• East Asian Economic Review
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• 제20권2호
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• pp.191-228
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• 2016

This paper analyzes the role of absorptive capacity in R&D spillovers through strategic R&D investments in a game-theoretic framework. In the model, a firm's effective R&D is composed of idiosyncratic R&D, which produces its own innovations, and identical R&D, which improves absorptive capacity. The model shows that in the presence of absorptive capacity firms have a tendency to underinvest (overinvest) in idiosyncratic (identical) R&D relative to the social optimum. As the spillover becomes larger, firms decrease their own R&D while they become more inclined towards strategic exploitation of rivals' efforts. Since the former effect overpowers the latter, the total amount of R&D decreases as the spillover increases. This is socially undesirable, providing a potential justification for a governmental subsidy for idiosyncratic R&D and a tax on identical R&D. The findings may have important implications for newly industrialized or emerging countries that consider a redirection of national R&D policy and intellectual property rights (IPR) regime.

• 통상정보연구
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• 제11권3호
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• pp.363-390
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• 2009

This study investigates the role of private participation in FTA Negotiation in case of US, Mexico and Japan. We utilize Putnam(1988)'s two stage negotiation model, Schelling Conjecture and Principal-Agent(P-A) theory to understand the role of private sector in FTA Negotiation. Those theories are useful to understand the behavior and interaction of key players such as private sector, congress and government in FTA negotiation. Putnam(1988)'s two stage negotiation model divides the FTA negotiation process into two processes: the external negotiation with foreign country and domestic negotiation with domestic interest group. Principal-Agent(P-A) theory provides the theoretical foundation of Putnam's two stage negotiation model, which is that principal's interest is not identical to the interest of Agent. We showed that the private sector and congress play an important role in FTA negotiation in United States. In case of Mexico, the private sector and government occupy the dominant position in FTA negotiation. In particular, the cooperation of industry and government has been successfully established via COECE in Mexico. In contrast to these countries, the role of private participation in trade policy is relatively low in Japan and Korea.

• 대한교통학회지
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• 제1권1호
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• pp.43-47
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• 1983

Within the conventional transportation planning process, "trip distribution" has a significant role to play. The most widely applied trip distribution model is the gravity model, for which Wilson provided the theoretical basis in 1967. The concept of the gravity model, however, still remains ambiguous if we analyze the "trip distribution" with a disaggregate data set. Thus, this paper hypothesizes that the gravity technique is still valid even with the disaggregate data set, by proving that the estimated coefficients of the gravity model, which is derived under the principle of entropy maximization, are identical with those of the multinomial logit model, which is derived under the principle of individual utility maximization.tility maximization.

• 기술혁신연구
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• 제12권3호
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• pp.49-71
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• 2004

Using panel data, this paper investigates the impacts of the strengthening of intellectual property rights (IPRs) on innovative activity. The estimation results indicate the following important implications. First, IPRs alone do not play a significant role. Second, the effect of IPRs is strong and significant only when it is interacted with complementary environments for innovation. This finding suggests that IPRs play a significant role only via a specific channel of interaction such as the stage of economic development, institutional environment and trade openness. Third, the significant correlation is not identical across countries implying that some countries were positively affected while others were negatively affected. Those countries are identified as well.

• Asia pacific journal of information systems
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• 제14권1호
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• pp.101-123
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• 2004

User satisfaction has been widely used by information system(IS) researchers as the most appropriate surrogate variable for the systems success since Bailey and Pearson(1983) provided their user satisfaction measurement. Because user satisfaction is a perceived performance measure by users, not a real or objective measure for systems success, however, perceived user satisfaction by users may not be exactly identical with the real systems performance. In this regard, if the user's ultimately perceived satisfaction is different from the real systems performance, we need to investigate why these two measures are different and which factors may cause the difference. From the perspective of disconfirmation of user expecations, this study examined why user satisfaction and real systems performance may not be identical each other. Expectaion-disconfirmation theory which has had a central role in marketing in explaining the effects of expectation and disconfirmation on consumer satisfaction was similarly adopted in this study to explain the role of expectation and disconfirmation in user satisfaction in the IS environment. Based on the expectation-disconfirmation theory, the current study developed a research model to examine the effects of expectation, system performance, and disconfirmation on user satisfaction in particular. Six research hypotheses derived from the research model were empirically tested using the partial least squares(PLS) method. The results of the statistical analysis indicate that the effects of system performance and disconfirmation were fairly strong on user satisfaction, while the user's expectation has shown insignificant influences on user satisfaction.

• Molecules and Cells
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• 제20권3호
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• pp.392-400
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• 2005

The genes encoding the DNA gyrase A (GyrA) and B subunits (GyrB) of Methylovorus sp. strain SS1 were cloned and sequenced. gyrA and gyrB coded for proteins of 846 and 799 amino acids with calculated molecular weights of 94,328 and 88,714, respectively, and complemented Escherichia coli gyrA and gyrB temperature sensitive (ts) mutants. To analyze the role of type II topoisomerases in the intrinsic quinolone resistance of methylotrophic bacteria, the sequences of the quinolone resistance-determining regions (QRDRs) in the A subunit of DNA gyrase and the C subunit (ParC) of topoisomerase IV (Topo IV) of Methylovorus sp. strain SS1, Methylobacterium extorquens AM1 NCIB 9133, Methylobacillus sp, strain SK1 DSM 8269, and Methylophilus methylotrophus NCIB 10515 were determined. The deduced amino acid sequences of the QRDRs of the ParCs in the four methylotrophic bacteria were identical to that of E. coli ParC. The sequences of the QRDR in GyrA were also identical to those in E. coli GyrA except for the amino acids at positions 83, 87, or 95. The $Ser^{83}$ to Thr substitution in Methylovorus sp. strain SS1, and the $Ser^{83}$ to Leu and $Asp^{87}$ to Asn substitutions in the three other methylotrophs, agreed well with the minimal inhibitory concentrations of quinolones in the four bacteria, suggesting that these residues play a role in the intrinsic susceptibility of methylotrophic bacteria to quinolones.

• Tuberculosis and Respiratory Diseases
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• 제72권1호
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• pp.30-36
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• 2012

Background: Patients with ventilator-associated pneumonia (VAP) in intensive care unit (ICU) have a high mortality rate. The routine surveillance cultures obtained previously or an ATS guideline for hospital-acquired pneumonia was used in selecting initial antimicrobials. The object of this study was to compare the respiratory samples before VAP and bronchoalveolar lavage (BAL) culture. Methods: 54 patients underwent fiberoptic bronchoscopy to obtain BAL samples. We reviewed microbiologic specimen results of prior respiratory specimens (pre-VAP) and BAL. Results: Among 51 patients with 54 VAP episodes, 52 microorganisms of pre-VAP and 56 BAL samples were isolated. Pre-VAP included 21.2% of MRSA, and 32.6% of multidrug resistant-Acinetobacter baumannii (MDR-AB). BAL samples comprised 25.0% of MRSA, 26.7% of MDR-AB, 14.3% of Stenotrophomonas maltophilia and 3.6% of Klebsiella pneumonia in order. In pre-VAP samples compared to BAL samples, only 35.2% were identical. In BAL samples compared to pre-VAP samples obtained in 5 days before the onset of VAP, only 43.6% were identical. However, among BAL samples compared to pre-VAP samples obtained after more than 5 days, 13.3% were identical (p=0.037). Conclusion: Based on these data, pre-VAP samples obtained prior to 5 day onset of VAP may help to predict the causative microorganisms and to select appropriate initial antimicrobials.

• Journal of Nutrition and Health
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• 제27권9호
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• pp.949-956
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• 1994

The effect of zinc deficiency on certain immunological parameters was investigated using intragastric tube feeding to obviate decreased food intake and altered eating pattern. Male, Fischer 344 rats were bilaterally adrenalectomized(ADX) or sham operated(SHAM). ADX rats received 0.9% NaCl in their drinking water and corticosterone injections at the dose of 1mg/kg of body weight three times per day. After recovery, one half of ADX and SHAM animals were tube-fed a purified, liquid diet containing either two ppm of zinc(zinc-deficient, force-fed ; ZDF) or 50ppm(zinc-replete, force-fed ; ZRF) for 19 days. They received identical amounts of diet based on the intake of ad libitum-fed, zinc-replete rats. Although they received identical amounts of food, ZDF rats grew at a slower rate compared to ZRF rats in both SHAM and ADX rats. Regardless of surgery, force-feeding rats the zinc-deficient diet resulted in a substantial decrease in serum zinc levels. The weights of the thymus, lymph node, and spleen were lower in SHAM-ZRF rats compared to SHAM-ARF rats. Marginal zinc deficiency caused lymphopenia in SHAM animals. However, these differences in lymphoid tissues and cells between SHAM-ZDF and SHAM-ZRF rats disappeared in ADX rats. These results indicate that the impaired growth of lymphoid tissues observed in zinc-deficient, sham-operated animals can be attributed to elevated serum corticosterone levels under the conditions of our experiments.

• 한국의류학회지
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• 제19권1호
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• pp.129-141
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• 1995

The Purpose of this study was to investigate the preference of fashion style, the clothing attitude and the preferred fashion style based on sex-role attitude. Sample.; in this study were 305 white collar adult male in Seoul, Korea. The stimuli consisted of 16 color photographs made by identical manipulations of 4 independent variables (jacket, pants, vest, neck-tie) consisting of two levels each (classic and fashion style). For analyzing data, frequency analysis, percent, mean, standard deviation, ANOVA, $X^2$ test, Duncan test, and Cronbach's u were used The results are as follows. 1. According to the preference analysis of the fashion style, white collar adult male prefer to wear clothing style than fashion in all clothing style, except for rolled-up pants. 2. According to the fashion interest (I) based on the preference analysis of the fashion style, the fashion oriented group had high fashion interest (I) in jacket, pants, and neck-tie. 3. According to the clothing attitude based on the preference analysis of the fashion style; for jacket, the fashion oriented group had high fashion interest, but had no relation with status symbols consciousness, clothing conformity, individuality; for vest, the fashion oriented group had high fashion interest (II) and individuality, but had no relation with status symbols 4. According to the clothing attitude based on the sex-role attitude, the group of masculine and feminine had high score in fashion interest (II), status symbols consciousness, and individuality

• IMMUNE NETWORK
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• 제11권3호
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• pp.175-181
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• 2011

Background: CM1 (centrocyte/-blast marker 1) was defined by a mAb against concavabalin-A (ConA) activated PBMC. It is expressed in germinal center of human tonsil and on the surface of activated PBMC as well as cancer cells. Recently, increased productions of pro-inflammatory mediators were detected from activated PBMC by CM1 ligation. Methods: However, there is a limitation to explain the exact role of CM1 on inflammation and its related mechanisms, since the identity of CM1 is still not clarified. In our previous study, we have already confirmed that soluble form of CM1 was produced by Raji. Therefore, we performed Q-TOF analysis after immunoprecipitation of concentrated Raji culture supernatant using anti-CM1 mAbs. Results: As a result, we found that CM1 is identical to enolase-1(ENO1), a glycolytic enzyme, and we confirmed that results by silencing ENO1 using siRNA. It was also confirmed through competition assay between anti-CM1 and anti-ENO1 mAbs. Finally, we investigated the possible role of CM1 in inflammatory response and cancer. The ligation of CM1 on Raji cells with anti-CM1 mAbs induces the extensive production of prostaglandin $E_2(PGE_2)$. In addition, the increased activity of matrix metalloproteinase (MMP)-2/9 was shown in NCI-N87, stomach cancer cell line by CM1 stimulation. Conclusion: CM1 is identical to ENO1 and it might be an important role in the regulation of inflammatory responses.