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Effects of Radiotherapy on the Risk of Developing Secondary Malignant Neoplasms in Hodgkin's Lymphoma Survivors

  • Abou-Antoun, Tamara;Mikhael, Rachelle;Massoud, Marcel;Chahine, Georges;Saad, Aline
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.2
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    • pp.749-754
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    • 2016
  • Extended follow-up of Hodgkin lymphoma (HL) survivors indicates that these patients are at high risk of secondary malignant neoplasms (SMNs) contributing to increased morbidity and mortality. This study examined the characteristics of HL survivors who developed SMNs with the aim to report any correlation with radiotherapy (RT) dose. In this retrospective multi-center cohort study of HL patients treated between 1990 and 2011 at three major teaching hospitals in Lebanon, classification was into two groups including those treated with combined modality (RT and chemotherapy-CHT) and those treated with CHT alone. Approval from the University Institutional Review Board (IRB) was obtained. Of the 112 patients evaluated, 52.7% (59) received the combined modality while 47.3% (53) received CHT alone. There were 6 cases of SMNs in the combined modality cohort and 5 cases in the CHT cohort. The mean RT dose in the combined modality cohort was 34.5 Gray (Gy) ($SD{\pm}5.3$). A statistically significant increase (1.5 fold) in the risk of developing SMNs was observed among patients who received a dose higher than 41 Gy compared to a dose between 20 to 30 Gy (OR= 1.5; 95% confidence interval= 0.674 to 3.339, p=0.012). The risk of SMNs was not significantly higher among patients who received extended field compared to involved field RT (p=0.964). This study showed that the risk of developing SMNs is higher among patients treated with RT dose greater than 31 Gy, independent of the RT type used.

Study on the qualities of diet and life in Parkinson's disease patients according to their nutritional status (파킨슨병 환자의 영양 상태에 따른 식사의 질 및 삶의 질에 관한 연구)

  • Yun, Jae-Hee;Lim, Hyun-Jung;Woo, Mi-Hye;Ahn, Tae-Beom;Choue, Roy-Won
    • Journal of Nutrition and Health
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    • v.45 no.3
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    • pp.240-251
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    • 2012
  • Assessment regarding the nutritional status of Parkinson's disease (PD) patients is important because their nutritional status influences the outcome of disease. The purpose of this study investigated the dietary habits, dietary quality, and quality of life for Korean PD patients according to their nutritional status. Seventy PD patients were recruited from K University Hospital (KMC IRB#0918-07) from February 2010 to October 2011. To diagnose PD, the United Kingdom Parkinson's Society Brain Bank standards were used by a neurology physician. The participants were interviewed and assessed using various tools, including a general questionnaire, anthropometrics, questionnaires for dietary habits, dietary diversity score (DVS), dietary variety score (DVS), diet quality index-international (DQI-I), beck depression inventory (BDI), the Korean version of mini mental state examination (K-MMSE), and 36-item short-form health survey (SF-36). The results of the study were as follows: 1) Most of the PD patients (69.0%) were at risk of malnutrition, and 8.5% and 22.5% of the subjects were malnourished and well-nourished, respectively. 2) Clinical symptoms (swallowing and chewing difficulties) were obvious, and the quality of diet (DDS, DVS, DQI-I) was low in the malnourished group (p < 0.01). 3) The malnourished group had significantly lower scores regarding SF-36 (quality of life) as well as that of cognitive function (p < 0.05). 4) The nutritional status of PD patients was significantly correlated with their depression (p < 0.05) and quality of life (p < 0.01). These results indicate that appropriate nutritional management will improve the nutritional status and quality of life as well as the cognitive function in Parkinson's disease patients.

The Domestic Trends of Korean Medical Treatments for Neck Pain Caused by Whiplash Injury (편타성 손상으로 인해 발생된 경부통의 한의학적 치료에 대한 국내 연구 동향)

  • Jeong, Seong-Hyun;Lee, Hyun-Ho;Lee, Gi-Eon;Choi, Ji-Hoon;Kim, Donghoo;Lee, Jong-Ha
    • Journal of Korean Medicine Rehabilitation
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    • v.27 no.4
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    • pp.11-19
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    • 2017
  • Objectives We attempted to investigate the trends of Korean Medical treatments for neck pain caused by whiplash injury by analyzing domestic clinical studies. Methods We searched for studies listed on Korean electronic databases (KTKP, OASIS, RISS, KMbase, NDSL, KCI, and National Assembly Library). Clinical studies were chosen according to the inclusion criteria. Subsequently, we compared and analyzed the data. Results The search yielded 35 studies, of which there were 12 randomized controlled trials (RCTs), 15 non-randomized controlled trials (NRCTs), 6 case reports, and 2 before-after studies. Among these, 54.7% of participants were in the acute stage of the damage period. Pharmacopuncture was used the most in main treatment methods. Only 14.3% of studies mentioned approval by an institutional review board (IRB) and only 8.6% of studies considered side effects. Conclusions There is some evidence that Korean Medical treatment is effective for neck pain caused by whiplash injury. Since all studies, however, were exposed to the risk of bias. Therefore, future studies of a higher quality are required.

Review of Meta-analysis Research on Exercise in South Korea (국내 운동 관련 메타분석 논문의 질 평가)

  • Song, Youngshin;Gang, Moonhee;Kim, Sun-Ae;Shin, In-Soo
    • Journal of Korean Academy of Nursing
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    • v.44 no.5
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    • pp.459-470
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    • 2014
  • Purpose: The purpose of this study was to evaluate the quality of meta-analysis regarding exercise using Assessment of Multiple Systematic Reviews (AMSTAR) as well as to compare effect size according to outcomes. Methods: Electronic databases including the Korean Studies Information Service System (KISS), the National Assembly Library and the DBpia, HAKJISAand RISS4U for the dates 1990 to January 2014 were searched for 'meta-analysis' and 'exercise' in the fields of medical, nursing, physical therapy and physical exercise in Korea. AMSTAR was scored for quality assessment of the 33 articles included in the study. Data were analyzed using descriptive statistics, t-test, ANOVA and ${\chi}^2$-test. Results: The mean score for AMSTAR evaluations was 4.18 (SD=1.78) and about 67% were classified at the low-quality level and 30% at the moderate-quality level. The scores of quality were statistically different by field of research, number of participants, number of databases, financial support and approval by IRB. The effect size that presented in individual studies were different by type of exercise in the applied intervention. Conclusion: This critical appraisal of meta-analysis published in various field that focused on exercise indicates that a guideline such as the PRISMA checklist should be strongly recommended for optimum reporting of meta-analysis across research fields.

Design and Implementation of Automated Detection System of Personal Identification Information for Surgical Video De-Identification (수술 동영상의 비식별화를 위한 개인식별정보 자동 검출 시스템 설계 및 구현)

  • Cho, Youngtak;Ahn, Kiok
    • Convergence Security Journal
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    • v.19 no.5
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    • pp.75-84
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    • 2019
  • Recently, the value of video as an important data of medical information technology is increasing due to the feature of rich clinical information. On the other hand, video is also required to be de-identified as a medical image, but the existing methods are mainly specialized in the stereotyped data and still images, which makes it difficult to apply the existing methods to the video data. In this paper, we propose an automated system to index candidate elements of personal identification information on a frame basis to solve this problem. The proposed system performs indexing process using text and person detection after preprocessing by scene segmentation and color knowledge based method. The generated index information is provided as metadata according to the purpose of use. In order to verify the effectiveness of the proposed system, the indexing speed was measured using prototype implementation and real surgical video. As a result, the work speed was more than twice as fast as the playing time of the input video, and it was confirmed that the decision making was possible through the case of the production of surgical education contents.

Factors Influencing Creativity in Nursing Students (간호대학생의 창의성에 미치는 영향요인)

  • Park, Ju-young;Woo, Chung Hee;Kim, Doo Ree
    • Journal of the Korea Convergence Society
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    • v.8 no.5
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    • pp.107-115
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    • 2017
  • The purpose of this study was to investigate the factors affecting the creativity of nursing college students who should act as professional nurses in the future. In order to carry out this research, the data collected through structured questionnaires were analyzed for 209 nursing college students who were approved by the IRB of K University. The results of this study showed that the creativity and self-efficacy(r=.374, p<.001), thinking ability(r=.347, p<.001), and school environment perception(r=.246, p<.001) were found to be positively correlated. In addition, the factors influencing the creativity of nursing students were self-efficacy(${\beta}=0.249$, p=.001), thinking ability(${\beta}=0.152$, p=.043), school environment perception(${\beta}=0.188$, p=.005) and the explanatory power of these variables was 21.2%. In the future, it will be necessary to develop educational methods for creativity development of nursing college students.

A Comparative Study of Dietary and Weight Control Behavior of Female College Students in Korea and China (한·중 여대생들의 식생활과 체중조절 행동 비교 연구)

  • Song, Li;An, Na Young;Ryu, Ho Kyung
    • The Korean Journal of Community Living Science
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    • v.26 no.4
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    • pp.761-774
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    • 2015
  • This study examines the dietary life, weight control, perceived body image, self-esteem, and eating disorder of female college students residing in Korea and China. With approval by the IRB of Pusan National University, a survey was conducted in Korea and China. A total of 574 subjects participated in the survey, and they were divided into three groups: 153 Korean female college students residing in Korea (KSK), 180 Chinese female college students residing in Korea (CSK), and 241 Chinese female college students residing in China (CSC). The group of underweight subjects far exceeded the overweight and obese groups, but there was no significant difference (p<0.05). The CSC group showed the highest food intake frequency and eating habit scores, and the KSK group, the lowest (p<0.05). However, the KSK group showed the highest daily life habit score, followed by the CSK and CSC groups, in that order. All groups showed high weight control experience rates mainly for losing weight. In particular, the KSK group showed a much higher rate than the CSC and CSK groups. All groups wanted much thinner body shapes than their actual shapes, resulting in high percentages of body image dissatisfaction. The KSK group showed a higher self-esteem score than the CSC group. The average EAT-26 score was similar across the three groups, but the percentage of eating disorders was much higher in the KSK group than in the CSC and CSK groups.

Analysis of Quantitative Research Published by Korean Journal of Adult Nursing (1989~2011) (성인간호학회지(1989~2011)에 게재된 양적 연구의 동향 분석)

  • Kim, Young-Kyeong;Hwang, Sun-Kyung;Kim, In-Ja;Kim, Ju-Sung;Oh, Hee-Young;Lee, Jong-Kyung;Jung, Eun-Sook;Choi, Gui-Yun;Choi, Ja-Yun
    • Korean Journal of Adult Nursing
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    • v.24 no.1
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    • pp.85-97
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    • 2012
  • Purpose: The aims of this study were to examine the trend of quantitative study in Korean Journal of Adult Nursing published between 1989-2011 and to provide future directions for nursing research in adult health nursing. Methods: A total of 883 published articles were reviewed, and main subject and the methodology were analyzed using descriptive statistics. Results: The most frequently cited keywords were elderly, quality of life, depression, knowledge, stress and anxiety. The survey study was the most popular research design (67.6%) followed by experimental (26.5%), and methodological study (5.5%) design. Over 80% of studies with translated or developed instruments reported reliability for psychometric analysis, while only 18% of the studies reported validity of the instruments they used. In the periods of 2006~2011, significantly more studies utilized experimental design, obtained IRB approval and written consent, and included power analysis for sample size calculation. In recent experimental study, educational program and complimentary therapy were the two most frequently used interventions. Conclusion: Through the analysis of nursing studies published in Korean Journal of Adult Nursing, we found the number of experimental studies has increased and methodological rigor has improved in recent years.

A Study on the Reliability Assessment of Sasang Constitution Questionnaire Developed by KIOM for Japanese (일본인 대상자를 통해 살펴본 KIOM 체질 설문지의 신뢰도 평가)

  • Yoo, Jong-Hyang;Jang, Eun-Su;Kim, Yun-Yung;Park, Ki-Hyun;Lee, Si-Woo
    • Journal of Sasang Constitutional Medicine
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    • v.24 no.2
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    • pp.8-18
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    • 2012
  • 1. Objectives : This study aimed to assessing the reliability of questionnaire for Japanese as one of method to diagnose Sasang Constitution and evaluating the possibility of applying domestic questionnaire to foreign site. 2. Methods : A cross-sectional survey approved by IRB (Independent Review Board) at Tohoku University was performed for 119 participants with informed consent at a particular city in Japan using self-reported questionnaires developed by KIOM (Korea Institute of Oriental Medicine). Among the entire samples, 112 were retested. The test-retest reliability was assessed by Kappa for normal variables and internal consistency was evaluated by Cronbach's alpha. 3. Results : Four of 77 questions are impossible to calculate consistency owing to unsymmetric matrix between primary reply and secondary one. Seventeen of them (22%) showed 0.4 or below in Kappa, 56 were ranged from 0.4 to 0.8 and no question marked 0.8 or over. Internal consistency was possibly checked for several questions about character, digestion, sweat, excrement, urine, cold-heat pattern. Cronbach's alpha for questions except urine and cold-heat pattern was over 0.6 4. Conclusions : On the basis of Kappa value by two self reported questionnaire, 72.7% of questions showed 0.4 or over so that reliability were highly secured. And other questions except for urine and heat-cold pattern marked 0.6 or over in order that internal consistency was also successfully maintained. Accordingly, when subsequently applying KIOM questionnaire to foreign site, domestic questionnaire should be properly adjusted in social and cultural background, lifestyle, etc.

The Domestic Trends of Acupuncture Treatment on Lateral Epicondylitis : A literature review (주관절 외측상과염의 침치료에 대한 국내 연구 동향 분석)

  • Kim, Hyunseok;Lee, Chiho;Oh, Minseok
    • Journal of Haehwa Medicine
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    • v.25 no.1
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    • pp.1-13
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    • 2016
  • Objectives : Lateral epicondylitis on elbow is one of the most common causes of elbow pain. Lateral epicondylitis can be managed with acupuncture, but the evidence for its effectiveness is uncertain. The purpose of this review is to investigate the trends of acupuncture treatments on lateral epicondylitis. Methods : We investigated the studies about acupuncture treatments for lateral epicondylitis via searching 5 Korean web databases(KTKP, RISS, OASIS, KCI, Kisti) The key search terms were 'Lateral epicondylitis', 'Tennis elbow', 'External epicondylitis'. 12 research papers(10 case reports, 1 RCT, 1NRCT) were found to be analyzed according to their published year, the titles of journals, published institution, the types of study, the number of cases, the types of treatments, the instruments for assessment and ethical approvals. The effectiveness of acupuncture treatment was classified. Results : 12 papers were published since 2003. The studies on acupuncture treatments about lateral epicondylitis were mainly published in The journal of pharmacopuncture. 10 case reports, 1 non-randomized controlled trials, 1 randomized controlled trials had been under research. In most of the research, the number of the cases were not enough. In 9 cases of the studies, various korean medicine treatments including acupuncture were used to treat the symptoms. In 3 cases of the studies single method was used to treat the symptoms. Visual analogue scale(VAS) and range of motion(ROM), grip strength were used as primary assessments. Among 12 clinical studies, 1 of them were accepted by institutional review board(IRB). Conclusions : In this study, we analyzed the trends of acupuncture treatments on lateral epicondylitis. Reviewing the domestic trends of studies on acupuncture treatments for lateral epicondylitis and examining the strong and weak points of those treatments are essential for the future studies.