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The Prognostic Effect of Subpleural Lesions in Early Stage Non-small Cell Lung Cancer - Preliminary Report - (초기 비소세포 폐암 환자의 늑막하 병변이 예후에 미치는 영향; 예비 보고)

  • Lee, Ho-Jun;Lee, Hyung-Sik;Hur, Won-Joo;Lee, Ki-Nam;Choi, Pill-Jo
    • Radiation Oncology Journal
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    • v.16 no.4
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    • pp.425-431
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    • 1998
  • Purpose : We retrospectively analyzed the impact of subpleural lesions of early stage non-small cell lung cancer on the patterns of failure to support selection of postoperative adjuvant therapy. Methods and Materials : The study included 91 patients who underwent surgery for early stage non-small cell lung cancer at Dong-A University Hospital from Dec 1990 to Sep 1996. Twenty five patients were excluded due to postoperative mortality (four patients, 4.4$\%$) and stage III (21 patients). Of 66 patients, 22 patients were subpleural lesions (15 patients in stage I, and seven patients in stage II). Postoperative adjuvant radiation therapy was given to seven patients with T2Nl disease. The median follow-up duration was 29.5 months (range; 8-84 months). Results : The overall survival rate was 69.5$\%$ at 3 years. For all patients who presented with (22 patients) and without (44 patients) subpleural lesions, 3-year overall survival rates were 35.5$\%$ and 84.6$\%$, respectively (p=0.0017). For stage I patients who presented with (15 patients) and without (29 patients) subpleural lesions, 3-year overall survival rates were 33.1$\%$ and 92.3$\%$, respectively (p=0.001). For stage II patients who presented with (7 patients) and without (15 patients) subpleural lesions, 3-year overall survival rates were 53.3$\%$ and 45.7$\%$, respectively (p=0.911). For patients with T2N0 disease (34 patients) who presented with (11 patients) and without (23 patients) subpleural lesions, 3-year overall survival rates were 27.3$\%$ and 90.3$\%$, respectively (p=0.009). Conclusion : These observations suggest that the subpleural lesion play an important role as a prognostic factor for early stage non-small cell lung cancer. Especially for T2N0 disease, patients with subpleural lesions showed significantly lower survival rate than those without that.

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Assessment of Productivity and Vulnerability of Climate Impacts of Forage Corn (Kwangpyeongok) Due to Climate Change in Central Korea (국내 중부지역에 있어서 기후변화에 따른 사료용 옥수수의 생산성 및 기후영향취약성 평가)

  • Chung, Sang Uk;Sung, Si Heung;Zhang, Qi-Man;Jung, Jeong Sung;Oh, Mirae;Yun, Yeong Sik;Seong, Hye Jin;Moon, Sang Ho
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.39 no.2
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    • pp.105-113
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    • 2019
  • A two-year study was conducted from 2017 to 2018 by the establishment of a test field at Chungju-si and Cheongyang-gun. Plant height, number of leaves, insects and diseases, and fresh and dry matter yields for corn hybrid('Kwangpyeongok') were investigated. Daily average, maximum, and minimum temperature, monthly average temperature, daily precipitation, and sunshine duration during the growing season were investigated. We selected climate-critical factors to corn productivity and conducted an evaluation of vulnerability to climate change from 1999 to 2018 for both regions. In 2018, the dry matter yield of forage corn was 6,475 and 7,511 kg/ha in Chungju and Cheongyang, respectively, which was half of that in 2017. The high temperature and drought phenomenon in the 2018 summer caused the corn yield to be low. As well as temperature, precipitation is an important climatic factor in corn production. As a result of climate impact vulnerability assessment, the vulnerability has increased recently compared to the past. It is anticipated that if the high temperature phenomenon and drought caused by climate change continues, a damage in corn production will occur.

A Review of Recent Climate Trends and Causes over the Korean Peninsula (한반도 기후변화의 추세와 원인 고찰)

  • An, Soon-Il;Ha, Kyung-Ja;Seo, Kyong-Hwan;Yeh, Sang-Wook;Min, Seung-Ki;Ho, Chang-Hoi
    • Journal of Climate Change Research
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    • v.2 no.4
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    • pp.237-251
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    • 2011
  • This study presents a review on the recent climate change over the Korean peninsula, which has experienced a significant change due to the human-induced global warming more strongly than other regions. The recent measurement of carbon dioxide concentrations over the Korean peninsula shows a faster rise than the global average, and the increasing trend in surface temperature over this region is much larger than the global mean trend. Recent observational studies reporting the weakened cold extremes and intensified warm extremes over the region support consistently the increase of mean temperature. Surface vegetation greenness in spring has also progressed relatively more quickly. Summer precipitation over the Korean peninsula has increased by about 15% since 1990 compared to the previous period. This was mainly due to an increase in August. On the other hand, a slight decrease in the precipitation (about 5%) during Changma period (rainy season of the East Asian summer monsoon), was observed. The heavy rainfall amounts exhibit an increasing trend particularly since the late 1970s, and a consecutive dry-day has also increased primarily over the southern area. This indicates that the duration of precipitation events has shortened, while their intensity became stronger. During the past decades, there have been more stronger typhoons affecting the Korean peninsula with landing more preferentially over the southeastern area. Meanwhile, the urbanization effect is likely to contribute to the rapid warming, explaining about 28% of total temperature increase during the past 55 years. The impact of El Nino on seasonal climate over the Korean peninsula has been well established - winter [summer] temperatures was generally higher [lower] than normal, and summer rainfall tends to increase during El-Nino years. It is suggested that more frequent occurrence of the 'central-Pacific El-Nino' during recent decades may have induced warmer summer and fall over the Korean peninsula. In short, detection and attribution studies provided fundamental information that needed to construct more reliable projections of future climate changes, and therefore more comprehensive researches are required for better understanding of past climate variations.

Establishment of Geospatial Schemes Based on Topo-Climatology for Farm-Specific Agrometeorological Information (농장맞춤형 농업기상정보 생산을 위한 소기후 모형 구축)

  • Kim, Dae-Jun;Kim, Soo-Ock;Kim, Jin-Hee;Yun, Eun-Jeong
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.21 no.3
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    • pp.146-157
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    • 2019
  • One of the most distinctive features of the South Korean rural environment is that the variation of weather or climate is large even within a small area due to complex terrains. The Geospatial Schemes based on Topo-Climatology (GSTP) was developed to simulate such variations effectively. In the present study, we reviewed the progress of the geospatial schemes for production of farm-scale agricultural weather data. Efforts have been made to improve the GSTP since 2000s. The schemes were used to provide climate information based on the current normal year and future climate scenarios at a landscape scale. The digital climate maps for the normal year include the maps of the monthly minimum temperature, maximum temperature, precipitation, and solar radiation in the past 30 years at 30 m or 270 m spatial resolution. Based on these digital climate maps, future climate change scenario maps were also produced at the high spatial resolution. These maps have been used for climate change impact assessment at the field scale by reprocessing them and transforming them into various forms. In the 2010s, the GSTP model was used to produce information for farm-specific weather conditions and weather forecast data on a landscape scale. The microclimate models of which the GSTP model consists have been improved to provide detailed weather condition data based on daily weather observation data in recent development. Using such daily data, the Early warning service for agrometeorological hazard has been developed to provide weather forecasts in real-time by processing a digital forecast and mid-term weather forecast data (KMA) at 30 m spatial resolution. Currently, daily minimum temperature, maximum temperature, precipitation, solar radiation quantity, and the duration of sunshine are forecasted as detailed weather conditions and forecast information. Moreover, based on farm-specific past-current-future weather information, growth information for various crops and agrometeorological disaster forecasts have been produced.

Analysis of the Relationship Between the Characteristics of the Wind Damaged Trees and the Wind Caused by Typhoon 'Kompasu' (태풍 곤파스에 의해 발생한 풍도목 특성과 바람과의 관계 분석)

  • Youn, Ho Joong;Park, Ki Hyung;Lee, Myungbo;Won, Myoungsoo;Kim, Kyongha
    • Journal of Korean Society of Forest Science
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    • v.100 no.2
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    • pp.246-255
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    • 2011
  • This study was carried out to investigate the characteristics of wind damaged trees in the Hongneung Arboretumin Korea. Many trees in the Hongneung Arboretum were damaged by the 'Kompasu', the seventh typhoon in the year of 2010 having strong impacts on the central region of Korea. Damaged trees were divided into 3 damage types: windthrow, slanted and broken trees. Most of damaged trees (97.3%) were found at low slope (below 15 degree) or medium slope (15~20 degree). The 45.3% of damaged trees were coniferous and 54.7% were deciduous trees. The wind speed was recorded for the duration of the typhoon from 04:00 AM to 12:00 PM on September 2. The average wind speed and the maximum instantaneous wind speed inside the forest were 1.4 m/sec and 3.5 m/sec, respectively. The highest peak of the average and the maximum instantaneous wind speed inside of forest, 3.4 m/sec and 8.7 m/sec respectively, were recorded at 06:10 AM on September 2. To analyze relationship between wind characteristics and the damage types, the average wind speed and the frequency of wind wave was compared to those of pre-typhoon period (Feb. 13, Feb. 20, Apr. 21, Oct. 16, 2009 and Mar. 20, 2010). The results indicated that the damaged trees were affected by frequent wind wave rather than the wind speed itself. Also average wind direction inside the forest was analyzed to investigate the impact of wind direction on the damaged trees. The wind had mainly blown from SE and SW, and the maximum instantaneous wind direction was SE direction overall. Most of the damaged trees (84.0%) had fallen down to the NW or NE direction. This result showed that the fallen direction of the damaged trees and wind direction was highly related. Therefore, we found that the frequency of wind wave was the main factor of wind damages during the typhoon 'Kompasu' and wind direction was highly related to the fallen direction.

A study on the rainfall management target considering inter-event time definition (IETD) (무강우 지속시간(IETD)을 고려한 빗물관리 목표량 설정 방안 연구)

  • Baek, Jongseok;Kim, Jaemoon;Park, Jaerock;Lim, Kyoungmo;Shin, Hyunsuk
    • Journal of Korea Water Resources Association
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    • v.55 no.8
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    • pp.603-611
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    • 2022
  • In urban areas, the impermeable area continues to increase due to urbanization, which interferes with the surface penetrating and infiltrating of rainwater, causing most rainwater runoff to the surface, deepening the distortion of water circulation. Distortion of water circulation affects not only flood disasters caused by rainfall and runoff, but also various aspects such as dry stream phenomenon, deterioration of water quality, and destruction of ecosystem balance, and the Ministry of Environment strongly recommends the use of Low Impact development (LID) techniques. In order to apply the LID technique, it is necessary to set a rainwater management target to handle the increase in outflow after the development of the target site, and the current standard sets the rainwater management target using the 10-year daily rainfall. In this study, the difference from the current standards was analyzed through statistical analysis and classification of independent rainfall ideas using inter-event time definition (IETD) in setting the target amount of rainwater management to improve water circulation. Using 30-year rainfall data from 1991 to 2020, methods such as autocorrelation coefficient (AC) analysis, variation coefficient (VC) analysis, and annual average number of rainfall event (NRE) analysis were applied, and IETD was selected according to the target rainfall period. The more samples the population had, the more IETD tended to increase. In addition, by analyzing the duration and time distribution of independent rainfall according to the IETD, a plan was proposed to calculate the standard design rainfall according to the rainwater management target amount. Therefore, it is expected that it will be possible to set an improved rainwater management target amount if sufficient samples of independent rainfall ideas are used through the selection of IETD as in this study.

Analysis of Central Line-associated Bloodstream Infection among Infants in the Neonatal Intensive Care Unit: A Single Center Study

  • Kim, Minhye;Choi, Sujin;Jung, Young Hwa;Choi, Chang Won;Shin, Myoung-jin;Kim, Eu Suk;Lee, Hyunju
    • Pediatric Infection and Vaccine
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    • v.28 no.3
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    • pp.133-143
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    • 2021
  • Purpose: This study aimed to determine the incidence of central line-associated bloodstream infection (CLABSI) in the neonatal intensive care unit (NICU), evaluate the patients' clinical characteristics, and identify the etiologic agents for guidance in prevention and treatment. Methods: A retrospective chart review study of infants classified as having CLABSI was conducted at the NICU of Seoul National University Bundang Hospital from January 2016 to December 2020. Results: Of the 45 infants, 53 had CLABSIs within a follow-up period of 18,622 catheter days. The incidence of CLABSIs was 2.85 per 1,000 catheter days. The most common catheter type was a peripherally inserted central catheter (n=47, 81%). A total of 57 pathogens were isolated, of which 57.9% (n=33) were Gram-positive bacteria, 36.8% (n=21) were Gram-negative bacteria, and 5.3% (n=3) were Candida spp. The most common pathogens were Staphylococcus aureus (n=12, 21%) and coagulase-negative staphylococci (n=12, 21%), followed by Klebsiella aerogenes (n=8, 14%). The median duration of bacteremia was 2 days, and 19 episodes showed bacteremia for 3 days or more. The mortality rate of infants within 14 days of CLABSI was 13.3% (n=6). Conclusions: This study analyzed the incidence of CLABSI and the distribution of pathogens in the NICU. Continuous monitoring of CLABSI based on active surveillance serves as guidance for empiric antibiotic use and also serves as a tool to assess the necessity for implementation of prevention strategies and their impact.

Effects of drumming exercise on the autonomic nervous system in overweight women (드러밍 운동이 과체중 여성의 자율신경계에 미치는 영향)

  • Jeong In Kwon;Jae Hoon Lee;Joon Yong Cho;Yoo Sung Oh
    • Journal of the Korean Applied Science and Technology
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    • v.41 no.2
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    • pp.219-232
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    • 2024
  • The aim of this study was to explore the impact of body mass index (BMI) and drumming exercise on autonomic nervous system function in adult women. Ten adult women (aged 30-50) were divided into two groups based on their BMI: a normal BMI group (Low BMI, LBMI < 23 kg/m2) and an overweight BMI group (High BMI, HBMI > 23 kg/m2). Both groups participated in a drumming exercise program, consisting of 50-minute sessions, three times a week, for a duration of 8 weeks. Body composition and heart rate variability were assessed before and after the 8-week exercise period. Heart rate variability was evaluated using linear analysis in the time domain and frequency domain. Additionally, non-linear analysis was conducted using a Poincaré plot. The autonomic nervous system index was determined by measuring parasympathetic nervous system index and sympathetic nervous system index. Following the 8-week intervention, the HBMI group exhibited a significant decrease in weight (p=0.034), BMI (p=0.044), body fat mass (p=0.032), and waist circumference (p=0.013) compared to the LBMI group. Furthermore, the HBMI group demonstrated significant increases in RMSSD (p=0.018) and TP (p=0.033) in linear analysis, as well as SD1 (p=0.018) in non-linear analysis and PNS Index (p=0.040) compared to the LBMI group. RMSSD, SD1, and PNS Index serve as indicators of parasympathetic nervous system activity in linear and non-linear analyses, respectively. These findings indicate that drumming exercise significantly enhances autonomic nervous system function in overweight women.

Literature Analysis of Radiotherapy in Uterine Cervix Cancer for the Processing of the Patterns of Care Study in Korea (한국에서 자궁경부알 방사선치료의 Patterns of Care Study 진행을 위한 문헌 비교 연구)

  • Choi Doo Ho;Kim Eun Seog;Kim Yong Ho;Kim Jin Hee;Yang Dae Sik;Kang Seung Hee;Wu Hong Gyun;Kim Il Han
    • Radiation Oncology Journal
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    • v.23 no.2
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    • pp.61-70
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    • 2005
  • Purpose: Uterine cervix cancer is one of the most prevalent women cancer in Korea. We analysed published papers in Korea with comparing Patterns of Care Study (PCS) articles of United States and Japan for the purpose of developing and processing Korean PCS. Materials and Methods: We searched PCS related foreign-produced papers in the PCS homepage (212 articles and abstracts) and from the Pub Med to find Structure and Process of the PCS. To compare their study with Korean papers, we used the internet site 'Korean Pub Med' to search 99 articles regarding uterine cervix cancer and radiation therapy. We analysed Korean paper by comparing them with selected PCS papers regarding Structure, Process and Outcome and compared their items between the period of before 1980's and 1990's. Results: Evaluable papers were 28 from United States, 10 from the Japan and 73 from the Korea which treated cervix PCS items. PCS papers for United States and Japan commonly stratified into $3\~4$ categories on the bases of the scales characteristics of the facilities, numbers of the patients, doctors, Researchers restricted eligible patients strictly. For the process of the study, they analysed factors regarding pretreatment staging in chronological order, treatment related factors, factors in addition to FIGO staging and treatment machine. Papers in United States dealt with racial characteristics, socioeconomic characteristics of the patients, tumor size (6), and bilaterality of parametrial or pelvic side wail invasion (5), whereas papers from Japan treated of the tumor markers. The common trend in the process of staging work-up was decreased use of lymphangiogram, barium enema and increased use of CT and MRI over the times. The recent subject from the Korean papers dealt with concurrent chemoradiotherapy (9 papers), treatment duration (4), tumor markers (B) and unconventional fractionation. Conclusion: By comparing papers among 3 nations, we collected items for Korean uterine cervix cancer PCS. By consensus meeting and close communication, survey items for cervix cancer PCS were developed to measure structure, process and outcome of the radiation treatment of the cervix cancer. Subsequent future research will focus on the use of brachytherapy and its impact on outcome including complications. These finding and future PCS studies will direct the development of educational programs aimed at correcting identified deficits in care.

A Study on the Differences in Breeding Call of Cicadas in Urban and Forest Areas (도시와 산림지역 매미과 번식울음 차이 연구)

  • Kim, Yoon-Jae;Ki, Kyong-Seok
    • Korean Journal of Environment and Ecology
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    • v.32 no.6
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    • pp.698-708
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    • 2018
  • The purpose of this study was to investigate differences in the breeding call characteristics of cicada species found in urban and forest areas in the central region of Korea by examining the interspecific effects and environmental factors affecting the breeding calls and breeding call patterns. The selected research sites were Gyungnam Apartment in Bangbae-dong, Seoul for the urban area and Chiak Mountain National Park in Wonju for the forest area. The research method for both sites was to record cicada breeding calls for 24 hours with a recorder installed at the site and analyze the results. Data from the Korea Meteorological Administration were used for environmental factors. The research period was from June 19, 2017 to September 30, 2017. As a result of the study, there were differences in the emergence of species between the two research sites: while Platypleura kaempferi, Hyalessa fuscata, Meimuna opalifera, Graptopsaltria nigrofuscata, and Suisha coreana were observed at both sites, Cryptotympana atrata was observed in the urban area and Leptosemia takanonis in the forest area only. The emergence periods of cicadas at the two sites were also different. The activities of P. kaempferi and L. takanonis were noticeable in the forest area. In the urban area, however, L. takanonis was not observed and the duration of activity of P. kaempferi was short. In the urban area, C. atrata appeared and sang for a long period; H. fuscata, M. opalifera, and G. nigrofuscata appeared earlier than in the forest area. S. coreana appeared earlier in the forest area than in the urban area. According to the daily call cycle analysis, even cospecific cicada showed a wide variation in their daily cycle depending on the region and the interspecific effects between different cicadas, and the environmental differences between the urban and forest areas affected the calls of cicadas. The results of correlation analysis between each cicada breeding calls and environmental factors of each site showed positive correlation with average temperature of most cicadas except P. kaempferi and C. atrata. The same species of each site showed positive correlations with more diverse weather factors such as solar irradiance. Logistic regression analysis showed that cicadas with overlapping calling times had significant effects on each other's breeding calls. C. atrata, which appeared only in the urban area, had a positive effect on the calling frequency of H. fuscata, M. opalifera, and G. nigrofuscata, which called in the same period. Additionally, L. takanonis, which appeared only in the forest area, and P. kaempferi had a positive effect on each other, and M. opalifera had a positive effect on the calling frequency of H. fuscata and G. nigrofuscata in the forest area. For the environmental factors, the calling frequency of cicadas was affected by the average temperatures of the urban and forest areas, and cicadas that appeared in the forest area were also affected by the amount of solar radiation. According to the results of statistical analysis, urban cicadas with similar activity periods are influenced by species, especially with respect to urban dominant species, C. atrata. Forest cicadas were influenced by species, mainly M. opalifera, which is a forest dominant species. The results of the meteorological impact analysis were similar to those of the correlation analysis, and were influenced mainly by the temperature, and the influence of the insolation was more increased in the forests.