• Archives of Plastic Surgery
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• v.38 no.5
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• pp.576-584
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• 2011

Purpose: The shape and location, the amount of the wound and the characteristics of the remaining tissues are known to influence wound contraction. The previous studies using small animals have not been an appropriate model because the wound healing mechanisms and skin structures are different from those of the human. The purpose of this study is to evaluate wound contraction according to the shape and location of the wound using a $Micropig^{(R)}$. Methods: Four $Micropigs^{(R)}$ (Medikinetics, Pyeongtaek, Korea) that were 10 months of age weighed 25 kg were used. Full thickness skin defects were made by clearing all the tissues above the fascial layer in the shape of square, a regular triangle and a circle of 9 $cm^2$ each on the back around the spine. Eight wounds were created on the back of each pig, 50 mm apart from each other. The randomly chosen wound shapes included 11 squares, 11 regular triangles, and 10 circles. Wound dressing was done every other day with polyurethane foam. The wound size was measured using a Visitrak $Digital^{(R)}$ (Smith & Nephew, Hull, UK) on every other day after surgery from day 2 to day 28. A biopsy was performed on day 3, and 1, 2, 3 and 4 weeks to investigate the degree of acute and chronic inflammation, the number of microvesssel and myofibroblast density using H & E stain and immunohistochemistry. The wound contraction rate was calculated to figure out the differences among each of the shapes and the locations. Results: The ultimate shape of the circle wound was oval, and that of the regular triangle and square were stellate. The maximum contraction rate was obtained on 8 to 10 days for all the shapes, which corresponds with the immunohistochemical finding that myofibroblast increases in the earlier 2 weeks whereas it decreases in the later 2 weeks. Epithelialization was seen in the wound margin on day 7 and afterwards. The final wound contraction rates were highest for the regular triangle shapes; however, there were no statistically significant differences. The wound contraction rates by locations showed statistically significant differences. The wound in the cephalic area presented more contractions than that of the wounds in the caudal area. Conclusion: The location of a wound is more important factor than the wound shape in wound contraction.

• The Journal of Pediatrics of Korean Medicine
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• v.21 no.3
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• pp.33-55
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• 2007

Objectives In the present study, the author intended to investigate whether bojung-ikgitang-gamibang(BJGB) and seonbang-paedoktang(SBPT) significantly affect in vivo and in vitro mucin secretion from airway epithelial cells. Methods In vivo experiment, mice's mucin which is on a hypersecretion of airway mucin, mice's tracheal goblet cells in hyperplasia and mice's intraepithelial mucosubstances were exposed with SO2for3weeks. Effects of orally-administered BJGB and SBPT during 1 week on vivo mucin secretion and hyperplasia of tracheal goblet cells were assessed by using both enzyme-linked immunosorbent assay(ELISA) and staining goblet cells with alcian blue. In vitro experiment, confluent hamster tracheal surface epithelial(HTSE) cells were metabolically radiolabeled with 3H-glucosamine for 24hrs and chased for 30 min in the presence of each agent to figure out the effectiveness of 3H-mucin secretion. Total elution profiles of control spent media and treatment sample through Sepharose CL-4B column were analyzed. The effects of each agent on contractility of isolated tracheal smooth muscle and effects of each agent on MUC5AC gene expression in cultured HTSE cells were investigated. Also, possible cytotoxicities of each agent were assessed by measuring lactate dehydrogenase(LDH) release. Additionally, effects of BJGB and SBPT on both MUC5AC gene expression in cultured HTSE cells and TNF- or EGF-induced MUC5AC gene expression in human airway epithelial cells (NCI-H292) were investigated. Results (1) BJGB and SBPT inhibited hypersecretion of in vivo mucin. SBPT also inhibited the increase the number of goblet cells. However, BJGB did not affect the increase of number of goblet cells; (2) BJGB significantly increased mucin secretion from cultured HTSE cells, without significant cytotoxicity, and chiefly affected the 'mucin' secretion; (3) SBPT did not affect mucin secretion from cultured HTSE cells without significant cytotoxicity, and also did not affect the secretion of the other releseable glycoproteins; (4) BJGB and SBPT did not affect Ach-induced contraction of isolated tracheal smooth muscle; (5) SBPT significantly inhibit the expression levels of MUC5AC gene and BJGB significantly increased the expression levels of MUC5AC gene in both HTSE cells and NCI-H292 cells. Conclusions BJGB and SBPT can not only affect the secretion of mucin but also affect the expression of mucin gene. The author suggests that the effects BJGB and SBPT with their components should be further investigated and it is highly desirable to find from oriental medical prescriptions, novel agents which might regulate hypersecretion of mucin from airway epithelial cells.

• Korean Journal of Ecology and Environment
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• v.48 no.2
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• pp.122-128
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• 2015

This study aims to figure out the vegetation status and characteristics of the spatial distribution in Taeanhaean National Park. As a result, vegetation communities were Pinus thunbergii community, Pinus densiflora community, Pinus thunbergii-Pinus densiflora community, Camellia japonica community, Carpinus turczaninowii community, Carpinus turczaninowii-Pinus thunbergii community, Kalopanax septemlobus community, Koelreuteria paniculata community, Robinia pseudoacacia community, and sand dune and coastal wetland vegetation including Vitex rotundifolia community, Elymus mollis community, Calamagrostis epigeios community, Ischaemum anthephoroides community, Zoysia sinica community, Suaeda maritima community, and Phragmites communis community. Landscape types in actual vegetation map were Pinus thunbergii community (3.92%), Pinus densiflora community (1.40%), Robinia pseudoacacia community (0.05%), sand dune and coastal wetland vegetation (0.11%), field (0.46%), seashore (0.24%), thinning area (0.08%), bareground (0.16%), and sea (93.58%). Area of Pinus thunbergii community among vegetation type was $14.797km^2$ (3.92%) and the largest. Stratification structure and species composition of Pinus thunbergii community distributed in the seashore were different as a result of disturbance and human use. On the other hand, we assumed that succession will take place to the potential natural vegetation that is Quercus serrata and Quercus dentata in undisturbed Pinus thunbergii community. Meanwhile, Erechtites hieracifolia was occupied in understory of Pinus thunbergii community around the seashore and Diodia teres was invaded to sand dune vegetation. They may affect on natural species negatively. Therefore, monitoring and management plans are necessary.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.4
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• pp.202-217
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• 2018

Urban land use changes by human activities affect spatial configuration of urban areas and their surrounding ecosystems. Although it is necessary to identify patterns of urban land use changes and to simulate future changes for sustainable urban management, simulation of land use changes is still challenging due to their uncertainty and complexity. Cellular automata model is widely used to simulate urban land use changes based on cell-based approaches. However, cell-based models can not reflect features of actual land use changes and tend to simulate fragmented patterns. To solve these problems, object-based cellular automata models are developed, which simulate land use changes by land patches. This study simulate future land use changes in Hanam city using an object-based cellular automata model. Figure of merit of the model is 24.1%, which assess accuracy of the simulation results. When a baseline scenario was applied, urban decreased by 16.4% while agriculture land increased by 9.0% and grass increased by 19.3% in a simulation result of 2038 years. In an urban development scenario, urban increased by 22.4% and agriculture land decreased by 26.1% while forest and grass did not have significant changes. In a natural conservation scenario, urban decreased by 29.5% and agriculture land decreased by 8.8% while each forest and grass increased by 6% and 42.8%. The model can be useful to simulate realistic urban land use change effectively, and then, applied as a decision support tool for spatial planning.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.2
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• pp.76-82
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• 2019

This study has done to search for a solution to remove risk limitedly caused by separating weapon system acquisition from operation and maintenance at the view point of Logistic Commander who's responsible for stable operation and maintenance after acquiring weapon system. At the System development stage, unverified overhaul development plan may cause additional manpower and costs after the development, and furthermore it is likely to have risk to lower reliability of the military. Thus, research and development agency should write overhaul development plan at the System development stage, and it should be verified through evaluation and verification test. Secondly, during research and development, institutional supplementation is needed to calculate human and material resources writing overhaul development plan. Thirdly, it should be able to analyze proper operation & maintenance plan and cost for overhaul plan at the pre-investigation stage. Fourthly, the base which can develop overhaul concept and overhaul factors should be included in the need and need determination document. Lastly, for the weapon system which has small amount of high power figure, project management should be performed to be able to specify at the each acquisition level of weapon system to realize Article 28, clause 3 and 4 of Defense business law.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.6
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• pp.573-582
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• 2021

In this study, a series of processes for evaluating the effective protection against barriers that should be equipped in institutions that perform reliability tests on high-risk ammunition, such as high-explosive ammunition, were introduced. The impact that high-explosive bombs can have on personnel includes damage to the eardrum and lungs caused by explosion overpressure and penetrating wounds that can be received by fragments generated simultaneously with the explosion. Therefore, a high-explosive with COMP B explosives as its contents were set up, and an explosion protection theory investigation to calculate the degree of damage, numerical calculations and simulations were performed to verify the protection power. A numerical calculation revealed the maximum explosion overpressure on the protective wall when the high-explosive exploded and the penetration force of the fragment against a 50 mm-thick protective wall to be 77.74 kPa and 41.34 mm, respectively. In the simulation verification using AUTODYN, the maximum explosion overpressures affecting the firewall and personnel were 56.68 kPa and 18.175 kPa, respectively, and the penetration of fragments was 35.56 mm. This figure is lower than the human damage limit, and it was judged that the protective power of the barrier would be effective.

• The Journal of Korean Philosophical History
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• no.50
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• pp.113-138
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• 2016

The purpose of this research is to establish the foundation for understanding the appearance of development, inheritance and acceptance of Toegye Yi Hwang(退溪李滉, 1501~1570)'s theory after his life by examining Udam Jeong Sihan(愚潭 丁時翰, 1625~1707)'s view on the Ido-seol(理到說), the Toegye's latter theory. After Toegye, Ido-seol was translated as 'The principle of matters reaches the human mind'. Galam Yi Hyunil(葛庵 李玄逸, 1627~1704), the contemporary scholar with Udam, criticized this translation for applying the directivity and motility to 'Li', the immovable principle. However, Udam agreed with the conventional interpretation of Ido-seol and understood it as the consilience of mind which got the entire principle(體) of 'Li(理)' and contained the application(用) of all things. He extended this concept as the level of 'sameness between objects and self [物我爲一]' based on his former theory, the exquisite interpretation of 'application of Li'. The meaning of 'sameness between objects and self[物我爲一]' is not amalgamation but applepie order of matter's principle in mind. The Udam's viewpoint is differ from Galam who tried to overcome the structural limit of Ido-seol by transforming 'Do(到)', the predicate of 'Ido(理到)', into 'Jin(盡)'. It means that he tried to interpret 'Ido(理到)' on the more essential aspect. His view can be the useful tool for understanding the Toegye's neo-Confucianism system with 'Li(理)' as central figure. It suggested that Udam's theory of the principle and the applecation of 'Li' can be the important theory to investigate the formation of Toegye schools' though and its development.

• (The)Study of the Eastern Classic
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• no.33
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• pp.97-129
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• 2008

Sin-jeokdo (Hogye, 1574-1663) was a general of patriotic army who protected the region of Euseong at the time of Qing dynasty's invasion in 1627(Jungmyo) and 1636(Byongja). He was an prominent figure outside government as well as a faithful confucian who spent his life with reading and teaching junior scholars after disgraceful treaty in the year of Byongja. Hogye understood the neo-Confucianism in terms of the whole duty of men(綱常) and righteousness(義理) which was in the status of sole official academic subject and thought its practice only hinged upon the practice of filial piety and brotherly love together with loyalty and sincerity based on morals between sovereign and subject, father and son. He, therefore, emphasized that the righteousness only can be accomplished by dying of children and subjects for filial piety and fidelity respectively, at the time of commotion. This was his spirit of righteousness which repelled Japanese army in the Imjin War and he insisted on defeating Japanese army in accordance with this spirit. Hogye's practice of righteousness is grounded on the spirit of Chosun Confucianism which stressed actual practices of moral principles and duties. His practice of righteousness shows internalized cultural sinocentrism and moral-centric, ethic-centric characteristic of Chosun Confucianism. Moreover, the moral consciousness which was shown in Hogye's thought helped to keep Korean's pride and observe morality and it served itself as a basis of commencement of nationalistic military, religious movements afterwards.

• The Journal of Korean Philosophical History
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• no.37
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• pp.97-134
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• 2013

Kim Ee-man was born and grew up in Jecheon (堤川). As a government officer and a Confucian scholar belonging to Namin School, Kim Ee-man was active in the early and middle of 18th century. Kim Ee-man composed good poems since he was a child. In addition to being a good poet, Kim Ee-man later became a model government officer, who had thorough awareness on serving citizens (爲民). When he was a governor in Yangsan (梁山) county, he built an embankment for farmers by out of his own salary. The academic world of Kim Ee-man faithfully succeeded the basis of Toegyehak (退溪學) and he took Sohak (小學) as important. The reason of Kim Ee-man having established a practical guideline in the form of inscription and proverbs was also directly related to the issue of moral practice. Kim Ee-man also received the influence of ancient classic study from his teacher Lee Seo-woo (李瑞雨) and took Yookgyeong (六經, Six Classics in China) important in practice. Kim Ee-man started the study on Joojahak (朱子學, the doctrines of Chu-tzu) in later years. He became more thorough in being a public figure while reinforcing effort on differentiating the principle of heaven (天理) and human desire (人欲).

• Journal of the Korean Institute of Rural Architecture
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• v.24 no.3
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• pp.23-30
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• 2022

In this study, in order to grasp the current situation of indoor environmental pollution and indoor ventilation in one-room around the university in the post-corona era, we analyzed the experimental data and conducted a questionnaire survey on university students. By analyzing the content, the effects of formaldehyde, dust and other pollution on the human body, which are usually not easily detectable, are digitized and more easily taken into account. Among the experimental results, the concentration of VOC and HCHO, gas pollutants among indoor pollutants, exceeded the recommended criteria of the Ministry of Environment in most studio apartments. Overall, the average CO₂ concentration was lower than the Ministry of Environment's maintenance standard (1000ppm), but it was relatively high in summer and winter, and it is believed to be caused by cooling and heating in an enclosed space. The levels of PM2.5 and PM10, particulate pollutants, increased in November and December, and it is believed that ventilation defects due to degradation in external temperature. There was no clear difference between the two types, and there was a very high correlation between PM2.5 and PM10, HCHO and VOC. It was found that temperature was closely correlated with all sources except CO₂, and humidity was closely correlated with all sources except PM2.5 and PM10. Health risk assessment was conducted for formaldehyde. The average ECR of studio R2 in May was 3.91E^-4, and the ECR figure in September was 3.65E^-4, which was very high compared to other residential spaces. The R2 level was calculated as 4 people per 10,000 people in the lifetime risk of cancer of residents, exceeding the allowable risk. R8 also showed higher ECR results than other spaces after R2, especially in October, 2.01E^-4, six times higher than R7 measured in October, and 1.87E^-4 in July, four times higher than R9.