology and Bioprocess Engineering:BBE
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• 제11권6호
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• pp.510-515
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• 2006

The putative EPA synthesis gene cluster was mined from the entire genome sequence of Shewanella oneidensis MR-1. The gene cluster encodes a PKS-like pathway that consists of six open reading frames (ORFs): ORFSO1602 (multi-domain beta-ketoacyl synthase, KS-MAT-4ACPs-KR), ORFSO1600 (acyl transferase, AT), ORFSO1599 (multi-domain beta-ketoacyl synthase, KS-CLF-DH-DH), ORFSO1597 (enoyl reductase, ER), ORFSO1604 (phosphopentetheine transferase, PPT), and ORFSO1603 (transcriptional regulator). In order to prove involvement of the PKS-like machinery in EPA synthesis, a 20.195-kb DNA fragment containing the genes was amplified from S. oneidensis MR-1 by the long-PCR method. Its identity was confirmed by the methods of restriction enzyme site mapping and nested PCR of internal genes orfSO1597 and orfSO1604. The DNA fragment was cloned into Escherichia coli using cosmid vector SuperCos1 to form pCosEPA. Synthesis of EPA was observed in four E. coli clones harboring pCosEPA, of which the maximum yield was 0.689% of the total fatty acids in a clone designated 9704-23. The production yield of EPA in the E. coli clone was affected by cultivation temperature, showing maximum yield at $20^{\circ}C$ and no production at $30^{\circ}C$ or higher. In addition, production yield was inversely proportional to glucose concentration of the cultivation medium. From the above results, it was concluded that the PKS-like modules catalyze the synthesis of EPA. The synthetic process appears to be subject to regulatory mechanisms triggered by various environmental factors. This most likely occurs via the control of gene expression, protein stability, or enzyme activity.

• 디지털산업정보학회논문지
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• 제5권1호
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• pp.23-32
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• 2009

Although the web is becoming a widely accepted medium, it provides relatively poor performance and low availability. A cluster consists of a collection of interconnected stand-alone computers working together and provides a high-availability solution in application area such as web services or information systems. Web server clusters require a high-availability service with a proactive and practical fault management. However, as the system complexity grows, it is not easy to meet the requirement. Therefore, web server clusters must have self-fault management capability for meeting high-availability requirement. In this paper, we propose high availability web server clusters using self-healing technique with a minimal human intervention. Our experimental results show that a proposed method can be used to improve the availability of web server clusters.

• 디지털산업정보학회논문지
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• 제8권2호
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• pp.41-47
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• 2012

MANET has vulnerable structure on security owing to structural characteristics as follows. MANET consisted of moving nodes is that every nodes have to perform function of router. Every node has to provide reliable routing service in cooperation each other. These properties are caused by expose to various attacks. But, it is difficult that position of environment intrusion detection system is established, information is collected, and particularly attack is detected because of moving of nodes in MANET environment. It is not easy that important profile is constructed also. In this paper, conformal predictor - support vector machine(CP-SVM) based intrusion detection technique was proposed in order to do more accurate and efficient intrusion detection. In this study, IDS-agents calculate p value from collected packet and transmit to cluster head, and then other all cluster head have same value and detect abnormal behavior using the value. Cluster form of hierarchical structure was used to reduce consumption of nodes also. Effectiveness of proposed method was confirmed through experiment.

• 디지털산업정보학회논문지
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• 제13권3호
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• pp.43-51
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• 2017

MANET consists of only wireless nodes having limited processing capability. It processes routing and data transmission through cooperation among each other. And it is exposed to many attack threats due to the dynamic topology by movement of nodes and multi-hop communication. Therefore, the reliability of transmitted data between nodes must be improved and security of integrity must be high. In this paper, we propose a method to increase the reliability of transmitted data by providing a secure cryptography protocol. The proposed method used a hierarchical structure to provide smooth cryptographic services. The cluster authentication node issues the cluster authentication key pair and unique key to the nodes. The nodes performs the encryption through two steps of encryption using cluster public key and block encryption using unique key. Because of this, the robustness against data forgery attacks was heightened. The superior performance of the proposed method can be confirmed through comparative experiment with the existing security routing method.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2009년도 춘계학술대회 논문집
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• pp.1040-1046
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• 2009

Thanks to the recent development of computing technology, the various forms of high-performance computers are available. Among them, the parallel-clustering CPU machines are realized for the high performance computing. These supercomputers (cluster computers) can be applied to various industries due to the advantages of lower price. Especially in the field of numerical flow simulation, use of supercomputers can produce results quickly, and various engineering problems can be reviewed effectively case by case. In this paper, an application of supercomputers (cluster computers) were examined for railroad industry of fire flow simulation by using parallel computational method. It make sure that the supercomputers are very useful tools for railroad engineering.

• 기술경영경제학회:학술대회논문집
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• 기술경영경제학회 2002년도 제21회 하계학술발표회 논문집
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• pp.238-256
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• 2002

Competitiveness of a nation can be explained by the concept of national innovation systems(NIS). As components of NIS, industry clusters become the issue in analysing innovative activity of an economy. Innovative clusters can be identified by the innovation survey or other economic activity data. Input-output Table was used widely as a tool for quantitative analysis, This paper classifies seven clusters in Korean industry based on inter-industries trade of intermediary goods and services, Maximizing procedure method is used in analysing input-output table. Identified clusters are Textiles/chemicals, Construction/Material, Instrument/Equipment, Automobile, Services, Energy, and Agriculture/Food cluster, Among these clusters, some different characteristics in R&D portfolios are detected. R&D investment characteristics of each cluster give us significant implications in understanding innovative dynamics of Korean industry.

• 한국시스템다이내믹스연구
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• 제7권2호
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• pp.133-148
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• 2006

This study suggests a Causal Loop Diagram(CLD) of causality mechanism which are integrating matters of localization, networking, embeddedness & institutional thickness and collective learning. These five factors(localization, networking, embeddedness & institutional thickness, collective learning, innovative synergy) have been studied and proofed Also this study suggest a model of industry cluster based on holistic and global system thinking rather than local and linear thinking.