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Evaluation of Dose Change by Using the Deformable Image Registration (DIR) on the Intensity Modulated Radiation Therapy (IMRT) with Glottis Cancer (성문암 세기조절 방사선치료에서 변형영상정합을 이용한 선량변화 평가)

  • Kim, Woo Chul;Min, Chul Kee;Lee, Suk;Choi, Sang Hyoun;Cho, Kwang Hwan;Jung, Jae Hong;Kim, Eun Seog;Yeo, Seung-Gu;Kwon, Soo-Il;Lee, Kil-Dong
    • Progress in Medical Physics
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    • v.25 no.3
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    • pp.167-175
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    • 2014
  • The purpose of this study is to evaluate the variation of the dose which is delivered to the patients with glottis cancer under IMRT (intensity modulated radiation therapy) by using the 3D registration with CBCT (cone beam CT) images and the DIR (deformable image registration) techniques. The CBCT images which were obtained at a one-week interval were reconstructed by using B-spline algorithm in DIR system, and doses were recalculated based on the newly obtained CBCT images. The dose distributions to the tumor and the critical organs were compared with reference. For the change of volume depending on weight at 3 to 5 weeks, there was increased of 1.38~2.04 kg on average. For the body surface depending on weight, there was decreased of 2.1 mm. The dose with transmitted to the carotid since three weeks was increased compared be more than 8.76% planned, and the thyroid gland was decreased to 26.4%. For the physical evaluation factors of the tumor, PITV, TCI, rDHI, mDHI, and CN were decreased to 4.32%, 5.78%, 44.54%, 12.32%, and 7.11%, respectively. Moreover, $D_{max}$, $D_{mean}$, $V_{67.50}$, and $D_{95}$ for PTV were increased or decreased to 2.99%, 1.52%, 5.78%, and 11.94%, respectively. Although there was no change of volume depending on weight, the change of body types occurred, and IMRT with the narrow composure margin sensitively responded to such a changing. For the glottis IMRT, the patient's weight changes should be observed and recorded to evaluate the actual dose distribution by using the DIR techniques, and more the adaptive treatment planning during the treatment course is needed to deliver the accurate dose to the patients.

A Comparative Study on Radiation Safety Management Knowledge, Attitudes and Behavior of Career Dental Hygienists and New Dental Hygienists (경력 치과위생사와 신입 치과위생사의 방사선안전관리 지식, 태도 및 행위에 대한 비교조사 연구)

  • Yoon, Jung-Ae
    • Journal of dental hygiene science
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    • v.11 no.3
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    • pp.173-179
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    • 2011
  • This study identified knowledge, attitudes and behavior for radiation safety managemen of career dental hygienists and new dental hygienists. Results obtained from this study are as follows. 1. Regarding the knowledge level of radiation safety management, average score was $8.25{\pm}2.47$ for career dental hygienists and $7.42{\pm}2.77$ for new dental hygienists from 15 scale test.(p<.001). In addition, knowledge level of radiation safety management by general characteristics showed statistically significant difference according to health status(p<0.01). 2. Regarding the attitude level of radiation safety management, average score was $4.35{\pm}0.55$ for career dental hygienists and $4.19{\pm}0.60$ for new dental hygienists from 5 scale test.(p<0.01). 3. Regarding the behavior level of radiation safety management, average score was $3.14{\pm}0.98$ for career dental hygienists and $3.33{\pm}0.99$ for new dental hygienists from 5 scale test.(p<0.05). In addition, the behavior level by general characteristics showed statistically significant difference according to attendance rate of radiation safety management training (p<0.01) and defences of clinic (p<.001). 4. Based on the survey of relationship among knowledge, attitude and behavior of radiation safety management, we found that the higher the knowledge level of radiation safety management was, the higher the level of attitude was(p<.001).

Quality Verification for Respiratory Gated Proton Therapy (호흡동조 양성자치료의 Quality Verification)

  • Kim, Eun Sook;Jang, Yo Jong;Park, Ji Yeon;Kang, Dong Yun;Yeom, Doo Seok
    • The Journal of Korean Society for Radiation Therapy
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    • v.25 no.2
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    • pp.107-113
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    • 2013
  • Purpose: To verify accuracy of respiratory gated proton therapy by measuring and analyzing proton beam delivered when respiratory gated proton therapy is being performed in our institute. Materials and Methods: The plan data of 3 patients who took respiratory gated proton therapy were used to deliver proton beam from proton therapy system. The manufactured moving phantom was used to apply respiratory gating system to reproduce proton beam which was partially irradiated. The key characteristics of proton beam, range, spreat-out Bragg peak (SOBP) and output factor were measured 5 times and the same categories were measured in the continuous proton beam which was not performed with respiratory gating system. Multi-layer ionization chamber was used to measure range and SOBP, and Scanditronix Wellhofer and farmer chamber was used to measure output factor. Results: The average ranges of 3 patients (A, B, C), who had taken respiratory gated proton therapy or not, were (A) 7.226, 7.230, (B) 12.216, 12.220 and (C) 19.918, 19.920 $g/cm^2$ and average SOBP were (A) 4.950, 4.940, (B) 6.496, 6.512 and (C) 8.486, 8.490 $g/cm^2$. And average output factor were (A) 0.985, 0.984 (B) 1.026, 1.027 and (C) 1.138, 1.136 cGy/MU. The differences of average range were -0.004, -0.004, -0.002 $g/cm^2$, that of SOBP were 0.010, -0.016, -0.004 $g/cm^2$ and that of output factor were 0.001, -0.001, 0.002 cGy/MU. Conclusion: It is observed that the range, SOBP and output factor of proton beam delivered when respiratory gated proton therapy is being performed have the same beam quality with no significant difference compared to the proton beam which was continuously irradiated. Therefore, this study verified the quality of proton beam delivered when respiratory gated proton therapy and confirmed the accuracy of proton therapy using this.

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Comparison of Beam Delivery Modes in Prostate Cancer Proton Therapy: A Treatment Planning Comparison Study (전립선암 환자 양성자치료 시 빔 전달방식에 따른 치료계획 비교)

  • Kim, Youn Young;Youm, Doo Seok;Jang, Yo Jong;Kang, Dong Yun;Park, Jeong Hoon
    • The Journal of Korean Society for Radiation Therapy
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    • v.25 no.2
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    • pp.153-158
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    • 2013
  • Purpose: After making two plans, the Double Scattering (DS) Mode and The Pencil Beam Scanning (PBS) Mode, of patients on early prostate cancer, we not only compare the dose conformity and the dose homogeneity by analyzing each DVH, CN and HI, but also evaluate normal structures's sparing effect on each mode. Materials and Methods: Planes about nine patients, who did proton therapy, on prostate cancer was setted using the Eclipse proton external beam planning system. The prescription dose, every $2.5 Gy{\times}28$ fractions=70 Gy, was delivered to the PTV. The CN and the HI were getted by anlazing each DVHs for the DS Plan and the PBS Plan. Also, normal structures' %volumes according to dose of the PBS are campared with those of the DS. Results: The average CN of the PTV is increase 16.63% from DS $0.68{\pm}0.07$ to PBS $0.79{\pm}0.01$, and the average IN of the PTV is decrease -22.66 % from DS $0.12{\pm}0.03$ to PBS $0.09{\pm}0.01$. The PBS has litter %Volumes of normal structures than the DS about every patient except Rectum. The average %Volume of Left Femoral Head receiving ${\geq}30$ Gy shows most high decreasing rate, -79.93%, from DS to PBS and the average %Volume of Rectum receiving ${\geq}70$ Gy shows most low decreasing rate, -3.03%, from DS to PBS. Conclusion: Therefore, the PBS is more effective achieving the dose conformity and the dose Homogeneity than DS, and better to reduce unnecessary dose arriving normal structures, especially the femoral heads.

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Effectiveness of Real-time Oxygen Control in Fresh Produce Container Equipped with Gas-diffusion Tube (기체확산 튜브 부착 신선 농산물 용기에서의 실시간 산소농도 제어의 효과)

  • Jo, Yun Hee;An, Duck Soon;Lee, Dong Sun
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.19 no.3
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    • pp.119-123
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    • 2013
  • Simplified control logic was devised to fabricate and operate the modified atmosphere (MA) container of fresh produce equipped with gas-diffusion tube whose opening/closing was controlled in response to real time $O_2$ concentration. This is a simplified ramification of the previously developed control logic using both $O_2$ and $CO_2$ concentrations ([$O_2$] & [$CO_2$]). The developed logic was applied to and tested by a container system filled with spinach at $10^{\circ}C$ having optimum MA window of [$O_2$] of 7~10% and [$CO_2$] of 5~10%. It was shown that setting the proper on-off limit (11%) for $O_2$ control based on the assumed relationship $[O_2]+[CO_2]$=21% could attain the desired $CO_2$ concentration just below the upper tolerance limit ($[CO_2]_H$, 10%). The $O_2$ control point can be the lower tolerance limit or adjusted one (21-$[CO_2]_H$) depending on the commodity's MA requirement. The developed logic using single $O_2$ sensor could attain the equilibrated [$O_2$] of 11% with [$CO_2$] of 8~9% which was desired and similar to that of its predecessor ([$O_2$] of 9~10% with [$CO_2$] of 10%) using both $O_2$ and $CO_2$ sensors. Both MA containers (one only with single $O_2$ sensor control and one with $O_2$ and $CO_2$ sensors) could also keep the spinach quality without significant difference between them, but significantly better than perforated control package of air.

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Test Bed Studies with Highly Efficient Amine CO2 Solvent (KoSol-4) (고효율 습식 아민 CO2 흡수제(KoSol-4)를 적용한 Test bed 성능시험)

  • Lee, Ji Hyun;Kwak, No-Sang;Lee, In Young;Jang, Kyung Ryoung;Jang, Se Gyu;Lee, Kyung Ja;Han, Gwang Su;Oh, Dong-Hun;Shim, Jae-Goo
    • Korean Chemical Engineering Research
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    • v.51 no.2
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    • pp.267-271
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    • 2013
  • Test bed studies with highly efficient amine $CO_2$ solvent (KoSol-4) developed by KEPCO research institute were performed. For the first time in Korea, evaluation of post-combustion $CO_2$ capture technology to capture 2 ton $CO_2$/day from a slipstream of the flue gas from a coal-fired power station was performed. Also the analysis of solvent regeneration energy was conducted to suggest the reliable performance data of the KoSol-4 solvent. For this purpose, we have tested 5 campaigns changing the operating conditions of the solvent flow rate and the stripper pressure. The overall results of these campaigns showed that the $CO_2$ removal rate met the technical guideline ($CO_2$ removal rate: 90%) suggested by IEA-GHG and that the regeneration energy of the KoSol-4 showed about 3.0~3.2 GJ/$tCO_2$ which was, compared to that of the commercial solvent MEA (Monoethanolamine), about 25% reduction of regeneration energy. Based on these results, we could confirm the good performance of the KoSol-4 solvent and the $CO_2$ capture process developed by KEPCO research institute. And also it was expected that the cost of $CO_2$ avoided could be reduced drastically if the KoSol-4 is applied to the commercial scale $CO_2$ capture plant.

Biological Control of Tobacco Cutworm, Spodoptera litura (Lepidoptera: Noctuidae) by Steinernematid and Heterorhabditid Entomopathogenic Nematodes (Steinernematid와 Heterorhabditid 곤충병원성 선충을 이용한 담배거세미나방 (Spodoptera litura)의 생물적 방제)

  • Kim, Hyeong-Hwan;Cho, Sung-Rae;Choo, Ho-Yul;Lee, Sang-Myeong;Jeon, Heung-Yong;Lee, Dong-Woon
    • Korean journal of applied entomology
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    • v.47 no.4
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    • pp.447-456
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    • 2008
  • Five effective strains against tobacco cutworm, Spodoptera litura (Lepidoptera: Noctuidae), Steinernema carpocapsae (GSN1), Steinernema sp. (GSNUS-10), Steinernema sp. (GSNUS-14), Heterorhabditis bacteriophora Hamyang (HbH), and Heterorhabditis sp. (GSNUH-1) were selected among 14 isolates of Korean entomopathogenic nematode in laboratory tests. $LC_{50}$ values of above five strains against tobacco cutworm were various by different nematode strains and developmental stages of tobacco cutworm. $LC_{50}$ value of S. carpocapsae (GSN1) was the lowest by $4.0{\sim}8.3$ infective juveniles (Ijs) and 2nd instars of tobacco cutworm was most susceptible. Pathogenicity of five effective strains against tobacco cutworm depends on nematode strain, concentration, and application times. The most effective strain was determined as S. carpocapsae (GSN1). Two or three times of applications were effective regardless of nematode strain, or concentration. Efficacy of S. carpocapsae (GSN1), Steinernema (GSNUS-10), Steinernema (GSNUS-14), and Heterorhabditis (GSNUH-1) was variable depending on nematode strain, concentration, application times, and host variety. S. carpocapsae (GSN1) was the most effective and inoculation of 100,000 infective juveniles per m2 (720,000 Ijs/7.2 $m^2=1{\times}10^9$ Ijs/ha) resulted in higher efficacy. Three times of application of nematodes led to higher control efficacy than one or two applications. Efficacy of nematodes was higher on Chinese cabbage than cabbage or kale.

Effects of Supplementation of Trace Nutrients on Hanwoo Heifers (Bos taurus coreanae) under Hilly Pasture Grazing System (산지 방목기간 중 미량영양소 급여가 한우 암소의 생산성에 미치는 영향)

  • Yang, Seung Hak;Yang, Byoung Chul;Chung, Ki Yong;Jang, Sun Sik;Lee, Eun Mee;Cho, Sang Rae;Lee, Suk Dong;Park, Hyung Soo;Kwon, Eung Gi
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.36 no.4
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    • pp.387-392
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    • 2016
  • This study was conducted to ameliorate the productive performance of Hanwoo cow using hill pasture grazing system. Twenty seven animals aged 9 were designed to divide with 3 groups which were Control (restricted concentrate and hay for 5 months), T1 (restricted concentrate and pasture grazing ad libitum for 5 months) and T2 (restricted concentrate, 30 g/head of mineral nutrients and pasture grazing ad libitum for 5 months). Average daily gains increased higher in the order of T2, Control and T1. The conception rate of Control, T1 and T2 after artificial insemination during post-grazing period were 88.9%, 100%, 100%, respectively. In conclusion, the results indicated that hill pasture grazing system might enhance not only the productive performance of Hanwoo cow but also profit for conventional feeding system.

Enhanced Anaerobic Digestion Efficiency of Food Waste by Seaweed Addition (해조류 첨가를 통한 음식물쓰레기의 혐기성소화 효율 증대)

  • Shin, Sang-Ryong;Lee, Mo-Kwon;Kwon, Oh-Tae;Kim, Ji-Hoon;Han, Gyu-Hyeon;Kim, Dong-Hoon
    • Journal of the Korea Organic Resources Recycling Association
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    • v.25 no.3
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    • pp.55-62
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    • 2017
  • In this study, we investigated the effect of seaweed (SW) addition on the anaerobic digestion of food waste (FW). Anaerobic batch experiments were carried out at various substrate concentrations (2.5 to 10.0 g VS/L) and mixing ratios (FW:SW=100:0, 75:25, 50:50, 25:75 and 0:100 on VS basis) of FW and SW. The methane yield of FW alone was 394, 377, 276, $49mL\;CH_4/g\;VS_{added}$ at each substrate concentration (2.5 to 10.0 g VS/L). In cases of co-digestion, methane yield decreased (up to 15 %) with increasing mixing ratio of SW at low substrate concentration (2.5 to 5.0 g VS/L), while it increased (up to 240 %) at high substrate concentration (7.5 to 10.0 g VS/L). The synergistic effect was calculated based on the amount of methane generated from the single-feedstock digestion of FW and SW. The synergistic effect was not found at 2.5 and 5.0 g VS/L. However, the synergistic effect increased (up to 25% = synergistic increment/total methane production at 10.0 g VS/L, FW:SW=50:50) with increasing the ratio of seaweed at 7.5 and 10.0 g VS/L. At 10.0 g VS/L of FW alone, the accumulated amount of organic acids was 7,426 mg COD/L, which was decreased to 2,346 mg COD/L by seaweed (FW:SW=50:50) addition. The reason for the synergistic effect was to control the production rate of the organic acids by adding SW that has a relatively lower biodegradability compared to FW.

Evaluation of Lipid Peroxidation Inhibition and Nitrogen Oxide Scavenging Activity from Peel of Gardenia jasminoides Ellis Fructus Extracted by Various Solvents (치자(Gardenia jasminoides Ellis fructus) 껍질 용매 별 추출물의 지질과산화 저해 및 질소산화물 소거능)

  • Jin, Dong-Hyeok;Oh, Da-Young;Chung, Hun-Sik;Lee, Young-Guen;Seong, Jong-Hwan;Kim, Han-Soo
    • Journal of the Korean Applied Science and Technology
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    • v.34 no.2
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    • pp.244-253
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    • 2017
  • The aim of this study was to investigate the bioactivity and antioxidant activity of peel from Gardenia jasminoides Ellis fructus (GJE). We were separated into GJE peel. After that, we determined anthocyanin. GJE peel were extracted by 70% methanol, distilled water (DW) and ethyl acetate (EA) three solvents. To investigate by the solvent extract of total phenol content and value as a functional food ingredient of GJE peel through nitrogen oxide scavenging activity, antioxidant activity, reducing power and lipid peroxidation inhibition were performed. Solvent extract bioactivity of increasing concentrations (0.2, 0.4, 0.6 mg/mL) were significantly increased (p<0.05). GJE peel extracts showed lower activity than positive control (ascorbic acid, BHA, trolox). The total phenol contents of GJE peel extracts were highest in EA extract. However, the order of total phenol content of the solvent in the GJE peel and the results of analysis of various physiological activities were inconsistent. Considering the extraction yield and various physiological activities, it is expected to be effective when extracted from 70% methanol and DW extract. The results suggest that GJE peel is highly expected to be useful as a functional foods and natural antioxidant.