• BMB Reports
• /
• 제53권6호
• /
• pp.329-334
• /
• 2020

Inflammasomes are cytosolic, multiprotein complexes that act at the frontline of the immune responses by recognizing pathogen- or danger-associated molecular patterns or abnormal host molecules. Mesenchymal stem cells (MSCs) have been reported to possess multipotency to differentiate into various cell types and immunoregulatory effects. In this study, we investigated the expression and functional regulation of NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome in human umbilical cord blood-derived MSCs (hUCB-MSCs). hUCB-MSCs expressed inflammasome components that are necessary for its complex assembly. Interestingly, NLRP3 inflammasome activation suppressed the differentiation of hUCB-MSCs into osteoblasts, which was restored when the expression of adaptor proteins for inflammasome assembly was inhibited. Moreover, the suppressive effects of MSCs on T cell responses and the macrophage activation were augmented in response to NLRP3 activation. In vivo studies using colitic mice revealed that the protective abilities of hUCB-MSCs increased after NLRP3 stimulation. In conclusion, our findings suggest that the NLRP3 inflammasome components are expressed in hUCB-MSCs and its activation can regulate the differentiation capability and the immunomodulatory effects of hUCB-MSCs.

• 한국컴퓨터정보학회논문지
• /
• 제10권6호
• /
• pp.1-8
• /
• 2005

얼굴 분석은 얼굴 인식 머리 움직임과 얼굴 표정을 이용한 인간과 컴퓨터사이의 인터페이스, 모델 기반 코딩, 가상현실 등 많은 응용 분야에서 유용하게 활용된다. 이러한 응용 분야에서는 얼굴의 특징점들을 정확하게 추출해야 한다. 본 논문에서는 눈, 눈썹, 입술의 코너와 같은 얼굴 특징을 자동으로 추출하는 방법을 제안한다. 먼저, 입력 영상으로부터 AdaBoost 기반의 객체 검출 기법을 이용하여 얼굴 영역을 추출한다. 그 다음에는 계곡 에너지. 명도 에너지, 경계선 에너지의 세 가지 특징 에너지를 계산하여 결합한다. 구해진 특징 에너지 영상에 대하여 에너지 값이 큰 수평 방향향의 사각형을 탐색함으로써 특징 영역을 검출한다. 마지막으로 특징 영역의 가장자리 부분에서 코너 검출 알고리즘을 적용함으로써 눈, 눈썹, 입술의 코너를 검출한다. 본 논문에서 제안된 얼굴 특징 추출 방법은 세 가지의 특징 에너지를 결합하여 사용하고 계곡 에너지와 명도 에너지의 계산이 조명 변화에 적응적인 특성을 갖도록 함으로써, 다양한 환경 조건하에서 견고하게 얼굴 특징을 추출할 수 있다.

• 한국건축시공학회지
• /
• 제11권1호
• /
• pp.29-34
• /
• 2011

성능중심의 건축재료설계 수행과정에서 어떤 성능에 대한 시험 방법이 복수 존재할 경우 최적 대안 선택에 필요한 시험방법 DB 기반구축의 일환으로, 인체충돌시 바닥의 안전성을 예로서 시험방법간의 연관성을 분석하였다. 8종류의 바닥시험체를 대상으로 EN 1177의 한계하강높이 시험과 JIS A 6519의 헤드모델 시험을 적용한 결과, 주로 바닥의 강성(쿠션) 크기에 따라 각 시험방법의 적용상 한계가 있다는 것을 알 수 있었다. 또한 시험을 통해 측정하는 물리량 단위가 같은 경우라도 시험방법간 연관성이 불분명한 상태에서는 각각의 물리량이 호환되지 않는다는 것을 알수 있었다.

• 대한기관식도과학회지
• /
• 제5권2호
• /
• pp.119-126
• /
• 1999

Objectives : To analyze the effect of retinoids on the differentiation in HNSCC xenografts. Materials and Methods : RA (20mg/kg) or 13-cis-RA (60mg/kg) was orally administered once in a day for 30 days in the xenograft model we prepared using athymic nude mice with AMCHN-4 and -6. We carried out H & E staining and immunohistochemical staining with the monoclonal antibody against involucrin and cytokeratin 10. Results : Both RA and 13-cis-RA were found to suppress the differentiation of AMC-HN-4. Interestingly, RA enhanced the differentiation of AMC-HN-6, although 13-cis RA did not exhibit any effect on the differentiation. These results suggest that in vivo effect of retinoids on the HNSCC growth and differentiation might be various. Retinoids-induced P450 in AMC-HN-6 might be one of the mechanisms to explain the reason why the retinoids exhibit various functions in the HNSCC.

• 한국콘텐츠학회:학술대회논문집
• /
• 한국콘텐츠학회 2005년도 추계 종합학술대회 논문집
• /
• pp.633-638
• /
• 2005

얼굴 추출은 휴먼 인터페이스와 생체 인식 및 보안을 위해 매우 중요한 분야이다. 본 논문에서는 동영상에서 얼굴의 윤곽선을 추출하기 위해, DCM(Dilation of Color and Motion)필터와 동적 윤곽선 모델(Active Contour Model) 적용한다. 먼저, 본 논문에서 제안된 DCM 필터는 모폴로지의 팽창 연산이 적용된 얼굴 색상영상과 차영상을 결합하고 이를 다시 팽창한 것으로 동영상에서 복잡한 배경을 제거하고 얼굴 영역을 검출하기 위해 사용된다. 동적 윤곽선 모델은 초기 곡선에 영향을 많이 받으므로, 얼굴과 눈, 입의 기하학적인 비율을 이용하여 회전정도를 구한 후, 이를 이용하여 초기 곡선을 자동으로 설정한다. 에지가 약한 부분에서의 윤곽선 추출을 위해, 스네이크의 영상에너지로 에지영상과 밝기영상을 함께 사용하였다. 복잡한 배경이 있는 실내 환경에서 총 5명으로부터 양 눈이 보이는 다양한 헤드 포즈 영상을 25장씩 샘플링하여 총 125장에 대해 실험한 결과, 얼굴 윤곽선의 평균 추출률은 98.1%, 평균 처리시간은 0.2초로 나타났다.

• Journal of Ginseng Research
• /
• 제35권2호
• /
• pp.138-148
• /
• 2011

Exponential rise in the use of mobile communication devices has generated health concerns due to radiofrequency (RF) exposure due to its close proximity to the head. Calcium binding proteins like calretinin regulate the levels of calcium ($Ca^{2+}$) which plays an important role in biological systems. Ginseng is known for maintaining equilibrium in the human body and may play a beneficial radioprotectant role against electromagnetic field (EMF) exposure. In the present study, we evaluated the radioprotective effects of red ginseng (RG) extract in a mouse model. Calretinin (CR) expression was measured using a free-floating immunohistochemical method in the hippocampus of mice after 835 MHz EMF exposure for 5 h/d for 5 d at specific absorption rate=1.6 W/kg for the different experimental groups. The control animals were treated with NaCl while the experimental animals received 10 mg/kg ginseng, or 30 mg/kg; EMF exposed mice were also treated with NaCl, 10 mg/kg ginseng (E10), or 30 mg/kg (E30). Decreases in CR immunoreactivity (IR) along with loss of CA1 and CA3 interneurons and infragranular cells were observed in the ENaCl group while such losses were not observed in the E10 and E30 groups. CR IR significantly increased in the RG-treated group compared to control and EMF-exposed groups treated with NaCl. The study demonstrates that RG extract can serve as a radioprotective agent that maintains $Ca^{2+}$ homeostasis and prevents neuronal loss in the brain hippocampal region caused by RF exposure.

• Restorative Dentistry and Endodontics
• /
• 제18권1호
• /
• pp.103-113
• /
• 1993

The purpose of this study was to evaluate the tensile bond strength of composite resin inlays according to the their internal surface treatment and types of luting cement and compared them with the conventional direct resin filling thchnique. Class II cavities were prepared in 50 extracted human molar teeth, and then equally divided into five groups. Group 1 : Cavities of control group were directly filled with P-50. Group 2 : Cavities of resin inlay group were luted with resin cement. Group 3 : Cavities of resin inlay group were luted with luting G-I cement. Group 4 : Cavities of resin inlay group were luted with resin cement after sandblasting. Group 5 : Cavities of resin inlay group were luted with luting G-I cement after sandblasting. All specimens were polished with same method and stored in normal saline for 24 hours before testing. An Universal Testing machine(Model No. AGS-100A, Shimadzu, Japan) was used to apply tensile loads in the vertical direction, and the force required for separation was recorded with a cross-head speed of 5mm/min and 100kg in full scale. The results were as follows : 1. The mean tensile bond strength was lowest in group luted with luting G-I cement, with measurements of $14.45{\pm}0.78(kg/cm^2)$ and highest in group luted with resin cement after sandblasting, with measurements of $49.6{\pm}2.74(kg/cm^2)$. 2. The tensile bond strength was greater in resin inlay groups luted with resin cement than in control group and resin inlay groups luted with luting G-I cement(P<0.05). 3. The tensile bond strength was lower in resin inlay groups luted with luting G-I cement than in control group(P<0.05). 4. The tensile bond strength was greater in resin inlay groups luted with resin cement or luting G-I cement after sandblasting than without that(P<0.05).

• 한국정보통신학회논문지
• /
• 제25권10호
• /
• pp.1427-1434
• /
• 2021

본 연구는 사회성 상호작용 훈련자극에 반응하는 아동의 행동 및 정서적 긴장상태를 연산하는 심리반응 상태 추정 프로세스를 제안한다. 행동 중재에 필요한 훈련자극으로는 공동 주의(Joint attention) 사회성 훈련을 채택하고, 훈련프로토콜은 불연속 개별시도 훈련(DTT: Discrete trial training)기법이 적용된다. 공동 주의 훈련에서 사용자의 집중과 긴장 정도를 확인하기 위해 3가지 훈련자극용 콘텐츠를 구성한 후, 캐릭터 형태의 탁상 로봇을 이용하여 사용자에게 훈련자극을 수행하게 된다. 그런 다음, 비전 기반 헤드 포즈 인식기와 기하학 연산모델로 사용자 응시반응을 추정하고, PPG와 GSR의 생체신호를 심박변이도와 히스토그램 기법으로 신경계 반응을 분석한다. 로봇을 활용한 실험에서 공동 주의에 대한 각 콘텐츠 별 훈련에 사용자의 심리반응을 정량화 할 수 있음을 확인하였다.

• 항공우주의학회지
• /
• 제30권3호
• /
• pp.83-85
• /
• 2020

In commemoration of Vol. 30, Issue 3, our journal prepared five review articles and one original paper. The global outbreak of COVID-19 in 2020 has impacted our society, and especially the aviation and travel industries have been severely damaged. Kwon presented the aviation medical examination regulations related to COVID-19 announced by the Ministry of Land, Infrastructure, and Transport of the Republic of Korea. Lim summarized various efforts of airlines to overcome the crisis in the aviation industry. He also discussed the management of these aircraft as the number of airplanes landing for long periods increased. Finally, he suggested various quarantine guidelines at airports and onboard aircraft. COVID-19 has had a profound impact on mental health as well as physical effects. Kim investigated the impact of COVID-19 on mental health and suggested ways to manage the stress caused by it. The Internet of Things (IoT) refers to a technology in which devices communicate with each other through wired or wireless communication. Hyun explained the current state of the technology of the IoT and how it could be used, especially in the aviation field. In the area of airline service, various situations arise between passengers and crew. Therefore, role-playing is useful in performing education to prepare and respond to passengers' different needs appropriately. Ra introduced the conceptual background and general concepts of role-playing and presented the actual role-play's preparation process, implementation, evaluation, and feedback process. For a fighter to fly for a long time and perform a rapid air attack, air refueling is essential, which serves refueling from the air rather than from the aircraft base. Koo developed a questionnaire based on the HFACS (Human Factors Analysis and Classification System) model and used it to conduct a fighter pilot survey and analyze the results.

• 여성건강간호학회지
• /
• 제30권2호
• /
• pp.101-106
• /
• 2024

This paper discusses the implications of the birth notification system and the Protected Birth Act in Korea. Aiming to prevent infanticide and abandonment of infants, the law will enter into force on July 19, 2024 in South Korea. The birth notification system mandates that both parents and the head of the medical institution where the birth occurred must report the event. In parallel, the Protected Birth Act will be implemented, allowing pregnant women in crisis who wish to remain anonymous, the option to give birth outside of a hospital setting in a way that safeguards the life and health of the child. However, many issues are being raised in Korean society in advance of the implementation of the Protected Birth Act. There is widespread concern that the Protected Birth Act fails to protect either women or children, especially as it raises issues regarding the need for legislation to protect children with disabilities and to address gaps for migrant women and children. This paper examines the gender and healthcare issues relating to the Protected Birth Act, focusing on women's health and human rights. The Act continues to perpetuate discrimination against out-of-wedlock pregnancies and upholds the ideology of the traditional family model. Furthermore, the legislative process did not address protective measures for the various reasons behind child abandonment. Critical issues such as women's autonomy, safe pregnancy termination, and paternal responsibility in childbirth are also notably absent. However, with the Act set to take effect soon, it is crucial for healthcare providers to comprehend the rationale and procedures associated with birth notification and the Protected Birth Act, and to prepare for its nationwide implementation. The law defines the socially vulnerable as its main beneficiaries, and it is necessary to strengthen social safety nets to improve their access to healthcare, eliminate prejudice and discrimination against out-of-wedlock pregnancies, and embrace the diversity of our society. We eagerly anticipate future discussions on gender and healthcare issues, as well as amendments to the law that reflect real-world circumstances to provide genuine protection for pregnant women in crisis and their infants.