• Journal of KIBIM
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• v.9 no.3
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• pp.41-53
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• 2019

As a central part in smart construction, BIM has been rapidly spread in construction industry at large. However, the level of applying BIM in construction stage is still relatively lower than that in design stage due to unclear application method, inadequate design BIM model, technical faults of BIM itself, etc. Under these circumstances, public owners inevitably need to adjust the scope and pace in BIM application considering their internal support and capabilities of contractors. This study aims to suggest major BIM-applicable tasks during construction stage in the process of establishing gradual long-term and short-term introduction strategy for public apartment housing projects. Those major tasks were identified with the combination of the importance of tasks and the future benefits of BIM using IPA method. To do so, the degrees of contribution to achieving objectives in construction, current task execution, and communication requirement were investigated by internal site managers. On the other hand, the expected benefits and current level of using BIM were assessed by BIM experts. Among operational tasks by phases, design review, construction plan review, making as-built drawing, etc. were categorized as major tasks. In addition, progress control, regular meeting, master schedule development, work inspection, on-site quality check, etc. were also drawn as major tasks by management areas. The results of this study will provide the useful reference for owners concerned about the introduction of new technologies.

• Safety and Health at Work
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• v.2 no.4
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• pp.355-364
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• 2011

Objectives: Though sulfur dioxide (SO2) is used widely at workplaces, itseffects on humans are not known. Thresholds are reportedwithout reference to gender or age and occupational exposure limits are basedon effects on lung functioning, although localized effects in the upper airways can be expected. This study's aim is to determine thresholds with respect to age and gender and suggests a new approach to risk assessment using breathing reflexes presumably triggered by trigeminal receptors in the upper airways. Methods: Odor thresholds were determined by the ascending method of limits in groups stratified by age and gender. Subjects rated intensities of different olfactory and trigeminal perceptions at different concentrations of $SO_2$. During the presentation of the concentrations, breathing movements were measured by respiratory inductive plethysmography. Results: Neither age nor gender effects were observed for odor threshold. Only ratings of nasal irritation were influenced bygender. A benchmark dose analysis on relative respiratory depth revealed a 10%-deviation from baseline at about 25.27 mg/$m^3$. Conclusion: The proposed new approach to risk assessment appearsto be sustainable. We discuss whether a 10%-deviation of breathingdepth is relevant.

• The Journal of the Korea Contents Association
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• v.18 no.11
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• pp.406-415
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• 2018

Educational satisfaction is an important indicator of the educational field but the existing customer satisfaction index mainly focused on partial area because measurements could not reflect the alteration of university environment. The purpose of this research is to develop a new UCSI for university to improve the quality of university education. This research demonstrates validity and reliability of UCSI. This research uses the second-order confirmatory factor analysis. The results indicate that the reliability and validity of UCSI is verified. Education condition, education course, university development and student support are clarified to be appropriate components of the satisfaction survey. This research develops UCSI and applies it in a university. University managers can be used to measure the satisfaction level of university education and to improve the quality of university education.

• Biomolecules & Therapeutics
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• v.27 no.3
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• pp.302-310
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• 2019

Melanoma cells have been shown to respond to BRAF inhibitors; however, intrinsic and acquired resistance limits their clinical application. In this study, we performed RNA-Seq analysis with BRAF inhibitor-sensitive (A375P) and -resistant (A375P/Mdr with acquired resistance and SK-MEL-2 with intrinsic resistance) melanoma cell lines, to reveal the genes and pathways potentially involved in intrinsic and acquired resistance to BRAF inhibitors. A total of 546 differentially expressed genes (DEGs), including 239 up-regulated and 307 down-regulated genes, were identified in both intrinsic and acquired resistant cells. Gene ontology (GO) analysis revealed that the top 10 biological processes associated with these genes included angiogenesis, immune response, cell adhesion, antigen processing and presentation, extracellular matrix organization, osteoblast differentiation, collagen catabolic process, viral entry into host cell, cell migration, and positive regulation of protein kinase B signaling. In addition, using the PAN-THER GO classification system, we showed that the highest enriched GOs targeted by the 546 DEGs were responses to cellular processes (ontology: biological process), binding (ontology: molecular function), and cell subcellular localization (ontology: cellular component). Ingenuity pathway analysis (IPA) network analysis showed a network that was common to two BRAF inhibitorresistant cells. Taken together, the present study may provide a useful platform to further reveal biological processes associated with BRAF inhibitor resistance, and present areas for therapeutic tool development to overcome BRAF inhibitor resistance.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.26 no.3
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• pp.155-165
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• 2019

Purpose: Although emergency care is one of the most important capabilities for novice nurses, many novice nurses have shown difficulty in emergency care in the clinical field. The purpose of this study was to provide evidence data for the future development of educational programs by analyzing the priorities in emergency care of novice nurses using the Importance-Performance Analysis. Methods: This study was designed as a descriptive survey. The participants were 197 novice nurses who worked in general hospitals from August 1 to 31, 2018. The questionnaire consisted of 'common emergency care', 'cardiovascular emergency care', 'nervous system emergency care', 'respiratory system emergency care', 'communication and teamwork competency'. Results: As a result of this study, 'communication and teamwork' among emergency cares was evaluated as the most important capability in the clinical field. In the Importance-Performance Analysis, a total of 12 items were included in the quadrant A, including 5 items related to 'cardiovascular emergency care', 4 items to 'respiratory system emergency care', 2 items to 'nervous system emergency care' and 1 item to 'common emergency care'. The results showed a need for intensive improvement in items included in quadrant A which are the high importance low performance items. Conclusion: In order to improve the emergency care of novice nurses, a variety of emergency care education programs on the nervous system and respiratory system care should be implemented as well as cardiovascular emergency care education.

• Journal of Korean Society of Forest Science
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• v.108 no.1
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• pp.109-115
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• 2019

The objectives of this study was to analyze the importance and satisfaction (ISA) of forest healing instructor training program, targeting on the students educated in 2018. As a result, it was found that students older than forties are the majority as 81 %, and they preferred forest healing instructors as their second future job. When comparing the importance and satisfaction, the students evaluated satisfaction with low grade compared to importance with high grade in all questions. In ISA analysis, it was needed to improve the updated textbook information, to list the example problems by subject, to expose the test subjects in the textbooks, to disclose the test questions and answers, to control the test difficulty, to adjust the test pass rate, to expand the number of test and test sites, to increase the effort for making students understand, to prepare lectures appropriate to practice for forest healing instructor training program by priority.

• Journal of the Korea Institute of Building Construction
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• v.20 no.6
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• pp.545-554
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• 2020

As recent safety accidents at construction sites can lead to serious accidents that threaten the lives of workers, the role of safety managers in charge of safety management has emerged. However, the current construction safety management system requires the improvement and simplification of the work contents due to the excessive workload and inefficient safety tasks of each person. In this respect, the main purpose of this study is to reduce the occurrence of construction safety accidents by deriving correlations using 2×2 Matrix analysis techniques through expert opinion, simplifying unnecessary tasks and identifying areas requiring improvement. Therefore, if this research reduces inefficient safety manager work and reduces job stress caused by excessive simple document work, thereby efficiently reorganizing safety manager's work to prevent blind spots of hazards and risks, it will ultimately have a great effect on preventing safety accidents at construction sites.

• Journal of Microbiology and Biotechnology
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• v.29 no.7
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• pp.1155-1164
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• 2019

Lichens contain diverse bioactive secondary metabolites with various chemical and biological properties, which have been widely studied. However, details of the inhibitory mechanisms of their secondary metabolites against influenza A virus (IAV) have not been documented. Here, we investigated the antiviral effect of lichen extracts, obtained from South Korea, against IAV in MDCK cells. Of the lichens tested, Nipponoparmelia laevior (LC24) exhibited the most potent inhibitory effect against IAV infection. LC24 extract significantly increased cell viability, and reduced apoptosis in IAV-infected cells. The LC24 extract also markedly reduced (~ 3.2 log-fold) IAV mRNA expression after 48 h of infection. To understand the antiviral mechanism of LC24 against IAV, proteomic (UPLC-$HDMS^E$) analysis was performed to compare proteome modulation in IAV-infected (V) vs. mock (M) and LC24+IAV (LCV) vs. V cells. Based on Ingenuity Pathway Analysis (IPA), LC24 inhibited IAV infection by modulating several antiviral-related genes and proteins (HSPA4, HSPA5, HSPA8, ANXA1, ANXA2, $HIF-1{\alpha}$, AKT1, MX1, HNRNPH1, HNRNPDL, PDIA3, and VCP) via different signaling pathways, including $HIF-1{\alpha}$ signaling, unfolded protein response, and interferon signaling. These molecules were identified as the specific biomarkers for controlling IAV in vitro and further confirmation of their potential against IAV in vivo is required. Our findings provide a platform for further studies on the application of lichen extracts against IAV.

• Journal of Korean Society of Archives and Records Management
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• v.21 no.1
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• pp.97-116
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• 2021

This study aims to analyze the level of members' awareness of records management in the Republic of Korea Army within the institutional context extensively. Accordingly, in-depth interviews were conducted after comparing and analyzing the institutional systems that restricted the members' record management activities. As a result, it was identified that the members were confused by the inconsistency among the systems that defined the work procedures, and that the value of responsibility and efficiency in the records management system does not match the organization's goals. Therefore, the legal justification of the system should be improved in harmony with the responsibilities and efficiency and to match them with the organization's objectives. Moreover, the improved system should be internalized by the members through instructions that are relevant to the content of the system. This study intends to increase awareness in the records management system and improve the system as well.

• Journal of Digital Convergence
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• v.19 no.11
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• pp.45-52
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• 2021

This study conducted t-test and ANOVA analysis, influence of importance-satisfaction, regression analysis to local food and restaurants to the purchase intention in Busan. The subjects of this study were tourists who visited local restaurants in Busan, and the final 392 copies were used for empirical analysis. As a result of the study, first, there will be a significant difference in the recognition of local foods in Busan according to the visitor's region. In all samples, the recognition was high in the order of pork stock, wheat noodle, sauteed·fired soft eel, grilled·ell sashmi. On the other hand, sansung bulgogi, Dongrae pajeon, and sansung makkŏlli were the lowest. Second, in the difference between importance and satisfaction of local restaurants in Busan, 'there is a different taste compared to other regions' showed high satisfaction and importance. Third, In the relationship between the awareness of local restaurants in Busan and the purchase intention, it was found to be effective in service, facilities, prices and locality and cleanliness were rejected.